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Poster #86 Impaired Fasting Glucose Is Associated With Lower Rates of Sustained Virologic Response (SVR) in With Genotype Chronic Hepatitis C (CHC): Retrospective Analysis of the IDEAL Study M. S. Sulkowski, S. A. Harrison, L. Rossaro, 3 K.-Q. Hu, 4 E. J. Lawitz, 5 M. L. Shiffman, 6 A. J. Muir, 7 G. W. Galler, 8 J. McCone, 9 L. M. Nyberg, W. M. Lee, R. Ghalib, J. Long, 3 S. Noviello, 3 C. A. Brass, 3 L. D. Pedicone, 3 J. K. Albrecht, 3 J. G. McHutchison, 7 J. W. King 4 Johns Hopkins University School of Medicine, Baltimore, MD, USA; Brooke Army Medical Center, Fort Sam Houston, TX, USA; 3 University of California Davis Medical Center (UCDMC), Sacramento, CA, USA; 4 University of California Irvine Medical Center, Irvine, CA, USA; 5 Alamo Medical Research, San Antonio, TX, USA; 6 Liver Institute of Virginia, Bon Secours Health System, Newport News, VA, USA; 7 Duke Clinical Research Institute, Durham, NC, USA; 8 Kelsey-Seybold Research Foundation, Houston, TX, USA; 9 Mount Vernon Endoscopy Center, Alexandria, VA, USA; Kaiser Permanente, San Diego Medical Center, San Diego, CA, USA; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; The Liver Institute at Methodist Dallas, Dallas, TX, USA; 3 Schering-Plough Research Institute, now Merck & Co., Inc., Whitehouse Station, NJ, USA; 4 Louisiana State University Health Sciences Center, Shreveport, LA, USA Abstract Background/Aims: Impaired fasting glucose is independently associated with reduced likelihood of SVR with current therapy (NEJM, 9;36:58). However, the relationship between SVR, fasting blood glucose (FBG) and HBA has not been defined. Methods: 37 treatment-naive, CHC genotype patients (pts) received peginterferon (PegIFN) alfa-b or alfa-a plus ribavirin (RBV). All pts underwent pretreatment FBG determination and were categorized by their medical history of diabetes. Based on American Diabetes Association definition, pts with FBG mg/dl were defined as having impaired fasting glucose (IFG). Per protocol, pts with known diabetes and/or FBG 6mg/dL underwent HBA testing; those with HBA >8.5% were excluded. Pts with FBG between and 5mg/dL did not have HBA testing. Virologic response rates were analyzed. Results: 368 pts were included in the analysis. The frequency of IFG of mg/dl was 8.7% (88/368) and of a medical history of diabetes was 6.7% (6/368). Among those who underwent testing (n=34), median HBA was 6.% (interquartile range 5.6% - 6.6%). SVR according to baseline FBG for all pts and according to HBA for the subset with testing are shown (Table). SVR rate was significantly lower among pts with IFG compared to those with FBG <mg/dl (P<.); relapse rate was also higher in those with IFG. Pts with a history of diabetes had lower SVR rates than those without (.4% [44/6] vs 4.% [6/833]). However, among those tested, the SVR rate was not associated with HBA level (<6% vs 6%; P=.88). Conclusions: Impaired fasting glucose and the clinical diagnosis of diabetes were each strongly associated with lower SVR and higher relapse rates in CHC genotype pts treated with PegIFN/RBV. Among those who underwent testing, no association between HBA level and SVR was apparent; however, pts with HBA >8.5% were excluded from treatment. These data suggest that FBG should be routinely assessed prior to therapy; randomized trials are needed to determine if improvement in glucose control prior to treatment will lead to improved viral response. SVR EOT Response Relapse Fasting Blood Glucose (pretreatment) All Pts (n=368) 4 56 6 < mg/dl (n=88) 43 58 mg/dl (n=747) 3 5 34 > mg/dl (n=33) 44 4 HBA (pretreatment) Pts with protocol-defined criteria of diabetes and/or FBG 6mg/dL (n=34) 