Heart Health Matters PRAGUE CONGRESS CENTRE PRAGUE, CZECH REPUBLIC 28 SEPTEMBER 1 OCTOBER sponsorship opportunities 04/11/15 1

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Heart Health Matters PRAGUE CONGRESS CENTRE PRAGUE, CZECH REPUBLIC 28 SEPTEMBER 1 OCTOBER 2016 sponsorship opportunities 04/11/15 1

Join us in Prague Dear Friends, As President of The International Menopause Society and Chairman of the Organising Committee for the 15th World Congress on The Menopause it is my great pleasure to invite you to join in Prague, capital of the Czech Republic, from Wednesday 28 September to Saturday 1 October 2016. In the past IMS World Congresses have taken place every three years, but the IMS Board has now decided to move to a biannual cycle, commencing with this, our 15th World Congress. Prague is a wonderful venue: full of history, in the centre of Europe and vibrantly progressive at the same time. Our Scientific Committee, headed by Professor Susan Davis, has already begun planning what will be a highquality, globally-relevant programme befitting both a World Congress and the IMS's commitment to promote and advance communication, education and research on all aspects of adult women's health worldwide. Rod Baber President of The International Menopause Society and Chairman of the Organising Committee for the 15th World Congress on the Menopause On behalf of the IMS Scientific Programme Committee I invite you to join us for the 15th World Congress on the Menopause to be held in Prague, 2016. For the first time this flagship Congress of the IMS will have a theme: Heart Health Matters. This will give the delegates a focus and reinforces the IMS's overarching mission, to improve midlife women s health. Cancun 2014 was a great success and the feedback was resoundingly positive. We were delighted that the Cancun Congress stimulated a variety of suggestions for sessions in 2016 and we have taken these on board. This has led to a stellar line-up of international plenary and symposia speakers who have already agreed to speak at the Congress. They will be addressing issues pertaining to our core theme as well as a diverse range of health issues that affect women at midlife. We will hold a number of controversy and 'meet-the-expert sessions in order to enable delegates to interact, sharing their knowledge and experience. We expect this meeting will surpass the 2014 IMS World Congress on multiple levels. We have had the opportunity to build on the Cancun experience and Prague is a central, accessible and enticing destination. We look forward to sharing Prague 2016 with you. Susan R Davis Chair, Scientific Programme Committee for the 15th World Congress on the Menopause. IMS Officers and Board 2014-2016 President Rod Baber (AU) General Secretary Victor Henderson (US) Treasurer Mary Ann Lumsden (UK) Past President Tobie De Villiers (ZA) Board Peter Chedraui (EC) Susan Davis (AU) Steven Goldstein (US) Elaine Jolly (CA) Nilson de Melo (BR) Alfred Mueck (DE) Faustino Perez-Lopez (ES) Duru Shah (IN) Tommaso Simoncini (IT) Florence Tremollieres (FR) Svetlana Vujoic (RS) Cams President Camil Castelo-Branco (ES) Executive Director Lee Tomkins (UK) The Congress Chairman of the Congress Rodney Baber (AU) Chairman of the Local Organizing Committee Tomas Fait (CZ) Organizing Committee Chair Rodney Baber (AU) Committee Members Susan Davis (AU) Tobie De Villiers (ZA) Tomas Fait (CZ) Victor Henderson (US) Mary Ann Lumsden (UK Scientific Programme Committee Chair Susan Davis (AU) Co-Chair Tommaso Simoncini (IT) Committee Members Rodney Baber (AU) Robin Bell (AU) Peter Chedraui (EC) Nilson De Melo (BR) Steven Goldstein (US) Victor Henderson (US) Elaine Jolly (CA) Mary Ann Lumsden (GB) Alfred Mueck (DE) Sharon Parish (USA) Faustino Perez-Lopez (ES) Duru Shah (IN) Nimit Taechakraichana (TH) Florence Tremollieres (FR) Svetlana Vujovic (RS) Qu Yi (CN) Organizing Secretariat Biomedical Technologies srl www.btcongress.com Main Office and Accounting Department Via P. Cugia 1 09129 Cagliari Italy T. +39 070340293 F. +39 070307727 registrations: ims2016reg@btcongress.com information: ims2016@btcongress.com Marketing Office T. +39 068546198 marketing@btcongress.com Scientific Secretariat scientificsec@imsprague2016.com 2

