Radiology Oncology Surgical Robots Market Shares, Strategies, and Forecasts, Worldwide, 2016 to 2022

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Radiology Oncology Surgical Robots Market Shares, Strategies, and Forecasts, Worldwide, 2016 to 2022 Mountains of Opportunity Picture by Susan Eustis WinterGreen Research, Inc. Lexington, Massachusetts www.wintergreenresearch.com 781 853 5078

CHECK OUT THESE KEY TOPICS Radiology Oncology Surgical Robots Bring New Hope for Curing Cancer Radiology Oncology Surgical Robotics Radiology Medical Devices Oncology Healthcare Robotics Cyber Knife Cutting Enabling Technology Robotic-Assisted Minimally Invasive Surgery Robotic Radiology Surgical System Radiology Robotic Surgery Robotic Surgery Equipment Surgical Robot Applications Abdominal Surgical Robot Growth Strategy: Next Generation Robotic Surgery Flexible Robot Platform Minimally Invasive Surgery MIS Radiology Oncology Surgical Robot: Market Shares, Strategies, and Forecasts, Worldwide, 2016-2022 LEXINGTON, Massachusetts (January 6, 2016) WinterGreen Research announces that it has published a new study Radiology Oncology Surgical Robots: Market Shares, Strategy, and Forecasts, Worldwide, 2016 to 2022. The 2016 study has 557 pages, 82 tables and figures. Worldwide Radiology Oncology surgical robot markets are poised to achieve significant growth as next generation systems provide a way to improve traditional open surgery and use radiology for cancer surgery. New systems pinpoint the delivery of radiation precisely, eliminating the radiological overdosing that has been such a problem previously, limiting the quantity of radiation that can be delivered. Radiosurgery robots take cancer surgery far beyond what has been available, promising a cure for cancer. Radiology oncology surgical robots use mechanical mobility and continuous image guidance to remove tumors. The Accuray CyberKnife robotic system follows the oncology target throughout treatment, intelligently delivering sub-millimeter precision, sparing healthy tissue. A robotic manipulator and a compact, lightweight linear accelerator, can deliver beams from thousands of noncoplanar, isocentric or non-isocentric angles. Treatments have excellent tumor coverage, steep dose gradients, and tight dose conformality.

The radiation oncology market is growing globally due to a number of factors centered around the aging of the population and the benefits accrued from new technology. The number of new cancer cases diagnosed annually is projected to increase from 14.9 million in 2015 to 20 million by 2025. The increase in new cases is due to a steadily aging population. Both developed and developing countries have aging populations. Technology advances improve the precision and applicability of radiotherapy and radiosurgery. Expanding uses of radiotherapy and radiosurgery equipment occur because the units are able to treat a broader range of cases. Advances in hardware and software are creating a market for replacing an aging installed base. New designs are able to deliver higher standards of care. The rise in cancer cases, together with the increase in sophistication of new treatment protocols, have created demand for more automated products. Automation depends on integration of several devices into clinically practical systems. Integrated systems make treatments rapid and cost effective. Technology advances lead to improvements in patient care. The availability of advanced, automated and efficient clinical tools in radiation therapy has brought more precise forms of radiotherapy treatment (IMRT, IGRT, VMAT, SRS, SBRT, brachytherapy and proton therapy). Technology includes the EDGE and Truebeam, and the Accuray TomoTherapy H Series and CyberKnife M6 platforms that enable treatments that reduce treatment times and increase patient throughput. International markets are under-equipped to address the growing cancer incidence. Patients in many foreign countries must frequently endure long waits for radiotherapy. 9,000 additional treatment machines will be required by 2020 in developing countries. China, India and Brazil are estimated to require over 3,800, 1,200 and 400 additional machines. Demand in emerging markets, coupled with ever increasing incidences of cancer, represent additional drivers for continued growth. Radiology oncology surgical robot market driving forces relate to an opportunity to achieve change in medical practice regarding the treatment of cancer. Change would lead to utilization of stereotactic body radiosurgery more regularly as an alternative to surgery or other treatments. Radiosurgery is poised to revolutionize the treatment of cancer by eradicating tumors while not harming surrounding healthy tissue. The ability to use high doses of radiation to precisely eliminate a tumor while leaving healthy tissue unharmed is compelling. It means that high doses of radiation can be delivered without killing the person, that doses of radiation delivered can be enough to kill the cancer without killing the person, this represents a change in what has been possible previously. The Varian, Elekta, and Accuray radiology oncology surgical devices offer robust clinical treatment capabilities. Flexibility of the Accuray InCise Multileaf Collimator and robotic delivery permit treatment of tumors previously thought untreatable. With radiosurgery and SBRT cancer can be treated efficiently and effectively. The device offers accuracy.

