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Industry Research by Koncept Analytics Global Transcatheter Mitral Valve Repair & Replacement (TMVR) Market: Industry Analysis & Outlook ----------------------------------------- (2018-2022) March 2018 1

Executive Summary A human heart has four valves: Mitral valve, Tricuspid valve, Aortic valve and Pulmonary valve. Mitral valve is located on the left side of the heart and has two flaps which create a passage for oxygenated blood to travel from the left atrium to left ventricle. Mitral valve is attached by chordae tendinae to the papillary muscles which prevent the leaflets from prolapsing during ventricular contraction. When the mitral valve does not close properly, then this condition is called Mitral Regurgitation. Mitral Regurgitation (MR) is a valve disorder where blood leaks backward through the mitral valve with heart contractions and reduces the amount of blood pumped through the body, which over time can lead to heart dysfunction and heart failure. Mitral Regurgitation can be of two types: Functional Mitral Regurgitation (FMR) and Degenerative Mitral Regurgitation (DMR). Europe is a major contributor to the global TMVR market supported by increased ageing and obese population, better accessibility and favorable reimbursement policies for TMVR. The U.S. is also expecting a high growth rate in TMVR market due to rising development of TMVR devices and incidences of heart diseases. The global TMVR market is expected to grow in future due to increasing ageing population, obese population, rising healthcare expenditure and economic growth. Key trends of this market include leading causes of death in the U.S., factors affecting the development of TMVR devices, prevalence of mitral regurgitation by age group in the U.S. and growing adoption of minimally invasive therapies. However, there are some factors which can hinder the market growth including associated high risks and tough regulatory problems. The report by Koncept Analytics provides an extensive research and detailed analysis of the present market along with future outlook. The report discusses the major growth drivers and challenges of the market, covering the U.S., and Europe region along with the global market. The report profiles the key players of the market including Medtronic plc, Abbott Laboratories, Edwards and LivaNova Plc. 2

Units Growth of global TMVR market is likely to result from growing adoption of minimally invasive therapies, increasing ageing and obese population, development of innovative devices.. Global TMVR Market Value Forecast (2017-2022) Global TMVR market is expected to reach US$.. million in the year 2022, increasing from US$.. million in the fiscal year 2017 at a CAGR of..%. In the year 2017, Europe held a major share of..% in the global TMVR Market value. In year 2022, global TMVR market volume is expected to reach units, increasing from..units in 2017, at a CAGR of..%. Global TMVR Market by Region (2017) Global TMVR Market Volume Forecast (2017-2022) Europe The U.S. 3

The U.S. TMVR market is expected to grow with the growing incidences of heart diseases, increasing prevalence of mitral regurgitation in older populace, improving TMVR product pipeline.. Units The U.S. TMVR Market Value Forecast (2017-2022) The U.S. TMVR market is expected to reach US$.. million in the year 2022, increasing from US$.. million in the fiscal year 2017 at a CAGR of..%. In the year 2022, the U.S. TMVR market volume is expected to reach units, increasing from units in 2017. In year 2022, European TMVR market is expected to reach US$.. million, increasing from US$.. million in 2017, at a CAGR of..%. The U.S. TMVR Market Volume Forecast (2017-2022) Europe TMVR Market Value Forecast (2017-2022) 4

Contact Us: Disclaimer This is a licensed product of Koncept Analytics. You cannot reproduce, publish, distribute, publicly display, sell or create other works from this report or use them in any way for commercial purpose without our prior permission. Further, you cannot copy this material, by any means (including electronic copies), for distribution to others unless you have purchased the corporate license of this report. We believe the sources are reliable, but Koncept Analytics does not warranty the accuracy or completeness of the data. The data presented in the report is updated at the publication date but is subject to change at subsequent releases. All possible efforts have been made to ensure accuracy of data. However, investors should not completely rely on the information given in this report and must make decisions based on their own investment strategy, risk management and capital adequacy. Koncept Analytics CS-36, First Floor, Ansal Plaza Vaishali, Ghaziabad, U.P. 201010 T: +91-120-4130959 M: +91-9811715635 vikas@konceptanalytics.com www.konceptanalytics.com 5