SCIENTIFIC PROGRAM. The First Franco-Romanian Meeting

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SCIENTIFIC PROGRAM RCCC Annual Meeting 27 th -29 th of September 2018 The First Franco-Romanian Meeting Thursday 27 th of September 2018 7.30-8.15 Registration 8.15-9:45 Meet the experts The therapeutic decision at the border between RCTs and RWE from the physician s and pharmacologist perspective to the perspective of regulation. Speakeri: Juan Esplugue (Spania), Mircea Diculescu, Robert Ancuceanu 9.45-10.00 Opening ceremony. Cristina Cijevschi, Mircea Diculescu Franco - Romanian Meeting 10.00-11.00 Session I Introduction Matthieu Allez, Mircea Diculescu Short conferences Epidemiology of IBD across Europe Mircea Diculescu (Bucarest, Roumanie) IBD and Nutrition Does it matter? Xavier Hebuterne (Nice, France) 11.00-11.30 Coffee Break

11.30-12.30 Session II Clinical case I- Crohn s Disease Peri-ileal Abscesss - Matthieu Allez (Fr), Roxana Zaharie (RO) Presentation of the case with multiple steps (drainage, nutrition, surgery versus medical therapy post op management) 12.30-13.00 - Short Conference IBD and Pregnancy Lucine Vuiton (Besancon, France) Round table 13.00-14.00 Lunch 14.00-16.00 Session III Clinical case II - Crohn s disease Fistulising perianal Crohn s Disease Franck Carbonnel (France), Mircea Mănuc (RO) Presentation of the case with multiple steps (exploration, drainage medical therapy management) Round table Clinical case III Ulcerative colitis Mild left ulcerative colitis - Lucine Vuiton (France), Mihai Ciocirlan (RO) Presentation of the case with multiple steps (control with 5 ASA, poor adherence and then relapse with ASA failure - management) Round Table

16.00-16.30 Coffee Break 16.30-17.30 Session IV Clinical Case IV Ulcerative Colitis Severe acute colitis - Xavier Hebuterne (FR), Traian Dumitrascu (RO) Presentation of the case with multiple steps (assessment of severity, management, medical therapy and discussion on surgery, management) Round Table 17,30-18. 00 CONFERENCE New therapeutic objectives in the management of IBD Franck Carbonnel (France) 18.00-18.10 - Conclusions of the meeting. Matthieu Allez, Mircea Diculescu 18.20-18.40 Pharma Symposium ALFASIGMA Managementul bolii diverticulare intr-o noua lumina - rolul rifaximinei-α! - Mircea Diculescu 19.30 WELLCOME COCKTAIL Friday 28 th of September 2018 8.00-9.30 Session I. IBD in Romania Epidemiological update. Adrian Goldis, Razvan Iacob, Catalina Mihai 1. New epidemiological data in NE Romania - IBDProspect. Catalina Mihai, Anca Trifan, Cristina Cijevschi Prelipcean 2. IBD Center Cluj-Napoca - Temporal changes in incidence and phenotypic manifestations of patients with Crohn's disease from northwestern Romania. Roxana Zaharie, Alina Tantau, Marcel Tantau.

3. Epidemiology of malnutrition in IBD patients- data from IBDProspect. Maria Ciocîrlan, Razvan Iacob, Liana Gheorghe, Daniela Dobru, Alina Tantau, Adrian Goldis, Gabriel Constantinescu, Cristina Cijevschi, Anca Trifan, Mircea Diculescu 4. Environmental and behavioural risk factors for Inflammatory Bowel Disease in an emerging IBD country. Ichim S, Dimitriu A, Iacob R, Cojocaru M, Balaban V, Gheorghe C, Diculescu M, Gheorghe L. 5. Dynamics of biological therapy in a tertiary referral center 5 years follow-up of IBDProspect hospital-based cohort. Iacob R, Stoica B, Vadan R, Gheorghe L, Diculescu M, Gheorghe C. 6. Epidemiological trends in IBD - lessons from IBDProspect and Epicom - Adrian Goldis 9.30-10.00. Coffee Break 10.00-11.30 Session II. Best practice in IBD care: role of IBD centers. Liana Gheorghe, Lucian Negreanu, Alina Tantau 1. The backbone of excellence strategy in IBD Liana Gheorghe 2. Minimal criteria for an IBD centre Lucian Negreanu 3. Best care of IBD: Cluj-Napoca experience Alina Tantau 4. Best care of IBD: Timisoara experience Adrian Goldis 5. Best care of IBD: Constanta Eugen Dumitru 6. IBD in primary care: educate GPs to recognize, refer and manage IBD patients - Ligia Mosneaga 7. Patients empowerment: key actions - Isabella Grosu 11.30-12.00. State of the Art Lecture I. Malignancies and IBD - Andreas Sturm (Germany)