According to Susan Eustis, lead author of the study, Existing open brain and abdominal cancer surgery can be replaced in large part during the forecast period by robotic radiological oncology surgery. Radiologic robotic surgical approaches complement existing open surgery techniques, but will replace them as more physicians and surgeons become skilled in manipulating the x-ray devices. Soon, all oncology surgery will be considered in the context of what part of the oncology procedure will be undertaken with at least some aspects of robotic radiologic surgery replacing or complementing open cancer surgery. The aging US population has supported demand for robotic Radiology Oncology surgery. Since the occurrence of health issues that require medical devices is higher in the elderly population the more astute baby boomers have been looking to understand what surgical alternatives are open to them.. Buoyed by strong demand and sales, industry profit margins have increased considerably during the past five years. Hospitals are adopting robotic surgical devices to improve their outcomes numbers. Hospitals are measured on outcomes, robots for surgery, when used by a trained physician are improving outcomes significantly. Hundreds of universities worldwide have research programs in robotics and many are awarding degrees in robotics. These roboticists are increasingly being hired by Global 2000 organizations to link mobile robots (mobile computers) into existing IT systems. Robot-assisted surgery gives the surgeon better control over the surgical instruments and a better view of the surgical site. Surgeons no longer have to stand throughout the surgery and do not tire as quickly. Hand tremors are filtered out by the robot s computer software. The surgical robot can continuously be used by rotating surgery teams. Radiology Oncology surgical robot device markets at $4 billion in 2015 are anticipated to reach $7.3 billion by 2022 as next generation devices, systems, and instruments are introduced to manage cancer surgery through radiation excision that eliminates open cutting in the body. Patients tolerate the surgery well, walking out of the hospital after the procedure no longer bothered by healing or infection from an incision. The complete report provides a comprehensive analysis including procedure numbers, units sold, market value, forecasts, as well as a detailed competitive market shares and analysis of major players success, challenges, and strategies in each segment and sub-segment. The reports cover markets for Radiology Oncology robotic surgery medical specialties and sub-specialties. WinterGreen Research is an independent research organization funded by the sale of market research studies all over the world and by the implementation of ROI models that are used to calculate the total cost of ownership of equipment, services, and software. The company has 35 distributors worldwide, including Global Information Info Shop, Market Research.com, Research and Markets, Bloomberg, and Thompson Financial. It conducts its business with integrity.

WinterGreen Research is an independent research organization funded by the sale of market research studies all over the world and by the implementation of ROI models that are used to calculate the total cost of ownership of equipment, services, and software. The company has 35 distributors worldwide, including Global Information Info Shop, Market Research.com, Research and Markets, Bloomberg, and Thompson Financial. WinterGreen Research is positioned to help customers facing challenges that define the modern enterprises. The increasingly global nature of science, technology and engineering is a reflection of the implementation of the globally integrated enterprise. Customers trust wintergreen research to work alongside them to ensure the success of the participation in a particular market segment. WinterGreen Research supports various market segment programs; provides trusted technical services to the marketing departments. It carries out accurate market share and forecast analysis services for a range of commercial and government customers globally. These are all vital market research support solutions requiring trust and integrity. Key Words: Radiology Oncology Surgical Robotics, Radiology Medical Devices, Oncology Healthcare Robotics, Cyber Knife Cutting Enabling Technology, Robotic-Assisted Minimally Invasive Surgery, Robotic Radiology Surgical System, Radiology Robotic Surgery, Robotic Surgery Equipment, Surgical Robot Applications, Next Generation Robotic Surgery, Flexible Robot Platform, Minimally Invasive Surgery, MIS., Companies Profiled Market Leaders Varian Elekta Accuray Market Participants Best Theratronics, Ltd Brainlab AG Mitsubishi Heavy Industries ViewRay

