University of Groningen Diminished ovarian reserve and adverse reproductive outcomes de Carvalho Honorato, Talita IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): de Carvalho Honorato, T. (2017). Diminished ovarian reserve and adverse reproductive outcomes: Epidemiologic studies on their association [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 08-10-2018
Diminished ovarian reserve and adverse reproductive outcomes Epidemiologic studies on their association Talita de Carvalho Honorato
The research presented in this thesis was financially supported by the Abel Tasman talented Program, University of Groningen and by the Department of Obstetrics and Gynaecology of the University Medical Centre Groningen. The printing of this thesis was financially supported by the University of Groningen, the University Medical Centre Groningen and the SHARE research institute of the Graduate School of Medical Sciences. ISBN 978-94-034-0126-3 (hardcopy) 978-94-034-0125-6 (digital) Copyright 2017 TC Honorato All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without written permission of the author and the publisher holding respective copyrights of the published articles, if applicable. Cover design: Talita de Carvalho Honorato Printed by NetzoDruk Groningen B.V.,The Netherlands
Diminished ovarian reserve and adverse reproductive outcomes Epidemiologic studies on their association PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday October 9 2017 at 12.45 hours by Talita de Carvalho Honorato born on 17 April 1984 in Araraquara-SP, Brazil
Supervisors Prof. A. Hoek Prof. H.M. Boezen Co-supervisors Dr. H. Groen Dr. M.L. Haadsma Assessment committee Prof. C.M.A. van Ravenswaaij-Arts Prof. J.J.H.M Erwich Prof. M.J. Eijkemans
Paranymphs Violeta Stojanoviska Marcin Rzeszewicz
Table of contents Chapter 1 Introduction, hypothesis and aim of this thesis 9 Chapter 2 Follicle pool, ovarian surgery and the risk for a subsequent trisomic pregnancy 29 Human Reproduction (2015) 30 (3): 717-722 Chapter 3 Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy 43 Accepted Reproductive BioMedicine Online Chapter 4 Miscarriage risk in women with repeated poor ovarian response during IVF treatment 59 Submitted Chapter 5 Miscarriage risk for women exposed to cigarette smoke in-utero 75 Accepted Menopause Chapter 6 In-utero cigarette smoke exposure and the risk of earlier menopause 95 Submitted Chapter 7 Summary, general discussion and future perspectives 115 References 129 Summary English 149 Summary Dutch 152 Acknowledgments 155 Research Institute SHARE 160 About the author 165