Facts and Figures from the previous edition (2014) from Africa from Oceania from North America 2014, Cancun Mexico more than 1700 participants Web activity (between February and May 2014) 13.903 visits - 8.016 visitors from South America from Asia from Europe "It was a very important opportunity to exchange experiences and update knowledge" The exhibiton area was 3400 m 2, the biggest booths were were over 100m² big The Congress was supported by 20 Pharma companies, 19 of which also decided to be part of the exhibition area Congress Sessions in 2014 Pieter Van Keep Lecture 1 Symposia / Hot Topic 33 Lunch Symposia 5 Plenary Lectures 13 Meet the Expert / Controversy 23 CAM Sessions / Scientific Society 18 Abstracts received 468 Abstracts accepted 272 > presented as Oral Communications 207 > presented as posters 65 Scientific Societies who supported the Congress in 2014 During IMS Congresses numerous scientific societies organize a session in order to share data. The following societies were present in 2014: IMS CAM Societies network AMEC Asia Pacific Menopause Society Brazilian Menopause Society Indian Menopause Society SIGMA Colombian Menopause Society European Progestogen Club SOCHEG AAPEC NAMS EMAS Spain Menopause Society Indonesia Menopause Society Sociedad Ecuatoriana Climaterio Bolivian Menopause Society British Menopause Society International Society of Gynecological Endocrinology Korean Menopause Society Sociedad Chilena de Climaterio FRACSYM A 3

Congress Venue Ground Floor Congress Secretariat Secretariat First Floor Panorama Hall (400 PAX) Meeting Hall 1 (400 PAX) Club B Club C Club D Poster area Second Floor Forum Hall (1000 PAX / 650 PAX) North Hall 1 (220 PAX) 4

FORUM (1000) PANORAMA (400) MEETING 1 (400) NORTH HALL (220) DAY 1 Wednesday, Sept. 28 th 09.00-10.15 Exhibition Area Opening CAMS General Assembly 10.30-11.00 Plenary Lecture 11.00-12.30 Oral Communications 12.30-13.00 Visit to the Exhibition Area 13.00-14.30 Lunch Symposium 14.30-14.45 Visit to the Exhibition Area 14.45-16.15 Symposium Symposium Symposium Symposium 16.15-17.15 Controversy Controversy Controversy Scientific Society 17.30-18.00 Pieter van Keep Lecture 18.00-18.15 Henry Burger Oration 18.15-18.45 Opening Ceremony 19.00 Welcome reception PL CT MTE SY SC OC Plenary Lecture Controversy Meet the Expert Symposium Symposium by Scientific Societies Oral Communication FORUM (650) PANORAMA MEETING 1 NORTH HALL CLUB B CLUB C CLUB D DAY 2 Thursday, Sept. 29 th 07.45-08.45 SC SC SC SC SC SC 09.00-09.30 PL 09.30-10.00 PL 10.00-11.00 MTE MTE MTE MTE MTE MTE 11.00-12.30 SY SY SY SY 12.30-12.45 Visit to the Exhibition Area 12.45-14.15 Lunch SY Lunch SY 14.15-14.30 Visit to the Exhibition Area 14.30-16.00 SY OC OC OC OC 16.05-17.05 CT CT SC CT SC 17.10-17.40 PL 17.40-18.10 PL DAY 3 Friday, Sept. 30 th 07.45-08.45 SC SC SC SC SC SC 09.00-09.30 PL 09.30-10.00 PL 10.00-11.00 MTE MTE MTE MTE MTE MTE 11.00-12.30 SY SY SY SY 12.30-12.45 Visit to the Exhibition Area 12.45-14.15 Lunch SY Lunch SY 14.15-14.30 Visit to the Exhibition Area 14.30-16.00 SY OC OC OC OC 16.05-17.05 CT CT CT SC SC 17.10-17.40 PL 17.40-18.10 PL Poster Session IMS General Assembly FORUM (650) PANORAMA NORTH HALL CLUB B CLUB C CLUB D DAY 4 Saturday, Oct.1 st 07.45-08.45 SC SC SC SC SC 09.00-09.30 PL 09.30-10.00 PL 10.00-11.30 SY OC OC OC OC OC 11.30-12.30 MTE MTE MTE MTE MTE MTE 12.30-12.45 Visit to the Exhibition Area 12.45-14.30 Lunch SY 14.30-14.45 Visit to the Exhibition Area 14.45-16.15 SY SY SY SC 5