Radiology Oncology Surgical Robot: Market Shares, Strategies, and Forecasts, Worldwide, 2016 to 2022 Report Methodology This is the 656th report in a series of primary market research reports that provide forecasts in communications, telecommunications, the Internet, computer, software, telephone equipment, health equipment, and energy. Automated process and significant growth potential are a priority in topic selection. The project leaders take direct responsibility for writing and preparing each report. They have significant experience preparing industry studies. They are supported by a team, each person with specific research tasks and proprietary automated process database analytics. Forecasts are based on primary research and proprietary data bases. The primary research is conducted by talking to customers, distributors and companies. The survey data is not enough to make accurate assessment of market size, so WinterGreen Research looks at the value of shipments and the average price to achieve market assessments. Our track record in achieving accuracy is unsurpassed in the industry. We are known for being able to develop accurate market shares and projections. This is our specialty. The analyst process is concentrated on getting good market numbers. This process involves looking at the markets from several different perspectives, including vendor shipments. The interview process is an essential aspect as well. We do have a lot of granular analysis of the different shipments by vendor in the study and addenda prepared after the study was published if that is appropriate. Forecasts reflect analysis of the market trends in the segment and related segments. Unit and dollar shipments are analyzed through consideration of dollar volume of each market participant in the segment. Installed base analysis and unit analysis is based on interviews and an information search. Market share analysis includes conversations with key customers of products, industry segment leaders, marketing directors, distributors, leading market participants, opinion leaders, and companies seeking to develop measurable market share.

Over 200 in depth interviews are conducted for each report with a broad range of key participants and industry leaders in the market segment. We establish accurate market forecasts based on economic and market conditions as a base. Use input/output ratios, flow charts, and other economic methods to quantify data. Use in-house analysts who meet stringent quality standards. Interviewing key industry participants, experts and end-users is a central part of the study. Our research includes access to large proprietary databases. Literature search includes analysis of trade publications, government reports, and corporate literature. Findings and conclusions of this report are based on information gathered from industry sources, including manufacturers, distributors, partners, opinion leaders, and users. Interview data was combined with information gathered through an extensive review of internet and printed sources such as trade publications, trade associations, company literature, and online databases. The projections contained in this report are checked from top down and bottom up analysis to be sure there is congruence from that perspective. The base year for analysis and projection is 2011. With 2011 and several years prior to that as a baseline, market projections were developed for 2012 through 2018. These projections are based on a combination of a consensus among the opinion leader contacts interviewed combined with understanding of the key market drivers and their impact from a historical and analytical perspective. The analytical methodologies used to generate the market estimates are based on penetration analyses, similar market analyses, and delta calculations to supplement independent and dependent variable analysis. All analyses are displaying selected descriptions of products and services. This research includes referencde to an ROI model that is part of a series that provides IT systems financial planners access to information that supports analysis of all the numbers that impact management of a product launch or large and complex data center. The methodology used in the models relates to having a sophisticated analytical technique for understanding the impact of workload on processor consumption and cost. WinterGreen Research has looked at the metrics and independent research to develop assumptions that reflect the actual anticipated usage and cost of systems. Comparative analyses reflect the input of these values into models.

