Two: Chronic kidney disease identified in the claims data. Chapter

Two: Chronic kidney disease identified in the claims data Though leaves are many, the root is one; Through all the lying days of my youth swayed my leaves and flowers in the sun; Now may wither into the truth. William Butler Yeats, The Coming of Wisdom with Time Chapter

dentifying chronic kidney disease is a significant challenge, as most datasets lack the biochemical data that provides, in comparison to diagnosis codes, the greatest precision in identifying the disease. And while random samples such as the NHANES dataset do include biochemical information, such studies rarely include event rates or economic data, making it difficult to evaluate access to care for this high-risk population, or to examine the interactions of CKD with diabetes and cardiovascular disease. The USRDS obtains several datasets which we have, in past ADRs, used to assess the recognized CKD population. This year we have developed methods to examine this population by looking at services performed by providers when CKD diagnoses are reported. n this chapter we define two such methods, using claims data and looking as well at the new CD-9-CM diagnosis codes for CKD, introduced in 6. Data come from the MarketScan database, in which most of those covered are self-insured, and from the ngenix i3 dataset, in which most are not. We compare the prevalence of CKD in these datasets, and show a true estimate from the NHANES samples, providing a sense of the under-recognition of this disease. On the next page we present a schematic for defining the CKD population in the 5 percent sample. With the point prevalent method we identify CKD from diagnosis codes within a single calendar year. Since this approach defines the disease only from codes in that year excluding patients without CKD codes in that year, even if they had codes in prior years it may limit the number of actual cases. To address this potential loss of patients we also developed a period prevalent method. All patients alive on January 1 of a year have data reviewed in the prior year for a diagnosis of CKD, defining a point prevalent population known to have CKD. New cases of CKD within the current year are then added, completing a period prevalent cohort. This method is similar to the one used to define period prevalent cohorts in the ESRD population. Additional information on these two approaches is available in Appendix A. Using the point prevalent method, with a single year to define the CKD population, 6.4 percent of the population carries a diagnosis of CKD. Using the two-year period prevalent method, the number rises to 9 percent. The latter method provides a case definition that can be used to address expenditures in a way similar to that used with the ESRD population. Because the and ngenix i3 populations, however, have fewer years of consistent claims, we have used the first method to examine them. On the next spread we use the point prevalent method to look at the prevalence of CKD in the population, comparing that identified through a full constellation of diagnosis codes (discussed in Appendix A) to that identified solely through the new CD-9-CM diagnosis codes for CKD. t is clear that the comprehensive codes provide a greater yield, a reality of the early introduction of any new codes to the payment system and to providers. For this reason we also use the comprehensive codes to illustrate the increasing amount of recognized CKD which is still significantly less than the actual prevalence of the disease indicated by true population estimates (Chapter One). With s coding methods required across all state and regional fiscal intermediaries, the consistency of billing rules and procedures may differ from that in the employer group health plans. payment rules, for example, indicate that all claims now need to use the new CD-9-CM codes for CKD, and allowed no