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DIGITAL DIABETES CARE MARKET 2018-2022 READY TO TAKE OFF www.research2guidance.com A market study about diabetes apps, connected devices, and services 3 rd edition, 3 rd September 2018 Research2Guidance 2018

WHAT IS THIS REPORT ABOUT IN A NUTSHELL This report is the third publication based on our digital diabetes care market coverage. The main aim of this report is to analyze what impact digital solutions have and will have on the global diabetes markets. The report provides details about the current status and size of the global digital diabetes care market, discusses and evaluates trends, identifies top-10 countries and competitors and provides an outlook for the future market development. DIABETES IS A GLOBAL EPIDEMIC 425 million people suffered from the condition in 2017 and this group is expected to grow to 629 million in 2045 1 Diabetes is one of the major cost drivers in the healthcare systems of countries most affected by the epidemic Global spending for diabetes related care amounted to more than $700B in 2017 2 IMPACT OF DIGITAL DIABETES SOLUTIONS TODAY AND IN FIVE YEARS Digital solutions for diabetics promise to disrupt the diabetes care market, but what impact do they currently have and how will it change in the next five years? Best-in-class digital diabetes care solutions today are ecosystems that consist of apps, connected devices, coaching services, and HCP dashboards There are more than 2,000 digital services for diabetes patients available globally Millions of diabetes patients are already using digital diabetes care solutions and they are coming from all regions of the world Payer organizations have started to accept and close hundreds of partnership deals with digital diabetes care providers Multiple studies demonstrate the positive impact of digital care on HbA1C levels and to a lesser degree on cost savings Market revenues tripled since last year building on six main revenue sources. Forecast for 2022 pegged at almost $1B Leading digital diabetes care companies are now valued at more than $500M THE THE MARKET MARKET IS IS CURRENTLY CURRENTLY BEST BEST DESCRIBED DESCRIBED AS AS READY READY TO TO TAKE TAKE FF OFF WHAT OTHERS HAVE SAID: The report by research2guidance is comprehensive and far reaching. It is a really valuable piece of market intelligence. - Petra Wilson, Former President, IDF Once again, with the latest Diabetes App Market Report Research2Guidance publishes the definitive industry overview on the current state and future trends in app delivered digital diabetes care. - Jeff Dachis CEO, Founder, OneDrop 1 IDF 2017 2 IDF Diabetes Atlas, 8th Edition (2017) Full market study report Market history 2008-2017 5-year forecast 2018-2022 Trends State-of-the-art digital solutions for diabetes patients HCP and payer services Top 10 countries Top 10 digital solution providers 99 pages 59 graphs Published September 2018 3 rd edition ABOUT R2G Research2Guidance is a strategy advisory and market research company. We concentrate on the mobile app eco-system. We are convinced that mobile health solutions will make a difference in people s lives and that the impact on the healthcare industry will be significant. We provide market insights to assist in making this happen and assist in successfully businesses. leading CONTACT THE ANALYST Oleksiy Danilin oleksiy.danilin@ research2guidance.com +49 30 609 893 360 2