The variables and assumptions provided in the market research study and the ROI models are based on extensive experience in providing research to large enterprise organizations and data centers. The ROI models have lists of servers from different manufacturers, Systems z models from IBM, and labor costs by category around the world. This information has been developed from WinterGreen research proprietary data bases constructed as a result of preparing market research studies that address the software, energy, healthcare, telecommunicatons, and hardware businesses. YOU MUST HAVE THIS STUDY Radiology Oncology Surgical Robot Market Shares, Strategy, and Forecasts, 2016 to 2022 Table of Contents Radiology Oncology Surgical Robots: Executive Summary The study is designed to give a comprehensive overview of the Radiology Oncology Surgical Robots equipment market segment. Research represents a selection from the mountains of data available of the most relevant and cogent market materials, with selections made by the most senior analysts. Commentary on every aspect of the market from independent analysts creates an independent perspective in the evaluation of the market. In this manner the study presents a comprehensive overview of what is going on in this market, assisting managers with designing market strategies likely to succeed. Table of Contents RADIOLOGY ONCOLOGY SURGICAL ROBOT EXECUTIVE SUMMARY 20 Radiology Oncology Surgical Robot Market Driving Forces 20 Surgical Radiology Robotics Market Driving Forces 23 Radiology Surgical Robot Key Procedures As Elements Of Strategy 27 Radiosurgery As Stereotactic Radiotherapy 28 Radiology Oncology Surgical Robots Market Share Analysis 29 Radiology Surgical Robots Market Forecasts 31 1. RADIOLOGY SURGICAL ROBOT MARKET DESCRIPTION AND MARKET DYNAMICS 35 1.1 Radiotherapy, Radiation Therapy, Radiosurgery, And Brachytherapy Market Description 35 1.1.1 IMRT 36

1.1.2 VMAT 37 1.1.3 IGRT 37 1.1.4 SRS and SBRT 38 1.1.5 Brachytherapy 38 1.1.6 Proton Therapy 39 1.2 Current Radiation Therapy Limitations 40 1.3 Radiology Robotic Surgical Clinical Facilities and Clinical Diagnosis 42 1.3.1 Cancer Robotic Surgery Learning Curves 44 1.3.2 Robotic Radiological Surgery Equipment 44 1.3.3 Medicare and Medicaid Impact 46 1.3.4 Medical Robotic Surgery by Segment 46 1.3.5 Robotic Cancer Surgery 46 1.3.6 Cancer 47 1.4 Brain Tumors 48 1.4.1 Causes of Brain Tumor 49 1.4.2 Tumor Grading 49 1.4.3 Types of Treatment 50 1.4.4 Biopsies 51 1.4.5 U.S. Markets For Diagnostic Oncology-Related X-Ray-Based Imaging Products 51 2D X-Ray Systems Market Driving Forces 53 2. RADIOLOGY ONCOLOGY SURGICAL ROBOT MARKET SHARES AND MARKET FORECASTS 55 2.1 Radiology Oncology Surgical Robot Market Driving Forces 55 2.1.1 Surgical Radiology Robotics Market Driving Forces 58 2.1.2 Radiology Surgical Robot Key Procedures As Elements Of Strategy 62 2.1.3 Radiosurgery Is Stereotactic Radiotherapy 63 2.2 Radiology Oncology Surgical Robots Market Share Analysis 64 2.2.1 Accuray 67 2.2.2 Accuray Clinical Studies 68 2.2.3 Accuray Goal 69 2.2.4 Accuray Revenue 71 2.2.5 Varian 75 2.2.6 Elekta 77 2.2.7 Brainlab 80 2.2.8 Radiology Surgical Robots Market Unit Analysis 81 2.3 Radiology Surgical Robots Market Forecasts 82 2.3.1 Advanced Surgical Robotic Radiation Therapy Systems 86 2.3.2 U.S. Markets For Diagnostic Oncology-Related X-Ray-Based Imaging Products 87 2.4 Cancer Incidence and Radiology Surgery Number of Procedures 88 2.5 Radiology Surgical Robots Regional Analysis 93 2.5.1 US Radiation Oncology Market 94 2.5.2 European Radiation Oncology Market 95 2.5.3 Asia Pacific Market Radiation Oncology Market 95 2.5.4 Accuray in China 96 2.5.5 Advantages of the Accuray Cyberknife treatment in China 99 2.5.6 GE Moves X-Ray Base to China to Tap Growth 100 2.5.7 Japanese Regulatory Approval for Accuray CyberKnife Robotic Full-body Radiosurgery System 101 2.5.8 Japan X-ray Systems Market 101 2.5.9 Philips Expands Global Reach Of X-Ray Solutions 101 2.5.10 Reimbursement Challenges 103 3. RADIOLOGY SURGICAL ROBOTS PRODUCT DESCRIPTIONS 105 3.1 Accuray CyberKnife M6 Series 105 3.1.1 Accuray CyberKnife M6 FIM System 111 3.1.2 Accuray CyberKnife M6 System 115 3.1.3 Accuray / CyberKnife VSI System 117 3.1.4 Accuray / TomoTherapy System 120 3.1.5 Accuray Clinical Studies 124 3.1.6 Accuray TomoTherapy System Clinical Studies 126 3.1.7 Accuray CyberKnife System Clinical Study 126

