New Treatment Research Facility Project at Koji Noda Research Center for Charged Particle Therapy National Institute of Radiological Sciences IPAC10, Kyoto, JAPAN, 25th May, 2010
Contents 1. Introduction 2. Design and specifications 3. Overview of project status 4. Summary
Introduction Physical Advantage of Heavy Ion High longitudinal dose localization due to the Bragg peak. 5 4 Lateral biological dose distribution C proton Relative dose (%) 100 80 60 40 20 Dose (GyE) 3 2 1 0-8 -6-4 -2 0 2 4 6 8 lateral position (cm) 0 0 5 10 15 Depth in water (cm) C ion n gam m a-ray proton High transverse dose localization due to the low scattering.
Biological Advantage Introduction RBE,O E R 4 3 2 1 H RBE OER C Si 0 1 10 100 1000 10000 LET LET (kev (kev/μm) /μ) LET dependence on RBE, OER Biological Dose (GyE) 5 4 3 2 1 0 Biological Depth-Dose Distribution of 6cm SOBP Normal tissue Tumor 0 5 10 15 20 Depth in Water He C Ne Proton
Milestone of Radiotherapy Introduction 1984: Heavy ion therapy project started under National Comprehensive 10-year Strategy for Cancer Control. 1988-93: Construction of. 1994 : Carbon-ion RT started at 21 st June 1994 2003 : approved Highly Advanced Medical Technology 2004-05 : Design and R&D for Downsized C-ion RT Facility 2006-09 : Construction of Pilot Facility at Gunma Uni. 2010 : 1 st Patient treated at Gunma at 16 th March 2010. 2006-10 : New Treatment Research Facility Project for further development of treatment.
Introduction facility Ion species: High LET (100keV/μm) charged particles He, C, Ne, Si, Ar Range: 30cm in soft tissue 800MeV/u (Si) Maximum irradiation area: 22cmΦ Dose rate: 5Gy/min Beam direction: horizontal, vertical (Heavy Ion Medical Accelerator in Chiba)
Milestone of Radiotherapy Introduction 1984: Heavy ion therapy project started under National Comprehensive 10-year Strategy for Cancer Control. 1988-93: Construction of. 1994 : Carbon-ion RT started at 21 st June 1994 2003 : approved Highly Advanced Medical Technology 2004-05 : Design and R&D for Downsized C-ion RT Facility 2006-09 : Construction of Pilot Facility at Gunma Uni. 2010 : 1 st Patient treated at Gunma at 16 th March 2010. 2006-10 : New Treatment Research Facility Project for further development of treatment.
Progress of treatment number Introduction Num of Treatments 800 700 600 500 400 300 200 100 0 Treatment Period: 43 wks 1st Term(Apr Aug): 18.5wks 2nd Term(Sept Feb):24.5wks Treatment: 4 days per week 949596979899 0 1 2 3 4 5 6 7 8 9 FY
Milestone of Radiotherapy Introduction 1984: Heavy ion therapy project started under National Comprehensive 10-year Strategy for Cancer Control. 1988-93: Construction of. 1994 : Carbon-ion RT started at 21 st June 1994 2003 : approved Highly Advanced Medical Technology 2004-05 : Design and R&D for Downsized C-ion RT Facility 2006-09 : Construction of Pilot Facility at Gunma Uni. 2010 : 1 st Patient treated at Gunma at 16 th March 2010. 2006-10 : New Treatment Research Facility Project for further development of treatment.
4. Compact Facility Gunma University Heavy-Ion Medical Center Treatment Room Synchrotron 10Ghz-ECR Injector Linac APF-IH
Milestone of Radiotherapy Introduction 1984: Heavy ion therapy project started under National Comprehensive 10-year Strategy for Cancer Control. 1988-93: Construction of. 1994 : Carbon-ion RT started at 21 st June 1994 2003 : approved Highly Advanced Medical Technology 2004-05 : Design and R&D for Downsized C-ion RT Facility 2006-09 : Construction of Pilot Facility at Gunma Uni. 2010 : 1 st Patient treated at Gunma at 16 th March 2010. 2006-10 : New Treatment Research Facility Project for further development of treatment.
Introduction Motivation therapy needs to be upgraded. Upgrading irradiation system - raster scanning system - rotating gantry system Upgrading control system Upgrading patient handling system Upgrading treatment planning system Further development of heavy-ion therapy - Adaptive therapy - Intensity modulated Ion Therapy (IMIT) New facility Hospital New treatment facility project
Introduction Motivation ~ adaptive therapy Intra & interfractional changes from time resolved imaging (seconds to days) using CT/FPD devices could be feed-back to the treatment planning. The rich information could extend to replan, 4D plan and patient registration etc.
