MONSANTO MATERIAL SAFETY DATA 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: GENESIS Hybridizing Agent MSDS Number: S00012446 Date: May 18, 1996 Chemical Name: Formulation Synonyms: MON 21250 CAS Reg. No.: Not applicable, Formulated product CAS Reg. No. Active Ingredient: 82697-71-0 MONSANTO COMPANY, 800 N. LINDBERGH BLVD., ST. LOUIS, MO 63167 FOR EMERGENCY MEDICAL INFORMATION (call collect): (314) 694-4000 FOR CHEMICAL EMERGENCY, SPILL LEAK, FIRE, OR ACCIDENT Call CHEMTREC - Day or Night - 1-800-424-9300 Toll free in the continental U.S., Hawaii, Puerto Rico, Canada, Alaska, or Virgin Islands. For calls originating elsewhere: 703-527-3887 (collect calls accepted) For additional non-emergency information, call: 1-800-332-3111 2. COMPOSITION/INFORMATION ON INGREDIENTS Component CAS No. % by weight Active Ingredient: MON 21200; 2-(4-Chlorophenyl)-3-ethyl-2,5-dihydro-5- oxo-4-pyridazinecarboxylic acid, potassium salt* 82697-71-0 22.5% Inert ingredients: Trade Secret+ 77.5% * Hazardous chemical(s) under the criteria of the OSHA Hazard Communication Standard (29 CFR 1910.1200). +The specific chemical identity is withheld because it is trade secret information of Monsanto Company. 3. HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Appearance and Odor: dark brown liquid with no obvious odor WARNING STATEMENTS
GENESIS Hybridizing Agent Page 2 of 6 Keep out of reach of children. CAUTION! CAUSES EYE IRRITATION REFORMULATION IS PROHIBITED. LIMITATIONS SEE INDIVIDUAL CONTAINER LABELS FOR REPACKAGING POTENTIAL HEALTH EFFECTS Likely Routes of Exposure: skin contact and inhalation Eye Contact: Skin Contact: Inhalation: Ingestion: No more than slightly irritating based on toxicity studies. May cause pain, redness and tearing based on toxicity studies. No more than slightly toxic and slightly irritating based on toxicity studies. No more than slightly toxic based on toxicity studies. No more than slightly toxic based on toxicity studies. No significant adverse health effects are expected to develop if only small amounts (less than a mouthful) are swallowed. Refer to Section 11 for toxicological information. 4. FIRST AID MEASURES If in eyes: Immediately flush with plenty of water. If easy to do, remove any contact lenses. Remove material from skin and clothing. Get medical attention. NOTE: For additional human emergency first aid or treatment guidance, call collect, anytime, day or night, 314-694-4000. 5. FIRE FIGHTING MEASURES Flash Point: >200 degrees F (>93.3 degrees C) Hazardous Products of Combustion: None known Extinguishing Media: In case of fire, use water spray (fog), foam, dry chemical, or CO2. Unusual Fire and Explosion Hazards: None known Fire Fighting Equipment: Fire fighters and others exposed to products of combustion should wear self-contained breathing apparatus. Equipment should be thoroughly decontaminated after use. 6. ACCIDENTAL RELEASE MEASURES Observe all protection and safety precautions including use of rubber boots or overshoes when cleaning up spills -- see Exposure Controls/Personal Protection, Section 8.