3.1.8 Accuray TomoTherapy System Clinical Study 126 3.1.9 Class A User Licenses for Accuray Products Awarded to 16 Hospitals in China 127 3.1.10 Accuray Open Systems Software Benefits 128 3.2 Elekta 129 3.2.1 Elekta Gamma Knife Surgery 132 3.3 Varian 137 3.3.1 Varian Image Guided Radiation Therapy, Cone-Beam CT (CBCT 140 3.3.2 Varian Trilogy 140 3.3.3 Varian Edge Radiosurgery Suite 142 3.3.4 Varian Oncology Systems 144 3.4 ViewRay 147 4. RADIOLOGY SURGICAL ROBOTS TECHNOLOGY AND RESEARCH 151 4.1 Accuray Radiology to Treat Head Cancer And Spinal Cancer 151 4.1.1 Fiducial Markers Implantation 151 4.1.2 Molding Of A Plastic Body Cradle 151 4.1.3 Treatment Planning 152 4.1.4 Programming of the Accuray Cyberknife System 152 4.1.5 Treatment Procedure 152 4.1.6 Postoperative Supervision 153 4.2 Varian Medical TrueBeam Systems Advanced Platform 153 4.2.1 Potential of High Definition Radiotherapy 154 4.3 C-Arm Surgical X-Rays 156 4.4 X-Ray Digital Workflow 157 4.5 Stereotactic Radiosurgery 160 4.5.1 Image-Guided Stereotactic Radiosurgery 160 4.5.2 Image-Guided Stereotactic Radiosurgery Safety 160 4.6 Siemens Ysio Max (Advances in X-Ray) 161 4.7 MD Anderson Gamma Knife Radiosurgery 162 4.7.1 MD Anderson Proton Therapy Center 163 4.8 Partners Healthcare Massachusetts General Hospital Radiation Cancer Treatment 164 4.8.1 Partners Healthcare / Dana Farber 164 4.8.2 Three-Dimensional Conformal Radiation Therapy (3D-CRT) 165 4.8.3 Image Guided Radiation Therapy (IGRT) 166 4.8.4 Intensity Modulated Radiation Therapy (IMRT) 166 4.8.5 RapidArc Volumetric Modulated Radiotherapy 166 4.8.6 Total Body Irradiation (TBI) 167 4.8.7 Accelerated Whole Breast Radiation Therapy 167 4.8.8 Stereotactic Radiosurgery (SRS) 167 4.8.9 High Dose Rate (HDR) Brachytherapy 168 4.8.10 Robotic Transrectal Ultrasound (TRUS) Guided Radiation Therapy 168 4.9 Memorial Sloan Kettering Radiation Cancer Treatment 169 4.9.1 Memorial Sloan Kettering IMRT & IGRT 169 4.9.2 Memorial Sloan Kettering Stereotactic Radiation Therapy 170 4.9.3 Memorial Sloan Kettering Whole-Brain Radiation Therapy Stereotactic Radiosurgery, SRS 171 4.10 U.S. Regulations 172 4.10.1 Foreign Regulations 173 5. RADIOLOGY SURGICAL ROBOTS COMPANY DESCRIPTIONS 175 5.1 Accuray 175 5.1.1 Accuray Revenue for Second Quarter of Fiscal Year 2015 176 5.1.2 Accuray Revenue Three Months Ended September 30, 2015 177 5.1.3 Accuray Revenue 183 5.1.4 Accuray Non-Invasively Delivers High Doses Of Radiation To Tumors With Extreme Accuracy And Intense Precision 186 5.1.5 Accuray Products 187 5.1.6 Accuray CyberKnife System 187 5.1.7 Accuray Strategy 189 5.1.8 Accuray International Presence 192 5.1.9 Accuray Competition 193