6 45 4 <6% (n=39) 45 44 6 <7% (n=33) 3 46 46 7 8.5% (n=5) 33 4 5 Background A number of previous studies have reported that insulin resistance is negatively associated with sustained virologic response (SVR) in patients receiving peginterferon alfa plus ribavirin for chronic hepatitis C (as reviewed by Harrison et al ) In the IDEAL study, stepwise multivariable logistic regression analysis identified normal baseline fasting glucose as an independent predictor of SVR SVR rates were 4% to 44% in patients with baseline fasting glucose <5.6 mmol/l (< mg/dl) and 8% to 33% in those with baseline fasting glucose 5.6 mmol/l ( mg/dl) Aim To define the relationship between SVR, fasting blood glucose, and HbA in patients receiving peginterferon (PEG-IFN) plus ribavirin in the IDEAL trial and Methods Study Design IDEAL was a phase 3b, randomized, parallel-arm trial conducted at 8 academic and community centers in the United States (Figure ) PEG-IFN alfa-b dose was double-blinded, and PEG-IFN alfa-a and RBV were administered as open-label treatments with a detectable, <-log decline in HCV-RNA at week, or with detectable HCV-RNA at week 4 were discontinued from treatment Figure. IDEAL study design. Screening Weeks* *HCV-RNA assessments PEG-IFN = peginterferon; RBV = ribavirin. n = 9 PEG-IFN alfa-b.5 µg/kg/wk + RBV 8 mg/d 48 weeks n = 6 PEG-IFN alfa-b. µg/kg/wk + RBV 8 mg/d 48 weeks n = 35 PEG-IFN alfa-a 8 µg/wk + RBV - mg/d 48 weeks 4 4 48 4 4 37 treatment-naive patients with chronic hepatitis C, genotype infection, aged 8 to 7 years and weighing 4 to kg Assessments All patients underwent pretreatment fasting blood glucose (FBG) determination and were categorized by their medical history of diabetes Based on the American Diabetes Association definition, patients with baseline FBG mg/dl were defined as having impaired fasting glucose (IFG) Per protocol, patients with a medical history of diabetes and/or FBG 6 mg/dl underwent HbA testing Those with pretreatment baseline HbA >8.5% were excluded from participation in the study with a baseline FBG <6 mg/dl did not require HbA testing FBG (in all patients) and HbA (in diabetics or those with FBG 6 mg/dl) levels were assessed at pretreatment baseline visit, treatment weeks, 4, 36, and 48, and follow-up week 4. In addition, patients with diabetes had an additional HbA assessment at treatment week 4 SVR was defined as undetectable HCV-RNA (lower limit of quantitation of 7 IU/mL by Roche COBAS TaqMan HCV-RNA assay) at the end of the 4-week follow-up period Results 368 patients were included in the analysis 8.7% (88/368) of patients had baseline FBG mg/dl and were considered to have IFG 6.7% (6/368) of patients had a medical history of diabetes Among those who underwent testing (n = 34), median HbA was 6.% (interquartile range, 5.6% 6.6%) Virologic Response Virologic response rates were lower in patients with a medical history of diabetes and/ or baseline FBG 6 mg/dl compared with the study population (Figure ) Figure. Virologic response rates in all patients and those with a medical history of diabetes and/or baseline fasting blood glucose 6 mg/dl. 5 All patients (n = 368) Protocol-defined criteria of diabetes and/or FBG 6 mg/dl (n = 34) 56 45 4 4 6 6 Virologic Response in With Impaired Fasting Glucose SVR rate was significantly lower among patients with IFG (FBG mg/dl) compared with those with baseline FBG < mg/dl (3.3% [67/88] vs 43.3% [947/88]; P <.) (Figure 3) Relapse rate was also higher in those with IFG (34.7% [4/46] vs.4% [7/3]) Figure 3. Virologic response rates according to baseline fasting blood glucose. 