TIPS TO HELP MANAGE CERTAIN SIDE EFFECTS

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TIPS TO HELP MANAGE CERTAIN SIDE EFFECTS If you experience any side effects, call your oncology doctor. He or she may need to: Treat you with an additional medication Reduce your dose Pause treatment for a short period of time, or stop treatment in severe cases Contacting My Oncology Doctor Name Number Please note: The following tips have been developed based on information from a variety of organizations that provide information and support to people affected by cancer.

None of the products referenced in these tips are owned by Exelixis, Inc. or its affiliates. These tips are not endorsing those products and other similar products may be used, and the owners of those products have not endorsed these tips. 2018 Exelixis, Inc. 09/18 CA-0935

DIARRHEA Diarrhea is a common side effect of certain cancer treatments. If it is not managed, diarrhea can be very serious, so it is important to speak to your oncology doctor or nurse if you have any signs and symptoms and/or your stools are happening more often than normal. Call your oncology doctor or nurse right away if you: Have 6 or more loose bowel movements a day for 2 days in a row Have blood around the anal area or blood in your stool Lose 5 or more pounds after the diarrhea starts Have pain in your belly or cramps start and last for 2 or more days Don t urinate for 12 or more hours Get a puffy or swollen belly

Tips to Help With Diarrhea Drink plenty of clear liquids. Try not to drink many caffeinated drinks (such as coffee and soft drinks) or dairy products (such as milk) Eat small, light meals many times a day (such as bananas, rice, applesauce, dry toast, or mashed potatoes) Try not to eat foods that are spicy, greasy, fatty, or high in fiber (such as fast food, raw vegetables, and nuts) Keep track of how often you have diarrhea, the amount of fluid you drink, and your weight After each bowel movement, gently clean your anal area well with a mild soap or baby wipes, and pat dry. Once dry, you may apply petroleum jelly or A+D ointment to the outer rectal area Loperamide (anti-diarrheal tablets) are included in your care kit. Read the package and talk with your doctor about taking loperamide to make sure it s safe for you. If your doctor approves your use of loperamide: Take 2 caplets after the first loose stool and 1 after each loose stool thereafter. Do not take more than 4 caplets in a 24-hour time frame

MOUTH CARE Certain medications used to treat cancer may cause mouth problems such as: Canker sores Gum or mouth pain Infections in your mouth or gums Burning sensation of the tongue Red, swollen, or bleeding gums Change in how things taste Call your oncology doctor or nurse if you have pain in your mouth or throat OR if your mouth looks or feels different. Check your mouth 2 times a day. Use a small flashlight and a padded tongue depressor to: Look for small cuts, ulcers, or sores in your mouth on your gums, on your tongue, or under your tongue See if the inside of your mouth is redder than usual or swollen See if there is blood in your mouth Tips for Mouth Care See your dentist regularly Brush your teeth gently after each meal Use a soft toothbrush and children s toothpaste Floss your teeth at least once a day Tell your dentist about the treatments you are taking

Tips for Mouth Care (cont d) If you have mouth sores or dryness, rinse your mouth after you eat and before you go to bed Use a salt and baking soda mixture: Add 1 teaspoon of salt and 1 teaspoon of baking soda to 1 quart of warm water; stir or shake well. Sip the solution, swish it around in your mouth, gently gargle, and then spit it out. Don t swallow! Do not use mouthwash with alcohol Use a lip balm such as ChapStick to keep your lips moisturized If you have mouth pain Suck on ice chips or ice pops Drink through a straw Talk to your oncology doctor about over-the-counter medications that can be used for the pain Eat soft foods that you can swallow easily Try not to eat hard, crusty, salty, sticky, sugary, or spicy foods Try not to eat or drink fruits or juices that are acidic, such as tomatoes, oranges, grapefruits, limes, and lemons

NAUSEA AND VOMITING You may feel nauseated (queasy) or vomit (throw up) during your cancer treatment. Call your oncology doctor or nurse right away if you: Vomit more than 3 times an hour for more than 3 hours See blood in your vomit Vomit and it looks like coffee grounds Can t have more than 4 cups of liquid or ice chips in a day Haven t been able to eat for more than 2 days Are weak, dizzy, or confused Lose 2 or more pounds in 2 days Have dark-yellow urine Tips for Managing Nausea and Vomiting For nausea (upset stomach) Drink plenty of clear liquids such as ginger ale, apple juice, or broth Eat bland foods (with little to no taste) such as dry toast and crackers. Do not eat heavy, fatty meals, or greasy foods Try to stay away from strong odors