grace or phase-in periods. Our analyses show that the adoption of these codes in the system was much greater than in the private sector. The USRDS Coordinating Center will monitor these coding changes and report on their utility in health services research. n the early phase of the changes, however, it appears that the full constellation of kidney disease codes still provides a better indication of recognized CKD than do the new 585.x CD-9-CM diagnosis codes on their own. Trends in the amount of recognized CKD (Figures.3 and.5) do suggest that providers are documenting more CKD in their service claims, though the prevalence of CKD is still far less than that noted in the population estimates reported from the NHANES 1999 6 data. Despite these limitations, the specificity of the disease codes is very high, at over 9 percent; the sensitivity, however, is much lower. The high specificity allows researchers to assess care in those known to have the disease, providing insights into access to care in this high-risk population. As mentioned earlier, laboratory data allow a more accurate identification of CKD. The ngenix i3 dataset contains information on prescription drugs and laboratory data reported to United Healthcare contract laboratories, and these data provide a different view of the prevalence of CKD than that identified in the CD-9-CM diagnosis codes. We use two formulas, based on serum creatinine levels, to define estimated glomerular filtration rates (egfrs): the Modification of Diet in Renal Disease (MDRD) equation and that published by Rule et al. The prevalence of CKD as defined through an egfr <6 ml/min/1.73 m is greater

.1 Comparison of point & period prevalent methods for identifying CKD cohorts Point prevalent Year 1 Jan. 1, Year 1 Dec. 31, Year 1 Survive all of Year 1 Enrolled all of Year 1 Have qualifying diagnosis during Year 1 Do not develop ESRD during Year 1 Year 1 is the analysis year 1.% CKD 6.4% CHF 9.6% than that defined from the diagnosis codes. n addition, the comorbidity burden based on this CKD definition shows a high prevalence of congestive heart failure and other cardiovascular disease. n Figure.6 we illustrate the relationship between CKD stage reported from the claims and that identified from the laboratory data. As CKD stage, identified from the diagnosis codes, Period prevalent Year 1 Jan. 1, Year 1 Dec. 31, Year 1 Survive all of Year 1 Enrolled all of Year 1 Have qualifying diagnosis during Year 1 Do not develop ESRD during Year 1 progresses, the estimated GFR decreases. There are, however, notable exceptions, which may relate to early use of the codes in the employer group health plan (EGHP) claims data. At Stage 5 (CD-9-CM code 585.5), the laboratory egfr appears to be a mean of 35 ml/min/1.73 m higher than the expected level of <15 from the definition. These irregularities are important for researchers to consider, and the relationship between the timing of the laboratory data and the reporting of the diagnosis codes should be explored. We will continue to assess these areas. There are clearly important challenges in any attempt to define the CKD population from administrative datasets. The 5 percent data appears to provide a greater reporting of recognized CKD, possibly because of the consistency of coding and billing procedures compared to those used by EGHPs. The low prevalence of reported CKD in the EGHP population would appear to be addressed with more complete laboratory data on this population. And there is little doubt that the data would also be improved with the addition of laboratory data, the basis of the case definition. Any development of CKD cohort definitions from administrative data should acknowledge that there is significant underreporting of the disease. As awareness of CKD grows in the medical community, based on studies of the disease s interaction with diabetes and cardiovascular disease, it is likely