To: Medical Groups, DHB Hospital Pharmacies and Interested Parties

24 September 2008 To: Medical Groups, DHB Hospital Pharmacies and Interested Parties CONSULTATION ON TENDER OF CERTAIN PHARMACEUTICALS ALL RESPONSES DUE BY 5PM, WEDNESDAY 5 NOVEMBER 2008 In accordance with PHARMAC s objective of securing for eligible people in need of pharmaceuticals, the best health outcomes that are reasonably achievable from pharmaceutical treatment and from within the amount of funding provided, PHARMAC is consulting on the possibility of tendering for Sole Subsidised Supply and/or Hospital Supply Status of certain pharmaceuticals listed in Schedule One of this document. Attached to this letter is a list of pharmaceuticals that we are considering tendering for Sole Subsidised Supply to community pharmacies and/or Hospital Supply Status for supply to DHB Hospital pharmacies. Pharmaceuticals are listed alphabetically by chemical, form and strength in therapeutic groups and have a C and/or H next to them to indicate whether they are being tendered for community and/or hospital supply. In general, the proposed Tender process would be similar to the 2007/08 Tender. A copy of the 2007/08 Invitation to Tender is available either on our website: www.pharmac.govt.nz, or by contacting PHARMAC. Comments Sought We seek comments on the approach outlined in the following pages, in particular the following: the proposed process and timetable; the actual or potential clinical implications of awarding Sole Subsidised Supply and/or Hospital Supply Status to the pharmaceuticals listed in Schedule One; and for hospital pharmaceuticals what the appropriate Discretionary Variance Limit for each pharmaceutical would be, where a 1% Discretionary Variance Limit is considered clinically unacceptable. All comments, whether on the above described matters or not, received by 5 November 2008 will be considered by PHARMAC prior to finalisation of the 2008/09 Tender process and the list of pharmaceuticals to be tendered for Sole Subsidised Supply and/or Hospital Supply Status. A232709 - qa12214 1

Background Since 1997 PHARMAC has been using the strategy of tendering for sole supply of pharmaceuticals for a fixed period of time. Tendering has proven to be an effective way to encourage competition among suppliers of off patent pharmaceuticals. It is proposed that the community Tender and hospital Tender processes continue to be run in unison, however the pharmaceutical list for community and hospital pharmacies may be different. Key Aspects of Awarding a Tender for Community Pharmaceuticals: For the community pharmaceuticals the Tender winning brand would be the only subsidised brand for approximately 2½ years. The Sole Subsidised Supply period would conclude on 30 June 2012 for all awarded Tenders. The Sole Subsidised Supply brand would be fully subsidised for the Tender period which means a pharmaceutical that currently carries a manufacturer s surcharge (that is the additional patient charge above that of the patient copayment), would become fully subsidised if a Tender was awarded. No other brand of the pharmaceutical could be listed (or subsidised) on the during the Tender period (subject to any Alternative Brand Access, as proposed). Other brands could continue to be marketed, sold and dispensed in New Zealand, however they would not receive a Government subsidy. Key Aspects of Awarding a Tender for the DHB Hospital Pharmaceuticals: For the DHB Hospital pharmaceuticals, the Hospital Supply Status brand would be the only brand DHB Hospitals could purchase (excluding any allowance for alternative brands under the agreed Discretionary Variance Limits) for approximately 2½ years. The Hospital Supply Status period would conclude on 30 June 2012 for all awarded Tenders. No other brand of the pharmaceutical would be listed (or purchased) on Section H of the during the Tender period except as allowed under any DV Limits. The Process The Tender process is run annually; the proposed timelines for the 2008/09 Tender are as follows: Date September/October 2008 A232709 - qa12214 Event Consultation with suppliers, medical groups and interested parties on the proposed pharmaceutical list and draft Invitation to Tender. 5 November 2008 Final date for all consultation to be received. November 2008 Meeting of the Tender Medical Evaluation Subcommittee of PTAC to consider clinical issues in relation to the proposed Tender list. 2