5.1.10 New Data Validates CyberKnife SBRT for Prostate Cancer Treatment 195 5.1.11 Accuray Recall in 2013 196 5.2 Best Theratronics, Ltd 197 5.3 Brainlab AG 200 5.3.1 Brainlab AG Revenue 202 5.3.2 Brainlab 203 5.4 Elekta 204 5.4.1 Elekta Gamma Radio Surgery System 205 5.4.2 Elekta - Interim report May October 2015/16 206 5.4.3 Elekta Transformation program on track 207 5.5 Mitsubishi Heavy Industries 210 5.5.1 Mitsubishi Heavy Industries Vero Sterotactic Body Radiotherapy 210 5.6 Varian Medical Systems 212 5.6.1 Varian Oncology Systems Business Segment 212 5.6.2 Varian Revenue 213 5.7 ViewRay 216 5.8 Accuray Locations 220 5.9 2D X-ray Equipment Leading Vendors 546 List of Tables and Figures Table ES-1 23 Innovative Radiology Surgical Robot Features 23 Table ES-2 24 Surgical Robotics Market Driving Forces 24 Table ES-3 25 Radiology Surgical Robot Market Positioning 25 Table ES-4 26 Accuray CyberKnife M6 Series Systems Adoption Trends 26 Table ES-5 28 Radiological Surgical Robot Medical Sub-Specialties 28 Figure ES-6 30 Radiology Surgical Robots Market Shares, Shipments, Dollars, Worldwide 2015 30 Figure ES-7 34 Radiology Surgical Robot Systems Forecasts, Dollars, Worldwide, 2015-2021 34 Table 1-1 40 Current Radiation Therapy Process and Limitations 40 Table 1-2 43 Advanced Clinical Decision Support 43 Table 1-3 45 Radiological Surgical Robots Benefits 45 Figure 1-4 47 X-ray Diagnosing and Tracking Cancer 47 Table 1-5 48 Factors That May Increase The Risk Of Complications With Radiology Cancer Surgery 48 Table 1-6 53 X-Ray Equipment Market Driving Forces 53

Table 2-1 58 Innovative Radiology Surgical Robot Features 58 Table 2-2 59 Surgical Robotics Market Driving Forces 59 Table 2-3 60 Radiology Surgical Robot Market Positioning 60 Table 2-4 61 Accuray CyberKnife M6 Series Systems Adoption Trends 61 Table 2-5 63 Radiological Surgical Robot Medical Sub-Specialties 63 Figure 2-6 65 Radiology Surgical Robots Market Shares, Shipments, Dollars, Worldwide 2015 65 Table 2-7 66 Radiology Surgical Linear Accelerator Market Shares, Dollars, Worldwide, 2015 66 Figure 2-8 70 Accuray Patient Station 70 Table 2-9 71 Accuray CyberKnife Features 71 Table 2-10 72 Accuray Regional Revenue Shifts 72 Table 2-11 77 Elekta Gamma Knife Benefits 77 Table 2-12 78 Elekta Gamma Knife Positioning 78 Table 2-13 79 Elekta Gamma Knife Perfexion Treatment Benefits 79 Table 2-14 80 Elekta Gamma Knife Features 80 Table 2-15 81 Radiology Surgical Linear Accelerator, Market Shares, Units and Dollars, Worldwide, 2015 81 Figure 2-16 85 Radiology Surgical Robot Systems Forecasts, Dollars, Worldwide, 2016-2022 85 Table 2-17 86 Radiology Surgical Robot Market Segment Forecasts, Dollars and Units, Worldwide, 2016-2022 86 Table 2-18 89 New Cancer Cases in US, 2015, 1,658 Thousand 89 Figure 2-19 90 Cancer Incidence and Mortality, Worldwide 90 Table 2-20 91 Accuray Surgical Robotic Advantages 91 Figure 2-21 93 Radiology Surgical Robots Regional Analysis 93 Table 2-22 94 Radiology Surgical Robots Market Segments 94