that reported codes will increase. The new initiatives passed by Congress to address CKD education in Stage 4 may influence provider recognition of the condition, as may the quality improvement assessments currently being discussed in relation to CKD performance measures. Lastly, since CKD in its advanced stages has such an impact on morbidity and mortality, it may be worth considering a registration system for CKD, with surveillance data that will further the analyses of outcomes and access to care. + Year Jan. 1, Year Dec. 31, Year Survive at least 3 months in Year Enrolled at least 3 months in Year Have qualifying diagnosis in Year Censored at the earliest of death, change in enrollment status, development of ESRD, or end of Year Year is the analysis year 3.6% CKD 8.7% CHF 13.5% figure.1 point & period prevalent populations for 6, estimated from 5 percent sample using standard methods (see Appendix A for further details). CHF, diabetes, & CKD determined from claims. highlights figure.3 The standard methodology identifies a higher percentage of patients with CKD (6.4 percent) than that obtained with the new stagespecific codes. figure.3 Among patients, the prevalence of CKD identified through claims has increased dramatically in the last ten years, from 1.8 percent in 1995 to 6.4 percent in 6. figure.4 The population age 64 shows about one-tenth the CKD prevalence of the cohort age 65 and older. figure.8 NHANES data on participants with CKD of Stages 1 5 show a generally higher prevalence of CKD than do other datasets, both claims-based and lab-based. figure.13 There is a clear pattern of increasing comorbidity by decreasing egfr. contents CKD as defined by the new CD-9-CM codes 4 in and data: definition of CKD stages trends in CKD prevalence comparison of CKD prevalence using old & new codes defining CKD through laboratory data 4 metabolic abnormalities agreement of CKD definitions through diagnosis codes & laboratory data CKD prevalence, by dataset, CKD stage, & patient characteristics summary of CKD prevalence in the datasets comorbidity burden in patients with & without CKD 44 prevalence of comorbidities, by dataset & CKD stage diabetes, CHF, hypertension, & cancer, by CKD stage

. CKD stages as defined by old & new CD-9-CM codes: point prevalent patients age 65 & older, 6 4 figure. The standard methodology (one or more inpatient diagnosis codes or two or more outpatient codes) identifies a higher percentage of patients with CKD (6.4 percent) than that obtained with the new stagespecific codes (4. percent for all 585 codes combined). Within these stage-specific codes, the most commonly used codes are 585.9 (unknown) and 585.3 (Stage 3). The use of these codes began late in 5, and providers are still adjusting to their use. Both their use and their accuracy should increase over time. figure.3 Among patients, the prevalence of CKD identified through claims has increased dramatically in the last ten years, from 1.8 percent in 1995 to 6.4 percent in 6. Much of this growth is probably due to increasing recognition and/or coding of earlier stages of CKD..3 7 6 5 4 3 1 Mean age: 75.3 All codes 585 585.1 585. 585.3 585.4 585.5 585.9 CD-9-CM codes 7 6 5 4 3 1 Trends in CKD prevalence: point prevalent patients age 65 & older All codes New codes 585.1 585. 585.3 585.4 585.5 585.9 96 98 4 6 table.a Data here show generally increasing levels of comorbidity with increasing CKD stage as defined by the 585.1 585.5 codes. Although the pattern is not universal, agreement appears to be best between the old method and CD-9-CM code 585.4..a Patient characteristics & comorbidity distributions using the old & new CD-9-CM codes: data (column percents) point prevalent patients age 65 & older, 6 All New CD-9-CM codes** codes* 585 585.1 585. 585.3 585.4 585.5 585.9 Age 65-74 36.6 34.8 36.4 45.5 39.9 33. 35. 8.6 Age 75+ 63.4 65. 63.6 54.5 6.1 66.8 64.8 71.4 White 84. 83. 8. 8. 84.3 83. 