GENESIS Hybridizing Agent Page 3 of 6 Liquid spills on floor or other impervious surfaces should be contained or diked and should be absorbed with attapulgite, bentonite or other absorbent clays. Collect contaminated absorbent, place in a plastic lined metal drum and dispose of in accordance with instructions provided under DISPOSAL CONSIDERATIONS. Thoroughly scrub floor with a strong industrial type detergent solution and rinse with water. Liquid spills that soak into the ground should be dug-up, placed in plastic-lined metal drums and disposed of in accordance with instructions provided under DISPOSAL CONSIDERATIONS. Leaking containers should be separated from non-leakers and either the container or its contents transferred to a plasticlined drum or other non-leaking container. Dispose of leaking container in accordance with instructions provided under disposal. Refer to Section 13 for disposal information and Section 15 for reportable quantity information. 7. HANDLING AND STORAGE HANDLING: Avoid contact with eyes or clothing. Wash thoroughly with soap and water after handling. Do not apply directly to water, to areas where surface water is present or to intertidal areas below the high water mark. Do not contaminate water when disposing of equipment washwaters. Emptied container retains vapor and product residue. Observe all labeled safeguards until container is cleaned, reconditioned, or destroyed. DO NOT REUSE THIS CONTAINER. Storage: Long term stability is being determined. However, shelf life stability of at least two years is expected. Store under cool, dry conditions (below 120 degrees F). Do not store under moist conditions. Do not store below 40 degrees F. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Eye Protection: Does not cause significant eye irritation or eye toxicity requiring special protection. Use good industrial practice to avoid eye contact. Skin Protection: Does not present significant skin concern requiring special protection. Respiratory Protection: This product is not likely to present an airborne exposure concern under normal use. Use NIOSH/MSHA approved respiratory protection equipment when airborne exposure is excessive. Consult respirator manufacturer to determine appropriate type equipment for given application. Observe respirator use limitations specified by NIOSH/MSHA or the manufacturer. Respiratory protection programs must comply with 29 CFR '1910.134. Ventilation: Provide natural or mechanical ventilation to minimize exposure. The use of local mechanical exhaust ventilation at sources of air contamination such as open process equipment is preferred. Airborne Exposure Limits: Product/Component OSHA PEL ACGIH TLV GENESIS7 hybridizing Agent None established None established MON 21200 None established None established
GENESIS Hybridizing Agent Page 4 of 6 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance: dark brown liquid Odor: no obvious odor ph: 8.0 @ 24 degrees C Viscosity: 3.39 mpa.s at 20 degrees C Specific Gravity: 1.12 g/ml @ 20 degrees C Molecular Weight: 316.8 NOTE: These physical data are typical values based on material tested but may vary from sample to sample. Typical values should not be construed as a guaranteed analysis of any specific lot or as specifications for the product. 10. STABILITY AND REACTIVITY Stability: Stable. Some sedimentation on bottom of container is expected. Materials to Avoid: None known Hazardous Decomposition Products: None known Hazardous Polymerization: Will not occur Incompatibility: None known 11. TOXICOLOGICAL INFORMATION Data from Monsanto studies with this material are listed below: Oral LD 50 (Rat): Dermal LD 50 (Rat): Eye Irritation (Rabbit): Skin Irritation (Rabbit): Acute Inhalation (Rat, 4-hr LC 50 ): Sensitization (G. Pig): >5000 mg/kg, Practically Nontoxic (Category IV) >5000 mg/kg, Practically Nontoxic (Category IV) Slightly Irritating (Category III) Slightly Irritating (Category IV) >9.2 mg/l in air (Category IV) Negative COMPONENTS Data on Monsanto studies and from the available literature on the components of this material which have been identified under the criteria of the OSHA Hazard Communication Standard (29 CFR '1910.1200) are discussed below: MON 21200 MON 21200 is considered slightly toxic (LD 50 > 5000) following single oral administration to rats. It is practically nontoxic (LD 50 > 5000) following dermal application to rats. It is moderately irritating in a rabbit eye study and nonirritating in a rabbit skin irritation study. MON 21200 was not a sensitizer in a dermal sensitization study with guinea pigs. No evidence of genotoxicity was observed in a standard battery of in vitro and in vivo studies. Subchronic studies have been conducted in rats, mice and dogs. No effects were noted in mice at a dietary concentration of 7,000 ppm (approximately 1000 mg/kg/day). Equivocal effects on weight gain and kidney weight were noted in rats at 20,000 ppm while no effects were noted at 5000 ppm (approximately 250 mg/kg/day). Excessive toxicity (mortality, vomiting, anemia, some indications of potential neurotoxicity, and histopathological lesions of the thymus and testes) were
