Manchester Royal Infirmary Renal & Pancreas Transplant Unit 211 / 212 Activity Annual Report Vicki Bowman Renal Transplant Audit & Data Manager Dr Susan Martin Consultant Clinical Scientist / Transplantation Laboratory Director Mr Titus Augustine Consultant Transplant Surgeon / Clinical Manager June 212
Contact Details 2 Central Manchester University Hospitals NHS Foundation Trust Renal and Pancreas Transplant Unit and Transplantation Laboratory Manchester Royal Infirmary Oxford Road Manchester M13 9WL Tel: 161 7 11894 Fax: 161 27 66148 Email: Vicki Bowman Renal Transplant Data & Audit Manager victoria.bowman@cmft.nhs.uk Dr Susan Martin Consultant Clinical Scientist / Transplantation Laboratory Director susan.martin@cmft.nhs.uk Mr Titus Augustine Consultant Transplant Surgeon / Clinical Manager titus.augustine@cmft.nhs.uk Copies of this report are freely available on request both in paper and electronic (pdf) format on contacting Vicki Bowman, Renal Transplant Data & Audit Manager, as above. If you wish to make use of charts from this report in a presentation, please contact Vicki, as before.
3 Table of Contents Page Abbreviations and Definitions 4 Introduction and Acknowledgments 5 All transplants 6 Fig 1: All transplants by quarter, by type 211/12 7 Fig 2: All transplants by type 211/12 7 Kidney alone transplants Fig 3: Adult kidney alone transplants by financial year 8 Pancreas transplants Fig 4: Adult pancreas transplants by financial year 8 Paediatric Transplants Fig 5: Paediatric transplants by type, by financial year 9 Adult Living Donor Transplants Fig 6: Adult living donor transplants by quarter, 29/1 211/12 1 Fig 7: Adult living donor transplants by donor relation, 211/12 1 Pre-emptive Transplantation Fig 8: Pre-transplant renal replacement therapy, adult recipients 29/1 11 211/12 Fig 9: Pre-emptive adult living donor transplants, 29/1 211/12 12 Deceased Donor Transplants Fig 1: Kidney and pancreas transplants 211/12 by donor age 12 Fig 11: Deceased donor transplants by organ origin, 21/11 and 211/12 13 Fig 12: Cold ischaemia time 14 The CMFT Kidney and Pancreas Transplant Waiting List Fig 13: Transplants by year vs waiting list, 21/2 to 211/12 15 Demographics and summary table 15 Paediatric waiting list demographics and summary 16 Fig 14: CMFT kidney and pancreas transplant list by organ required 16 Fig 15: CMFT kidney and pancreas transplant list by age range 17 Fig 16: CMFT transplant list status, April 212 18 Fig 17: CMFT transplant list status by referral centre, April 212 18 Fig 18: Median time to enter CMFT transplant list by referral centre, 211/12 19 Fig 19: Time waited by patients on the CMFT transplant list, April 212 19 Five Year Cohort Study on Waiting Time 2 Fig 2: Post-registration outcome for patients listed for transplantation in 27 2 Source of transplant referrals by referral network sector & transplant list status 21 Transplantation and transplant listing in a population context 22 Fig 21: Transplant listing and deceased donor transplants per million population 22 by area Graft Survival Fig 22: 1 year graft survival by transplant type, 26-29 23 Fig 23: 5 year graft survival by transplant type, 23-25 23 Patient Survival Fig 24: 1 year patient survival by transplant type, 26-29 24 Fig 25: 5 year patient survival by transplant type, 23-25 24 Appendix: Referral Network Sectors 25
Abbreviations 4 Abbreviation Full Explanation DBD Donation after brain death Referring to a donor with confirmed (Heartbeating Donor) brain death. DCD Donation after Cardiac Death Referring to a donor with confirmed cardiac death (Non Heartbeating Donor) DBD Kidney Donation after brain stem Kidney transplant from a donor with death kidney confirmed brain death DCD Kidney Donation after cardiac Kidney transplant from a donor with death kidney confirmed cardiac death Living Donor Living donor Kidney transplant from a living donor. Donation after brain stem Simultaneous pancreas and kidney DBD SPK death simultaneous transplant from a donor with pancreas & kidney confirmed brain death DCD SPK DBD PAK DCD PAK DBD PTA DCD PTA DBD SHK Islets Cell Tx Donation after cardiac death simultaneous pancreas & kidney Donation after brain stem death pancreas after kidney Donation after cardiac death pancreas after kidney Donation after brain stem death pancreas transplant alone Donation after cardiac death pancreas transplant alone Donation after brain stem death simultaneous heart & kidney Pancreatic islet transplantation Simultaneous pancreas and kidney transplant from a donor with confirmed cardiac death Pancreas transplant from a donor with confirmed brain death with the recipient having previously received a kidney transplant Pancreas transplant from a donor with confirmed cardiac death with the recipient having previously received a kidney transplant Pancreas alone transplant from a donor with confirmed brain death Pancreas Alone transplant from a donor with confirmed cardiac death Simultaneous heart and kidney transplant from a donor with confirmed brain death Transplantation of insulin-producing beta cells of the Islets of Langerhans extracted from deceased donor pancreata Definitions Adult recipient Paediatric recipient A person receiving a transplant who is aged 19 years or over on the date of transplant. A person receiving a transplant who is aged under 19 years on the date of transplant.