5 43 3 FBG < mg/dl (n = 88) FBG mg/dl (n = 747) FBG > mg/dl (n = 33) 58 5 Virologic Response in With Diabetes or Elevated Fasting Blood Glucose SVR rate for patients with diabetes and/or FBG 6 mg/dl was 6% (83/34) End-of-treatment (EOT) response rate was 45% (45/34), with a relapse rate of 4% (56/39) Among this subgroup of patients, there was a trend for lower SVR rates in patients with lower baseline HbA levels (Table ) However, the SVR rate was not associated with HbA level (<6% vs 6%; P =.88) Table. Virologic Response Rates According to Baseline HbA Level SVR, 44 EOT Response, 34 4 Relapse, Pretreatment baseline HbA <6% (35/39) 45 (63/39) 44 (7/6) 6% <7% 3 (3/33) 46 (6/33) 46 (6/57) 7% 8.5% 33 (7/5) 4 (/5) 5 (3/) EOT = end-of-treatment; SVR = sustained virologic response. Changes in hemoglobin (Hb) concentrations correlated with changes in HbA levels at treatment weeks 4 (n = 7) and (n = 7) (Figure 4) Pearson correlation coefficient was estimated as.44 at treatment week 4 Pearson correlation coefficient was estimated as.4 at treatment week Given a decrease in Hb of g/dl, the predicted decrease of HbA would be.4% at treatment week 4 and.6% at treatment week Figure 4. Relationship between hemoglobin concentration and HbA at treatment weeks 4 (n = 7) and (n = 7). Change in HbA From Baseline 3 - - -9 - - Week 4 Week with a history of diabetes had a lower SVR rate than those with no history of diabetes (.4% [44/6] vs 4.% [6/833]) For patients with both treatment-week and week- values, changes in Hb concentrations correlated with changes in HbA levels at treatment weeks 4 and (n = 3) (Figure 5) Pearson correlation coefficient was estimated as.39 at treatment week 4 Pearson correlation coefficient was estimated as. at treatment week Given a decrease in Hb of g/dl, the predicted decrease of HbA would be.% at treatment week 4 and.7% at treatment week Figure 5. Relationship between hemoglobin concentration and HbA at treatment weeks 4 and for patients with values at both time points (n = 3). Change in HbA From Baseline - - - - Week 4 Week Summary IFG and the clinical diagnosis of diabetes were each strongly associated with lower SVR and higher relapse rates There was no apparent association between HbA level and SVR; however, patients with HbA >8.5% were excluded from treatment Conclusions These data suggest that FBG should be routinely assessed prior to treatment of chronic hepatitis C Randomized trials are needed to determine if improvement in glucose control prior to treatment would lead to improved viral response Anemia may be associated with a decrease in HbA Clinicians should be aware of this relationship, and perhaps use alternative measures of glucose control (eg, fingerstick glucose monitoring and/or fructosamine) Acknowledgments The authors thank the other IDEAL study investigators: N. Afdhal, A. Al-Osaimi, B. Bacon, L. Balart, M. Bennett, D. Bernstein, E. Bini, M. Black, J. Bloomer, H. Bonilla, T. Box, T. Boyer, N. Brau, K. Brown, R. Brown, C. Bruno, W. Cassidy, R. Chung, D. Clain, J. Crippin, D. Dalke, C. Davis, G. Davis, M. Davis, F. Felizarta, R. Firpi-Morell, S. Flamm, J. Franco, B. Freilich, J. Galati, A. Gibas, E. Godofsky, F. Gordon, J. Gross, J. Herrera, S. Herrine, R. Herring, J. Israel, I. Jacobson, S. Joshi, M. Khalili, A. Kilby, P. King, A. Koch, E. Krawitt, M. Kugelmas, P. Kwo, L. Lambiase, E. Lebovics, J. Levin, R. Levine, S. Lidofsky, M. Lucey, M. Mailliard, L. Marsano, P. Martin, T. McGarrity, D. Mikolich, T. Morgan, K. Mullen, S. Munoz, D. Nelson, F. Nunes, A. Nyberg, S. Oh, P. Pandya, M. P. Pauly, C. Peine, R. Perrillo, G. Poleynard, F. Poordad, A. Post, J. Poulos, D. Pound, M. Rabinovitz, N. Ravendhran, J. Ready, R. Reddy, R. Reindollar, A. Reuben, L. Rothman, R. Rubin, V. Rustgi, M. Ryan, E. Schiff, W. Schmidt, W. Semon, T. Sepe, K. Sherman, M. Sjogren, R. Sjogren, C. Smith, L. Stein, R. Strauss, M. Swaim, G. Szabo, J. Thurn, M. Tong, J. Vierling, G. Wu, R. Yapp, Z. Younes, A. Zaman References. Harrison SA. Clin Gastroenterol Hepatol. 