November/December 2008 Late December 2008 Late February 2009 From March 2009 30 June 2012 Consultation and Board decisions on Alternative Commercial Proposals to tendering from pharmaceutical suppliers. Issuing of the 2008/09 Invitation to Tender. Invitation to Tender closes. Board decisions on the first Tender winners announced. End of the sole supply period for all pharmaceuticals where a Tender is awarded from the 2008/09 Tender. Terms after the End Date may apply. Reference Pricing in the Community Reference pricing is based on the classification of pharmaceuticals into Therapeutic Subgroups. A Therapeutic Subgroup is defined as a set of pharmaceuticals that produce the same or similar therapeutic effect in treating the same or similar condition(s). The draft list contains pharmaceuticals that belong in an existing Therapeutic Subgroup. In some cases, PHARMAC may be considering tendering more than one pharmaceutical in a Therapeutic Subgroup. Where this is the case it gives rise to a number of scenarios in the community market including: 1) It is possible that awarding Sole Subsidised Supply to one pharmaceutical could result in changes to the subsidies for other pharmaceuticals in the same Therapeutic Subgroup. 2) Where more than one pharmaceutical in a Therapeutic Subgroup is included on the list, PHARMAC may award Sole Subsidised Supply to each pharmaceutical (and therefore not apply reference pricing in the usual way) or may only award Sole Subsidised Supply to one pharmaceutical and apply reference pricing to the others. Such scenarios could give rise to new or increased manufacturer surcharges. We ask that you consider any clinical considerations associated with such scenarios. Contractual obligations for suppliers A copy of the draft contractual requirements which would form the terms of the contract with successful suppliers in the 2008/09 Tender is available on the PHARMAC website: www.pharmac.govt.nz, or by phoning PHARMAC on 0800 66 00 50. Unresolved Tender Bids PHARMAC would review any unresolved Tender Bids from the Invitation to Tender dated 15 December 2006 (2006/07 Tender) and the Invitation to Tender dated 21 December 2007 (2007/08 Tender) prior to issuing the 2008/09 Tender. Should any unresolved Tender Bids be declined, PHARMAC would consider re-tendering those pharmaceuticals when the Invitation to Tender is issued in December 2008. Currently unresolved Tender Bids have not been included in the draft pharmaceutical list set out A232709 - qa12214 3

in Schedule One of this document. PHARMAC is currently seeking comments from suppliers about keeping any unresolved Tender Bid(s) open for acceptance. Access to Alternative Brands PHARMAC is continuing work to identify mechanisms that can reduce the impact on patients of brand changes. We will keep you informed as this work continues to progress. In the meantime, PHARMAC has undertaken a preliminary assessment to determine which products are appropriate for inclusion in this years tender. We welcome specific comments in relation to any implications of tendering items included in Schedule Two. Distribution of Consultation Documents Please note that this consultation letter has been widely distributed however should you consider that a particular person, group or agency should receive this and future Tender documents please feel free to contact PHARMAC (also available from our website). We also invite any person or group to contact PHARMAC should you wish to have a meeting to discuss this consultation document. Please direct any queries you may have to Yvonne Chen [DDI: (04) 916 7556] at PHARMAC for questions in relation to community supply, and Andrew Davies [DDI: (04) 916 7531] for questions in relation to hospital supply. Yours sincerely Steffan Crausaz Manager, Funding and Procurement A232709 - qa12214 4

