From Biostatistics Using JMP: A Practical Guide. Full book available for purchase here. Chapter 1: Introduction... 1

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From Biostatistics Using JMP: A Practical Guide. Full book available for purchase here. Contents Dedication... iii Acknowledgments... xi About This Book... xiii About the Author... xvii Chapter 1: Introduction... 1 1.1 Background and Overview... 1 1.2 Getting Started with JMP... 2 1.3 General Outline... 4 1.4 How to Use This Book... 5 1.5 Reference... 5 Chapter 2: Data Wrangling: Data Collection... 7 2.1 Introduction... 7 2.2 Collecting Data from Files... 8 2.2.1 JMP Native Files... 8 2.2.2 SAS Format Files... 9 2.2.3 Excel Spreadsheets... 10 2.2.4 Text and CSV Format... 11 2.3 Extracting Data from Internet Locations... 14 2.3.1 Opening as Data... 14 2.3.2 Opening as a Webpage... 15 2.4 Data Modeling Types... 17 2.4.1 Incorporating Expression and Contextual Data... 18 2.5 References... 19 Chapter 3: Data Wrangling: Data Cleaning... 21 3.1 Introduction... 21 3.2 Tables... 21 3.2.1 Stacking Columns... 24 3.2.2 Basic Table Organization... 26 3.2.3 Column Properties... 31 3.3 The Sorted Array... 32

vi 3.4 Restructuring Data... 34 3.4.1 Combining Columns... 35 3.4.2 Separating Out a Column (Text to Columns)... 36 3.4.3 Creating Indicator Columns... 36 3.4.4 Grouping Inside Columns... 38 3.5 References... 41 Chapter 4: Initial Data Analysis with Descriptive Statistics... 45 4.1 Introduction... 45 4.2 Histograms and Distributions... 45 4.2.1 Histograms... 46 4.2.2 Box Plots... 55 4.2.3 Stem-and-Leaf Plots... 57 4.2.4 Pareto Charts... 58 4.3 Descriptive Statistics... 64 4.3.1 Sample Mean and Standard Deviation... 66 4.3.2 Additional Statistical Measures... 67 4.4 References... 69 Chapter 5: Data Visualization Tools... 71 5.1 Introduction... 71 5.2 Scatter Plots... 72 5.2.1 Coloring Points... 75 5.2.2 Copying Better-Looking Figures... 77 5.2.3 Multiple Scatter Plots... 79 5.3 Charts... 81 5.4 Multidimensional Plots... 84 5.4.1 Parallel Plots... 84 5.4.2 Cell Plots... 87 5.5 Multivariate and Correlations Tool... 89 5.5.1 Correlation Table... 91 5.5.2 Correlation Heat Maps... 92 5.5.3 Simple Statistics... 93 5.5.4 Additional Multivariate Measures... 93 5.6 Graph Builder and Custom Figures... 94 5.6.1 Graph Builder Custom Colors... 96 5.6.2 Incorporating Contextual Data... 98 5.7 References... 99

Chapter 6: Rates, Proportions, and Epidemiology... 101 6.1 Introduction... 101 6.2 Rates... 101 6.2.1 Crude Rates... 101 6.2.2 Adjusted Rates... 105 6.3 Geographic Visualizations... 108 6.3.1 National Visualizations... 108 6.3.2 County and Lower Level Visualizations... 116 6.4 References... 120 Chapter 7: Statistical Tests and Confidence Intervals... 123 7.1 Introduction... 123 7.1.1 General Hypothesis Test Background... 124 7.1.2 Selecting the Appropriate Method... 125 7.2 Testing for Normality... 126 7.2.1 Histogram Analysis... 126 7.2.2 Normal Quantile/Probability Plot... 128 7.2.3 Goodness-of-Fit Tests... 131 7.2.4 Goodness-of-Fit for Other Distributions... 132 7.3 General Hypothesis Tests... 133 7.3.1 Z-Test Hypothesis Test of Mean... 133 7.3.2 T-Test Hypothesis Test of Mean... 135 7.3.3 Nonparametric Test of Mean (Wilcoxon Signed Rank)... 136 7.3.4 Standard Deviation Hypothesis Test... 140 7.3.5 Tests of Proportions... 141 7.4 Confidence Intervals... 144 7.4.1 Mean Confidence Intervals... 144 7.4.2 Mean Confidence Intervals with Different Thresholds... 144 7.4.3 Confidence Intervals for Proportions... 145 7.5 Chi-Squared Analysis of Frequency and Contingency Tables... 146 7.6 Two Sample Tests... 150 7.6.1 Comparing Two Group Means... 150 7.6.2 Paired Comparison, Matched Pairs... 154 7.7 References... 156 Chapter 8: Analysis of Variance (ANOVA) and Design of Experiments (DoE)... 159 8.1 Introduction... 159 vii