5 Introduction & Acknowledgments 211/12 was a record year for the transplant unit, with more transplants performed than any previous year since the inception of the unit. The compilers of this report acknowledge the contributions from each and every member of the transplant team: Medical, Ward particularly Nursing, Outpatient staff, SNODs, Recipient Coordinators, Live donor coordinators, Specialist Nurses, Secretarial, Administrative, Clerical and Transplantation Laboratory staff of all grades, and others from associated dialysis centres who have contributed to make this another successful year. Special thanks must also go to living donors and the families of deceased donors, without whom no transplants would have been possible.
All Transplants, 211/12 6 Summary Table by Financial Year, 28/9 211/12 28/9 29/1 21/11 211/12 All transplants 178 [+ 11.9%] 21 [+18.%] 27 [-1.4%] 233 [+12.6%] Paediatric recipient 17 (9.6%) 15 (7.1%) 18 (8.7%) 13 (5.6%) transplants (<19 years) All kidney alone 147 (82.6%) 182 (86.7%) 181 (87.4%) 23 (87.1%) transplants Pancreas alone or 31 (17.4%) 27 (12.9%) 25 (12.1%) 28 (12.%) pancreas and kidney transplants Islet cell 1 (.5%) 1 (.5%) 2 (.9%) transplantation All DBD transplants 11 (56.7%) 86 (41.%) 19 (52.7%) 19 (46.8%) All DCD transplants* 23 (12.9%) 53 (25.2%) 19 (9.2%) 48 (2.6%) Living donor 54 (3.3% 68 (32.4%) 73 (35.3%) 71 (3.5%) transplants - ABO compatible Living donor transplants ABO incompatible 2 (1.%) 5 (2.4%) 5 (2.2%) *In 21/11 both kidneys from a DCD donor were implanted in the same recipient. This is referred to throughout this report as a single transplant. Summary Table by Calendar Year, 28-211 28 29 21 211 All transplants 184 [+11.5%] 173 [-6.%] 212 [+22.5%] 232 [+9.4%] Paediatric recipient 16 (8.7%) 13 (7.5%) 16 (7.5%) 18 (7.8%) transplants (<19 years) All kidney alone 151 (82.1%) 146 (84.4%) 191 (9.1%) 2 (86.2%) transplants Pancreas alone or 33 (17.9%) 27 (15.6%) 2 (9.4%) 3 (12.9%) pancreas and kidney transplants Islet cell 1 (.4%) 2 (.9%) transplantation All DBD transplants 15 (57.1%) 77 (44.5%) 1 (47.2%) 116 (5.%) All DCD transplants 25 (13.6%) 38 (22.%) 33 (15.6%) 37 (16.%) Living donor 54 (29.3%) 56 (32.4%) 75 (35.4%) 73 (31.4%) transplants ABO compatible Living donor transplants ABO incompatible 2 (1.1%) 3 (1.4%) 6 (2.6%) () indicates % of total [ ] indicates % change from previous year
7 All transplants by type All transplants 211/12 by quarter, by type 8 7 54 64 55 6 Number of transplants 6 5 4 3 2 1 April/May/June Jul/August/Sept Oct/Nov/Dec Jan/Feb/March Islets 1 1 DBD PTA 1 DCD SPK 1 1 3 DBD SPK 1 6 3 3 DCD Kidney 5 14 12 12 DBD Kidney 22 18 22 22 Living donor 16 24 17 19 Fig.1: A summary of the year s activity by transplant type. Kidney and Pancreas transplants 211/12 by type DBD Kidney 36.1%(84) DCD Kidney 18.5%(43) All pancreas/islet 13%(3) DCD SPK 2.1%(5) DBD PTA.4%(1) DBD SPK 9.4%(22) Islets.9% (2) Living donor 32.6%(76) Fig 2: Kidney and pancreas transplant activity 211/12 showing relative proportion of activity by transplant type. The magnified part of the pie chart details pancreas transplant activity.
