ESPE Science School (ESS) May 16-20, Heraklio, Crete, Greece

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ESPE Science School (ESS) May 16-20, 2012 - Heraklio, Crete, Greece November 27, 2011 Dear ESPE member, RE: Call for ESS Student applications This is our annual call for ESPE members to have their younger colleagues apply for ESS, including the NICHe Conference, which will be on Stress Response and Child Health in May 16-20, 2012 in Heraklio, Crete, Greece. Applicants for ESS can be postdoctoral fellows, last year PhD students or young research faculty in Pediatric Endocrinology within 5 years of their fellowship or PhD. The program (attached) is based on core lectures (marked by C), research concepts (R) and new technologies (N), as well as projects presentation and discussion by the students, and practical exercise in reviewing an article. ESS will cover travel and participation costs. Applications should include a letter of application, CV and a letter by the direct supervisor, and should be submitted to the, Mr. Kavadias, by email only [KKavadias@era.gr] until January 10th, 2012. Decisions will be announced by January 31st, 2012. On behalf of the, MD, MACP, MACE, FRCP (London) ESPE Science School Coordinator

ESPE Science School (ESS) May 16-20, 2012 - Heraklio, Crete, Greece Scientific Program C - Core lectures, R - Research concepts, N - New technologies Wednesday, May 16 08.45-09.00 Opening, 09.00-09.45 R Linking the CNS to the endocrine system George Chrousos (Athens, Greece) 09.45-10.30 R Evolutionary Medicine, Ze ev Hochberg (Haifa, Israel) 10.30-11.00 Break 11.00-11.45 C Epidemiology, (Paris, France) 11.45-12.30 R New insights into steroidogenesis, (London, UK) 12.30-14.00 Lunch 14.00-14.45 N A genome wide approach to studying nuclear receptor actions John Cidlowski (NC, USA) 14.45-15.30 N Dissecting the molecular basis of 17,20-lyase deficiency Walter Miller (San Francisco, CA, USA)

15.30-16.00 Break 16.00-16.45 Projects discussion, students in groups 16.45-17.30 R Endocrine disruptors, Olle Soder (Stockholm, Sweden) 17.30-18.00 Break 18.00-18.45 Projects discussion, students in groups 18.45-19.30 C Designing a clinical trial Anita Hokken-Koelega (Amersfoort, The Netherlands) 19.30 Dinner Thursday, May 17 09.00-09.45 C Designing a basic science research project Andreas Margioris (Heraklio, Greece) 09.45-10.30 Reviewing an article, students in groups 10.30-11.00 Break 11.00-11.45 N Strategies to detect a new gene and prove its importance Mehul Dattani (London, UK) 11.45-12.30 C Career development, Olle Soder (Stockholm, Sweden) 12.30-14.00 Lunch 14.00-14.45 R Cross-talk between neurosteroids and neurotrophins in brain development and aging, Achilleas Gravanis (Heraklio, Greece) 14.45-15.30 N Assessing neurosteroid function in vivo and in vitro Synthia Mellon (San Francisco, CA, USA) 15.30-16.15 N How to develop a new hormone, (La Jolla, CA, USA) 16.15-16.45 Break

16.45-17.30 R Recent advances in glucocorticoid receptor research Tomoshige Kino (Bethesda, MD, USA) 17.30-18.15 C How to write and appraise a scientific paper Nancy Gough (Washington DC, USA) 18.15 Course summary, George Chrousos 19.30 Dinner Friday - Sunday, May 18-20 NICHe Conference: Stress Response and Child Health

NICHe Conference Stress Response and Child Health Friday, May 18 SESSION 1: INTRODUCTION 08.45-09.00 Opening, 09.00-10.00 Concepts of stress and neuroendocrinology of the stress response (Athens, Greece) 10.00-11.00 Stress-system disorders: Overview of behavioral homeostasis Gold PW (Bethesda, MD, USA) 11.00-11.30 Break 11.30-12.30 Evolutionary perspective in the stress response Ze ev Hochberg (Haifa, Israel) 12.30-14.00 Lunch SESSION 2: ENDOCRINOLOGY OF THE STRESS RESPONSE 14.00-15.00 The CRF family of peptides and their role in stress responsiveness and behavior Wylie W. Vale (La Jolla, CA, USA)