8;6(8):8646.. McHutchison JG, et al. N Engl J Med. 9;36(6):58-93. Disclosures M. S. Sulkowski serves as advisor for Roche, Schering-Plough, Merck, Human Genome Sciences, BIPI, Gilead, Vertex, Tibotec, Bristol-Myers Squibb, and Pfizer and receives grant/research support from Mederax, Peregrine, Debiopharm, and Abbott. S. A. Harrison has received research grants and served on speaker bureaus for Schering-Plough and Roche. L. Rossaro has received research grants from Novartis, Salix, and Vertex and has served on speaker bureaus or advisory committees for Schering-Plough, Roche, Three Rivers, Gilead, Intermune, and Onyx/Bayer. K.-Q. Hu has received research grants from Roche, Schering-Plough, Bristol-Myers Squibb, Gilead, and Onyx and has served on speaker bureaus for Bristol-Myers Squibb, Gilead, Onyx, and Schering-Plough. E. J. Lawitz has received research and grant support from Schering-Plough and Roche and lecture fees from Schering-Plough. M. L. Shiffman serves as advisor for Gilead, Schering-Plough, Anadys, Vertex, Biolex, Human Genome Sciences, Novartis, and Zymogenetics, consults for Roche and Pfizer, receives grant/research support from Roche, Schering-Plough, Vertex, Biolex, GlaxoSmithKline, GlobeImmune, Human Genome Sciences, Idenix, Tibotec, Zymogenetics, and Gilead, and speaks for Roche and Schering-Plough. A. J. Muir consults for Zymogenetics, receives grant/ research support from Schering-Plough, Valeant, Vertex, and Zymogenetics, and speaks for Schering-Plough. G. W. Galler serves as advisor for Schering-Plough and Gilead and speaks for Takeda. J. McCone speaks for Schering-Plough and Roche. L. M. Nyberg has received research and grant support from Schering-Plough, Roche, Vertex Pharmaceuticals, Conatus Pharmaceuticals, Human Genome Sciences, and Idenix, lecture fees from Schering-Plough, and consulting/advisory fees from Vertex Pharmaceuticals. W. M. Lee has received research and grant support from Schering-Plough, Vertex Pharmaceuticals, GlobeImmune, Bristol-Myers Squibb, GlaxoSmithKline, and Beckman, lecture fees from Schering-Plough, and consulting or advisory fees from Gilead, Lilly, Novartis, and Westat. R. Ghalib receives grant/research support from Roche, Schering-Plough, Gilead, Vertex, Pharmasset, Debio, Biolex, Abbott, Merck, Medarex, Bristol-Myers Squibb, Idenix, Idera, Cleveland Clinic, and Duke Clinical Research and speaks for Roche and Three Rivers. J. G. McHutchison consults for Abbott, Anadys, Biolex, Gilead, National Genetics Institute, Pharmasset, Pfizer, and United Therapeutics and receives grant/research support from GlaxoSmithKline, GlobeImmune, Human Genome Sciences, Idera, Intarcia, Medtronics, Novartis, Roche, Schering-Plough, Vertex Pharmaceuticals, Virochem, and Osiris Therapeutics. J. W. King has received research support from Schering-Plough Corporation, now Merck & Co., Inc. J. Long is an employee of Merck & Co., Inc. S. Noviello is a former employee and now consultant of Schering-Plough Research Institute, now Merck & Co., Inc., and is a stockholder of Schering-Plough Corporation, now Merck & Co., Inc. C. A. Brass, L. D. Pedicone, and J. K. Albrecht are employees of Schering-Plough Research Institute, now Merck & Co., Inc., and are stockholders of Schering-Plough Corporation, now Merck & Co., Inc. Presented at the 6st Annual Meeting of the American Association for the Study of Liver Diseases, October 9 November,, Boston, MA. Supported by Schering-Plough Corporation, now Merck & Co. Inc., Whitehouse Station, NJ, USA.