Introduction Motivation ~ IMIT IMIT plan example 0 deg 0 d e g Gantry with 3D scanning makes it possible to realize Intensity Modulated Ion Therapy (IMIT). 288 deg 72 deg Volume [%] 100 80 60 40 PTV IMIT PTV Sngl GTV IMIT GTV Sngl CRD IMIT CRD Sngl 20 0 0 20 40 60 80 100 120 Dose [%] 216 deg 144 deg - Improved dose conformity and steeper dose gradients - Further reduction of integral dose - Less sensitivity to range uncertainties and other sources of uncertainty
Contents 1. Introduction 2. Design and specifications 3. Overview of project status 4. Summary
Design & Spec Design and specifications New facility 1. Ion species: 12C, 16O (11C, 15O) 2. Irradiation method: Hybrid raster scanning 3. Range: ~ 30cm in water 4. Maximum irradiation area: 22cm square 5. Delivered Intensity: 10 7 10 9 pps (for C ions) 6. Treatment rooms: 3 = 2 H&V + 1 rotating gantry
3D Scanning Method R&D Work Adaptive Therapy by 3D Scanning 1) Beam utilization efficiency 100% 2) Irradiation on irregular shape target 3) No bolus & collimator 1) Sensitive beam error 2) Longer irradiation time 3) Sensitive to organ motion Scanner Monitor Range Shifter Beam Dose distribution of pencil beam
3D Scanning Method R&D Work Adaptive Therapy by 3D Scanning Rescanning with Gated Irradiation 100 120 140 160 180 200 1) Beam utilization efficiency 100% -40 2) Irradiation on irregular shape target 3) No bolus &-20 collimator 0 0.1 0.2 0.3 0.4 1) Sensitive beam 0 error 2) Longer irradiation time 20 3) Sensitive to organ motion 40 Scanner Monitor 0.4 0.5 0.6 0.7 0.8 0.9 1.0 Range 1.1 Shifter 1.1 Beam Dose distribution of pencil beam
Fast 3D Scanning Design & Spec In order to realize the rescanning with gating within acceptable irradiation time, we have studied following strategy. 1. Treatment planning for fast scanning 5 2. Modification of acc. operation 2 3. Fast scanning magnet 10 100-times speed up!! (A) 50 y (m m ) 0-50 -50 0 x (m m ) 50 (B) (C)
Design & Spec Fast scanning system 3D scanning irradiation Max field size 220 mm 2 Max SOBP 150 mm Max energy 430 MeV/u Moving target OK beam size 3~6 mm (1σ) Ene. change RSF Design and R&D work were carried out. Vertical line Horizontal line Room E Beam test : Dec. 2008 ~ Feb. 2010
Design & Spec Fast scanning system Design and R&D work were carried out. Vertical line Horizontal line Room E Beam test : Dec. 2008 ~ Feb. 2010
Design & Spec Fast scanning system Design and R&D work were carried out. Vertical line Scanning Magnet Horizontal line Room E Beam test : Dec. 2008 ~ Feb. 2010
Design & Spec Fast scanning system Design and R&D work were carried out. Vertical line Pos. Moni. Horizontal line Dose Moni Room E Beam test : Dec. 2008 ~ Feb. 2010
Design & Spec Fast scanning system Design and R&D work were carried out. Vertical line Range Shifter Horizontal line Room E Beam test : Dec. 2008 ~ Feb. 2010
Design & Spec Gantry design 1) IMIT 2) Reduction of Patient s Load 3D scanning irradiation Max field size 150 mm 2 Max SOBP 150 mm Max energy 430 MeV/u Moving target OK beam size 3~6 mm (1σ) Ene. change RSF Total weight 350 ton
Design & Spec Floor plan Treatment rooms : 3 Simulation rooms : 2 Preparation rooms: 6
Contents 1. Introduction 2. Design and specifications 3. Overview of project status 4. Summary
Building Overview Mar. 2010, new treatment building construction has been completed.
Building Overview April, 2010 Mar. 2010, new treatment building construction has been completed.
Overview Treatment room / Simulation room Simulation room Treatment room
Overview Treatment room / Simulation room Simulation room Treatment room April, 2010
Overview Treatment Hall Entrance Preparation room
Overview Treatment Hall Entrance Preparation room
Overview Beam line devices Beam line dipole magnet Quadrupole magnet Installation of devices is in progress.
Contents 1. Introduction 2. Design and specifications 3. Overview of project status 4. Summary
Summary Summary Construction of the building is completed. Performance of 3D rescanning is verified. Installation & commissioning will be carried out in this year. First patient is scheduled in next March.
Acknowledgement Thank you for your attention