15.00-16.00 Glucocorticoid receptor isoforms and the networks of glucocorticoid actions John Cidlowski (NC, USA) 16.00-16.30 Break 16.30-17.30 Alterations in the circadian rhythm of glucocorticoid secretion: Potential clinical implications Tomoshige Kino (Bethesda, MD, USA) 17.30-18.30 Alterations in the ultradian glucocorticoid secretion: Implications for GRmediated gene transcription Gordon Hager (Bethesda, MD, USA) 19.30 Dinner Saturday, May 19 09.00-10.00 P450 oxidoreductase deficiency: A new disorder of steroidogenesis with multiple clinical manifestations Walter Miller (San Francisco, CA, USA) 10.00-11.00 Allopregnanolone: Neurosteroids as regulators of stress Synthia Mellon (San Francisco, CA, USA) 11.00-11.30 Break SESSION 3: EFFECTS OF CHRONIC HYPERACTIVATION OR HYPOACTIVATION OF THE STRESS SYSTEM 11.30-12.30 The effects of acute and chronic stress on growth Lars Sävendahl (Stockholm, Sweden) 12.30-14.00 Lunch

14.00-15.00 The effects of acute and chronic stress on puberty/reproduction Jean Claude Carel (Paris, France) 15.00-16.00 Stress and cognition Seckl JR (Edinburgh, UK) 16.00-16.30 Break 16.30-17.30 Long-term effects of social status and psychological stress on health and longevity M.G. Marmot (London, UK) 17.30-18.30 The effects of acute and chronic stress on diabetic control Franco Chiarelli (Chieti, Italy) 19.30 Dinner Sunday, May 20 09.00-10.00 Stress and Sleep Alexandros Vgontzas (Hershey, PA, USA) 10.00-11.00 Primary Generalized Glucocorticoid Resistance and Hypersensitivity States: The End-organ Involvement in the Stress Response (Athens, Greece) 11.00-11.30 Break 11.30-12.30 Effects of intrauterine stress exposure on long-term human health and disease risk outcomes: focus on metabolism, HPA function, immunity, cognition and cellular aging Pathic Wadhwa (Irvine, CA, USA) 12.30-13.00 Concluding Remarks - George Chrousos

ESPE Science School (ESS) May 16-20, 2012 - Heraklio, Crete, Greece Supported by an educational grant by Pfizer Health care APPLICATION FOR REGISTRATION Please type or use block letters and return this form to the Meeting Secretariat:., 17, Asklipiou Str. 106 80, Athens - Greece, Tel.: +30 210 3634 944, Fax: +30 210 3631 690, E-mail: info@era.gr Web Site: www.era.gr PERSONAL INFORMATION Family name:... First name(s):... Title: Prof. Dr. Mr. Ms. Date of birth:. Contact Address / University:... Hospital:..... Department:.... City:...Zip code:... Country:... Tel:... Mobile Tel. Number:... Fax:... E-mail*:... Qualifications:........... Current post:. Higher degrees and details:. Clinical /Basic science training:.

5 most important papers: 1. 2. 3. 4. 5. Scholarly achievements:. * Please fill in legibly to avoid time consuming correspondence. All correspondence will be made via e-mail. I do / I do not allow giving my address details to third parties. In case your application is approved ESS will cover travel and participation costs therefore please fill the below boxes. TRAVEL INFORMATION Departure date/time Return date/time Airport you wish to depart from 1st choice: Airline company you prefer 2nd choice: Your air ticket will be issued by ERA LTD and will be sent to you by courier or electronically, up to May 1st, 2012 ACCOMMODATION INFORMATION Double room FOR SINGLE USE Check in date: Check out date: Notes: Applications are to include this letter of application, a CV and a letter by the direct supervisor, and be submitted to the meeting secratariat by email only, at info@era.gr by January 10th, 2012. Decisions will be announced by January 31st, 2012. Signature Date:.../.../...