74.4 84.3 African American 11.3 1.1 13.8 13. 11. 11.9 18.1 11.5 Asian/Pacific slander 1.4 1.4 1.9 1.5 1.4 1.6.3 1.1 Other/unknown 3.3 3.3 4.1 3. 3.1 3.5 5. 3.1 Non-Hispanic 98.1 98. 97.5 98.3 98.3 97.9 96.7 98.3 Hispanic 1.9 1.8.5 1.7 1.7.1 3.3 1.7 Male 48.5 5.1 5.7 5.3 51.7 46.9 46.6 49.7 Female 51.5 49.9 49.3 47.7 48.3 53.1 53.4 5.3 ASHD 47.7 49.6 44. 45.1 47.4 48.3 5.7 5.9 CHF 37.1 4.3 35.9 3.5 34.1 41.3 49. 46.4 CVA/TA..1 19.1 18. 17.1 18.1.9 3.4 PVD 31.9 31. 7.1 7.4 9.1 3.4 36.8 33.6 Other cardiac disease 3.5 31.4 7.6 8.3 8.1 8.6 36.6 35.4 COPD 6.5 6.9 4.4 4.6 3.3 4. 8.4 31.4 G disease 9.6 9.7 8.6 7.7 7.7 8.7 1.9 11.7 Liver disease 1.9 1.9.5 1.6 1.7 1.5 3.6.1 Arryhthmia 37.8 38.8 34.6 34. 34. 35.7 41.1 44.9 Cancer 18.9 16.3 15.5 15.5 16.5 15.4 16.3 16.7 46.4 47.7 47. 49.4 49.7 5.1 51.9 44.4 Anemia 48.8 54. 49.1 43.7 5.5 69.4 7.1 51.3 Hypertension 89.9 9. 89.5 9.5 93.9 94. 93. 89.8

.4.8 CKD stages as defined by old & new CD-9-CM codes: point prevalent patients age 64, 6 Mean age: 44.8 8 USRDS Annual Data Report chronic kidney disease as defined by the new diagnosis codes CKD the claims in data.5.6.4.. All codes 585 585.1 585. 585.3 585.4 585.5 585.9 CD-9-CM codes.7.6.5.4.3..1. Trends in CKD prevalence: point prevalent patients age 64 All codes New codes 585.1 585. 585.3 585.4 585.5 585.9 99 1 3 4 5 6 figure.4 The population age 64 shows about one-tenth the CKD prevalence of the cohort age 65 and older (shown in Figure.). The distribution of new stage-specific codes compared to the old method is similar to that found in the cohort; there appears, however, to be less use of the new stage codes in the data. Of these stage-specific codes, 585.3 is the most commonly used in the cohort. Again, the use and accuracy of these codes in the EGHP datasets should improve over time. figure.5 With a pattern similar to that observed in the data, the prevalence of claims-identified CKD has risen substantially since 1999. ncreased recognition and coding of earlier-stage CKD again most likely accounts for much of this increase. 41.b Patient characteristics & comorbidity distributions using the old & new CD-9-CM codes: data (column percents) patients age 64, 6 All New CD-9-CM codes** codes* 585 585.1 585. 585.3 585.4 585.5 585.9 Age -49 9.1 1.8 39. 6. 16. 18.6 5.5 4.1 Age 5-64 7.9 78. 61. 74. 83.8 81.4 74.5 75.9 Male 53.9 57.7 5.4 59. 59. 5.6 54.7 6.6 Female 46.1 4.3 47.6 4.8 41. 47.4 45.3 39.4 ASHD 15.6 18.3 9.5 1.9.1 17.6 19.9.7 CHF 1.5 1.9 5. 8.3 1.7 15. 18.6 17.5 CVA/TA 5.8 6.1 3.4 4. 5.7 6.9 8.3 8.8 PVD 1.8 9.7 6. 7.4 9. 1.3 13.9 1.7 Other cardiac disease 11.9 1.1 7.9 8.3 11. 1.5 16.7 17.5 COPD 8.3 8.3 6.3 6.9 7.8 7.4 8.3 1.4 G disease 3.6 3.3 1.9 1.9 3. 3.4 6.1 4.6 Liver disease.6. 1.9 1.8 1.8 1.8 4.8 3. Arryhthmia 1.1 1.6 5.6 7.1 11. 1.4 1.8 14.6 Cancer 15.5 8.1 6. 7. 7.6 7.5 9.8 1.7 37.8 44. 3.6 38.7 47.3 5.7 44.4 41.8 Anemia 17.4 4. 13.1 1.6 3.4 41.7 41.8 3. Hypertension 48. 59.9 5.8 57.1 6.5 6.3 64.1 61. table.b As in the cohort, data show generally increasing levels of comorbidity with increasing CKD stage, as defined by the new codes. n this dataset, the best general agreement between the old method and the new codes seems to be with Stage 3, identified with CD-9-CM code 585.3. New CD-9-CM codes 585.1 Chronic kidney disease, Stage 1 585. Chronic kidney disease, Stage (mild) 585.3 Chronic kidney disease, Stage 3 (moderate) 585.4 Chronic kidney disease, Stage 4 (severe) 585.5 Chronic kidney disease, Stage 5 (excludes 585.6: Stage 5, requiring chronic dialysis^) 585.9 Chronic kidney disease, unspecified figures. 3 & table.a point prevalent general patients age 65 & older, surviving all of 6 with as primary payor & not enrolled in an HMO. ESRD patients excluded. CKD & other comorbidities defined by diagnosis codes in 6. figures.4 5 & table.b point prevalent patients age 64, surviving all of 6, & enrolled in a fee-for-service plan. ESRD patients excluded. CKD & other comorbidities defined by diagnosis codes in 6. *All codes: CKD identified through one or more inpatient/outpatient institutional claims (inpatient hospitalization, skilled nursing facility, or home health agency), or two or more institutional claims (outpatient) or physician/supplier claims, the method used in other USRDS studies. **CKD identified through the 585.x CD-9-CM codes. ^n USRDS analyses, patients with CD-9-CM code 585.6 are considered to have code 585.5; see Appendix A for details.

