THE JOSEPH B. MARTIN CONFERENCE CENTER AT HARVARD MEDICAL SCHOOL BOSTON, MASSACHUSETTS

SEPTEMBER 23 24, 2011 THE JOSEPH B. MARTIN CONFERENCE CENTER AT HARVARD MEDICAL SCHOOL BOSTON, MASSACHUSETTS COURSE DIRECTORS Umakanth Khatwa, MD Sanjeev Kothare, MD PRESENTED BY Division of Respiratory Diseases, Department of Medicine and

Sleep disorders are common problems encountered in pediatric practice, yet under recognized to a large extent. The consequences of under-diagnosed and untreated sleep problems may include significant emotional, behavioral, cardiovascular and neurocognitive dysfunction. The major objective of this course is to provide a comprehensive overview of the common pediatric sleep disorders. It is aimed towards pediatricians, family practitioners, sub-specialists, and nurse practitioners treating children and young adults. It will include review of normal sleep physiology in children and circadian rhythm sleep-cycle. Specific areas of emphasis will be towards evaluation and treatment of sleep apnea, night-time awakenings in childhood, difficulty with initiating and maintaining sleep and promoting good sleep hygiene in adolescents. It will review the current standards of practice, and give cutting edge updates about recent developments in the diagnosis and treatment of pediatric sleep disorders. There will be a break-out session which will cover various technical aspects of pediatric sleep studies.

O B J E C T I V E S At the conclusion of the course, participants will be able to: Describe normal sleep patterns in children of different ages, including the circadian sleep cycle and sleep homeostasis Understand and describe the impact of various sleep disorders in the pediatric population Have a working knowledge of diverse sleep disorders in children Incorporate recent trends in pediatric sleep medicine into their current practice Have specific questions answered by our expert panel H I G H L I G H T S Key note lecture titled Obesity and OSA: Epidemiology and Genetics by Dr. Susan Redline, MD, MPH, Peter C. Farrell Professor of Sleep Medicine at Harvard, Boston, MA Break-out session on technical aspects of pediatric sleep studies Clinical case presentations and review of common pediatric tracings Going Green, we will not have paper syllabus. However syllabus will be available to download on-line 1 week before the conference Will receive a CD-ROM containing PDF versions of all the PowerPoint slides along with a several important reference articles The Registration fee will include 2 days tuition, breakfast, tea/ coffee and lunch

C O U R S E S C H E D U L E FRIDAY, SEPTEMBER 23, 2011 7.30 am Registration and Breakfast 7.45 7.50 am Welcome: Course Directors: Umakanth Khatwa & Sanjeev Kothare 7.50 8.00 am Felicitation to Dr. Richard Ferber 8.00 8.30 am Normal Sleep in Children Kiran Maski, MD 8.30 9.00 am Introduction to Circadian Biology Steve Lockley, PhD 9.00 9.30 am Evaluation of Sleep Disorders: Clinical and Polysomnography Kiran Maski, MD 9.30 9.45 am Tea/Coffee Break 9.45 10.30 am Key Note Address: Obesity and OSA: Epidemiology and Genetics Susan Redline, MD 10.30 11.00 am Obstructive Sleep Apnea: Pathogenesis, Co-morbidities and Consequences Eliot Katz, MD 11.00 11.25 am Obstructive Sleep Apnea: Positive Airway Pressure Therapy and Compliance Dennis Rosen, MD 11.25 11.50 am Pediatric Tracing: Review Eliot Katz, MD 11.50 am 12.15 pm 12.15 1.00 pm Lunch Break 1.00 1.20 pm Treatment of OSA: ENT perspective Michael Cunningham, MD 1.20 1.40 pm Treatment of OSA: Maxillofacial Perspective Bonnie L. Padwa, MD 1.40 2.00 pm Treatment of OSA: Dental Perspective B. Gail Demko, DMD 2.00 2.30 pm Sleep Disordered Breathing in Special Populations Umakanth Khatwa, MD 2.30 3.00 pm 3.00 3.15 pm Tea/Coffee Break 3.15 3.45 pm Infant Sleep Apnea and SIDS Eliot Katz, MD 3.45 4.15 pm Central Sleep Apnea Syndromes Umakanth Khatwa, MD 4.15 4.45 pm Clinical Case Presentations 4.45 5.15 pm Note: Program/Speaker changes may be made without notice