Possible pharmaceuticals for tender for sole supply Order of pharmaceuticals in this Annex The pharmaceuticals have been listed in therapeutic groups according to the classification system used in the. Below is a list of the groups, and the corresponding page numbers for your ease of reference. Please note that pharmaceuticals with indications that may apply to multiple therapeutic groups will only appear in one. Therapeutic Group Page Numbers Alimentary Tract and Metabolism 7 8 Blood and Blood Forming Organs 8 9 Cardiovascular System 9 12 Dermatologicals 12 13 Extemporaneously Compounded Preparations 13 Genito-Urinary System 13 Hormone Preparations Systemic excluding contraceptives 13 14 Infections Agents for Systemic Use 14 17 Musculo-Skeletal System 17 18 Nervous System 18 22 Oncology and Immunosuppressants 22 24 Respiratory System and Allergies 24 25 Sensory Organ 25 Special Foods 25 26 Information provided for each pharmaceutical For each pharmaceutical (as defined by chemical name, form and strength) we have provided the following information: the current ex-manufacturer subsidy per unit of measure as at 1 September 2008; number of subsidised or partially subsidised units sold in the community in the year ending 30 June 2008; estimated annual community market value at current subsidies; and comments specifically relating to the Tender of the line item and/or its current listing on the. The figures for the number of units subsidised in community pharmacies are approximate and are based on the year ending June 2008. These figures are indicative only and sales are not guaranteed. PHARMAC makes no representation as to the level of sales or likely sales of any tender item. There are no figures available for hospital pharmaceuticals. A232709 - qa12214 5

We have estimated market value by multiplying the volume of units subsidised in the year ending 30 June 2008 by the relevant listed unit subsidy as at 1 September 2008. Patents A number of pharmaceuticals included in this list may still be on patent. Based on information available to PHARMAC, we believe these patents will expire by within the sole supply period. While PHARMAC has taken care in preparing the information contained in this table, it does not make any representation as to the accuracy of this information and accepts no liability in the event that the information is incorrect. Suppliers remain responsible for ensuring they do not infringe patents. Suppliers are responsible for their own independent assessment of the information and must decide for themselves whether or not to make an investment and on what terms. Explanation of terms, symbols and abbreviations Most terms and abbreviations used are self explanatory: tab means tablet, cap means capsule, liq means liquid, inj means injection, suppos means suppository, grans mean granules and OP means original pack to be dispensed. The following table explains the symbols used in the draft pharmaceutical list: Symbol Explanation Pharmaceutical line items where a sole supply contract is in force are underlined. The price and subsidy for these pharmaceuticals are fixed until 30 Underline June 2009 unless otherwise stated in the Comments column and a listing of a new brand could only occur until after that date. C To be tendered for Sole Subsidised Supply (community pharmaceuticals). H To be tendered for Hospital Supply Status (DHB Hospital pharmaceuticals). A reference in the Invitation to Tender to allow Pharmaceuticals Cancer PCT Treatments to be listed in Section B of the as part of PHARMAC s Pharmaceutical Cancer Treatments project. + PHARMAC has been advised of the existence of a process patent. There is no fully funded product available for this line item (in relation to * community supply). A232709 - qa12214 6

Alimentary Tract and Metabolism Acarbose Tab 50 mg 501,151 $122,504 $0.2444 Tab 100 mg 178,370 $61,439 $0.3444 Amphotericin B Emulsion for infusion 5 mg per ml Liposomal Inj 50 mg Not currently listed in the Ascorbic Acid Inj 500 mg per 5 ml H 1% Tab 50 mg Tab 100 mg 1,163,211 $40,131 $0.0345 Tab 250 mg Atropine Sulphate Inj 400 mcg, 1 ml Not currently listed in the Inj 600 mcg, 1 ml 74,203 $38,586 $0.5200 Inj 1200 mcg, 1 ml 8,555 $5,475 $0.6400 Calcitriol Cap 0.25 mcg 2,655,022 $357,100 $0.1345 Cap 0.5 mcg 374,927 $93,544 $0.2495 Calcium Carbonate with Aminoacetic Acid Tab 400-420 mg with aminoacetic acid 180 mg 1,309,386 $39,282 $0.0300 Dose range of 400-420 mg elemental calcium per tablet required Calcium Gluconate Inj 10%, 10 ml 1,666 $3,565 $2.1400 Famotidine Tab 20 mg 794,073 $25,728 $0.0324 C Tab 40 mg 663,356 $30,116 $0.0454 C Glycopyrronium Inj 0.2 mg per ml, 1 ml H 1% Hydrocortisone Acetate Rectal foam 10 %, CFC-free 246,692 $246,692 $1.0000 Iodine Soln aqueous BP C. A Special Authority or endorsement (for use during pregnancy and breastfeeding only) may be applied. 7