table.c This table illustrates the percentage of patients with metabolic-related abnormalities in CKD Stages 3 5, using the two different estimating equations. Among non-ckd patients, the percentage with each abnormality is similar for both equations. For patients with CKD of Stages 3 5, however, the percentages are considerably higher when CKD is identified using the Rule method as compared to the MDRD equation. The largest difference is observed for Stage 3, which agrees with the general finding that the MDRD formula identifies significantly more individuals as Stage 3 than does the Rule equation, but similar numbers within Stages 4 and 5..c Percentage of patients with metabolic abnormalities point prevalent ngenix i3 patients age 64, 6 4 Non-CKD Stages 3 5 Stage 3 Stage 4 Stage 5 MDRD Rule MDRD Rule MDRD Rule MDRD Rule MDRD Rule Uric acid 7.7 mg/dl 9.3 1. 5.5 49.7 3.7 47.3 6.1 6.5 41. 44.9 Calcium 8.9 mg/dl 6.9 6.7 5.6 11. 5. 8.1.3 3.8 46.6 46.4 Parathyroid hormone 81.7 pg/ml 7.8 8. 6. 39.6 13.1.1 54.6 56. 74. 75. Reduced HDL 9.6 9.7 31.8 4. 31.5 39.1 45.4 47. 5.3 49.1 Elevated triglycerides 3.8 33.1 38.3 51. 38. 5.3 55.9 56.9 5.9 5. Abnormal glucose (out of normal range) 37.3 37.7 43.4 56.9 4.9 56. 6.4 61.1 58.8 59.8 WHO anemia 7.5 7.6 1.1 3.7 1.6 6.5 57.8 6.4 7.5 73..6 Estimated GFR (MDRD method), by CKD stage, 6 ngenix i3 pts age 64.d Agreement between CKD defined from egfr (MDRD formula) & CKD defined from claims point prevalent ngenix i3 patients age 64, 6 egfr (ml/min/1.73 m ) 1 8 6 4 CKD 585.1 585.3 585.5 Non-CKD 585 585. 585.4 585.9 figure.6 Agreement between CKD as identified from claims (old versus new codes) and as identified through egfr (using the MDRD equation) shows a pattern of generally decreasing egfr with increasing stage, and unknown stage from codes being a mixture of all stages. The average egfr for patients with CKD, identified through the old method, seems to correspond approximately to Stage as identified in the claims. egfr cutoff Proportion Proportion with CKD with CKD Sensitivity Specificity PPV NPV Kappa by egfr from claims < 1.96.98.3 1..5.1.19 < 15.97.98.5 1..9.1.19 <.93.98.8 1..14..19 < 5.88.98.1 1....19 < 3.81.98.16 1..6.4.19 < 35.71.99.1 1..3.6.19 < 4.58.99.7 1..36.9.19 < 45.45.99.34.99.38.14.19 < 5.3.99.41.98.34.5.19 < 55.19.99.48.96.5.49.19 < 6.1.99.56.9.14.17.19 < 65.6.99.63.8.8.188.19 < 7.4.99.69.7.5.33.19 < 75.3.99.75.58.3.44.19 < 8.3.99.8.4..584.19 < 85..99.85.34.1.667.19 < 9..99.9..1.785.19 < 95..99.9.14..859.19 table.d This table presents a detailed assessment of agreement between egfr using serum creatinine, and of CKD identified from claims (using the old method). The right-most column shows the (unchanging) proportion with CKD from claims about 1.9 percent. Each row represents a different egfr cutoff used to identify patients with CKD, representing a changing gold standard. The parameters of sensitivity (most probable of having CKD from claims, given an egfr less than cutoff), specificity (most likely of not having CKD identified from claims, given an egfr > cutoff), positive predictive value (PPV, the probability of having an egfr < cutoff given CKD identified in claims), and negative predictive value (NPV, the probability of having an egfr > cutoff given CKD not identified in claims) are shown for each level of egfr. Although the choice of the egfr cutoff giving best agreement with claims is a tradeoff of each of these four