C O U R S E S C H E D U L E SATURDAY, SEPTEMBER 24, 2011 8.00 8.45 am Behavioral Insomnia of Childhood Richard A. Ferber, MD 8.45 9.30 am Sleep in Teenagers Mary A. Carskadan, PhD 9.30 10.00 am Circadian Rhythm Sleep Disorders Jonathan Lipton, MD 10.00 10.20 am Questions and Answers 10.20 10.30 am Tea/Coffee Break 10.30 11.00 am Parasomnias and Nocturnal Events Sanjeev V. Kothare, MD 11.00 11.45 am Narcolepsy and Hypersomnia Christian Guilleminault, MD 11.45 am 12.15 pm 12.15 1.00 pm Lunch Break 1.00 1.30 pm Insomnia in Special Populations Ronald E Becker, MD 1.30 2.00 pm Restless Leg Syndrome, Periodic Limb Movement Disorder & Bruxism Jonathan Lipton, MD 2.00 2.30 pm Sleep Pharmacology Sanjeev V. Kothare, MD 2.30 3.00 pm Clinical Case Presentations 3.00 3.30 pm 3.30 pm Closing Remarks by Course Directors Umakanth Khatwa & Sanjeev Kothare BREAK OUT SESSION (Seating is limited; please select this option at the time of registration) SATURDAY, SEPTEMBER 24 8.00 10.20 am Technical Aspects of Pediatric Sleep Studies: Moderator: Maria G. Gabriel, REEGT, MBA 8:00 8:30 am Pediatric Studies: Set-ups & Challenges Michelle SanGiuliano, RPSGT 8:30 9:00 am Pediatric CPAP Introduction and Desensitization Michael Gunnuscio, RPSGT 9:00 9:30 am Pediatric Sleep Studies: Scoring Rebecca Fitzgerald, RPSGT Michael Gunnuscio, RPSGT 9:30 10:00 am Trouble Shooting During Polysomnography Jack Connolly, REEGT 10:00 10:20 am 10: 20 10. 30 am Tea/Coffee Break Note: Program/Speaker changes may be made without notice

F A C U L T Y COURSE FACULTY Richard A. Ferber, MD Director, Center for Pediatric Sleep Disorders Associate Professor of Neurology, Harvard Sanjeev V. Kothare, MD Associate Director (Neurology) Fellowship Director, Pediatric Sleep Medicine Training Program Associate Professor of Neurology, Harvard Dennis Rosen, MD Associate Director (Pulmonary) Division of Respiratory Diseases Instructor in Pediatrics, Harvard Eliot Katz, MD Division of Respiratory Diseases Instructor in Pediatrics, Harvard Umakanth A. Khatwa, MD Asst. Fellowship Director, Pediatric Sleep Medicine Training Program Center for Aerodigestive Disorders Division of Respiratory Diseases Instructor in Pediatrics, Harvard Jonathan Lipton, MD, PhD Instructor in Neurology, Harvard Kiran Prasad Maski, MD Instructor in Neurology, Harvard Ronald E. Becker, MD Department of Medicine Division of Developmental Medicine Instructor in Medicine, Harvard Michael J. Cunningham, MD Otolaryngologist-in-Chief Professor of Otolaryngology, Harvard Bonnie L. Padwa, DMD, MD Oral Surgeon-in-Chief, Section of Oral and Maxillofacial Surgery Associate Professor, Harvard School of Dental Medicine Susan Redline, MD, MPH Senior Physician, Division of Sleep Medicine Department of Medicine, Brigham and Women s Hospital Physician, Division of Pulmonary Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Peter C. Farrell Professor of Sleep Medicine, Harvard Steve Lockley, PhD Associate Neuroscientist, Division of Sleep Medicine Department of Medicine, Brigham and Women s Hospital Assistant Professor of Medicine, Harvard VISITING FACULTY B. Gail Demko, DMD Sleep Apnea Dentists of New England 140 Merriam Street Weston, MA 02493 Christian Guilleminault, MD, BiolD Stanford Sleep Medicine Center Stanford, CA, 94305 Professor of Psychiatry, Behavioral Sciences and Neurology Stanford School of Medicine Mary A. Carskadan, PhD Director of Chronobiology and Sleep Research at Bradley Hospital Professor of Psychiatry & Human Behavior Warren Alpert at Brown University Providence, RI 02903 TECHNICAL FACULTY Maria G. Gabriel, REEGT, BS, MBA Technical Director Division of Epilepsy & Clinical Neurophysiology Michelle SanGiuliano, RPSGT, BS Technical Manager Sean Cosgrove, RPSGT, BS Polysomnography Technologist Team Leader Michael Gunnuscio, RPSGT, BS Polysomnography Technologist (scorer) Rebecca Fitzgerald, RPSGT Polysomnography Technologist (scorer) Jack Connolly, REEGT Technical Specialist Program Director, END Technology Program Division of Epilepsy and Clinical Neurophysiology