Iodine Tab 150-200 mcg C. A Special Authority or endorsement (for use during pregnancy and breastfeeding only) may be applied. A combination product would be considered; however it must contain 150 mcg -200 mcg of iodine. Lansoprazole Cap 15 mg 134,230 $20,618 $0.1536 Cap 30 mg 1,155,646 $354,536 $0.3068 Mesalazine Enema 1 g per 100 ml 44,152 $295,818 $6.7000 Metformin Hydrochloride Tab 500 mg 65,764,349 $1,282,405 $0.0195 Tab 850 mg 14,906,417 $477,005 $0.0320 Miconazole Oral gel 20 mg per g 627,525 $140,409 $0.2238 C Mucilaginous Laxatives Dry 52,686,510 $927,283 $0.0176 Dry-original flavour, regular texture only 7,344,541 $129,264 $0.0176 Sugar Free 1,074,077 $18,904 $0.0176 Pyridoxine Hydrochloride Tab 50 mg 1,329,155 $46,866 $0.0353 C Thiamine Hydrochloride Inj 100 mg per ml, 2 ml Vitamin B Complex Tab, strong, BPC 2,181,455 $52,791 $0.0242 C Vitamins Tab (BPC cap strength) 26,540,856 $392,805 $0.0148 C Blood and Blood Forming Organs Aprotinin Inj 10,000 mcg per ml, 100 ml Inj 10,000 mcg per ml, 200 ml Atorvastatin Tab 10 mg 4,043,571 $543,052 $0.1343 * C Tab 20 mg 5,720,682 $1,119,537 $0.1957 * + C Tab 40 mg 7,361,373 $1,997,140 $0.2713 * + C + 8

Atorvastatin Tab 80 mg + C Filgrastim Inj 0.3 mg per ml, 1 ml H 1% Folic Acid Tab 0.8 mg 2,762,493 $45,581 $0.0165 C Tab 5 mg 5,910,478 $77,900 $0.0132 C Gemfibrozil Cap 300 mg Hydroxocobalamin Inj 1 mg per ml, 1 ml 229,445 $704,396 $3.0700 Currently two different subsidies, unit subsidy reflects the lower of the two Magnesium Sulphate Inj 49.3%, 5 ml H 1% Nicotinic Acid Tab 25 mg C Tab 50 mg 1,158,927 $58,873 $0.0508 C Tab 100 mg C Tab 500 mg 725,913 $127,761 $0.1760 C Phenindione Tab 10 mg H 1% Tab 25 mg H 1% Tab 50 mg H 1% Potassium Chloride Tab long-acting 600 mg 11,543,083 $300,120 $0.0260 Sodium Bicarbonate Inj 8.4%, 50 ml 1,927 $38,444 $19.9500 Inj 8.4% 100 ml 2,203 $45,162 $20.5000 Inf 5%, 500 ml H 1% Tranexamic Acid Inj 100 mg per ml, 5 ml H 1% Urokinase Inj 10,000 iu H 1% Inj 500,000 iu H 1% Cardiovascular System 9