Kidney alone transplants 8 Adult recipient kidney alone transplants by type, 29/1-211/12 2 167 163 19 18 16 14 48 17 43 Number of transplants 12 1 8 6 61 8 78 4 2 58 66 69 29/1 21/11 211/12 DCD Kidney 48 17 43 DBD Kidney 61 8 78 Living donor 58 66 69 Financial year Fig 3: A summary of adult kidney alone transplant activity over the last 3 financial years. Pancreas transplants Adult pancreas/kidney and pancreas alone transplants, 29/1-211/12 3 27 25 28 25 Numbe r of transplants 2 15 1 5 29/1 21/11 211/12 DCD PTA DBD PTA 3 1 1 DCD PAK 1 1 DBD PAK 3 3 DCD SPK 1 1 5 DBD SPK 19 19 22 Fig 4: A summary of pancreas transplant activity over the last 3 financial years. It is of note that a national allocation scheme for pancreas from DBD and DCD was introduced in December 21.
Paediatric Transplants* 9 Paediatric transplants by type, 29/1-211/12 2 18 16 6 Number of transplants 14 12 1 8 6 3 12 13 6 DBD kidney Living donor 4 7 2 29/1 21/11 211/12 Financial Year Fig 5: Paediatric kidney transplants over the last 3 financial years by type Paediatric Recipients Referral Origin 29/1 21/11 211/12 RMCH 8 (53%) 14 (73.7%) 9 (64.3%) Alder Hey 5 (33%) 4 (21%) 1 (7.1%) Adult Services 1 (7%) 1 (5.3%) 2 (14.3%) Out of Region 1 (7%) 2 (14.3%) TOTAL 15 19 13 * One patient aged 19 transplanted in 21/11 is included as a paediatric transplant on this page for purposes of analysis. This patient was treated on a paediatric ward by the paediatric transplant team. This differs from the figures in the summary table at the beginning of this report which was calculated solely on age
Adult Living Donor Transplantation 1 Adult living donor transplants by quarter 29/1-211/12 25 2 Number of transplants 15 1 29/1 21/11 211/12 5 April/May/June Jul/August/Sept Oct/Nov/Dec Jan/Feb/March 29/1 9 12 19 17 21/11 11 15 23 17 211/12 17 14 22 16 Fig 6: Adult living donor transplantation in 211/12 by quarter. Donor Relation Adult living donor transplants 211/12 by donor relation Mother 14.5% (1) Unrelated Wife Daughter 15.9%(11) Friend 2.9%(2) Altruistic 1.4%(1) Unrelated 2.9%(2) 2.9%(2)2 Other relation 4.3%(3) Father 5.8%(4) Son 5.8%(4) Brother 11.6%(8) Paired/pooled 1.1%(7) Unrelated Husband 7.2%(5) Sister 7.2%(5) Partner 7.2%(5) Fig 7: An illustration of relationships of living donors to recipients, 211/12.
