University of Groningen Carcinoembryonic Antigen (CEA) in colorectal cancer follow-up Verberne, Charlotte IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Verberne, C. (2016). Carcinoembryonic Antigen (CEA) in colorectal cancer follow-up [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-02-2018
Carcinoembryonic Antigen (CEA) in colorectal cancer follow-up Charlotte Julia Verberne
Carcinoembryonic Antigen (CEA) in colorectal cancer follow-up The studies in this thesis have been carried out with financial support from the Netherlands Organisation for Health Research and Development, project number 171002209, and the Jan Kornelis de Cock Stichting. Their support is gratefully acknowledged. Cover: Martinitoren Groningen, the Netherlands Cover design: Charlotte Julia Verberne Layout and typesetting: Michal Slawinski, thesisprint.eu ISBN 978-90-367-8549-5 Copyright 2015. C.J. Verberne, the Netherlands All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission from the author or, when appropriate, permission from the publishers.
Carcinoembryonic Antigen (CEA) in colorectal cancer follow-up Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 3 februari 2016 om 14.30 uur door Charlotte Julia Verberne geboren op 19 juni 1983 te Zierikzee
Promotores Prof. dr. T. Wiggers Prof. dr. G.H. de Bock Beoordelingscommissie Prof. dr. R.J. Porte Prof. dr. E. Buskens Prof. dr. J. Stoker
Voor Pieter Laurens en Valerie
Contents Chapter 1 Introduction and outline of the thesis Chapter 2 The role of high frequency dynamic threshold (HiDT) serum carcinoembryonic antigen (CEA) measurements in colorectal cancer surveillance: a (revisited) hypothesis paper Chapter 3 Evaluation of the use of decision-support software in Carcinoembryonic Antigen (CEA)-based follow-up of patients with colorectal cancer Chapter 4 Detection of recurrences during follow-up after liver surgery for colorectal metastases: Both Carcinoembryonic Antigen (CEA) and imaging are important Chapter 5 Intensified follow-up in colorectal cancer patients using frequent Carcinoembryonic Antigen (CEA) measurements and CEA-triggered imaging: results of the randomized CEAwatch trial Chapter 6 Sensitivity and specificity of Carcinoembryonic Antigen (CEA) in an intensified colorectal cancer follow-up protocol Chapter 7 Costs and cost-effectiveness analysis of a Carcinoembryonic Antigen (CEA)-based follow-up program for colorectal cancer (the CEAwatch trial) Chapter 8 Psychological effects of the intensified follow-up of the CEAwatch trial after treatment for colorectal cancer Chapter 9 Tumor markers in finding recurrent disease in colorectal cancer: a diagnostic review Chapter 10 Summary and Future Perspectives 11 25 45 59 77 97 113 129 147 169 Samenvatting en toekomstperspectief 181 Dankwoord en Nawoord 193
Juli 2007 Lac d Annecy, Frankrijk Met Pieter Laurens