Poster #86 Impaired Fasting Glu With Geno M. S. Sulkowski, S. A. Harrison, L. Johns Hopkins University School of Medicine, Baltimore, MD, USA; Broo 6 Liver Institute of Virginia, Bon Secours Health System, Newport News, V University of Texas Southwestern Medical Center at Dallas, Da Abstract Background/Aims: Impaired fasting glucose is independently associated with reduced likelihood of SVR with current therapy (NEJM, 9;36:58). However, the relationship between SVR, fasting blood glucose (FBG) and HBA has not been defined. Methods: 37 treatment-naive, CHC genotype patients (pts) received peginterferon (PegIFN) alfa-b or alfa-a plus ribavirin (RBV). All pts underwent pretreatment FBG determination and were categorized by their medical history of diabetes. Based on American Diabetes Association definition, pts with FBG mg/dl were defined as having impaired fasting glucose (IFG). Per protocol, pts with known diabetes and/or FBG 6mg/dL underwent HBA testing; those with HBA >8.5% were excluded. Pts with FBG between and 5mg/dL did not have HBA testing. Virologic response rates were analyzed. Results: 368 pts were included in the analysis. The frequency of IFG of mg/dl was 8.7% (88/368) and of a medical history of diabetes was 6.7% (6/368). Among those who underwent testing (n=34), median HBA was 6.% (interquartile range 5.6% - 6.6%). SVR according to baseline FBG for all pts and according to HBA for the subset with testing are shown (Table). SVR rate was significantly lower among pts with IFG compared to those with FBG <mg/dl (P<.); relapse rate was also higher in those with IFG. Pts with a history of diabetes had lower SVR rates than those without (.4% [44/6] vs 4.% [6/833]). However, among those tested, the SVR rate was not associated with HBA level (<6% vs 6%; P=.88). Conclusions: Impaired fasting glucose and the clinical diagnosis of diabetes were each strongly associated with lower SVR and higher relapse rates in CHC genotype pts treated with PegIFN/RBV. Among those who underwent testing, no association between HBA level and SVR was apparent; however, pts with HBA >8.5% were excluded from treatment. These data suggest that FBG should be routinely assessed prior to therapy; randomized trials are needed to determine if improvement in glucose control prior to treatment will lead to improved viral response. SVR EOT Response Relapse Fasting Blood Glucose (pretreatment) All Pts (n=368) 4 56 6 < mg/dl (n=88) 43 58 mg/dl (n=747) 3 5 34 > mg/dl (n=33) 44 4 HBA (pretreatment) Pts with protocol-defined criteria of diabetes and/or FBG 6mg/dL (n=34) 6 45 4 <6% (n=39) 45 44 6 <7% (n=33) 3 46 46 7 8.5% (n=5) 33 4 5 Background A number of previous studies have reported that insulin resistance is negatively associated with sustained virologic response (SVR) in patients receiving peginterferon alfa plus ribavirin for chronic hepatitis C (as reviewed by Harrison et al ) In the IDEAL study, stepwise multivariable logistic regression analysis identified normal baseline fasting glucose as an independent predictor of SVR SVR rates were 4% to 44% in patients with baseline fasting glucose <5.6 mmol/l (< mg/dl) and 8% to 33% in those with baseline fasting glucose 5.6 mmol/l ( mg/dl) Aim To define the relationship between SVR, fasting blood glucose, and HbA receiving peginterferon (PEG-IFN) plus ribavirin in the IDEAL trial in patients and Methods Study Design IDEAL was a phase 3b, randomized, parallel-arm trial conducted at 8 academic and community centers in the United States (Figure ) PEG-IFN alfa-b dose was double-blinded, and PEG-IFN alfa-a and RBV were administered as open-label treatments with a detectable, <-log decline in HCV-RNA at week, or with detectable HCV-RNA at week 4 were discontinued from treatment Presented at the 6st Annual Meeting of the American Association for the Study of Liver Diseases, Oc

