GCE Human Biology Advanced Subsidiary GCE Unit F: Molecules, Blood and Gas Exchange Mark Scheme for June 0 Oxford Cambridge and RSA Examinations
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F Mark Scheme June 0 a A mitochondrion / mitochondria ; B nucleolus ; C Golgi (apparatus / body) ; C IGNORE SER D rough endoplasmic reticulum / Rough ER / RER ; E lysosome / vesicle ; E DO NOT CREDIT vacuole b type of leucocyte ( mark) neutrophil / granulocyte ; Mark the first answer. If a further answer is given that is incorrect or contradicts the correct answer then = 0 marks reason ( mark) lobed nucleus or granular cytoplasm ; c (i) maintains cell structure ; AVP ; (ii) palisade mesophyll cells have lower energy demands / AW ; have lower metabolic rate ; do not have a role in phagocytosis ; (iii) chloroplast ; permanent vacuole ; tonoplast ; starch grains ; max max max Total 0 Mark the first answer. If a further answer is given that is incorrect or contradicts the correct answer then = 0 marks ACCEPT supports the cell e.g. stops the cell bursting freely permeable idea of protection ora for leucocyte DO NOT CREDIT produce less energy CREDIT plants have lower metabolic rate CREDIT named metabolic reaction e.g. active transport ACCEPT large or central vacuole DO NOT CREDIT 'starch' alone
F Mark Scheme June 0 a adaptation of lungs feature air brought into the alveoli by ventilation is rich in oxygen endothelium of capillaries is made of flattened cells there are millions of alveoli in each lung A ; C ; B ; the wall of each alveolus is folded B ; b idea of gases only diffusing through two layers of cells ; air in alveolus has higher oxygen concentration than in, blood / capillary ; ora oxygen diffuses from, air / alveolus, into, blood / capillary ; air in alveolus has lower CO concentration than in, blood / capillary ; ora carbon dioxide diffuses from, blood / capillary, into, air / alveolus ; (diffusion) down concentration gradient / described ; max DO NOT CREDIT short distance for diffusion as this is stated in stem of the question Statement needs to be comparative Statement needs to be comparative ACCEPT carbon dioxide takes the opposite route if mp 3 has already been awarded ACCEPT down a diffusion gradient
F Mark Scheme June 0 c (i) surfactant ; lowers surface tension of alveoli or prevents alveoli from sticking together or prevent alveoli collapsing or reduces the effort required to breathe in (lung compliance) ; c (ii) gases must diffuse through a thicker than normal layer of fluid ; (so) longer diffusion pathway / AW ; rate of gas exchange is decreased / slower diffusion ; max Total ACCEPT decreases efficiency of gas exchange 3
F Mark Scheme June 0 3 a 3 6 7 8 9 globular (protein) ; idea of proteins having primary, secondary and tertiary structure ; (has) quaternary structure ; four polypeptide chains ; two alpha and two beta (polypeptide) chains ; contains prosthetic group(s) ; each polypeptide has a haem (prosthetic) group ; haem group contains iron ; (shape of) molecule held by named bonds ; 3 max DO NOT CREDIT beta-pleated or alpha helix chains CREDIT has four haem groups 9 e.g. ionic / disulfide (disulphide) / hydrogen / hydrophobic / hydrophilic Q b (i).0 ;; QWC ~ technical terms used in correct context and correctly spelt ; terms from: globular quaternary polypeptide alpha beta prosthetic Correct answer = marks If the answer is incorrect or is given to the wrong number of decimal places, CREDIT mark for working 6.0.3
F Mark Scheme June 0 (ii) (iii) cause ( mark) iron deficiency or AVP ; reason ( mark) idea of mass of haemoglobin (per 00 cm 3 of blood) is lower than normal or idea of mass of haemoglobin (per 00 cm 3 of blood) is outside normal (reference) range ; B has fewer erythrocytes (than in smear A) ; (some) erythrocytes that are larger (than in smear A) ; erythrocytes more varied in shape / AW ; max Total 0 e.g. liver disease / kidney disease / vit B deficiency (pernicious anaemia) / sickle cell anaemia (as lower no of RBCs) / undergoing cancer treatment DO NOT CREDIT childbirth (as = loss of blood) ACCEPT red blood cells / RBCs throughout
F Mark Scheme June 0 a X sinoatrial node ; ACCEPT SAN / SA node Y atrioventricular node ; ACCEPT AVN / AV node DO NOT CREDIT VAN b 3 Z Bundle of His ; (electrical impulse) spreads across atria ; (through) branched / interconnecting, cardiac muscle (cells) ; (impulse) can not pass (to ventricles) due to, fibrous / non-conducting, tissue ; 3 ACCEPT Purkyne / Purkinje, fibres heart tissue stated in Q 6 7 8 9 (impulse) passes to, Y / AVN ; (impulse is) delayed at Y / AVN ; impulse then passes down the septum ; (through) Z / bundle of His ; impulse reaches apex of the heart ; (impulse) spreads through, ventricle (walls) / Purkyne fibres ; max 9 ACCEPT Purkinje instead of Purkyne Q QWC ~ technical terms used in correct context and correctly spelt ; Total 8 terms from: atria OR atrium OR atrial ventricle(s) OR ventricular bundle of His atrioventricular node Purkyne fibres apex 6
F Mark Scheme June 0 a put on (sterile) gloves ; 3 check wound for objects (e.g. glass) / do not remove object from wound ; (if nothing in wound) place pad over / make a pad around the object ; 6 b (i) prothrombin ; (ii) fibrinogen ; (iii) cofactors ; press firmly / secure pad in place ; if blood soaks through apply a second pad (on top) ; if wound is in, limb / arm / leg, raise it (above heart) ; (iv) less, inactive molecule / M / prothrombin, produced (by diseased liver) ; 3 max Correct spelling only ACCEPT phonetic spelling e.g. fibrinigen CREDIT less substrate or less fibrinogen produced less, active enzyme / thrombin, formed ; idea of fewer, successful collisions / active sites occupied / ES complexes produced ; slow(er), reaction / rate of reaction ; less, fibrin / product, produced ; 3 max Total 9 If fibrinogen is used in answer to mp then credit less substrate for the enzyme thrombin for mp CREDIT less fibrinogen broken down by thrombin 7
F Mark Scheme June 0 6 a oxygen has, slight / small / delta / δ, negative (charge) ; hydrogen has, slight / small / delta / δ, positive (charge) ; ACCEPT d (lower case) for δ ACCEPT d (lower case) for δ dipole is formed / molecule has unequal distribution of charge ; δ + H O δ δ + H b glucose is polar and lipids are non-polar ; c (i) B or C ; (ii) A ; (iii) B ; glucose, attracts water molecules / is hydrophilic ; lipids, repel water molecules / are hydrophobic ; d (i) anaemia ; during / after, surgery ; blood loss after childbirth ; AVP ; max max max Allow max for incorrect molecular structure of water ACCEPT thalassaemia e.g. excessive blood loss after trauma chemotherapy leukaemia 8
F Mark Scheme June 0 (ii) idea of cells and diluting solution needing the same water potential ; (solute) lowers water potential of solution ; 3 6 7 if water potential (of solution) is lower than red cell then water will leave cells ; ora by osmosis ; down water potential gradient / described ; cells will, crenate / shrivel ; ora blood cells will not be suitable for use in the body / AW ; mp 3 and mp 6 must be consistent with direction of water movement DO NOT CREDIT along water potential gradient 3 max Total 9
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