Pre-emptive Transplantation 11 Referral Network Sector Haemodialysis Peritoneal Dialysis Pre-Transplant RRT Pre-emptive transplants 211/12 Total 29/1 21/11 211/12 GM East 37 6 12 (23.5%) 15 (23.4%) 14 (24.6%) 57 GM West 39 15 2 (28.6%) 17 (32.7%) 17 (23.9%) 71 Cumbria & Lancashire 35 13 4 (11.1%) 1 (25.6%) 6 (11.1%) 54 ECR 6 2 2 (2%) 8 Total 117 36 38 (22.8%) 42 (25.8%) 37 (19.5%) 19 ( ) indicates proportion of patients transplanted pre-emptively Pre-transplant renal replacement therapy, adult kidney alone recipients transplanted 29/1-211/12 2 18 16 37 Number of recipients 14 12 1 8 38 42 43 32 36 Pre emptive transplants Peritoneal dialysis Haemodialysis 6 116 4 86 89 2 29/1 21/11 211/12 Financial year Fig 8: RRT type prior to transplant in adults. Pre emptive transplantation accounted for 19.5% of kidney alone transplants in 211/12.
Pre emptive living donor transplantation 12 Adult living donor transplants with number pre-emptive, 29/1-211/12 8 7 58 66 69 6 21 (3.4%) Number of transplants 5 4 3 2 (34.5%) 27 (4.9%) 48 Pre emptive Non pre emptive 2 38 39 1 29/1 21/11 211/12 Financial Year Fig 9: Living donor transplants with proportion performed pre-emptively. This will now be a CQUIN measure. Deceased Donors 211/12 Deceased kidney and pancreas donors by age range, 211/12 45 4 39 35 3 28 Number of donors 25 2 15 14 23 Kidney SPK/pancreas 1 1 8 11 5 4 4 2 2-18 19-3 31-4 41-5 51-6 61-7 7+ Age range Fig 1: This graph illustrates the age of kidney and pancreas donors for transplants which took place during 211/12. The median kidney donor age was 53.7 (47.6 in 21/11) and the median pancreas donor age was 4.1 (4.4 in 21/11).
Deceased Donors 211/12 13 All DBD and DCD kidney and pancreas transplants by organ origin, 21/11 and 211/12 1 9 8 91 82 7 Number of transplants 6 5 4 3 27 37 21/11 211/12 2 1 5 11 17 14 Import DBD Import DCD Local DBD Local DCD Organ origin Fig 11: Donor organ origin by financial year. During 211/12 a considerably higher proportion of deceased donors, both DBD and DCD, were retrieved locally than during the previous year.
Cold Ischaemia Time 14 Cold Ischaemia Time, Deceased Donor Kidney Transplants 28/9 to 211/12 by crossmatch method XM Test Virtual XM 36:: 32:: 28:: 24:: 28/9 29/1 21/11 211/12 CIT time 2:: 16:: 12:: 8:: 4:: :: 1/4/28 31/5/28 Median CIT = 17:22 3/7/28 28/9/28 27/11/28 26/1/29 27/3/29 Median CIT = 15:43 Median CIT = 14:59 Median CIT = 15:37 26/5/29 25/7/29 23/9/29 22/11/29 21/1/21 22/3/21 21/5/21 Date Median CIT = 15:15 2/7/21 18/9/21 Median CIT = 13:22 17/11/21 16/1/211 17/3/211 16/5/211 15/7/211 13/9/211 Median CIT = 13:5 12/11/211 11/1/212 11/3/212 Fig 12: Cold ischaemia time for adult DBD and DCD kidney alone transplants, 28/9 to 211/12. The median CIT time is shown for each financial year, as well as annually following the introduction of virtual crossmatching in December 28. The scatter plot and median CIT times show a significant reduction in median cold ischaemia times since this method was introduced. Once again a reduction was seen during the last financial year.