cose Is Associated With Low otype Chronic Hepatitis C (C L. Rossaro, 3 K.-Q. Hu, 4 E. J. Lawitz, 5 M. L. Shiffman, 6 A. J. M C. A. Brass, 3 L. D. Pedicone, 3 J. K. Alb ooke Army Medical Center, Fort Sam Houston, TX, USA; 3 University of California Davis M, VA, USA; 7 Duke Clinical Research Institute, Durham, NC, USA; 8 Kelsey-Seybold Researc Dallas, TX, USA; The Liver Institute at Methodist Dallas, Dallas, TX, USA; 3 Schering-Plo Figure. IDEAL study design. Screening n = 9 PEG-IFN alfa-b.5 µg/kg/wk + RBV 8 mg/d 48 weeks n = 6 PEG-IFN alfa-b. µg/kg/wk + RBV 8 mg/d 48 weeks n = 35 PEG-IFN alfa-a 8 µg/wk + RBV - mg/d 48 weeks Weeks* 4 4 48 4 4 *HCV-RNA assessments PEG-IFN = peginterferon; RBV = ribavirin. 37 treatment-naive patients with chronic hepatitis C, genotype infection, aged 8 to 7 years and weighing 4 to kg Assessments All patients underwent pretreatment fasting blood glucose (FBG) determination and were categorized by their medical history of diabetes Based on the American Diabetes Association definition, patients with baseline FBG mg/dl were defined as having impaired fasting glucose (IFG) Per protocol, patients with a medical history of diabetes and/or FBG 6 mg/dl underwent HbA testing Those with pretreatment baseline HbA the study >8.5% were excluded from participation in with a baseline FBG <6 mg/dl did not require HbA testing FBG (in all patients) and HbA (in diabetics or those with FBG 6 mg/dl) levels were assessed at pretreatment baseline visit, treatment weeks, 4, 36, and 48, and follow-up week 4. In addition, patients with diabetes had an additional HbA assessment at treatment week 4 SVR was defined as undetectable HCV-RNA (lower limit of quantitation of 7 IU/mL by Roche COBAS TaqMan HCV-RNA assay) at the end of the 4-week follow-up period Results 368 patients were included in the analysis 8.7% (88/368) of patients had baseline FBG mg/dl and were considered to have IFG 6.7% (6/368) of patients had a medical history of diabetes Among those who underwent testing (n = 34), median HbA was 6.% (interquartile range, 5.6% 6.6%) Virologic Response Virologic response rates were lower in patients with a medical history of diabetes and/ or baseline FBG 6 mg/dl compared with the study population (Figure ) Figure. Virologic response rates in all patients and those with a medical history of diabetes and/or baseline fasting blood glucose 6 mg/dl. All patients (n = 368) Protocol-defined criteria of diabetes and/or FBG 6 mg/dl (n = 34) 5 56 45 4 4 6 6 October 9 November,, Boston, MA.

er Rates of Sustained Virolog HC): Retrospective Analysis uir, 7 G. W. Galler, 8 J. McCone, 9 L. M. Nyberg, W. M. Lee, brecht, 3 J. G. McHutchison, 7 J. W. King 4 edical Center (UCDMC), Sacramento, CA, USA; 4 University of California Irvine Medical C ch Foundation, Houston, TX, USA; 9 Mount Vernon Endoscopy Center, Alexandria, VA, US ough Research Institute, now Merck & Co., Inc., Whitehouse Station, NJ, USA; 4 Louisian Virologic Response in With Impaired Fasting Glucose SVR rate was significantly lower among patients with IFG (FBG mg/dl) compared with those with baseline FBG < mg/dl (3.3% [67/88] vs 43.3% [947/88]; P <.) (Figure 3) Relapse rate was also higher in those with IFG (34.7% [4/46] vs.4% [7/3]) Figure 3. Virologic response rates according to baseline fasting blood glucose. 