parameters, the column labeled Kappa is a measure of overall agreement between egfr and CKD from claims. This value is highest (.38) when an egfr cutoff of <45 ml/min/1.73 m is used, suggesting that CKD from claims generally identifies patients with an egfr <45. Some caveats are important to mention. These analyses of egfr using serum creatinine are on patients with measured creatinines a subset of all ngenix patients. Also, data on race are not available; egfr is calculated for each individual without considering race, and is therefore an underestimate for African American individuals.

8 USRDS Annual Data Report defining chronic kidney disease through laboratory data CKD the claims in data Prevalence of chronic kidney disease: summary.7.8 CKD defined by diagnosis codes 7 6 5 4 3 1 1 CKD prevalence, by CKD stage & dataset point prevalent patients: age 65 & older; & ngenix i3 age 64 ngenix i3 CKD 585 585.1 585. 585.3 585.4 585.5 585.9 CKD defined by lab data (ngenix i3) 1 1 8 6 4 Stages 3-5 Stage 3 Stage 4 Stage 5 CKD prevalence, by dataset, age, gender, & presence of CHF & diabetes point prevalent patients/ participants: age 65 & older; & ngenix i3 age 64; NHANES 1999 6 age & older 6 Age Gender CHF & diabetes 5 4 3 ngenix i3 claims ngenix i3 lab (Stages 3-5)** NHANES Stages 1-5 figures.7 8 We show here the distribution of CKD stages, using claims-based methodology in the,, and ngenix i3 datasets, and lab-based methodology in the ngenix i3 dataset. Claims-based case identification is much more frequent for patients. The discrepancy between lab-based and claims-based case identification in the ngenix i3 dataset is notable, with claims suggesting that just.13 percent of subjects have CKD Stages 3 5, compared to 1.5 percent identified with laboratorybased estimates. We further show claims-based comparisons of CKD prevalence using the three claims-based methods, and we apply two lab-based methods to the U.S. population and to ngenix i3 patients. Among adults younger than 65, CKD prevalence estimates are broadly similar with the two lab-based methods. t is likely that the vast majority of subjects with CKD in the ngenix i3 database are never formally identified. 43-49 5-64 65+ Male Female CHF Diabetic table.c & figure.6 point prevalent ngenix i3 patients age 64, surviving all of 6 & enrolled in a fee-for-service plan. ESRD patients excluded. CKD defined by egfr in Figure.c & by diagnosis codes in Figure.6; see Appendix A for details of MDRD & Rule methods. Last serum creatinine value of 6 used for egfr calculation. Uric acid & parathyroid hormone abnormalities defined by 95th percentile from NHANES data; calcium abnormality defined by 5th percentile from NHANES data; & glucose abnormality based on normal range from ngenix i3 data. Reduced HDL: <4 mg/dl in men, <5 mg/dl in women; based on criteria proposed by the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP ), with elevated triglycerides 15 mg/dl. WHO anemia: males, hemoglobin <13 g/ dl; females, hemoglobin <1 g/dl. Error bars in Figure.6 show 5th & 75th percentiles. table.d point prevalent ngenix i3 patients age 64, surviving all of 6 & enrolled in a fee-for-service plan. egfr calculated using MDRD method, using last serum creatinine value of 6. figures.7 8 : point prevalent general patients age 65 & older, surviving all of 6 with as primary payor & not enrolled in an HMO. & ngenix i3: point prevalent & ngenix i3 patients age 64, surviving all of 6 & enrolled in a fee-for-service plan. ESRD patients excluded. CKD & comorbidities defined by diagnosis codes in 6. NHANES: NHANES 1999 6 participants, age & older. CHF & diabetes are self-reported; CKD defined through serum creatinine values. CKD stages: Stage 3, egfr <15 ml/min/1.73 m ; Stage 4, 15 egfr < 3; Stage 5, 3 egfr < 6. ^n USRDS analyses, patients with CD-9-CM code 585.6 are considered to have code 585.5; see Appendix A for details. New CD-9-CM codes 585.1 Chronic kidney disease, Stage 1 585. Chronic kidney disease, Stage (mild) 585.3 Chronic kidney disease, Stage 3 (moderate) 585.4 Chronic kidney disease, Stage 4 (severe) 585.5 Chronic kidney disease, Stage 5 (excludes 585.6: Stage 5, requiring chronic dialysis^) 585.9 Chronic kidney disease, unspecified