The Scientific Program This is the state of the program as of April 2015. More sessions will be added. The most up-to-date version is available via the Congress website. T The Congress's Scientific Program will be based on the IMS Mission Statement: to promote and advance communication, education and research on all aspects of the health of adult women world-wide. Key experts will update you on the latest scientific evidence that can be related to daily clinical practice and basic research. The most relevant new developments will be addressed by the best speakers in the Plenary sessions at the Congress. Basic research will be presented in Oral Communication and Poster sessions. Controversial topics will be debated by experts. 'Meet the Expert' sessions will enable more personal contact with experts. The Scientific Committee will ensure that the Program contains the most up-to-date topics, controversies and the best available Faculty, as per our Mission Statement. Plenary Lectures Doris Taylor (US) Rebuilding a broken heart Rod Baber (AU) Pieter van Keep lecture Phillipe Bouchard (FR) Progestogens and breast cancer: causation and prevention Gunter Von Minckwitz (DE) Understanding the health consequences of adjunct breast cancer therapy Giuseppe Rosano (IT) Cardiovascular disease in women, is it different to men? Bart Fauser (NL) Does PCOS cause heart disease? John Ionnadis (US) Can we believe the data? Harald Hampel (DE) Can we prevent the Alzheimer tsunami? Alex Miras (UK) What is the role of bariatric surgery in the management of obesity? Tobie de Villiers (ZA) Future strategies for fracture prevention Robin Daly (AU) Lifestyle approaches to prevent falls, fractures and frail bones: an update of the evidence Symposia Hormones and the heart: do they help or hurt? Susan Davis (AU) Androgens Regine Sitruk-Ware (US) Progestogens Hormones and the brain Claudio Soares (CA) Is it depression or menopause? Martha Hickey (AU) Predictors and time course of depression across the menopause transition Pauline Maki (US) Depression and cognition in the menopausal transition Challenges in breast cancer Alfred O. Mueck (DE) Do all progestogens increase breast cancer risk? Hadji Peyman (DE) Breast cancer effects on bones and joints Nicoletta Biglia (IT) Coping with the menopause after breast cancer: quality of life and sexual well-being What have we learned from longitudinal studies of women s health? Gita Mishra (AU) What are we learning from InterLACE? Kunihiko Hayashi (JP) Lessons from the Japan Nurses Health Study Alissa Goodman (UK) Lessons from the National Child Development Study (1958 cohort) Fat matters Angelica Linden Hirshberg (SW) Neuroendocrine basis of fat accumulation at the time of the menopause Tommaso Simoncini (IT) Metabolic and cardiovascular implications of fat accumulation at the time of the menopause Irene Lambrinoudaki (GR) Dietary and lifestyle interventions to counteract fat accumulation at the menopausal transition 6