Radiology Surgical Robot Regional Market Segments, Dollars, 2015 In Millions of Dollars MM$ 2015 % United States 2,624.1 65.0 Europe 807.4 20.0 China 403.7 10.0 Asia Pacific / Japan 161.5 4.0 Rest of World 40.4 1.0 Total 4,037.1 100.0 Source: WinterGreen Research, Inc. 94 Table 2-23 96 Accuray Regional Revenue Shifts 96 Table 2-24 98 Accuray Cyberknife Radiosurgery System Treats The Following Diseases In China: 98 Table 2-25 99 Advantages of the Cyberknife Treatment in China 99 Table 3-1 105 Accuray CyberKnife M6 Series Benefits: 105 Table 3-2 106 Accuray CyberKnife M6 Series Functions 106 Table 3-3 107 Accuray CyberKnife M6 Series Uses 107 Table 3-4 108 Accuray CyberKnife M6 Series Features 108 Table 3-5 109 Accuray CyberKnife M6 Patient Comfort Features 109 Figure 3-6 110 Accuray Radiology Surgical Robot 110 Figure 3-7 111 Accuray CyberKnife M6 FIM System 111 Table 3-8 112 Accuray CyberKnife M6 FIM System Features 112 Figure 3-9 113 Accuray CyberKnife M6 FM System 113 Table 3-10 114 Accuray CyberKnife M6 FM System Design Features 114 Figure 3-11 115 Accuray CyberKnife M6 FI System 115 Figure 3-12 117 Accuray / CyberKnife VSI System 117 Table 3-13 118 Accuray CyberKnife VSI Radiosurgery System Functions 118

Table 3-14 119 Accuray CyberKnife VSI Radiosurgery System Treatment Options 119 Figure 3-15 120 Accuray TomoTherapy System 120 Table 3-16 121 Accuray TomoTherapy System Benefits 121 Table 3-17 123 Accuray Cancer Conditions Treated via Surgical Robot 123 Table 3-18 128 Accuray Open Systems Software Benefits 128 Table 3-19 129 Accuray Open Systems Software Challenges 129 Figure 3-20 130 Human Brain with Cancer Tumors 130 Figure 3-21 131 Elekta Lexsell Gamma Knife PERFEXIONTM System 131 Table 3-22 134 Conditions for Elekta Gamma Knife Efficacy 134 Table 3-23 135 Advantages of Elekta Gamma Knife 135 Figure 3-24 136 Elekta Market Leading Solutions Portfolio 136 Figure 3-25 137 Varian Radiosurgery System 137 Figure 3-26 139 Varian Radiation Surgery Capabilities 139 Figure 3-27 141 Varian Trilogy 141 Table 3-28 145 Varian Oncology Product Set 145 Table 3-28 (Continued) 146 Varian Oncology Product Set 146 Figure 3-29 147 ViewRay On-Table Dose Prediction And Re-Optimization 147 Figure 3-30 149 ViewRay MRIdian System 149 Table 3-31 150 ViewRay MRIdian System Functions 150 Figure 4-1 157 X-Ray Digital Workflow 157 Figure 4-2 158 Digital X-Ray Equ9pm3n35 Part of Paperless Workflow in Hospital 158 Figure 4-3 159 Departmental Picture Archiving And Communication System PACS: Clinical Productivity 159 Table 4-4 162 Elekta Gamma Knife Surgery Targets 162 Accuray Regional Revenue Shifts 176 Table 5-1 190 Accuray Strategy 190 Table 5-2 191 Accuray Key Elements Of Strategy 191 Table 5-3 198 Best Theratronics, Ltd Radiation Therapy - Gammabeam 500 Total Body Irradiator Features 198