IT IS A DATA AND FACT BASED REPORT ABOUT DIGITAL SERVICES Graphics and illustrations highlight insights, trends and forecasts. It is a very data driven report. To ease reading, each chapter is headed by a short summary. DIGITAL SERVICES Current offerings MARKET EVOLUTION Year 2008-17 FORECASTS Year 2017-22 TRENDS Top 20 COUNTRIES PROFILED 1. China 2. USA 3. India 4. Mexico 5. Germany 6. Brazil 7. Russia 8. Turkey 9. Japan 10. Spain COMPANIES PROFILED Profiles are used to describe top 10 countries and top 10 digital diabetes app publishers and their service offerings. Country profiles help to identify market opportunities. Competitor profiles show market performance and perceived digital strategy. 1. LifeScan 2. Social Diabetes 3. Informed Data Systems 4. MySugr 5. H2 6. cream.software 7. Dottli 8. Sirma Medical Systems 9. Dexcom 10. Airstrip Technologies COUNTRY DASHBOARD Demographics & Publishers COMPANY DASHBOARD All Key Apps Performances Country X, 2016-2017 Company X: app portfolio performance DEMOGRAPHICS MARKET SIZE AND PERFORMANCE People with diabetes: 20.5M 2016 2017 % change # of apps 400 598 + 48% Addressable market: 5.5M (Top 5) DLs 1350 DLs/app 750 DLs/app - 45% Total DLs, 2016 500K 42% 58% DLs, 2017 600K 41% 59% MAUs 300K 72% 28% (end 2017) TOP 3 MOST DOWNLOADED PUBLISHERS Publisher, flagship app name Category # of DLs % of DLs of total Top 3 market share 1. Publisher1, App1 Diary Tracker 100K 20% 38% 2016 2. Publisher2, App2 Diary Tracker 50K 10% 3. Publisher3, App3 Device 10K 2% Country s market size, existing players and markets leaders Number of apps Downloads in 2017 1 650,000 6.3% of global diabetes DLs 1 Top 3 Portfolio downloads 2015-2017 750K 560K, 299% 500K 250K 140K, 250% 40K 0K 2015 2016 2017 ios Android Name Platform Published NA Users, end of 2017 LATAM Portfolio downloads by region Downloads 2016-2017 by region 2017 66% NA 43% 2016 2017 2% 10% 100,000 2% of global diabetes users Top 15 Updates: 2017/total APAC 22% EMEA % of portfolio by DLs in 2017 Digital revenue in 2017 2% LATAM % of portfolio by users in 2017 $2,500,000 Bundle sales, Coaching 29% 25% EMEA APAC Avg. Global Rating Company s performance statistics shown in dashboard format 1. Publisher1, App1 Diary Tracker 150K 15% 2017 2. Publisher2, App2 Diary Tracker 110K 11% 3. Publisher3, App3 Device 70K 7% Source Data: research2guidance, App Annie, Prioridata, Apple App Store, Google Play and other sources Research2Guidance 33% ios App ios April 2016 47/80 70% 90% (3.7) Android App Android October 2017 40/54 30% 10% (4.5) Source: research2guidance, Prioridata, App Annie, Apple App Store, Google Play Store and other sources. Data retrieved in Dec ember 2016 - January 2017. Users are estimated by number of people who used the app at least once in December 2017. Yearly downloads are calculate d based on the app portfolio of the given year. Average global ratings for portfolio apps are given for the period April -June 2018. Research2Guidance Questions answered: Table of Contents: What is the current status of digital solutions available in the market? Which countries offer the largest markets? What are the market prices for digital content, coaching services or bundles? Who are the key market players and what is their perceived strategy? What constitutes a "state-of-the-art" digital diabetes solution today? What is the potential market size for coaching services, connected devices, digital content and other revenue sources? And many more 1. Scope of the report 2. Management summary 3. Global digital diabetes opportunity 4. Status of the diabetes app market 5. Diabetes market status per country in 2017 6. Competitive landscape of diabetes app publishers 7. Top 10 diabetes publishers by market share: Portfolios, performance, strategies 8. Trends and evolving strategies in the digital diabetes care market 9. Outlook: The next five years to 2022 10. Appendix 3

TABLE OF CONTENTS 1 Scope of the report... 4 2 Management summary... 6 3 Global digital diabetes opportunity... 9 3.1 The addressable target group size... 9 3.2 The addressable market value... 11 4 Current status of the market... 13 4.1 Diabetes apps dynamics: the net growth of the apps number is decreasing... 13 4.2 Diabetes apps ecosystem: The popularity of the nine diabetes app category types 17 4.3 Diabetes app publisher growth (2008-2017)... 19 4.4 Download trends and developments in the diabetes app market (2015-2017)... 20 4.5 Supply and demand analysis: number of apps vs downloads... 24 4.6 Revenue trends and developments in the diabetes app market (2015-2017)... 24 4.7 The current pricing ranges of digital diabetes care service offerings... 28 4.8 Clinical trials by digital diabetes solution providers: current status... 31 5 Diabetes market status per country in 2017... 33 5.1 Top-10 country markets: summary... 33 5.2 China... 35 5.3 USA... 36 5.4 India... 37 5.5 Mexico... 38 5.6 Germany... 39 5.7 Brazil... 40 5.8 Russia... 42 5.9 Turkey... 43 5.10 Japan... 44 5.11 Spain... 45 6 Top 10 diabetes publishers by market share: portfolios, performance, strategies... 47 6.1 Competitive landscape of diabetes app publishers... 47 6.2 LifeScan Inc.... 50 6.3 Social Diabetes... 52 6.4 One Drop... 54 6.5 mysugr GmbH (Roche)... 58 4