The IMS thanks members of the Scientific Program Committee for their considerable efforts in developing the Scientific Program. No pharmaceutical company has been involved in the selection of either topics or speakers. Endometriosis update Areepan Sophonsritsuk (TH) The immunological aspect and epigenetics of endometriosis Ludwig Kiesel (DE) Medical treatment of endometriosis at the menopausal transition and beyond Charles Chapron (FR) Surgical approach to endometriosis in peri- and postmenopausal women Osteoporosis: from the womb to the grave Cyrus Cooper (UK) Epigenetic mechanisms in the developmental origins of osteoporosis, and implications for life course prevention Florence Tremollieres (FR) A clinical approach to early menopausal osteopenia and osteoporosis Joon Kiong Lee (MY) Postmenopausal osteoporosis in Asia: unmet needs? Focus on sexual health Sharon J. Parish (US) Beyond the DSM V: update in the classification and treatment of female sexual disorders Annamaria Giraldi (DK) New pharmacological therapy for FSD: focus on centrally acting agents Woet Giannotten (NL) Sexuality in the aged woman Caring for women with Turner syndrome Wendy Wolfman (CA) Optimizing hormone therapy in TS Claus Gravholt (DK) CVD and TS women: what are the risks and when and how to screen Camil Castelo-Branco (ES) Improving well-being and sexual function in women with TS in addition Special Symposium The Hot Flush Naomi Rance (US) Understanding the etiology of the hot flush Rebecca Thurston (US) CVD risk and flushing Controversies Can we effectively treat menopausal symptoms without hormones? Common vulval conditions in periand postmenopausal women Do hormones cause thrombosis? Contraception during female midlife Basics in biostats: understanding the published literature and introduction to study design Can women at risk of cardiovascular disease be treated with hormone therapy? Ovarian insufficiency before 40 what s new? Disorders of sleep Meeting the challenge of health equity for women across the globe Duru Shah (IN) Optimizing access to health care for aging women in India Qi Yu (CN) Attitude and know-how towards menopause and menopause management among Chinese women and medical workers Nicole Jaff (ZA) Meeting the challenge of menopause in South Africa Peter Chedraui (EC) Meeting the needs of women at midlife in South America The stroke in women James Simpkins (US) Are hormones protective for stroke? Christel Renoux (CA) Hormone therapy: dose, formulation and risk of ischemic stroke Screening for gynecological cancers Daniela Fischerova (CZ) Ultrasound in screening for gynecological malignancy Usha Menon (UK) Screening for ovarian cancer Rengaswamy Sankaranarayanan (FR) Screening for cervical cancer in lowto middle-income countries 7

Sponsorship General Information Insurance It is essential for companies participating in the commercial exhibition to insure all goods and any materials exhibited at their stand. Third party public liability insurance should also be secured. The organization is not responsible for any damages to exhibited goods, nor any damages which may be caused to third parties by goods from the commercial exhibition. Cancellations Cancellations should be requested in writing, sent by email, fax or post and receipt confirmed. Cancellations of reservations made before June 28th 2016 carry a 50% charge on the total amount. No refunds will be made if the cancellation occurs after June 28th 2016. Symposia audio/video recording Symposia audio/video recording is available through the congress organization. The speakers' authorization to record and distribute must be provided by the session sponsor. Special conditions Those exhibitors who wish to use audiovisual systems in their stands should contact the Technical Secretariat in order to allow the Organizing Committee to assess and approve its use. Requests should be submitted in writing, outlining the characteristics, running and purpose of these systems. Method of payment Payments deadlines are defined in each contract. Usually a 50% deposit is to be paid within 30 days following the reservation. No bookings will be confirmed until the deposit has been paid. The outstanding balance is to be paid before June 28th 2016. Payments should be made by bank transfer to the bank account indicated in the corresponding invoice. Register groups of delegates Registration Fees Until June 28 th 2016 After June 28 th 2016 Delegate IMS Member / Developing countries / Trainees 550,00 700,00 Delegate 650,00 800,00 Registration Fee includes: Opening Ceremony Closing Ceremony Access to all sessions Access to exhibition area Congress kit Abstract Book/CD CME credits Group registration: Companies and Agencies must include all the personal data indicated on the registration form when submit their list of registrants. The Organizing Secretariat can provide a sample excel file to be filled out and emailed to ims2016reg@btcongress.com. Accommodation can be accepted only upon pre-registration. For inquiries about registration or delegate participation please contact ims2016reg@btcongress.com. EFPIA It is the Sponsors' and Exhibitors' responsibility to comply with the local authority's regulations, the EFPIA (European Federation of Pharmaceuticals Industries & Associations - www.efpia. org) and the IFMPA (International Federation of Pharmaceutical Manufacturers & Associations - www.ifpma.org) Code of Practice on the Promotion of Medicines. 8