Figure 5-4 199 Best Theratronics, Ltd Radiation Therapy - Gammabeam 500 Total Body Irradiator 199 Figure 5-5 200 Brainlab Collaborative Workspace 200 Figure 5-6 201 Brainlab AG Worldwide Presence, Headquarters in Germany 201 Figure 5-7 205 Elekta Gamma Radio Surgery System 205 Figure 5-8 211 Mitsubishi Heavy Industries Vero RadioTherapy 211 Table 5-9 218 ViewRay Early Adopters: 218

ABOUT THE COMPANY WinterGreen Research, research strategy relates to identifying market trends through reading and interviewing opinion leaders. By using analysis of published materials, interview material, private research, detailed research, social network materials, blogs, and electronic analytics, the market size, shares, and trends are identified. Analysis of the published materials and interviews permits WinterGreen Research senior analysts to learn a lot more about markets. Discovering, tracking, and thinking about market trends is a high priority at WinterGreen Research. As with all research, the value proposition for competitive analysis comes from intellectual input. WinterGreen Research, founded in 1985, provides strategic market assessments in telecommunications, communications equipment, health care, Software, Internet, Energy Generation, Energy Storage, Renewable energy, and advanced computer technology. Industry reports focus on opportunities that expand existing markets or develop major new markets. The reports access new product and service positioning strategies, new and evolving technologies, and technological impact on products, services, and markets. Innovation that drives markets is explored. Market shares are provided. Leading market participants are profiled, and their marketing strategies, acquisitions, and strategic alliances are discussed. The principals of WinterGreen Research have been involved in analysis and forecasting of international business opportunities in telecommunications and advanced computer technology markets for over 30 years. The studies provide primary analytical insight about the market participants. By publishing material relevant to the positioning of each company, readers can look at the basis for analysis. By providing descriptions of each major participant in the market, the reader is not dependent on analyst assumptions, the information backing the assumptions is provided, permitting readers to examine the basis for the conclusions. WinterGreen Research is positioned to help customers facing challenges that define the modern enterprises. The increasingly global nature of science, technology and engineering is a reflection of the implementation of the globally integrated enterprise. Customers trust wintergreen research to work alongside them to ensure the success of the participation in a particular market segment. WinterGreen Research supports various market segment programs; provides trusted technical services to the marketing departments. It carries out accurate market share and forecast analysis services for a range of commercial and government customers globally. These are all vital market research support solutions requiring trust and integrity. ABOUT THE PRINCIPAL AUTHORS Ellen T. Curtiss, Technical Director, co-founder of WinterGreen Research, conducts strategic and market assessments in technology-based industries. Previously she was a member of the staff of Arthur D. Little, Inc., for 23 years, most recently as Vice President of Arthur D. Little Decision Resources, specializing in strategic planning and market development services. She is a graduate of Boston University and the Program for Management Development at Harvard Graduate School of Business Administration. She is the author of recent studies on worldwide telecommunications markets, the top ten internet equipment companies, the top ten contract manufacturing companies, and the Top Ten Telecommunications market analysis and forecasts.

Susan Eustis, President, co-founder of WinterGreen Research is a senior analyst. She has done research in communications and computer markets and applications. She holds several patents in microcomputing and parallel processing. She has the original patents in electronic voting machines. She has new patent applications in format varying, mulitprocessing, and electronic voting. She is the author of recent studies of the Solar REnewable Energy, Wind Energy, Thin Film Batteries, Business Process Management marketing strategies, Internet equipment, biometrics, a study of Internet Equipment, Worldwide Telecommunications Equipment, Top Ten Telecommunications, Digital Loop Carrier, Web Hosting, Web Services, and Application Integration markets. Ms. Eustis is a graduate of Barnard College. Worldwide Who s Who named her Top Female CEO of 2012.