Aprotinin Inj 10,000,000 iu per ml, 50 ml * Arginine Inj 5%, 500 ml H 1% Atenolol Tab 50 mg 9,451,084 $122,864 $0.0130 Tab 100 mg 3,407,916 $77,019 $0.0226 Celiprolol Tab 200 mg 6,179,652 $652,571 $0.1056 Clonidine Inj 150 mcg per ml, 1 ml 8,495 $23,786 $2.8000 Tab 25 mcg 2,622,929 $459,799 $0.1753 Tab 150 mcg 507,228 $153,842 $0.3033 TDDS 2.5 mg, 100 mcg per day 36,752 $195,613 $5.3225 TDDS 5 mg, 200 mcg per day 12,937 $99,583 $7.6975 TDDS 7.5 mg, 300 mcg per day 9,885 $96,626 $9.7750 Dobutamine Inj 12.5 mg per ml, 20 ml H 1% Enalapril Tab 2.5 mg Tab 5 mg 4,518,231 $109,944 $0.0243 Tab 10 mg 3,869,420 $118,662 $0.0307 Tab 20 mg 3,152,044 $128,884 $0.0409 Enalapril With Hydrochlorothiazide Tab 20 mg with hydrochlorothiazide 12.5 mg 426,921 $47,246 $0.1107 * Felodipine Tab long-acting 2.5 mg 8,177,612 $2,829,454 $0.3460 Tab long-acting 5 mg 14,589,483 $2,674,739 $0.1833 Tab long-acting 10 mg 10,114,257 $2,697,135 $0.2667 Flecainide Acetate Cap long-acting 100 mg 648,558 $925,687 $1.4273 Cap long-acting 200 mg 522,648 $1,317,596 $2.5210 Inj 10 mg per ml, 15 ml 18 $176 $9.8040 Tab 50 mg 249,598 $178,138 $0.7137 Tab 100 mg 239,890 $302,381 $1.2605 Frusemide Tab 40 mg 36,001,746 $414,020 $0.0115 10

Frusemide Tab 500 mg 220,562 $26,467 $0.1200 Glyceryl Trinitrate Inj 1 mg per ml, 5 ml H 1% Inj 1 mg per ml, 50 ml H 1% Inj 5 mg per ml, 1 ml H 1% Inj 5 mg per ml, 10 ml H 1% Hydralazine Inj 20 mg per ml, 1 ml 463 $2,398 $5.1800 Hydrochlorothiazide Tab 12.5 mg Tab 25 mg Lisinopril Tab 2.5 mg C C Tab 5 mg 606,533 $56,205 $0.0927 Tab 10 mg 575,487 $60,618 $0.1053 Tab 20 mg 717,210 $93,476 $0.1303 Lisinopril with Hydrochlorothiazide Tab 20 mg with hydrochlorothiazane 12.5 mg Losartan Tab 12.5 mg 1,423,394 $825,569 $0.5800 Tab 25 mg 105 $76 $0.7254 This was recently listed on the Pharmaceutical Schedule Tab 50 mg 2,186,442 $1,683,560 $0.7700 Tab 100 mg 165,131 $194,855 $1.1800 Tab 50 mg with hydrochlorothiazide 12.5 mg 569,215 $569,215 $1.0000 Tab 100 mg with hydrochlorothiazide 25 mg Not currently listed in the Metaraminol Tartrate Inj 10 mg per ml, 1 ml H 1% Milrinone Inj 1 mg per ml, 10 ml H 1% Noradrenaline Acid Tartrate Inj 0.1 mg per ml, 100 ml bag H 1% Phenoxybenzamine Inj 100 mg per 2 ml H 1% 11

Pindolol Tab 5 mg 311,631 $14,023 $0.0450 Tab 10 mg 318,076 $26,559 $0.0835 Tab 15 mg 155,255 $18,631 $0.1200 Propranolol Cap long-acting 160 mg 657,431 $111,106 $0.1690 Tab 10 mg 1,986,827 $70,532 $0.0355 Tab 40 mg 2,286,674 $106,330 $0.0465 Timolol maleate Tab 10 mg 193,209 $20,384 $0.1055 C Acitretin Dermatologicals Cap 10 mg 286,675 $271,625 $0.9475 C Cap 25 mg 87,123 $177,470 $2.0370 C Betamethasone Valerate Scalp app 0.1% 3,105,621 $163,045 $0.0525 Calamine Crm, aqueous, BP 176,113 $5,319 $0.0302 C Lotn, BP 4,284,946 $41,650 $0.0097 C Chlorhexidine Crm 1% obstetric H 1% Chlorhexidine Gluconate Handrub 0.5% - 1% with ethanol 70% 2,168,302 $23,418 $0.0108 C Chlorhexidine strengths from 0.5% to 1% would be considered Ciclopiroxolamine Crm 1% 36,090 $1,805 $0.0500 * C Nail soln 8% 58,828 $635,510 $10.8029 * C Soln 1% 35,599 $7,761 $0.2180 * C Clobetasol Propionate Crm 0.05% 2,450,584 $191,962 $0.0783 Oint 0.05% 2,357,714 $125,745 $0.0533 Scalp app 0.05% 595,476 $63,517 $0.1067 Hydrocortisone Crm 1% (pack size 15 g or less) 17,399,193 $424,540 $0.0244 Volume is aggregated for all pack sizes of hydrocortisone cream Crm 1% (pack size greater than 15 g and 100 g or less) 17,399,193 $424,540 $0.0244 Volume is aggregated for all pack sizes of hydrocortisone cream 12

