Patient: Ima Sample. Accession: Shiloh Rd, Ste 101. Collected: 9/4/2018. Received: 9/6/2018 Alpharetta GA

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GI-MAP TM DNA Stool Analysis Patient: Ima Sample Accession: 20180906-0001 5895 Shiloh Rd, Ste 101 Collected: 9/4/2018 Received: 9/6/2018 Alpharetta GA 30005 877-485-5336 DOB: 9/1/2009 Completed: 9/6/2018 Ordered by: Diane Farhi, MD Pathogens Bacterial Pathogens Campylobacter <dl <1.00e3 C. difficile, Toxin A <dl <1.00e3 C. difficile, Toxin B <dl <1.00e3 Enterohemorrhagic E. coli <dl <1.00e3 E. coli O157 <dl <1.00e3 Enteroinvasive E. coli/shigella <dl <1.00e2 Enterotoxigenic E. coli LT/ST <dl <1.00e3 Shiga-like Toxin E. coli stx1 <dl <1.00e3 Shiga-like Toxin E. coli stx2 <dl <1.00e3 Salmonella <dl <1.00e4 Vibrio cholerae <dl <1.00e5 Yersinia enterocolitica <dl <1.00e5 Parasitic Pathogens Cryptosporidium <dl <1.00e6 Entamoeba histolytica <dl <1.00e4 Giardia 3.75e2 <5.00e3 Viral Pathogens Adenovirus 40/41 <dl <1.00e10 Norovirus GI/II <dl <1.00e7 1

H. pylori Helicobacter pylori 3.5e4 High <1.0e3 Virulence Factor, baba Positive Negative Virulence Factor, caga Negative Negative Virulence Factor, dupa Negative Negative Virulence Factor, icea Negative Negative Virulence Factor, oipa Negative Negative Virulence Factor, vaca Negative Negative Virulence Factor, virb Positive Negative Virulence Factor, vird Negative Negative Bacterial Flora Bacteroides fragilis 8.0e10 1.60e9-2.50e11 Bifidobacterium spp. 4.2e11 >6.70e7 Enterococcus spp. 4.8e5 1.9e5-2.00e8 Escherichia spp. 2.1e7 3.70e6-3.80e9 Lactobacillus spp. 6.7e7 8.6e5-6.20e8 Clostridium spp. 9.83e5 1.20e3-1.00e6 Enterobacter spp. 1.85e8 High 1.00e6-5.00e7 Phyla Microbiota Bacteroidetes 5.19e12 High 8.61e11-3.31e12 Firmicutes 7.40e10 5.70e10-3.04e11 Firmicutes:Bacteroidetes Ratio 0.01 <1.00 2

Opportunistic Bacteria Additional Dysbiotic/Overgrowth Bacteria Bacillus spp. 1.04e4 <1.50e5 Enterococcus faecalis 3.65e2 <1.00e4 Enterococcus faecium <dl <1.00e4 Morganella spp. <dl <1.00e3 Pseudomonas spp. <dl <1.00e4 Pseudomonas aeruginosa <dl <5.00e2 Staphylococcus spp. <dl <1.00e4 Staphylococcus aureus 9.67e0 <5.00e2 Streptococcus spp. 4.10e2 <1.00e3 Potential Autoimmune Triggers Citrobacter spp. <dl <5.00e6 Citrobacter freundii 2.04e5 <5.00e5 Klebsiella spp. <dl <5.00e3 Klebsiella pneumoniae <dl <5.00e4 M. avium subsp. paratuberculosis <dl <5.00e3 Prevotella copri <dl <1.00e7 Proteus spp. <dl <5.00e4 Proteus mirabilis <dl <1.00e3 Fungi/Yeast Candida spp. 1.01e2 <5.00e3 Candida albicans 1.42e2 <5.00e2 Geotrichum spp. <dl <3.00e2 Microsporidium spp. <dl <5.00e3 Rodotorula spp. <dl <1.00e3 Viruses Cytomegalovirus <dl <1.00e5 Epstein Barr Virus <dl <1.00e7 3

Parasites Protozoa Blastocystis hominis 1.98e3 <2.00e3 Chilomastix mesnili <dl <1.00e5 Cyclospora spp. <dl <5.00e4 Dientamoeba fragilis <dl <1.00e5 Endolimax nana <dl <1.00e4 Entamoeba coli <dl <5.00e6 Pentatrichomonas hominis <dl <1.00e2 Worms Ancylostoma duodenale Not Detected Not Detected Ascaris lumbricoides Not Detected Not Detected Necator americanus Not Detected Not Detected Trichuris trichiura Not Detected Not Detected Taenia spp. Not Detected Not Detected Intestinal Health Digestion Elastase-1 407 >200 ug/g Steatocrit 7 <15 % GI Markers b-glucuronidase 2178 <2486 U/mL Occult Blood - FIT 0 <10 ug/g Immune Response Secretory IgA 1188 510-2010 ug/g Anti-gliadin IgA 54 0-157 U/L Inflammation Calprotectin 113 High <50 ug/g Add-on Test Zonulin 32.4 <107 ng/g Antibiotic Resistance Genes, phenotypes Helicobacter Clarithromycin Positive Absent A2142C Absent A2142G Absent A2143G Present Fluoroquinolones Positive Absent gyra N87K Absent gyra D91N Present gyra D91G Absent gyrb S479N Absent gyrb R484K Absent Expected 4

Antibiotic Resistance Genes, genotypes Universal Microbiota Resistance Genes b-lactamase Negative Absent TEM-70 Absence CTXM3 Absence SHV-24 Absence VEB-1 Absence OXA-30 Absence CTXM35 Absence toho-3 Absence CTXM63 Absence PER-1 Absence PER-2 Absence GES-3 Absence NDM-1 Absence Fluoroquinolones Negative Absent qnra2 Absence qnrb Absence Macrolides Positive Absent erma Absence ermb Presence ermc Absence mefe Presence Vancomycin Negative Absent vana1 Absence vana2 Absence vanb Absence vanc Absence 5