University of Groningen. Real-world influenza vaccine effectiveness Darvishian, Maryam

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University of Groningen Real-world influenza vaccine effectiveness Darvishian, Maryam IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Darvishian, M. (2016). Real-world influenza vaccine effectiveness: New designs and methods to adjust for confounding and bias [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-02-2018

Real-world influenza vaccine effectiveness New designs and methods to adjust for confounding and bias Maryam Darvishian

Real-world influenza vaccine effectiveness New designs and methods to adjust for confounding and bias. ISBN: 978-90-367-8942-4 ISBN Ebook: 978-90-367-8941-7 Printed by: Ridderprint BV, Ridderkerk, the Netherlands Lay-out by: Ridderprint BV, Ridderkerk, the Netherlands Cover design by: James Jardine (www.jardinemedia.com); Maryam Darvishian The printing of this thesis was financially supported by: University of Groningen, University Medical Center Groningen, Graduate School of Medical Sciences SHARE and Pfizer bv. Copyright M. Darvishian, Groningen 2016 All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any other form or by any means, without the written permission from the author or, when appropriate, from the publishers of the publications.

Real-world influenza vaccine effectiveness New designs and methods to adjust for confounding and bias PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on Tuesday 21 June 2016 at 11.00 hours by Maryam Darvishian born on 6 March 1983 in Tehran, Iran

Supervisors Prof. E. Hak Prof. E.R. van den Heuvel Assessment Committee Prof. T.J.M. Verhij Prof. G.H. de Bock Prof. A.L.W. Huckriede

Paranymphs Franklin Christiaan Karel Dolk Heng Liu

Table of contents Chapter 1. General introduction 9 Chapter 2. After adjusting for bias in meta-analysis seasonal influenza 19 vaccine remains effective in community-dwelling elderly J Clin Epidemiol. 2014 Jul;67(7):734-44 Chapter 3. Effectiveness of seasonal influenza vaccine in community- 73 dwelling elderly people: a meta-analysis of test-negative design case-control studies Lancet Infect Dis. 2014;14(12):1228-39 Chapter 4. A generalized linear mixed model for meta-analysis of test-negative 119 design case-control studies Submitted for publication Chapter 5. Influenza vaccine effectiveness among elderly population: 145 evidence from individual participant data meta-analysis In preparation for submission Chapter 6. Influenza vaccine effectiveness in the Netherlands from 2003/2004 177 through 2013/2014: the importance of circulating influenza virus types and subtypes Under review Chapter 7. Influenza vaccine effectiveness estimates in the Dutch population 199 from 2003 to 2014: the test-negative design case-control study with different control groups Under review Chapter 8. General discussion 221 Chapter 9. Summary 239 Netherlandse samenvatting 245 Acknowledgement 249 About the author 253 Other SHARE dissertations 255