12.00-13.00 Pharma Symposium: ABBVIE PROACTIVE NOT REACTIVE: The appropriate management for IBD patients Chair: Mircea Diculescu Speakers: Daniela Dobru, Liana Gheorghe, Eugen Dumitru 13.00-14.00 Lunch break 14.00-15.00 Educational Session. The evolution of the treatment landscape and personalized medicine approaches for management of UC 15.00-16.00 Session III. Management of IBD from childhood to elderly Daniela Serban, Dan Gheonea, Mariana Jinga Peculiarities of therapeutic approach in children with IBD - Daniela Serban Transition in IBD - from child to adulthood - Daniel Vasile Balaban, Mariana Jinga Inflammatory bowel disease in elderly: an old problem in new clothes - Cristina Cijevschi Prelipcean, Catalina Mihai 16.00-16.30 Coffee break 16.30-17.45 Session IV. Standard of care in endoscopy for IBD- Cristian Gheorghe, Eugen Dumitru, Adrian Saftoiu Upper G-I endoscopy, videocapsule, enteroscopy: how to choose, how to exam, and how to write a quality report - Lucian Negreanu Quality of the colonoscopy and its reporting is mandatory for standard of care in IBD - Cristian Gheorghe

High resolution and chromoendoscopy- standard of care for diagnosis and therapy of IBD dysplasia - Eugen Dumitru (Endoscopic) ultrasound for diagnosis of perianal Crohn's disease - Adrian Saftoiu 17.45-18.45 Session V. Current therapeutic strategies in 2018 - Daniela Dobru, Gabriel Constantinescu, Mirela Ionescu 1. Evolution of treatment targets and strategies in IBD - Catalina Diaconu, Gabriel Constantinescu 2. Influence of microbiota in the strategy of treatment in IBD - Liana Gheorghe 3. Biologic therapy and new oral targeted therapies in IBD - Cristian Țieranu, Mirela Ionescu 4. Personalized therapy in IBD Lucian Negreanu 18.45-19.45 Pharma Symposium TAKEDA- Evolving Treatment goals with Gut-Selective therapy "Beyond remission and mucosal healing In Crohn s Disease- Mircea Diculescu "Optimizing new data in Ulcerative Colitis" - Lucian Negreanu 20.00 Romanian IBD Society Dinner

Saturday 29th of September 2018 8.00-9.30 Session VI. Original Research Forum. Chair: Ciprian Brisc, Bogdan Mateescu, Carmen Preda 1) Diet in ethiopathogenesis of inflammatory bowel diseases: an original prospective study. Carmen Preda, Doina Proca, Teodora Manuc, Mircea Manuc, Mircea Diculescu. 2) Correlations between US measurements and biomarkers in IBD. Anda Les, Razvan Iacob, Liana Gheorghe, Radu Dumitru, Cristian Gheorghe. 3) Histopathological features the last piece of the puzzle in differentiation of Crohnʼs disease from ulcerative pancolitis. Monica Cojocaru, Gabriel Becheanu, Mona Dumbrava, Liana Gheorghe, Bogdan Cotruta, Razvan Iacob, Roxana Vadan, Oana Stanciulea, Ioana Lupescu, Cristian Gheorghe. 4) Diagnostic yield of small-bowel capsule endoscopy in suspected Crohn's disease. Ana Maria Singeap, Oana Stoica, Carol Stanciu, Anca Trifan. 5) Lipidomic Signatures Of Inflammatory Bowel Diseases: In Search Of Putative Biomarkers By Ultra High Performance Liquid Chromatography/Mass Spectroscopy. Cristian Tefas, Carmen Socaciu, Corina Morar, Marcel Tanțău. 6) Quality of Life in IBD patients- what is good enough? State M., Voiosu T., Bengus A., Mateescu B. 7) Capsule endoscopy in a treat to target approach in Crohn s disease-a case series. Stemate Ana, Sadagurschi Roxana, Babiuc Ruxandra, Negreanu Lucian. 8) Microbiota, IBD and joint impairment: a causal triad or a clinical epiphenomenon?. Anca Cardoneanu, Elena Rezus, Cristina Cijevschi, Aida Badescu, Igor Jelikovschi, Catalina Mihai 9.30-10.00 State of the Art Lecture II. "Innovation in IBD - How do We Advance the Field?" Florin Selaru (USA) 10.00-10.15 Pharma Symposium Nestle The role of dietary fiber in gut transit function- Mircea Mănuc

10.15-10.45 Coffee Break 10.45-12.15 Session VII. Novel therapeutics in IBD. Chair: Anca Trifan, Corina Pop, Andrada Seicean Molecules targeting Il23 /Th17 in IBD. Andrada Seicean Janus Kinase Inhibitors in Crohn s Disease. Camelia Cojocariu, Anca Trifan Combine new drugs with different mechanisms. Cora Pop 12.15-12.45 Multidisciplinary approach of a patient with IBD 12.15-12.30. Bioethical concerns and engagement in patient care with inflammatory bowel disease. Elena Toader, Mihaela Dranga 12.45-13.15 Review of recent Clinical Trials in IBD. Liana Gheorghe, Roxana Vadan 13.15-13.45. Conclusions. Prizes Award Ceremony 13.45-14.15. RCCC General Assembly, changes in the Statute Poster session Parallel Session Friday 28.09.2018 - SALA TRANSILVANIA 8.00 13.00 IBD Nurse Symposium 13.00-14.00 Leading Change in IBD