.e Comorbidity prevalence by patient demographic characteristics & CKD status (old vs. new codes) point prevalent patients, 6: age 65 & older; & ngenix i3 age 64 44 table.e n the data, the prevalence of each comorbid condition generally increases with increasing CKD stage defined by CD-9-CM codes 585.1 through 585.5. Not surprisingly, the prevalence of each comorbidity is considerably less in patients without any codes for CKD compared to those with CKD identified through either the traditional or new codes within, or in the or ngenix i3 datasets. Comorbidity generally increases by age, but there are inconsistent differences by gender and race. New CD-9-CM codes 585.1 Chronic kidney disease, Stage 1 585. Chronic kidney disease, Stage (mild) 585.3 Chronic kidney disease, Stage 3 (moderate) 585.4 Chronic kidney disease, Stage 4 (severe) 585.5 Chronic kidney disease, Stage 5 (excludes 585.6: Stage 5, requiring chronic dialysis^) 585.9 Chronic kidney disease, unspecified table.e & figures.9 1 : point prevalent general patients age 65 & older, surviving all of 6 with as primary payor & not enrolled in an HMO. & ngenix i3: point prevalent & ngenix i3 patients age 64, surviving all of 6 & enrolled in a fee-for-service plan. ESRD patients excluded. CKD & other comorbidities defined by diagnosis codes in 6. Table values are comorbidity prevalence within each cell defined by patient demographics (rows) & CKD status (old vs. new codes). figure.13 point prevalent ngenix i3 patients, surviving all of 6. Comorbidity defined by diagnosis codes in 6, & egfr calculated from mean of serum creatinine levels in 6. n USRDS analyses, patients with CD-9-CM code 585.6 are considered to have code 585.5; see Appendix A for details. AM CHF CVA/TA Cancer Hypertension ngenix i3 No Any No No CKD CKD 585 585.1 585. 585.3 585.4 585.5 585.9 CKD CKD CKD CKD All 19.5 46.4 47.7 47. 49.4 49.7 5.1 5. 44.4 5. 37.9 4.6 36.5 49.3 3.5.4 4.5 5 64 9.5 43.7 9.7 44.7 65 74 19.7 54.7 57.6 56.3 57. 58.3 61.7 61. 55. 75+ 19. 41.6 4.5 4. 43.1 44.1 44.4 46.9 4.1 Female 18.8 46.3 47.9 48. 48.6 5. 5. 53.4 44.5 4.7 34.8 4.1 33. Male.5 46.5 47.6 46.3 5.1 49.5 5. 5.3 44.3 5.8 4.5 5. 39.5 White 18.3 44.1 45.4 44.4 47. 47.6 47.3 49.4 4.3 Af Am 9.4 57.3 58.1 57. 59.7 59.9 6.7 58.9 54.6 Unk/oth race 6.1 61.9 6.3 61. 6.9 65. 66.9 6.9 58.6 All.3 11.3 11.7 9. 9. 9.6 1. 1.7 14.7. 3.1..8 49.1 1.4.1 1. 5 64.4 3.8.6 3.9 65 74 1.9 1.4 1.9 8.1 7.8 8.9 9.9 1.8 14.9 75+.8 11.9 1.1 9.6 1.1 1.1 1.1 1.6 14.6 Female 1.8 9.8 1.1 7.3 8.5 8. 8.8 1.7 1.7.1..1 1.9 Male 3. 1.9 13.3 1.7 9.5 11. 11.4 15. 16.7.3 3.9.4 3.6 White.4 11.6 1. 9.1 9.4 9.8 1.3 13.7 15. Af Am 1.8 1. 1. 9.4 7.6 9.1 7.7 8.4 1.5 Unk/oth race 1.6 9.7 1.8 7.9 6.7 8. 11. 13. 13.9 All 7.7 37.1 4.3 35.9 3.5 34.1 41.3 49. 46.4.4 1.5.4 9.4 49. 4.8. 4.7 5 64.9 1.8 1. 1.7 65 74 4.6 9.4 33. 7.8.7 8.3 37.6 41.3 4. 75+ 11.1 41.5 44. 4.5 36.9 37.9 43. 53.4 48.9 Female 7.7 37.7 4.6 37. 31.1 33.6 4.6 49.4 47.3.4 8.9.3 7.6 Male 7.7 36.4 39.9 34.8 9.9 34.5 4.1 48.9 45.6.5 11.8.5 1.9 White 7.7 37. 4.6 35.9 3.6 34.3 41.5 5. 47. Af Am 8.7 37. 38.7 39.4 9. 33.1 4. 45.4 43.7 Unk/oth race 6.7 34.5 37.9 7.3 33. 3.4 4.9 48.6 41.7 All 7.5..1 19.1 18. 17.1 18.1.9 3.4.5 5.8.5 4.6 49..3.. 5 64 1. 7.3 1.1 6.3 65 74 5.1 17.1 17.3 17.9 14.3 14.3 16.9 1.1 1.4 75+ 1.. 1.5 19.8 1. 19. 18.7 3.8 4. Female 7.5.5. 18.9 18.6 17. 18. 1.7 3.5.5 5.4.5 4.3 Male 7.4 19.8. 19.3 17.4 17. 18. 4. 3.3.5 6..5 4.9 White 7.4 19.8 19.7 18.7 17.7 17. 17.5..8 Af Am 8..9. 3.1 19.1 16.5. 5.8 6.7 Unk/oth race 6.7.4 1.7 15.8 19.1 17..9.6 6.8 All 9.4 18.9 16.3 15.5 15.5 16.5 15.4 16.3 16.7 1.8 15.5 1.6 13.6 49.8 9.4.8 7.9 5 64 3.4 18.1 3.4 17.5 65 74 8.4 18.6 14.8 14.6 1.7 14.9 1.8 14. 