NICHe Conference Stress Response and Child Health May 18-20, 2012 - Heraklio, Crete, Greece December 1, 2011 Dear Colleagues and friends ESPE members, It is a pleasure to invite you to participate in the 2012 New Inroads to Child Health (NICHe) Conference (http://www.eurospe.org/meetings/niche.html) on May 18-20, 2012, in Crete, on the topic STRESS RESPONSE AND CHILD HEALTH. This is the fifth in ESPE series of high-profile conferences devoted to future research directions in child health. The series is based on our conviction that it is the responsibility of those of us involved in today s biomedical research enterprise to translate the remarkable scientific innovations we are witnessing into health gains for children. The Scientific Committee is pleased to invite those interested to register with the Conference Organizer [kkavadias@era.gr] before January 10th, 2012. Twenty five slots are available for ESPE members on a first-come, first-served basis. For participants the conference will cover the cost of scientific sessions, registration, accommodation and provision of meals. Travel expenses are not covered by the conference organization. We look forward to see you in Crete. On behalf of the scientific committee, MD, MACP, MACE, FRCP (London) Professor and Chairman, First Department of Pediatrics University of Athens Medical School Athens 115 27, Greece

NICHe Conference Stress Response and Child Health Scientific Program Friday, May 18 SESSION 1: INTRODUCTION 08.45-09.00 Opening, 09.00-10.00 Concepts of stress and neuroendocrinology of the stress response (Athens, Greece) 10.00-11.00 Stress-system disorders: Overview of behavioral homeostasis Gold PW (Bethesda, MD, USA) 11.00-11.30 Break 11.30-12.30 Evolutionary perspective in the stress response Ze ev Hochberg (Haifa, Israel) 12.30-14.00 Lunch

SESSION 2: ENDOCRINOLOGY OF THE STRESS RESPONSE 14.00-15.00 The CRF family of peptides and their role in stress responsiveness and behavior Wylie W. Vale (La Jolla, CA, USA) 15.00-16.00 Glucocorticoid receptor isoforms and the networks of glucocorticoid actions John Cidlowski (NC, USA) 16.00-16.30 Break 16.30-17.30 Alterations in the circadian rhythm of glucocorticoid secretion: Potential clinical implications Tomoshige Kino (Bethesda, MD, USA) 17.30-18.30 Alterations in the ultradian glucocorticoid secretion: Implications for GRmediated gene transcription Gordon Hager (Bethesda, MD, USA) 19.30 Dinner Saturday, May 19 09.00-10.00 P450 oxidoreductase deficiency: A new disorder of steroidogenesis with multiple clinical manifestations Walter Miller (San Francisco, CA, USA) 10.00-11.00 Allopregnanolone: Neurosteroids as regulators of stress Synthia Mellon (San Francisco, CA, USA) 11.00-11.30 Break

SESSION 3: EFFECTS OF CHRONIC HYPERACTIVATION OR HYPOACTIVATION OF THE STRESS SYSTEM 11.30-12.30 The effects of acute and chronic stress on growth Lars Sävendahl (Stockholm, Sweden) 12.30-14.00 Lunch 14.00-15.00 The effects of acute and chronic stress on puberty/reproduction Jean Claude Carel (Paris, France) 15.00-16.00 Stress and cognition Seckl JR (Edinburgh, UK) 16.00-16.30 Break 16.30-17.30 Long-term effects of social status and psychological stress on health and longevity M.G. Marmot (London, UK) 17.30-18.30 The effects of acute and chronic stress on diabetic control Franco Chiarelli (Chieti, Italy) 19.30 Dinner Sunday, May 20 09.00-10.00 Stress and Sleep Alexandros Vgontzas (Hershey, PA, USA) 10.00-11.00 Primary Generalized Glucocorticoid Resistance and Hypersensitivity States: The End-organ Involvement in the Stress Response (Athens, Greece) 11.00-11.30 Break

11.30-12.30 Effects of intrauterine stress exposure on long-term human health and disease risk outcomes: focus on metabolism, HPA function, immunity, cognition and cellular aging Pathic Wadhwa (Irvine, CA, USA) 12.30-13.00 Concluding Remarks - George Chrousos