CMFT Kidney and Pancreas Transplant Waiting List 15 CMFT transplants by year with waiting list totals, 21/2 to 211/12 1 9 878 919 915 865 8 797 Number of transplants/patients 7 6 5 4 3 2 587 513 44 414 133 134 72 722 68 639 541 556 523 48 198 159 148 157 159 555 178 572 63 591 585 21 27 233 Transplants performed Patients on list at end of financial year Patients on active waiting list at end of financial year 1 21/2 22/3 23/4 24/5 25/6 26/7 27/8 28/9 29/1 21/11 211/12 Financial Year Fig 13: A graphical representation of the numbers of patients awaiting deceased donor transplant relative to transplants carried out each year over the last 1 years. During the last 2 years the number of active patients has remained static while the total number of patients on the waiting list has fallen. This suggests that long term suspended patients are being removed from the list. Demographics and Summary Table Data is based on all patients on the CMFT kidney and pancreas transplant waiting list at the end of each financial year 29/1 21/11 211/ 12 Patients on list at end of year 919 915 876 (-4.3%) Male 5 59 55 (57.6%) Age range (in years) 6-8 6-8 2-8 Time on transplant list range in months, active patients -37-319 -29 Median time on transplant list in months, active patients 19 2 21 Patients active 63 67 59 (67.4%) Patients suspended 316 39 286 (32.4%) Patients waiting for kidney alone transplant 815 82 776 [-5.4% Patients waiting for simultaneous kidney and pancreas transplant 89 85 77[-9.4% ] Patients waiting for simultaneous heart and kidney transplant 1 1 1 Patients waiting for pancreas alone transplant 14 9 7 [-22.2%] Patients waiting for islet transplant 5 7 11 (1.26%) () indicates % of total [ ] indicates % change from previous year
Paediatric patients on CMFT Kidney and Pancreas Transplant Waiting List 16 Demographics 29/1 21/11 211/12 No of paediatric patients waiting 19 21 18 Active on list 11 15 1 Suspended on list 8 6 8 Male 12 14 12 Female 7 7 6 Age range (years) 6.1 17.9 6.5 18.9 2.5-18.1 Time on list range (months) 2 34 1. 31 1-43 Median time on list (months) 8.2 11.5 8.7 CMFT Kidney and Pancreas Transplant List by Organ Required CMFT Kidney and Pancreas transplant list by organ required SHK.1% Kidney after liver.2% Kidney after thoracic.2% SPK 8.9% Kidney 89.7% All pancreas 9.7% PAK.8% Fig 14: Organs required by patients listed on the CMFT kidney and pancreas transplant waiting list.
CMFT Kidney and Pancreas Transplant List, April 212 by age 17 CMFT Kidney and Pancreas Transplant list by age range, April 212 25 2 24 25 164 Number of patients 15 1 87 Kidney Pancreas 5 18 47 29 34 18 51 4 1-18 19-3 31-4 41-5 51-6 61-7 71-8 8+ Age range Fig 15: This graph illustrates the age distribution among potential recipients listed for kidney and pancreas transplantation. The median age for adult kidney patients was 54.5, which shows no change from 21/11, and 44.3 for pancreas patients, a slight increase on last year s median of 41.8.
Transplant list status 18 At any one time a proportion of patients on a transplant list will be temporarily suspended. On the CMFT Kidney and Pancreas Transplant list as at 1 st April 212 this proportion was 3.9% for adults awaiting kidney alone transplantation, with 11% of all patients on the list having been suspended for over 12 months. In 21/11 these figures were 33.5% and 13% respectively. Adult kidney alone patients on CMFT Kidney and Pancreas Transplant list April 212 by transplant list status Suspended - 6 months to 1 year 4% Suspended - under 6 months 15% Active 7% All suspended 31% Suspended - over 1 year 11% Fig 16: An overview of the CMFT Renal and Pancreas Transplant list, April 212, by transplant list status. Transplant list status of adults awaiting deceased donor kidney transplantation, CMFT kidney & pancreas transplant list, April 212 3 25 33 2 15 3 1 19 1 35 2 1 59 Suspended - over 1 year Suspended - 6 months to 1 year Suspended - under 6 months Active 1 17 19 152 5 GM East GM West Cumbria & Lancashire ECR 17 5 Fig 17: A breakdown of adults awaiting kidney only transplantation on 1 st April 212 by status on list. It can be seen that while Cumbria & Lancashire has the highest proportion of patients suspended for less than 6 months (24.5% of patients), the number of patients suspended for over a year is one of the lowest (8.3%). This reflects differing practices for listing and activation of patients between regions.