Tips for Managing Nausea and Vomiting (cont d) Do not lie flat for at least 1 hour after eating. Rest by sitting up in a chair or recliner Suck on lemon or mint candy to make a bad taste go away Do not eat for 2 to 3 hours before you go to bed, and raise the head of your bed for sleeping For vomiting (throwing up what s in your stomach) Keep track of how often you are vomiting, the amount of fluid you drink each day, and your weight After vomiting stops, try to slowly sip a small amount of cool liquid. You might want to suck on some ice chips or frozen juice chips Your oncology doctor may also prescribe a medication for nausea and vomiting Queasy Drops are included in your care kit. Queasy Drops have ingredients that may help stop nausea and dry mouth. Talk to your doctor before using Suck on Queasy Drops just like hard candy Do not chew

FATIGUE Fatigue, or feeling tired, weak, or like you don t have any energy is a common side effect of certain cancer treatments. Call your oncology doctor or nurse if you: Are too tired to get out of bed and this lasts for 24 or more hours Can t think clearly Can t sleep at night Feel tired (out of breath or heavy/fast heartbeat) after doing small activities

Tips for Managing Fatigue Get a good night s sleep each night. The right amount varies by person, but is usually around 7 to 8 hours Try to keep good sleep habits Go to bed at the same time each night Wake up at the same time each day Try not to eat heavy meals before bedtime If you have caffeine, make sure it s 6 to 8 hours before you go to bed. Remember, caffeine is in liquids (such as soft drinks and coffee), food (such as chocolate), and some medicines Make sure your bedroom is quiet and dark and is a comfortable temperature Be as active as possible. Talk with your doctor about which types of activity may be right for you. It is best to start slowly. Only do more when you know you re able to Plan ahead. Decide which activities are most important to you. Try to schedule important activities throughout the day, if possible, so you can take breaks Eat a nutritious and well-balanced diet (make sure you have enough calories and protein to give your body the energy it needs) Consider meeting with a registered dietitian who specializes in helping people with cancer

HAND-FOOT SYNDROME (HFS) Certain medications used to treat cancer may cause HFS, which is a side effect that causes symptoms such as pain and swelling in your hands or feet. You may also hear your doctor call HFS palmar-plantar erythrodysesthesia syndrome (PPES). Call your oncology doctor or nurse if you have any of the following problems with your hands or feet: Your skin is red or swelling You feel tingling/burning or your skin is sensitive to touch You have thick calluses or blisters Your skin is cracked, flaking, or peeling Your skin has blisters, ulcers, or sores You have a hard time walking or using your hands (especially if it s because of pain) Start using Udderly Smooth Extra Care Cream now, included in your care kit. This cream may help with some symptoms of hand-foot syndrome when you apply it many times a day. Follow package directions or use as directed by your doctor You can also use other mild, fragrance-free lotions.

Tips to Help With Hand-foot Syndrome Heat may make your symptoms worse or more likely to happen Try not to put your hands or feet in hot water Try to stay out of direct sunlight or other heat sources If your hands and feet feel hot, use an ice pack to cool them for 15-20 minutes Take cool showers or baths Don t take hot showers Try to avoid pressure, friction, or rubbing Don t use hammers, shovels, knives, or other tools Wear loose clothing and comfortable, well-fitting footwear Gently pat your skin dry after washing your hands or bathing Use cotton gloves and socks to help protect your hands and feet Talk to your doctor about using creams such as clobetasol and halobetasol these can be found at your local drug store

HYPERTENSION (HIGH BLOOD PRESSURE) Hypertension is a common side effect in people taking certain cancer medicines. It is important to take your blood pressure before you start taking your medicine and regularly during your treatment. Keep a record of your blood pressure measurements so you can tell your doctor if there is a change. Call your oncology doctor or nurse if: Your blood pressure suddenly goes up Your blood pressure is outside the recommended range (normal blood pressure is 120/80). Talk to your doctor about your blood pressure goals You feel dizzy You have shortness of breath You have any new or worsening symptoms

Tips to Help With Hypertension Take your blood pressure regularly. Talk to your doctor before you get started Be healthy! Eat a diet of whole grains, fruits, vegetables, and low-fat dairy products (such as yogurt) Don t have too much salt, caffeine, or alcohol Exercising regularly can help with blood pressure. Examples of the best types of exercise include walking, jogging, cycling, or swimming. You may want to talk to your oncology doctor about what types of exercise he or she may recommend for you