Sponsored Symposia, Lectures, Courses Organization of Symposia The Organizing Committee has addressed the possibility for Sponsored Symposia at the following prices. - Please note that speakers and titles of all the sponsored symposia are subject to approval by the Scientific Committee. Opening Lunch Symposium (Wednesday September 28 th ) Time 120 1000 pax Lunch Symposia 80.000,00 + lunch box Time 650pax hall 400pax hall 90 50.000,00 + lunch box 40.000,00 + lunch box No other concurrent sessions. Two lunch symposia will be organized on Thursday and Friday. No other food will be provided by the Congress. Lunch boxes costs and menu will be decided with the sponsor. 90 40.000,00 + lunch box - One lunch symposia will be organized on Saturday. No other concurrent sessions. Lunch boxes costs and menu will be decided with the sponsor. Other Symposia Time 400pax halls 220pax halls 90 40.000,00 25.000,00 Included in the price of a Symposium Hall with a capacity in accordance with the chosen option. Sound system and audiovisual equipment Hostess/Attendant Publication of abstracts: Abstracts for sponsored symposia sessions will be published in the official meeting abstracts CD-Rom, provided they are received by the published deadline 6 full Congress registrations to be used for the sponsor s medical or marketing staff (cannot be used for speakers, chairs or delegates). Symposia: basic rules 2 chairpersons > One of them will be chosen by the Scientific Secretariat (also these chair costs will be charged to the sponsor) > A chairperson may not be both speaker and chair at the same session 3 to 4 speakers Titles and speakers must be submitted to the scientific committee no later than June 7 th 2016. Not included in the price (the sponsor must cover the following costs for speakers and chairpersons) X Registration at a regular fee X Hotel accomodation for the entire duration of the Congress X Travel Expenses from their domicile to Prague and back Invited speaker expenses (travel, hotel accommodation and fees) are not included in the cost of the Sponsored Symposia or Lecture. An invoice for 50% of the cost will be issued on receipt of the request. The session will not be registered as confirmed until this invoice is paid. An invoice for the remaining 50% will be issued before June 20th. 9

Exhibition Area Map First Floor 1 9x5 10 8x7 Access to Hall Meeting 1 400pax 2 3x3 3 4 5 6 4x3 13 9x5 15 3x3 16 17 12 3x3 11 3x3 Access to Hall Panorama 400pax 18 7 7x5 19 3x2 32 8 7x5 20 21 27 28 29 22 3x3 23 3x3 24 3x3 25 3x3 26 3x3 Poster Area 30 31 secretariat PREPAID 10

Exhibit at the Congress Prices of booth spaces Size Included in booth/exhibit display space: Floor space Power supply available throughout the hall Daily cleaning of public areas General Security Guard service covering the exhibit hall Exhibitor s Manual Company name included in official congress documents Two exhibitor badges for every 6m² of space allocated (up to a maximum of ten badges) X Rental of exhibit space does not include a display booth. Cost 6 m² 9.000,00 9 m² 12.000,00 12 m² 15.000,00 18 m² 21.000,00 24 m² 26.000,00 32 m² 32.000,00 48 m² 44.000,00 other upon request Payment schedule 50% deposit of the stand cost (+ VAT) to be paid at the time of reservation. No bookings will be confirmed until the deposit has been paid. The remaining 50% balance (+ VAT) must be settled before 28 June 2016. Booking forms received after 28 June 2016 must be accompanied by payment in full. Cancellation Policy Cancellations should be requested in writing, sent by email, fax or post and receipt confirmed. Reservations cancelled before before June 28th 2016 carry a 50% charge on the total amount. No refunds will be made if the cancellation occurs after June 28th 2016. Who came to visit my booth? (Barcode scanner - OPTIONAL) Barcodes will be printed on each badge. Barcode scanners are available for the exhibitors if ordered in advance. Further information and prices are available on request. Things to consider about the exhibition area The Congress will be held on the first and second floor of the Prague Convention Center. Each floor will offer numerous elements for delegates to discover. On the first floor there will be: the poster session 5 congress halls (3 for 70pax, 2 for 400pax; one of the daily lunch symposia will be held here) one part of the exhibition area. On the second floor delegates will find: 2 congress halls (one for 650pax that will be used for lunch symposia and one for 220pax) another part of the exhibition area. The first day Welcome Drinks will be held in the exhibition area and spread across both floors. 11