viii 8.2 One-Way ANOVA... 161 8.2.1 One-Way ANOVA with Fit Y by X... 161 8.2.2 Means Comparison, LSD Matrix, and Connecting Letters... 165 8.2.3 Fit Y by X Changing Significance Levels... 168 8.2.4 Multiple Comparisons, Multiple One-Way ANOVAs... 169 8.2.5 One-Way ANOVA via Fit Model... 171 8.2.6 One-Way ANOVA for Unequal Group Sizes (Unbalanced)... 176 8.3 Blocking... 179 8.3.1 One-Way ANOVA with Blocking via Fit Y by X... 179 8.3.2 One-Way ANOVA with Blocking via Fit Model... 182 8.3.3 Note on Blocking... 183 8.4 Multiple Factors... 183 8.4.1 Experimental Design Considerations... 184 8.4.2 Multiple ANOVA... 188 8.4.3 Feature Selection and Parsimonious Models... 191 8.5 Multivariate ANOVA (MANOVA) and Repeated Measures... 196 8.5.1 Repeated Measures MANOVA Background... 196 8.5.2 MANOVA in Fit Model... 197 8.6 References... 201 Chapter 9: Regression and Curve Fitting... 205 9.1 Introduction... 205 9.2 Simple Linear Regression... 206 9.2.1 Fit Y by X for Bivariate Fits (One X and One Y)... 206 9.2.2 Special Fitting Tools... 208 9.3 Multiple Regression... 211 9.3.1 Fit Model... 211 9.3.2 Stepwise Feature Selection... 214 9.3.3 Analysis of Covariance (ANCOVA)... 222 9.4 Nonlinear Curve Fitting and a Nonlinear Platform Example... 226 9.5 References... 232 Chapter 10: Diagnostic Methods for Regression, Curve Fitting, and ANOVA... 233 10.1 Introduction... 233 10.2 Computing Residuals with Fit Y by X and Fit Model... 234 10.2.1 Fit Y by X... 234 10.2.2 Fit Model... 234 10.3 Checking for Normality... 235

ix 10.4 Checking for Nonconstant Error Variance (Heteroscedasticity)... 236 10.5 Checking for Outliers... 238 10.6 Checking for Nonindependence... 242 10.7 Multiple Factor Diagnostics... 243 10.8 Nonlinear Fit Residuals... 245 10.9 Developing Appropriate Models... 246 10.10 References... 247 Chapter 11: Categorical Data Analysis... 249 11.1 Introduction... 249 11.2 Clustering... 250 11.2.1 Hierarchical Clustering... 250 11.2.2 K-means Clustering... 260 11.3 Classification... 263 11.3.1 JMP Data Preliminaries for Classification... 265 11.3.2 Example Data Sets... 267 11.4 Classification by Logistic Regression... 268 11.4.1 Logistic Regression in Fit Y by X... 268 11.4.2 Logistic Regression in Fit Model... 270 11.5 Classification by Discriminant Analysis... 273 11.5.1 Discriminant Analysis Loadings... 275 11.5.2 Stepwise Discriminant Analysis... 276 11.6 Classification with Tabulated Data... 277 11.7 Classifier Performance Verification... 280 11.8 References... 284 Chapter 12: Advanced Modeling Methods... 287 12.1 Introduction... 287 12.2 Principal Components and Factor Analysis... 288 12.2.1 Principal Components in JMP... 288 12.2.2 Dimensionality Assessment... 291 12.2.3 Factor Analysis in JMP... 293 12.3 Partial Least Squares... 296 12.4 Decision Trees... 302 12.4.1 Classification Decision Trees in JMP... 303 12.4.2 Predictive Decision Trees in JMP... 308 12.5 Artificial Neural Networks... 310 12.5.1 Neural Network Architecture... 311 12.5.2 Classification Neural Networks in JMP... 312 12.5.3 Predictive Neural Networks in JMP... 315

x 12.6 Control Charts... 317 12.7 References... 321 Chapter 13: Survival Analysis... 323 13.1 Introduction... 323 13.2 Life Distributions... 323 13.3 Kaplan-Meier Curves... 327 13.3.1 Simple Survival Analysis... 327 13.3.2 Multiple Groups... 330 13.3.3 Censoring... 331 13.3.4 Proportional Hazards... 335 13.4 References... 336 Chapter 14: Collaboration and Additional Functionality... 339 14.1 Introduction... 339 14.2 Saving Scripts and SAS Coding... 339 14.2.1 Saving Scripts to Data Table... 340 14.2.2 SAS Coding Functionality... 341 14.3 Collaboration... 342 14.3.1 Journals... 342 14.3.2 Web Reports... 344 14.4 Add-Ins... 347 14.4.1 Finding Add-Ins... 347 14.4.2 Developing Add-Ins... 348 14.4.3 Example Add-In: Forest Plot / Meta-analysis... 348 14.4.4 Add-In Version Control... 351 14.5 References... 352 Index... 331 From Biostatistics Using JMP : A Practical Guide by Trevor Bihl. Copyright 2017, SAS Institute Inc., Cary, North Carolina, USA. ALL RIGHTS RESERVED.