6.6 H2 Inc.... 61 6.7 cream.software... 64 6.8 Dottli... 66 6.9 Sirma Medical Systems... 68 6.10 Dexcom... 70 6.11 Airstrip Technologies... 75 7 Market trends and evolving state-of-the-art digital diabetes care solutions... 77 7.1 Twenty trends that have shaped the digital diabetes care market from 2016 to 2018..77 7.2 The state-of-the-art digital diabetes offering in 2018: ten major components... 81 8 Outlook: The next five years to 2022... 83 8.1 The global addressable target group size and active user forecast (2017-2022)... 84 8.2 The global market Revenue forecast (2017-2022)... 86 9 Appendix... 92 9.1 Clinical trials for diabetes apps... 92 9.2 Addressable target group and market size of 50 countries... 96 9.3 About research2guidance... 97 9.4 List of figures and tables... 98 9.4.1 LIST OF FIGURES... 98 9.4.2 LIST OF TABLES... 99 5

1 SCOPE OF THE REPORT This report is the third edition of the Diabetes App Market Report, with two previous editions being published in 2014 and 2016. The 2018 report takes into account the fact that available solutions can now be more described as ecosystems, which include and connect a growing number of devices, apps, and services to support diabetes patients and their caregivers. Mobile apps still are at the center of this ecosystem. However, current offerings today go far beyond the functionality offered within an app. To reflect this development, the title of this edition of the market report has been changed to Digital Diabetes Care Market Report. The main aim of this report is to analyze the current status and size of the global digital diabetes care market, discuss and evaluate trends, identify top-10 countries and competitors, and provide an outlook for the future market developments. The report pays special attention to the providers of digital diabetes services. It profiles in detail ten leading publishers in terms of their diabetes app portfolio, service offering, performance, and strategy. The top ten countries are analyzed in terms of each country s specific addressable market size for diabetes apps and the main diabetes apps market KPIs for 2016-2017. Corresponding top app publishers are also identified in each country. This analysis concentrates on digital solutions/ecosystems that focus on supporting patients and caregivers to manage diabetes. Other solutions that include people with diabetes as a secondary/additional target user group (e.g. a recipe app that labels certain dishes specifically for people with diabetes, but also offers other recipes), as well as general fitness or medical apps/solutions that can be used to support the treatment of people with diabetes but are not specifically designed for them (non-core diabetes), are excluded. With regard to mobile applications, the report includes apps that run on ios and Android operating systems and are listed in Apple App Store and Google Play. This edition of the market report covers the time frame between 2008 and 2017 to illustrate both the current status and the history of the market. Based on actual market sizes and future trends, the report also gives a five-year forecast for the period from 2018 to 2022. The current and future market (outlook) analysis is highlighting key market KPIs, including the following: The size of the addressable market for digital diabetes care solutions. Various metrics that show the size and development of the demand and supply side of the market: the number of downloads, active users, apps, publishers. A breakdown of current and future revenue streams from digital content, connected devices, services (including coaching), bundles, technology licencing, and advertising and promotion. The report pays special attention to evaluating the trends that have shaped the industry over the last 2-3 years. It also gives guidance for what constitutes a state-of-the-art digital diabetes care solution as of today. 6

Research2Guidance is monitoring the digital diabetes care market since 2010. Our market models are constantly updated based on regular trend watch analysis, interviews, and databases. 7

9 APPENDIX 9.3 ABOUT RESEARCH2GUIDANCE research2guidance is a strategy advisor and market research company. We concentrate on mobile app eco-systems and complex digital healthcare solutions. Our service offerings include: App Strategy: We help our clients inside and outside of the mobile industry to develop their app market strategy. Our consulting advisory projects are based on a set of predefined project approaches including: App strategy development, App Evaluation, App Market Segment Sizing, App Governance and App Marketing Spend Effectiveness. App Market Reports: Our app market reports explore major trends and developments affecting the app markets. Separate research papers provide both general and specific coverage of the market. The reports contain key insights for companies looking to enter or deepen their engagement with the mobile applications market, providing data and analysis on all relevant aspects of the market to ease investment decision-making. App Market Surveys: We leverage our 70.000 app eco-system database to conduct surveys and reports for our clients. research2guidance, Berlin, Germany, +49 (0)30 609 89 33 60 www.research2guidance.com Author Oleksiy Danilin Oleksiy is a Senior Analyst at research2guidance. He has conducted several consulting projects on digital diabetes solutions and other healthcare conditions. Currently, he is responsible for all premium report products in the company. Prior to joining research2guidance, Oleksiy worked as a telecom and digital analyst at Ovum (United Kingdom). He has a vast international experience due to his involvement in various consulting projects in Germany, the United Kingdom, Russia, and other East European countries. 8