Other Sponsorship Opportunities Bags * Delegate bags featuring the Congress name and the Company's logo, as well as pads and pens bearing the company logo Exclusive Sponsor 8.000,00 + pads, bags and pens production costs. Badges and lanyards * The Company s logo will be placed on the front of the badge, with a commercial advertising on the back; both sides will be printed in full color. Exclusive Sponsor 8.000,00 + lanyard production costs. * Companies which support the production of bags or lanyards are entitled to print the company name on the merchandise. The sponsors will provide the bags/ lanyards. Alternatively these can be produced by Biomedical Technologies, in which case Biomedical Technologies will invoice the production and delivery costs to the sponsors, in addition to the fee payable for advertising rights. Pocket programme Exclusive advertisement on the back cover of the pocket-size programme Exclusive Sponsor 10.000,00 The Congress provides many sponsorship opportunities which can increase an organization s visibility with attendees. The following is a list of options. However, the Organizing Committee is open to receiving other suggestions or proposals. Great visibility Delegates carry it with them, using it to locate the lectures they are interested in. Insertion of advertising leaflet in delegate bags 2.500,00 each Advertising in digital newsletters Each month newsletters strictly related to the Congress will be sent to a list of minimum 30.000 contacts. Spaces for different-sized banners will be available. Exclusive Sponsor: 1.500,00 per edition Multi-sponsor edition (max 3 sponsors): 800,00 per edition A great way to promote your symposium Reach people before the congress starts Advertising in the digital editions of the Preliminary and Advanced and Final Programme Exclusive sponsor: 2.500,00 per edition Multi-sponsor edition (max 3 sponsors): 1.500,00 per edition Digital editions of the programmes will be distributed through the Congress website. Advertising in the Final Programme Inside page 3.500,00 Inside front or inside back cover 5.000,00 Back cover 7.500,00 Abstracts USB stick Complete transcriptions of the abstracts from the Plenary Sessions, Plenary Lectures and Oral and Poster presentations. Sponsorship of this service includes a USB stick which automatically opens a page with Company advertising, the Company logo featured on the home page and the stick itself, as well as full acknowledgement in the Final Programme. USB sticks would be collected by each participant at the sponsor's booth. 20.000,00 Signs This sponsorship item includes acknowledgements in the Final Programme as well as the Company name and logo featured on each panel. Exclusive Sponsor: 20.000,00 A great way to bring delegates into your booth and give them a gadget The USB stick can also be used to store personal files. Most delegates will come to your booth to collect it. 12

Other Sponsorship Opportunities Congress Secretariat Place your company or product logo on the back of the Congress Secretariat. This sponsorship item includes acknowledgements in the Final Programme. Exclusive Sponsor: 10.000,00 Company logo on the halls screens Company or product logo projected on the halls screens at the end of each session. This sponsorship item includes acknowledgements in the Final Programme. Exclusive Sponsor: 15.000,00 Multi-sponsor edition: 8.000,00 Open Wi-Fi All devices with a Wi-Fi connection will be able to access to the internet and other e-services. Your company s name or another word indicated by the sponsor will be the password to access to the Wi-Fi. Exclusive Sponsor: 20.000,00 Boost your reputation When attendees have had to type a sponsor s name to gain Wi-Fi access in previous editions they have usually been very grateful to the sponsor! Web check-in station Provision of 4 computers, servers and internet access will be included in the package. Sponsorship of this service includes acknowledgements in the Final Programme and the Company logo on all computers in the centre. Exclusive Sponsor: 7.500,00 Networking Activities Opening Ceremony - Get together in the Exhibition Area This service includes the printing of invitation cards bearing the Company logo, as well as acknowledgements in the Final Programme. Exclusive Sponsor: 25.000,00 Poster Session This sponsorship item envisages the organization of the poster session, as well as the provision of light refreshments (finger food and cold beverages) during the session. Sponsorship includes the printing of invitation cards for all delegates, the Company logo featured on the poster panels, as well as acknowledgements in the Final Programme. Exclusive Sponsor: 25.000,00 Presidential Dinner This service includes a brief address to participants by a high-level company representative with the opportunity to promote the company s corporate mission and achievements to invited guests. Also included are the printing of invitation cards bearing the Company logo, as well as free entrance to the Dinner for ten of the Sponsor s guests. The dinner will host 250 pax. Exclusive Sponsor: 35.000,00 13

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