Time to enter CMFT Kidney and Pancreas Transplant Waiting list 19 The time taken to complete the transplant listing process is audited on an annual basis. This time period is measured by calculating the number of days elapsed between the date of the referring Nephrologist s signature on each patient s Request to List Form, the date this form is received by the Transplantation Laboratory and the date they enter the transplant list. The graph below illustrates median listing times for adult patients from each referral centre over the past year with a comparison to last year s median listing time. Median time to enter transplant list in days by referral centre, 211/12 1 9 8 14 24 Time to list in days 7 6 5 4 3 23 54 17 6 7 19 64 62 2 5 Laboratory to list Transplant referral to laboratory 2 1 GM East GM West Cumbria & Lancashire Referral centre ECR All adult centres All adult centres 21/11 Fig 18: Median tim e to enter transplant list by referral centre. Overall median time to list this year was 81 days. Waiting Time for patients on the transplant list Time waited by patients on the CMFT kidney and pancreas transplant list on 1st April 212 3.% 25.% 2.% % of patients 15.% 1.% Kidney alone All pancreas 5.%.% -5 months 6-12 months 13-24 months 25-36 months 37-6 months 61-84 months 85-12 months 121-18 months 181-24 months 241-3 months 3+ months Kidney alone 15.2% 14.9% 22.5% 15.5% 18.7% 5.6% 3.7% 1.9%.9%.9%.1% All pancreas 2.2% 19.% 26.2% 15.5% 16.7% 2.4%.%.%.%.%.% Time on list Fig 19: The median waiting time for kidney patients on the list is 22.5 months (23.4 months in 21/11) and for pancreas recipients the median time on the list is 18 months (15.5 months in 21/11).
Five Year Cohort Study on Waiting Time 2 In 212, waiting time to transplant was audited by studying a cohort of patients listed in the same calendar year. The 216 adult patients who were listed for kidney alone transplantation at CMFT in 27 were followed up 5 years later in August 212 and their outcomes assessed. The aim of this audit was to provide both clinicians and patients with realistic expectations of waiting time. Post registration outcome for 216 patients listed for kidney transplantation in 27 1% 9% 8% 17.1% 6.% 29.2% 7% % of patients 6% 5% 4% 75.% 32.9% Transplanted (living donor) Transplanted (deceased donor) Still waiting Transferred to another area Removed Died 3% 14.8% 2% 11.6%.9% 1% %.5%.5% 1.6%.9% 1 year 5 years Time since registration Fig 2: Patient outcome at 1 and 5 years following registration on the CMFT transplant list
Source of Transplant Referrals 21 Patients are referred to the CMFT Renal Transplant Unit from 3 network sectors, each encompassing a group of hospitals in the North West region. The Unit also receives Extra Contractual Referrals (ECRs) from outside these referral sectors. Paediatric patients aged 18 or under are referred from Alder Hey or Central Manchester Children s Hospitals, with occasional exceptions in special cases. Full lists of hospitals covered by each network sector are given in the appendix. The tables overleaf detail the referral network origin of patients receiving kidney alone deceased donor transplants during 211/12 and also those on the transplant list as at April 212 for purposes of comparison. The bottom rows of the table express the number of patients from each area transplanted during 211/12 as a percentage of the number listed from each area, and again as a percentage of the number active on the transplant list from each area. GM East Referral Network Sector Cumbria and GM West ECR Lancashire All Areas Adults transplanted* 211/12 (21/11) 37 (43) 44 (37) 36 (25) 4 (5) (11) Adults transplanted as % of total, 211/12 3.6% 36.4% 29.8% 3.3% Adults listed, April 212 (% of total) 229 (3.1%) 268 (35.2%) 241 (31.6%) 24 (3.1%) 762 Adults transplanted 211/12 as percentage of 24.9% 26.5% 22.4% 33.3% 24.9% number listed Adults transplanted 211/12 as percentage of number active Adults newly listed for transplant, 211/12 Adults permanently removed from the transplant list, 211/12 33.5% 37.4% 35.5% 47.1% 35.9% 57 97 77 14 244 2 32 1 1 63 Adult living donor 2 27 18 4 transplants, 211/12 *Kidney alone deceased donor transplant recipients, unless otherwise stated 69
Transplants and listings by referral network sector in a population context 22 The figures below detail the numbers of adults listed for kidney alone transplantation and those transplanted during 21/11 relative to each referral network sector s total population. There is considerable variation between the areas, with the highest proportion of people both listed and and transplanted in the GM West sector, and the lowest in Cumbria and Lancashire. These differences may be due to a number of factors; demographic differences, epidemiological factors and referral patterns for transplantation. Figures in brackets denote the previous year s figures. Estimated area population, 212* GM East GM West Referral Network Sector Cumbria & Lancashire Overall 1567156 12262 19957 478956 622 Patients active on Manchester transplant list per million population, 18.5 (118.7) 155. (146.) 76.16 (76.7) 16.9 (111.1) 11.7 (16.8) 211/12 Patients transplanted in Manchester per million 23.6 (24.1) 35.8 (26.9) 18.** (1.5) 24.4 (2.3) 26.88 (23.2) population, 211/12 *Sources: Strategic Framework for Kidney Care in Greater Manchester 28-213 Strategic Framework for Kidney Care in Cumbria and Lancashire 28-213 ONS 24 based population projections ONS mid-26 population estimates ONS mid-21 population estimates NHSBT Annual Activity Report 211/12 **6 additional transplants for the Cumbria & Lancashire sector were Carlisle patients transplanted at Newcastle. Transplant listings and deceased donor kidney transplants per million population by area, 211/12 UK 18 16 154.95 14 Patients per million population 12 1 8 6 4 2 18.48 23.61 35.88 76.16 18.4 11.7 26.88 Patients active on transplant list per million population Patients transplanted per million population GM East GM West Cumbria & Lancashire Referral network sector/area UK Fig 21: Adult kidney transplant listings and transplants undertaken relative to local population in three referral network sectors, showing UK figures for comparison.