C O U R S E D E T A I L S ACCREDITATION Harvard is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Harvard designates this live activity for a maximum of 15 AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. Application has been submitted for AAST CEUs. REFUND POLICY A handling fee of $60 is deducted for cancellation. Refund requests must be received by mail one week prior to the course. No refunds will be made thereafter. REGISTRATION Physicians $450.00 Group Rate of 3+ Physicians (per person) $400.00 Allied Health Professionals $300.00 Group Rate of 3+ Allied Health Professionals (per person) $250.00 Sleep Technologist $175.00 Group Rate of 3+ Sleep Technologist (per person) $150.00 Harvard Affiliate Physicians $150.00 Harvard Affiliate Allied Health Professional $150.00 Residents* and Fellows in Training* $100.00 All foreign payments must be made by a draft on a United States Bank or by Visa or MasterCard. If paying by CHECK, please make payable to Harvard Medical School and mail with completed registration form to Harvard Medical School Department of Continuing Education, PO Box 825, Boston, MA 02117 0825. If paying by credit card, telephone, fax or mail-in registrations are not accepted. Registrations paid by credit card may be made online at at www.cme.hms.harvard.edu/courses/ sleepdisorders. Please be sure to enter your three-digit source code found on the mailing panel above your address to ensure proper registration. Inquiries should be directed to the above address, made by phone: (617) 384 8600, Monday Friday, 10 AM to 4 PM (EST), or by email: hms cme@ hms.harvard.edu Upon receipt of your registration form an email confirmation from the HMS-DCE office will be sent to you. Therefore, be sure to include an email address that you check daily/ frequently. Your email address is used for critical information about the course including: registration confirmation, course evaluation and certificate. *A letter of verification from the Department Chair must accompany registration for a reduced fee.

C O U R S E D E T A I L S C O U R S E L O C AT I O N All sessions will be held at: THE JOSEPH B. MARTIN CONFERENCE CENTER AT HARVARD MEDICAL SCHOOL 77 Avenue Louis Pasteur Boston, MA 02115 TRAVEL Please do not make non-refundable airline reservations until your enrollment in the course has been confirmed. You can make your airline reservation by calling the HMS Travel Desk toll free 1(877)4-HARVMD (1-877-442-7863) Monday Friday 9 a.m. to 8 p.m. (EST). From outside the U.S., Canada and Virgin Islands, please call (617) 559-3764. HOTEL ACCOMMODATIONS Holiday Inn Boston 1200 Beacon Street Brookline, MA 02446 (P) 617-598-7649 (F) 617-734-5867 Courtyard Boston Brookline 40 Webster Street, Coolidge Corner Brookline, MA 02446 Toll-free: 1-866-296-2296 Longwood Inn 123 Longwood Avenue Brookline, MA 02446 (617) 566-8615 Hotel Room Release Date: August 23 rd, 2011 PARKING INFORMATION: Standard Parking (Located at Harvard COOP, 2 blocks) 333 Longwood Ave. Boston, MA 02115 Daily Maximum - $35 Trilogy 180 Brookline Ave (10 min. walk, 7 blocks) Boston, MA 02115 Daily Maximum - $20 Pilgrim Parking, Inc. Longwood Galleria Parking Garage (3 blocks) 350 Longwood Ave. Boston, MA 02115 Daily Maximum $35 For information on Handicap Accessible Parking please contact Stephanie Barros at 617-355-7819. MBTA The closest MBTA stops are the Longwood stops on the D or E line. For more information please go to www.mbta.com.

C O U R S E R E G I S T R A T I O N T H E R I C H A R D A. F E R B E R P E D I AT R I C S L E E P M E D I C I N E C O U R S E SEPTEMBER 23 24, 2011 Tuition Fee by Attendee: Physician $450.00 Group rate 3+ physicians: $400.00 per person Allied Health $300.00 Group rate 3+: $250.00 per person Sleep Technologist $175.00 Group Rate of 3+ Sleep Technologist $150.00 per person Harvard Affiliate Physician: $150.00 Harvard Affiliate Allied Health Professional: $150.00 Resident*/Fellow in Training*: $100.00 Total: $.00 (USD) Please print clearly. All fields required. Course # 3114323 Please check if you wish to attend the breakout session. Full Name: Mailing Address: First MI Last Degree City: State: Zip Code: Daytime Phone: Email Address: Fax Number: Upon receipt of your registration form an email confirmation from the HMS-DCE office will be sent to you. Therefore, be sure to include an email address that you check daily/frequently. Your email address is used for critical information about the course including: registration confirmation, course evaluation and certificate. Please check if you wish to be excluded from receiving email notices of future Harvard Department of Continuing Education Programs. Profession: Professional School Attended: Primary Specialty (Physicians Only): Organization Affiliation: Year of Graduation: Board Certified: Yes No PAYMENT INFORMATION If paying by check, make it payable to Harvard and mail with the completed registration form to: Harvard -Department of Continuing Education, PO Box 825, Boston, MA 02117-0825. If paying by credit card, telephone, fax or mail-in registrations are not accepted. Registrations paid by credit card may be made online at at www. cme.hms.harvard.edu/courses/sleepdisorders. Group Registrants: If paying by check, please copy this form and submit group member registrations together. Online registrants: ensure proper registration by adding the first three characters of the source code found by your name on the mailing panel.