16. 75+ 1.4 19.1 17.1 16. 17.8 17.5 16.7 17.5 16.9 Female 7. 14.1 11.3 11.1 11. 11.5 1.1 11. 11.7. 14.1. 1.3 Male 1.5 4.1 1.3 19.8 19.6 1. 1.4.5 1.8 1.5 16.8 1. 14.7 White 9.5 19. 16.4 15. 15.3 16.4 15.8 16.4 16.8 Af Am 9. 17.8 16.8 17.8 17.5 17.7 14.4 15.9 16.7 Unk/oth race 6.4 15.8 14.3 14.4 14.4 15. 11.8 16.5 13.9 All 54.5 89.9 9. 89.5 9.5 93.9 94. 93. 89.8 1. 48. 1. 61.8 49 5.1 33.3 6.4 44. 5 64 17.8 54.1 5. 73.7 65 74 49. 89. 9.6 9.4 9.5 94.4 93.9 93.9 9.1 75+ 6.3 9.4 91.8 89. 9.6 93.5 94.3 9.8 89.8 Female 58. 91.8 93.8 9. 94.4 95. 95.5 94.3 9.4 9.8 44.8 11.4 55.8 Male 49. 87.9 9.3 88.8 9.9 9.6 9.7 91.9 87.3 1.6 5.8 13.1 66.8 White 53.6 89. 91. 88.3 91.9 93. 93.6 9.3 88.9 Af Am 65.8 95.5 96.7 95.6 95.5 98. 97.4 96.1 95.9 Unk/oth race 55.6 91.4 94.5 9.1 95.4 95.8 96.6 94.3 9.8

figures.9 1 The figures below show the percentage of patients with diabetes, congestive heart failure, hypertension, and cancer, by dataset and CKD status, using the traditional method of identifying CKD and, for the dataset, the new CD-9-CM codes. Across all four conditions, the prevalence of each comorbidity is similar between the ngenix i3 and datasets. n the cohort there is no clear increase in comorbidity prevalence with increasing CKD stage using the new codes, with the exception of CHF, for which the relationship is more clear..9 Patients with diabetes, by dataset & CKD stage point prevalent patients, 6: age 65+; & ngenix i3 age 64.1 8 USRDS Annual Data Report comorbidity burden in patients with & without chronic kidney disease CKD the claims in data Patients with CHF, by dataset & CKD stage point prevalent patients, 6: age 65+; & ngenix i3 age 64 45 6 5 Percent of patients 5 4 3 1 ngenix i3 No CKD CKD Any 585 585.1 585. 585.3 585.4 585.5 585.9 Percent of patients 4 3 1 ngenix i3 No CKD CKD Any 585 585.1 585. 585.3 585.4 585.5 585.9.11 Patients with hypertension, by dataset & CKD stage point prevalent patients, 6: age 65+; & ngenix i3 age 64.1 Patients with cancer, by dataset & CKD stage point prevalent patients, 6: age 65+; & ngenix i3 age 64 1 Percent of patients 8 6 4 ngenix i3 No CKD CKD Any 585 585.1 585. 585.3 585.4 585.5 585.9 Percent of patients 15 1 5 ngenix i3 No CKD CKD Any 585 585.1 585. 585.3 585.4 585.5 585.9.13 Percent of patients 1 8 6 4 Loess curves of comorbidity prevalence across estimated glomerular filtration rates, 6 point prevalent ngenix i3 patients, 6 Cardiovascular disease Hypertension figure.13 Plotting patient-level comorbidity (CVD, diabetes, hypertension) presence ( versus 1) by estimated GFR, and then fitting a smoothed curve to each comorbid condition, shows a clear pattern of increasing comorbidity by decreasing egfr. and overall cardiovascular disease show similar relationships, while hypertension prevalence is higher at every level of egfr. 15 5 35 45 55 65 75 85 95 15 115 15 135 145 egfr (ml/min/1.73 m )

chapter summary 46 6.4 4. Percent of pts with CKD identified with traditional claims methods (.) 1.8% 1995 3.6-fold increase 6.4% 6 Relative increase of CKD prevalence in the population age 65+ (.3) Percent of pts with CKD identified through any 585 code (.4) 6.4.61.64 ngenix i3 5. 4.6 1 1 19.5 55 ngenix i3 ngenix i3 CKD prevalence, by data set (%,.7) Percent of non-ckd patients with diabetes, by data set (.9) Percent of non-ckd patients with hypertension, by data set (.11) 46 38 37 9 48 6 ngenix i3 ngenix i3 Percent of CKD patients with diabetes, by data set (.9) Percent of CKD patients with hypertension, by data set (.11) 11 1 84 83 White African American Percent of pts with CKD identified with traditional claims method (.a) White African American Percent of patients with CKD identified through any 585 code (.a) 46 9 48 9 Hypertension Percent of pts with CKD identified with traditional claims methods (.a) Hypertension Percent of pts with CKD identified through any 585 code (.a)