Graft Survival 23 The two graphs and table below illustrate graft survival for first deceased donor kidney alone transplants at CMFT, with patient survival given overleaf. Percentage survival for both CMFT and the UK by transplant type is given in the table at the bottom of the page. Graft survival is censored for death with functioning graft. 1 year graft survival, 1st adult kidney transplant recipients 26-29 by transplant type Cumulative Survival Living donor transplants (n=146) DBD kidney (n=215) DCD kidney (n=86) P=.68(NS) Time in years Fig 22: 1 year graft survival by transplant type. There is no significant difference between living donor, D BD and DCD graft survival 5 year graft survival, 1st adult kidney transplant recipients 23-25 by transplant type Cumulative Survival Living donor transplants (n=57) DBD kidney (n=232) DCD kidney (n=19) P=.64(NS) Time in years Fig 23: 5 year graft survival by transplant type. There is no significant difference between living donor, DBD and DCD graft survival Transplant Type 1 year graft survival 5 year graft survival, Recipients transplanted 26-29 Recipients transplanted 23-25 CMFT UK* CMFT UK* Living donor kidney 97% 99% 91% 92% DBD kidney 95% 94% 88% 84% DCD kidney 94% 95% 95% 86% * Source: NHSBT ODT Activity Report 21/11
Patient Survival 1 year patient survival, 1st adult kidney transplant recipients 26-29 by transplant type 24 Cumulative Survival Living donor transplants (n=146) DBD kidney (n=215) DCD kidney (n=86) P=.2 (S) Time in years Fig 24: 1 year patient survival by transplant type. There is a significant difference in patient survival between transplant types for this period. 5 year patient survival, 1st adult kidney transplant recipients 23-25 by transplant type Cumulative Survival Living donor transplants (n=57) DBD kidney (n=232) DCD kidney (n=19) P=.122(S) Time in years Fig 25: 5 year patient survival by transplant type. There is a significant difference in patient survival between types for this period. Transplant Type 1 year patient survival Recipients transplanted 26-29 5 year patient survival, Recipients transplanted 23-25 CMFT UK* CMFT UK* Living donor kidney 99% 99% 98% 96% DBD kidney 93% 96% 92% 89% DCD kidney 97% 95% 79% 88% * Source: NHSBT ODT Activity Report 21/ 11
Appendix: Referral Network Sectors (Adults only) 25 This is a division of patients by grouping of referring hospital and satellite units. Referral Network Main Hospital Satellite Hospitals North Manchester General Hospital Wythenshawe Hospital GM East Sector Manchester Royal Infirmary Tameside Hospital Macclesfield General Hospital GM West Sector Cumbria & Lancashire Hope Hospital Royal Preston Hospital Birch Hill Hospital Rochdale Infirmary Wigan Infirmary Royal Bolton Hospital Chorley and South Ribble Hospital Royal Blackburn Hospital Burnley General Hospital Westmorland General Hospital Blackpool Victoria Hospital Furness General Hospital Royal Lancaster Infirmary ECR - Extra Contractual Referrals All other hospitals/trusts outside these areas