University of Groningen Major role of the extracellular matrix in airway smooth muscle phenotype plasticity Dekkers, Bart IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2010 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Dekkers, B. G. J. (2010). Major role of the extracellular matrix in airway smooth muscle phenotype plasticity: Implications for chronic asthma Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-02-2018
Major role of the extracellular matrix in airway smooth muscle phenotype plasticity Implications for chronic asthma Proefschrift ter verkrijging van het doctoraat in de Wiskunde en Natuurwetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op vrijdag 25 juni 2010 om 16.15 uur door Bart Gerrit Jan Dekkers geboren op 28 januari 1981 te Hardenberg
Promotores: Beoordelingscommissie: Prof. dr. H. Meurs Prof. dr. J. Zaagsma Prof. dr. A.J. Halayko Prof. dr. K. Racké Prof. dr. W. Timens ISBN: 978-90-367-4423-2
Paranimfen: I.S.T. Bos T.J.H. Dekkers The research project described in this thesis was performed within the framework of the Groningen graduate school for behavioral and cognitive Neurosciences (BCN), and the Groningen research institute for asthma and COPD (GRIAC), and was financially supported by a grant from the Netherlands asthma foundation (grant 3.2.03.36). Printing of this thesis was financially supported by: Cover: The extracellular matrix by Jesper Julyan Dekkers. Copyright 2010 by Bart G.J. Dekkers. All rights reserved. No parts of this book may be reproduced in any manner or by any means without the permission from the publisher. Printing: Printpartners Ipskamp B.V., Enschede.
Table of contents Chapter 1 General introduction 7 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Airway structural components drive airway smooth muscle remodeling in asthma Proc Am Thoracic Soc (2009) 8:683-692 Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function Am J Physiol Lung Cell Mol Physiol (2007) 292: L1405-1413 Functional consequences of human airway smooth muscle phenotype plasticity Submitted (2010) Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype Am J Respir Cell Mol Biol (2009) 41:494-504 The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma Am J Respir Crit Care Med (2010) 181:556-565 The laminin 1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in chronic asthma Signalling pathways of collagen I-induced airway smooth muscle phenotype modulation Glucocorticosteroids and 2 -adrenoceptor agonists synergistically prevent the induction of a proliferative, hypocontractile airway smooth muscle phenotype 29 53 73 85 109 131 151 171 Chapter 10 General discussion and summary 189 Nederlandse samenvatting 203 Dankwoord 213 Curriculum vitae 215 List of publications 216 List of abbreviations 219
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