MASTERING PHARMACY UCEIMSURE & CERTIFICATION A CASE-RASED REVIEW DAVID C. KOSEGARTEN, PH.D., R.PH. Associate Professor of Pharmacology and Toxicology Massachusetts College of Pharmacy and Health Sciences Boston, Massachusetts DOUGLAS J. PISANO, PH.D., R.PH. Associate Professor of Pharmacy Administration Massachusetts College of Pharmacy and Health Sciences Boston, Massachusetts F. RANDY VOGENBERG, PH.D., R.PH. Director and National Practice Leader ASA Health System Education and Pharmaceutical Consulting Wellesley, Massachusetts Deans' Professor of Pharmacy Management Philadelphia College of Pharmacy Philadelphia, Pennsylvania MCGRAW-HILL, INC. MEDICAL PUBLISHING DIVISION New York San Francisco Washington, D.C. Auckland Bogota Caracas Lisbon London Madrid Mexico City Milan Montreal New Delhi San Juan Singapore Sydney Tokyo Toronto
Contents 8 9 10 II 12 13 14 15 16 17 18 19 Part I Case Presentations and Questions Coronary Artery Disease Hypertension Seizure Disorders Buffer Solutions Bacteremia and Sepsis Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) Oncology/Breast Cancer Medicinal Chemistry Case #1 Panic Disorder Renal Transplantation Controlled Substances Act (C.S.A.) Arrhythmias Hypertension Seizure Disorders Antibiotic Suspensions Bacteremia and Sepsis Opportunistic Infections Oncology/Prostate Cancer Medicinal Chemistry Case #2 3 5 7 9 II 13 15 17 18 20 22 26 29 31 33 35 37 39 41
<L Contents 20 Generalized Anxiety Disorder 42 21 Renal Transplantation 44 22 Controlled Substances Act (C.S.A.) 47 23 Arrhythmias 49 24 Diabetes Mellitus 52 Nicole Turcotte 25 Seizure Disorders 54 26 Constitution and Flow Rates 56 27 Bacteremia and Sepsis 58 28 Sexually Transmitted Diseases 60 29 Oncology/Colon Cancer 62 30 Medicinal Chemistry Case #3 64 31 Major Depression 65 32 Renal Transplantation 67 33 Controlled Substances Act (C.S.A.) 69 34 Coronary Artery Disease 71 35 Diabetes Mellitus 74 36 Seizure Disorders 76 37 Radiopharmaceuticals 78 38 Bacteremia and Sepsis 80 39 Sexually Transmitted Diseases and Human Immunodeficiency Syndrome (HIV) 82
Contents XI 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 Oncology/Lung Cancer Medicinal Chemistry Case #4 Major Depression Urinary Tract Infections Food, Drug, and Cosmetic Act (F.D.C.A.) Coronary Artery Disease Diabetes Mellitus Asthma Antacid Suspensions Respiratory Tract Infections Tuberculosis Oncology/Ovarian Cancer Medicinal Chemistry Case #5 Bipolar Disorder Urinary Tract Infections Food, Drug, and Cosmetic Act (F.D.C.A.) Coronary Artery Disease Asthma Ointments Respiratory Tract Infections Tuberculosis 84 86 87 89 91 93 95 97 99 101 104 106 108 109 III 114 117 120 122 124 126
XII Contents 61 Oncology/Lymphoma (Hodgkin's) 128 62 Medicinal Chemistry Case #6 130 63 Bipolar Disorder 131 64 Urinary Tract Infections 133 65 Prescription Drug Marketing Act (P.D.M.A.) 135 66 Coronary Artery Disease 137 67 Hypercholesterolemia 140 68 Asthma 142 69 Elixirs 144 70 Respiratory Tract Infections 146 71 Dermatology 148 72 Oncology/ALL (Pediatric) 150 73 Medicinal Chemistry Case #7 152 74 Schizophrenia 153 75 Parkinsons Disease 155 76 Mid-Level Practitioners 157 77 Congestive Heart Failure 158 78 Hypercholesterolemia 160 79 Asthma 162 80 Compounding Capsules 164 81 Soft Tissue Infections 166
Contents XIM 82 Dermatology/Acne 168 83 Oncology/CML (Adult) 170 84 Medicinal Chemistry Case #8 172 85 Schizophrenia 173 86 Parkinsons Disease 175 87 Poison Prevention Packaging Act (P.P.P.A.) 177 88 Congestive Heart Failure 178 89 Thyroid Disease 180 90 Chronic Obstructive Lung Disease 182 91 Parenteral Nutrition 184 92 Soft Tissue Infections 186 93 Osteoporosis 189 94 Oncology/Nausea and Vomiting Control 191 95 Medicinal Chemistry Case #9 193 96 Opiate Abuse 194 97 Parkinsons Disease 196 98 Expiration Dating and NDC Code 198 99 Arrhythmias 199 100 Thyroid Disease 202 101 Chronic Obstructive Lung Disease 204 102 Eye Drops 206
XIV Contents 103 Soft Tissue Infections 104 Osteoporosis 105 Oncology/Pain Control 106 Medicinal Chemistry Case #10 107 Alcohol Abuse 108 Over-the-Counter Drugs 109 Congestive Heart Failure/Arrhythmias 110 Thyroid Disease 111 Chronic Obstructive Lung Disease 112 Arrhythmias 113 Hypertension 114 Hypertension Down Chandler-Toufieli 115 Hypertension 116 Anticoagulation 117 Anticoagulation 118 Anticoagulation 119 Hypercholesterolemia 120 Hypercholesterolemia Part II Answers with Explanations and Answers Appendix Subject Index References 208 210 212 214 215 217 219 222 224 226 228 230 232 234 236 238 240 242 247 339 355