TEST MENU BY SPECIALTY

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1 TEST MENU BY SPECIALTY Breast Pathology Surgical excisions, needle core biopsies, and plastic surgery accepted from all sites Assessment of margins Axillary lymph node dissections Sentinel lymph nodes Axillary lymph node aspirations Breast Cytology Nipple discharge fluid HALO Breast Test (Nipple aspirate fluid- NAF) Fine needle aspirations (FNA) Tissue/FNA used for comprehensive evaluations for Lymphoma PathVysion TM FISH analysis of Her2/neu gene amplification for breast cancer Frozen section evaluation is also available! Estrogen, Progesterone receptor status Her2/neu Lymph node micrometastasis detection (PCK) MIB-1 (Ki-67)

2 Dermatopathology Skin and soft tissue biopsies using shave, punch or excision procedures. Excisions accepted from all sites. Fine need aspirations from soft tissue tumors CD34, CD117, CD138, CK7, CK20, DESMIN, EMA, FACTOR-XIIA, GCDFP-15, HMB45, KI67, MELAN-A, PCK, S100, SMA, TYROSINASE, VIMENTIN Complete panels for doctor evaluation of Mycoses Fungoides and Lymphomatoid Papulosis AFB, Alcian Blue, Congo Red, Colloidal Iron, Crystal Violet, Elastic, FITE, GMS, GIEMSA, GRAM, Iron, Melanin, MGP, Mucicarmine, PAS, Spirochete Tissue/FNA Used for diagnosing abnormalities in mycoses fungoides and subclassification of cutaneous lymphoid Lesions AcuProbe Melanoma AcuProbe Spitz AcuProbe Melanoma Comprehensive Used for confirmation of Malignant Melanoma and Spitz Nevus T-cell gene rearrangement studies for Mycoses Fungoides and other Cutaneous Lymphomas Direct Immunofluorescence (DIF)

3 ENT Pathology including bone lesions, cystic lesions, oral cavity, and tongue Brushings Fine needle aspirations Tissue/FNA Thyroid, lymph nodes (used for comprehensive evaluations for Lymphoma) Frozen section evaluation HPV, P16

4 Gastrointestinal Pathology Endoscopic biopsies and all surgical specimens from upper and lower gastrointestinal tracts including: Esophagus, stomach, small bowel, large bowel, rectum and anus Lymph node analysis Anal and esophageal brushings Routine H. Pylori stains on stomach biopsies, CD3, CD117 (c-kit), CDX-2, CK7/CK20, HER2, HSV I/II and CMV, KI67, MIB-1 (P53), Microsatellite Instability (MSI) markers for colon cancer Tissue/FNA Lymph nodes (used for comprehensive evaluations for Lymphoma) PathVysion TM FISH analysis of Her2/neu gene amplification for gastric and gastroesophageal junction cancer BE FISH for Barrett s Esophagus TERC FISH for anal inter-epithelial carcinoma Routine Alcian Blue on GE junction and esophageal biopsies Routine Alcian Blue/Periodic Acid-Schiff (PAS) on biopsies from stomach and duodenum PAS stains on esophageal biopsies

5 Gynecologic Pathology including cervix, endometrium, vagina, vulva Tissue/FNA (used for comprehensive evaluations for Lymphoma) Axillary lymph node aspirations Breast cytology Nipple discharge fluid HALO breast test (Nipple Aspirate Fluid- NAF) Fine needle aspirations Urine cytology Voided urine Post-cytoscopy HPV, KI67 and P16 on cervical biopsies

6 Ophthalmic Pathology including periocular neoplasms Tissue/FNA used for comprehensive evaluations for Lymphoma Frozen section evaluation is also available! IHC Stains Melanoma FISH Panel and AcuProbe Melanoma Oral Pathology including bone lesions, cystic lesions, oral cavity, and tongue Brushings Fine needle aspirations AFB, PAS, GMS Tissue/FNA (used for comprehensive evaluations for Lymphoma) Direct immunofluorescence (DIF)

7 Orthopedic Pathology Bone specimens can be submitted for pathologist to rule out osteomyelitis, and joint fluid for crystals to rule out gout Tissue/FNA Cerebral spinal fluid Polarizable crystals for Gout Brushings Fine needle aspirations Joint fluid analysis IHC Stains are also available! Contact your sales representative for more information.

8 Plastic Surgery Pathology including breast (reductions and gynecomastia), nasopharynx, skin and soft tissue, tonsils (including evaluations for lymphoma) Axillary lymph node aspirations Breast cytology Nipple discharge fluid HALO Breast test (Nipple aspirate fluid- NAF) Fine needle aspirations CD34, CD117, CD138, CK7, CK20, DESMIN, EMA, FACTOR-XIIIA, GCDFP-15, HMB45, KI67, MELAN-A, PCK, S100, SMA, TYROSINASE, VIMENTIN Complete panels for doctor evaluation of Mycoses Fungoides and Lymphomatoid Papulosis Tissue/FNA Used for diagnosing abnormalities in Mycoses Fungoides and subclassification of Cutaneous Lymphoid Lesions AcuProbe Melanoma AcuProbe Spitz AcuProbe Melanoma Comprehensive Used for confirmation of Malignant Melanoma and Spitz Nevus PathVysion FISH analysis of HER2/NEU, gene amplification for breast cancer HPV Tissue (ISH) subtyping T-cell gene rearrangement studies for Mycoses Fungoides and other Cutaneous Lymphomas Direct Immunofluorescence (DIF) AFB, Alcian Blue, Congo Red, Colloidal Iron, Crystal Violet, Elastic, FITE, GMS, GIEMSA, GRAM, Iron, Melanin, MGP, Mucicarmine, PAS, Spirochete

9 Podiatric Pathology including arthroscopic shavings, bone, bunion, hammer toe, nails, skin, and soft tissue Joint fluid analysis including fresh smears for gout Routine PAS and GMS on all nail biopsies GMS Stain AcuProbe Melanoma AcuProbe Spitz AcuProbe Melanoma Comprehensive Pulmonary Pathology Surgical biopsies accepted from all sites including lungs Bronchial brushings Bronchial washings Bronchio-alveolar lavage EBUS (Endobronchial Ultrasound) biopsies of mediastinal lymph nodes Fine need aspirations from lungs Sputum Lung panel: P63, CK 5/6, TTF-1, NAPSIN A, SYNAPTOPHYSIN, CHROMOGRANIN, CD56 Tissue/FNA used for comprehensive evaluations for Lymphoma Used for confirmation of Malignant Melanoma and Spitz Nevus Panel Epidermal Nerve Fiber Density Testing Polarizable crystals for Gout

10 Uropathology including bladder, prostate, testis, and vas deferens Urine CD34, CD117, CD138, CK7, CK20, DESMIN, PCK, SMA, VIMENTIN, EMA, FACTOR-XIIIA, GCDFP-15, HMB45, KI67, MELAN-A, S100, TYROSINASE, PTEN, ERG UroVysion TM FISH for bladder cancer recurrence AcuProbe PTEN for prostate cancer prognosis AcuProbe ERG for prostate cancer prognosis AcuProbe Prostate Comprehensive for prostate cancer prognosis Kidney Stone Analysis 7-10 Day TAT AFB, GMS Tissue/FNA used for comprehensive evaluations for Lymphoma