9.4 LIST OF FIGURES AND TABLES 9.4.1 LIST OF FIGURES Figure 1: Global addressable target group size for diabetes apps (2017)... 10 Figure 2: Top-ten largest country specific addressable target groups (2017)... 10 Figure 3: Global addressable market for diabetes apps (2017)... 11 Figure 4: Top 10 largest country-specific annual addressable market costs (2017)... 12 Figure 5: Global number of diabetes apps (2008 2017)... 14 Figure 6: Share of managed diabetes apps and their impact on downloads, 2016... 15 Figure 7: Number of diabetes apps in four global regions (2017)... 15 Figure 8: IAP apps and paid download apps as % of global number of diabetes apps (2008-2016)... 16 Figure 9: Shares of IAP apps and paid apps in the global number of diabetes apps (2017)... 17 Figure 10: Breakdown of diabetes apps by categories in 2016 and 2017 globally (% of the total number of apps)... 19 Figure 11: Global number of diabetes app publishers by platform (2008 2017)... 19 Figure 12: Global number of diabetes app downloads and monthly active users (2015-2017)... 21 Figure 13: Breakdown of core diabetes app categories in 2016 and 2017 globally (% of the total number of downloads)... 22 Figure 14: Global number of diabetes app downloads by platform (2015-2017)... 23 Figure 15: Supply and demand of diabetes apps by category in 2017... 24 Figure 16: Global digital diabetes care market revenue by major source 2016 vs 2017 (US$, % of total)... 26 Figure 17: App store revenue by category, 2017... 27 Figure 18: Pricing for digital diabetes care offers, end of 2017... 29 Figure 19: Addressable market coverage in the top-10 markets... 34 Figure 20: Diabetes apps download shares from ios and Android in the top-10 markets... 34 Figure 21: Top-10 publishers market shares, 2016-2017 (% of total diabetes app downloads)... 48 Figure 22: The global addressable target group (2017 2022)... 84 Figure 23: The global number of diabetes app downloads per platform (2017-2022)... 85 Figure 24: The global number of mobile active users (MAUs) of diabetes apps (2017-2022) 85 Figure 25: The global number of diabetes apps and downloads per app (2017-2022)... 86 Figure 26: Global digital diabetes care market revenue (2017-2022)... 88 Figure 27: Major digital diabetes care segments: Size, structure, and growth (2017 and 2022)... 89 Figure 28: The number of bundle and coaching users (2017-2022)... 89 9

9.4.2 LIST OF TABLES Table 1: China s diabetes app market... 36 Table 2: USA s diabetes app market... 37 Table 3: India s diabetes app market, 2016-2017... 38 Table 4: Mexico s diabetes app market, 2016-2017... 39 Table 5: Germany s diabetes app market... 40 Table 6: Brazil s diabetes app market... 41 Table 7: Russia s diabetes app market... 42 Table 8: Turkey s diabetes app market... 43 Table 9: Japan s diabetes app market... 44 Table 10: Spain s diabetes app market... 46 Table 11: LifeScan s OneTouch Reveal ecosystem... 50 Table 12: LifeScan s app portfolio performance... 51 Table 13: Social Diabetes s ecosystem... 53 Table 14: Social Diabetes s app portfolio performance... 54 Table 15: One Drop s app ecosystem overview... 55 Table 16: One Drop s app portfolio performance... 57 Table 17: mysugr s app ecosystem overview... 59 Table 18: mysugr s app portfolio performance... 60 Table 19: H2 s app ecosystem overview... 62 Table 20: H2 s app portfolio performance... 63 Table 21: cream.software s app ecosystem overview... 65 Table 22: cream.software s app store performance... 66 Table 23: Dottli s app ecosystem overview... 67 Table 24: Dottli s app portfolio performance... 68 Table 25: Sirma Medical Systems app ecosystem overview... 69 Table 26: Sirma Medical Systems app store performance... 70 Table 27: Dexcom s app ecosystem overview... 72 Table 28: Dexcom s app portfolio performance... 74 Table 29: Airstrip Technologies app portfolio performance... 76 Table 30: Clinical trials for diabetes management mobile solutions... 92 Table 31: Addressable target group and market size of 50 countries (2017)... 96 10