5 43 3 FBG < mg/dl (n = 88) FBG mg/dl (n = 747) FBG > mg/dl (n = 33) 58 5 Virologic Response in With Diabetes or Elevated Fasting Blood Glucose SVR rate for patients with diabetes and/or FBG 6 mg/dl was 6% (83/34) End-of-treatment (EOT) response rate was 45% (45/34), with a relapse rate of 4% (56/39) Among this subgroup of patients, there was a trend for lower SVR rates in patients with lower baseline HbA levels (Table ) However, the SVR rate was not associated with HbA level (<6% vs 6%; P =.88) Table. Virologic Response Rates According to Baseline HbA Level 44 34 4 SVR, EOT Response, Relapse, Pretreatment baseline HbA <6% (35/39) 45 (63/39) 44 (7/6) 6% <7% 3 (3/33) 46 (6/33) 46 (6/57) 7% 8.5% 33 (7/5) 4 (/5) 5 (3/) EOT = end-of-treatment; SVR = sustained virologic response. Changes in hemoglobin (Hb) concentrations correlated with changes in HbA treatment weeks 4 (n = 7) and (n = 7) (Figure 4) levels at Pearson correlation coefficient was estimated as.44 at treatment week 4 Pearson correlation coefficient was estimated as.4 at treatment week Given a decrease in Hb of g/dl, the predicted decrease of HbA at treatment week 4 and.6% at treatment week would be.4% Figure 4. Relationship between hemoglobin concentration and HbA at treatment weeks 4 (n = 7) and (n = 7). Change in HbA From Baseline 3 - - -9 - - Week 4 Week with a history of diabetes had a lower SVR rate than those with no history of diabetes (.4% [44/6] vs 4.% [6/833]) For patients with both treatment-week and week- values, changes in Hb concentrations correlated with changes in HbA levels at treatment weeks 4 and (n = 3) (Figure 5) Pearson correlation coefficient was estimated as.39 at treatment week 4 Pearson correlation coefficient was estimated as. at treatment week Given a decrease in Hb of g/dl, the predicted decrease of HbA would be.% at treatment week 4 and.7% at treatment week

ic Response (SVR) in of the IDEAL Study R. Ghalib, J. Long, 3 S. Noviello, 3 Center, Irvine, CA, USA; 5 Alamo Medical Research, San Antonio, TX, USA; SA; Kaiser Permanente, San Diego Medical Center, San Diego, CA, USA; na State University Health Sciences Center, Shreveport, LA, USA Figure 5. Relationship between hemoglobin concentration and HbA at treatment weeks 4 and for patients with values at both time points (n = 3). Change in HbA From Baseline - - - - Week 4 Week Summary IFG and the clinical diagnosis of diabetes were each strongly associated with lower SVR and higher relapse rates There was no apparent association between HbA level and SVR; however, patients with HbA >8.5% were excluded from treatment Conclusions These data suggest that FBG should be routinely assessed prior to treatment of chronic hepatitis C Randomized trials are needed to determine if improvement in glucose control prior to treatment would lead to improved viral response Anemia may be associated with a decrease in HbA Clinicians should be aware of this relationship, and perhaps use alternative measures of glucose control (eg, fingerstick glucose monitoring and/or fructosamine) Acknowledgments The authors thank the other IDEAL study investigators: N. Afdhal, A. Al-Osaimi, B. Bacon, L. Balart, M. Bennett, D. Bernstein, E. Bini, M. Black, J. Bloomer, H. Bonilla, T. Box, T. Boyer, N. Brau, K. Brown, R. Brown, C. Bruno, W. Cassidy, R. Chung, D. Clain, J. Crippin, D. Dalke, C. Davis, G. Davis, M. Davis, F. Felizarta, R. Firpi-Morell, S. Flamm, J. Franco, B. Freilich, J. Galati, A. Gibas, E. Godofsky, F. Gordon, J. Gross, J. Herrera, S. Herrine, R. Herring, J. Israel, I. Jacobson, S. Joshi, M. Khalili, A. Kilby, P. King, A. Koch, E. Krawitt, M. Kugelmas, P. Kwo, L. Lambiase, E. Lebovics, J. Levin, R. Levine, S. Lidofsky, M. Lucey, M. Mailliard, L. Marsano, P. Martin, T. McGarrity, D. Mikolich, T. Morgan, K. Mullen, S. Munoz, D. Nelson, F. Nunes, A. Nyberg, S. Oh, P. Pandya, M. P. Pauly, C. Peine, R. Perrillo, G. Poleynard, F. Poordad, A. Post, J. Poulos, D. Pound, M. Rabinovitz, N. Ravendhran, J. Ready, R. Reddy, R. Reindollar, A. Reuben, L. Rothman, R. Rubin, V. Rustgi, M. Ryan, E. Schiff, W. Schmidt, W. Semon, T. Sepe, K. Sherman, M. Sjogren, R. Sjogren, C. Smith, L. Stein, R. Strauss, M. Swaim, G. Szabo, J. Thurn, M. Tong, J. Vierling, G. Wu, R. Yapp, Z. Younes, A. Zaman References. Harrison SA. Clin Gastroenterol Hepatol. 