GENESIS Hybridizing Agent Page 5 of 6 noted in dogs at 500 mg/kg/day. Some toxicity was also noted at 200 mg/kg/day but no effects were reported at 50 mg/kg/day. The chronic toxicity of MON 21200 has been investigated in a two-year study in rats and a one-year study in dogs. The no-observed effect level in both studies was 5 mg/kg/day. Kidney and liver toxicity was observed in rats; liver, thymus and testicular effects were noted in dogs. The two-year study in rats and an 18-month study in mice showed no evidence of treatment-related tumors. Neither maternal nor developmental toxicity was noted when MON 21200 was administered to pregnant rats at dose levels up to 1000 mg/kg/day. Excessive maternal toxicity but only slight developmental toxicity was noted when pregnant rabbits were administered MON 21200 at a dose level of 500 mg/kg/day. No maternal or developmental effects were noted in rabbits at 150 mg/kg/day. In a reproductive toxicity study, MON 21200 was fed to rats at high dose levels for two successive generations. There were no effects on mating or fertility at any dose level up to 20,000 ppm (1000 mg/kg/day). Decreased pup survival and a slight reduction in pup weight were observed only at the two highest dose levels of 5000 and 20,000 ppm, where there was also parental toxicity. The no-observed-effect-level was 500 ppm (45 mg/kg/day) for both parental and reproductive toxicity. Results from rat metabolism studies indicate that MON 21200 is well absorbed orally but rapidly excreted (primarily unchanged) via the urine. 12. ECOLOGICAL INFORMATION Acute aquatic and wildlife toxicity studies have been conducted with MON 21200 and MON 21233 (a 22% aqueous solution of MON 21200). The results of these studies, expressed as MON 21200 acid equivalents are listed below. duck acute oral LD 50 : >2000 mg/kg quail acute oral LD 50 : 1414 mg/kg duck 5-day dietary LC 50 : >5200 ppm quail acute oral LD 50 : >5200 ppm honeybee contact LD 50 : >100 ug/bee honeybee dietary LC 50 >100 ug/bee earthworm LC 50 : >1000 ppm trout 96-hour LC 50 : >990 mg/l, practically nontoxic bluegill 96-hour LC 50 : >1000 mg/l, practically nontoxic carp 96-hour LC 50 : >1000 mg/l, practically nontoxic Daphnia 48-hour LC 50 : >5400 mg/l, practically nontoxic Selenastrum 96-hour EC 50 : 640 g/l (biomass), practically nontoxic 13. DISPOSAL CONSIDERATIONS This material when discarded is not a hazardous waste as that term is defined by the Resource, Conservation and Recovery Act (RCRA), 40 CFR 261. Wastes resulting from the use of this product that cannot be used or chemically reprocessed should be disposed of in a landfill approved for pesticide disposal or in accordance with applicable Federal, state or local procedures. Emptied container retains vapor and product residue. Observe all labeled safeguards until container is destroyed.
GENESIS Hybridizing Agent Page 6 of 6 Do not reuse emptied container. Triple rinse container, then puncture and dispose of in a sanitary landfill or by incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke. Consult your attorney or appropriate regulatory officials for further information on such disposal. 14. TRANSPORT INFORMATION The data provided in this section is for information only. Please apply the appropriate regulations to properly classify your shipment for transportation. This product is not hazardous under the applicable DOT, IMDG, or IATA/ICAO regulations 15. REGULATORY INFORMATION TSCA Inventory: All components are listed. SARA Hazard Notification Hazard Categories Under Title III Rules (40 CFR 370): Immediate Section 302 Extremely Hazardous Substances: Not applicable Section 313 Toxic Chemical(s): Not applicable CERCLA Reportable Quantity: Not applicable Refer to Section 2 for OSHA Hazardous Chemical(s) and Section 13 for RCRA classification. 16. OTHER INFORMATION Reason for revision: Routine review and conversion to the 16 section format. Supersedes MSDS dated 12/92 This Material Safety Data Sheet (MSDS) serves different purposes than and DOES NOT REPLACE OR MODIFY THE EPA-APPROVED PRODUCT LABELING (attached to and accompanying the product container). This MSDS provides important health, safety, and environmental information for employers, employees, emergency responders and others handling large quantities of the product in activities generally other than product use, while the labeling provides that information specifically for product use in the ordinary course. Use, storage and disposal of pesticide products are regulated by the EPA under the authority of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) through the product labeling, and all necessary and appropriate precautionary, use, storage, and disposal information is set forth on that labeling. It is a violation of federal law to use a pesticide product in any manner not prescribed on the EPA-approved label. Although the information and recommendations set forth herein (hereinafter "Information") are presented in good faith and believed to be correct as of the date hereof, Monsanto Company makes no representations as to the completeness or accuracy thereof. Information is supplied upon the condition that the persons receiving same will make their own determination as to its suitability for their purposes prior to use. In no event will Monsanto Company be responsible for damages of any nature whatsoever resulting from the use of or reliance upon Information. NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER NATURE ARE MADE HEREUNDER WITH RESPECT TO INFORMATION OR THE PRODUCT TO WHICH INFORMATION REFERS. GENESIS is a registered trademark of Monsanto Company Genesis.596.doc