8;6(8):8646.. McHutchison JG, et al. N Engl J Med. 9;36(6):58-93. Disclosures M. S. Sulkowski serves as advisor for Roche, Schering-Plough, Merck, Human Genome Sciences, BIPI, Gilead, Vertex, Tibotec, Bristol-Myers Squibb, and Pfizer and receives grant/research support from Mederax, Peregrine, Debiopharm, and Abbott. S. A. Harrison has received research grants and served on speaker bureaus for Schering-Plough and Roche. L. Rossaro has received research grants from Novartis, Salix, and Vertex and has served on speaker bureaus or advisory committees for Schering-Plough, Roche, Three Rivers, Gilead, Intermune, and Onyx/Bayer. K.-Q. Hu has received research grants from Roche, Schering-Plough, Bristol-Myers Squibb, Gilead, and Onyx and has served on speaker bureaus for Bristol-Myers Squibb, Gilead, Onyx, and Schering-Plough. E. J. Lawitz has received research and grant support from Schering-Plough and Roche and lecture fees from Schering-Plough. M. L. Shiffman serves as advisor for Gilead, Schering-Plough, Anadys, Vertex, Biolex, Human Genome Sciences, Novartis, and Zymogenetics, consults for Roche and Pfizer, receives grant/research support from Roche, Schering-Plough, Vertex, Biolex, GlaxoSmithKline, GlobeImmune, Human Genome Sciences, Idenix, Tibotec, Zymogenetics, and Gilead, and speaks for Roche and Schering-Plough. A. J. Muir consults for Zymogenetics, receives grant/ research support from Schering-Plough, Valeant, Vertex, and Zymogenetics, and speaks for Schering-Plough. G. W. Galler serves as advisor for Schering-Plough and Gilead and speaks for Takeda. J. McCone speaks for Schering-Plough and Roche. L. M. Nyberg has received research and grant support from Schering-Plough, Roche, Vertex Pharmaceuticals, Conatus Pharmaceuticals, Human Genome Sciences, and Idenix, lecture fees from Schering-Plough, and consulting/advisory fees from Vertex Pharmaceuticals. W. M. Lee has received research and grant support from Schering-Plough, Vertex Pharmaceuticals, GlobeImmune, Bristol-Myers Squibb, GlaxoSmithKline, and Beckman, lecture fees from Schering-Plough, and consulting or advisory fees from Gilead, Lilly, Novartis, and Westat. R. Ghalib receives grant/research support from Roche, Schering-Plough, Gilead, Vertex, Pharmasset, Debio, Biolex, Abbott, Merck, Medarex, Bristol-Myers Squibb, Idenix, Idera, Cleveland Clinic, and Duke Clinical Research and speaks for Roche and Three Rivers. J. G. McHutchison consults for Abbott, Anadys, Biolex, Gilead, National Genetics Institute, Pharmasset, Pfizer, and United Therapeutics and receives grant/research support from GlaxoSmithKline, GlobeImmune, Human Genome Sciences, Idera, Intarcia, Medtronics, Novartis, Roche, Schering-Plough, Vertex Pharmaceuticals, Virochem, and Osiris Therapeutics. J. W. King has received research support from Schering-Plough Corporation, now Merck & Co., Inc. J. Long is an employee of Merck & Co., Inc. S. Noviello is a former employee and now consultant of Schering-Plough Research Institute, now Merck & Co., Inc., and is a stockholder of Schering-Plough Corporation, now Merck & Co., Inc. C. A. Brass, L. D. Pedicone, and J. K. Albrecht are employees of Schering-Plough Research Institute, now Merck & Co., Inc., and are stockholders of Schering-Plough Corporation, now Merck & Co., Inc. Supported by Schering-Plough Corporation, now Merck & Co. Inc., Whitehouse Station, NJ, USA.