Hydrocortisone with Miconazole Crm 1% with miconazole nitrate 2% 3,308,557 $485,365 $0.1467 C Isotretinoin Cap 10 mg 1,079,577 $388,648 $0.3600 Information on appropriate use should be available on a website Cap 20 mg 1,942,915 $922,885 $0.4750 Information on appropriate use should be available on a website. Cap 40 mg Information on appropriate use should be available on a website. Not currently listed on the Pharmaceutical Schedule. Mupirocin Nasal oint 2% H 1% Paraffin White soft or yellow soft (pack size 30 g or less) H 1% Extemporaneously Compounded Preparations and Galenicals Sodium Bicarbonate Powder BP 168,898 $3,310 $0.0196 Genito-Urinary System Alprostadil Inj 0.5 mg per ml, 1 ml H 1% Ergometrine Maleate Inj 500 mcg per ml, 1 ml 2,106 $4,886 $2.3200 Norethisterone Tab 350 mcg 9,474,169 $806,432 $0.0851 C Oxytocin Inj 5 iu per ml, 1 ml 965 $1,042 $1.0800 Inj 10 iu per ml, 1 ml 4,462 $6,068 $1.3600 Inj 5 iu with ergometrine maleate 500 mcg per ml, 1 ml 2,783 $5,121 $1.8400 Pregnancy Tests - HCG Urine Urine diagnostic test 361,483 $274,727 $0.7600 Hormone Preparations - Systemic Excluding Contraceptive Hormones Clomiphene Citrate Tab 50 mg 44,271 $22,136 $0.5000 C Cyproterone Acetate Tab 50 mg 996,277 $468,250 $0.4700 Tab 100 mg 13

Danazol Cap 100 mg 12,211 $10,175 $0.8333 Cap 200 mg 30,018 $17,011 $0.5667 Dexamethasone Sodium Phosphate Inj 4 mg per ml, 1 ml 19,530 $83,979 $4.3000 Inj 4 mg per ml, 2 ml 72,426 $449,041 $6.2000 Ethinyloestradiol Tab 10 mcg 305,869 $53,833 $0.1760 C Etidronate Disodium Tab 200 mg 1,719,628 $653,459 $0.3800 Hydrocortisone Tab 5 mg 2,440,393 $194,011 $0.0795 Tab 20 mg 141,826 $28,294 $0.1995 Methylprednisolone Inj 500 mg 308 $5,067 $16.4500 Inj 1 g 290 $12,345 $42.5700 Tab 4 mg 26,618 $12,928 $0.4857 Tab 100 mg 17,765 $147,911 $8.3260 Methylprednisolone Sodium Succinate Inj 40 mg per ml, 1 ml 1,204 $7,291 $6.0560 Inj 62.5 mg per ml, 2 ml 834 $13,764 $16.5036 Oestrogens Conjugated, equine tab 300 mcg 1,203,803 $129,409 $0.1075 * C Testosterone Transdermal patch 2.5 mg per day 104,975 $139,963 $1.3333 Infections - Agents for Systemic Use Abacavir Sulphate Oral liq 20 mg per ml 26,298 $10,958 $0.4167 Tab 300 mg 72,537 $553,699 $7.6333 Abacavir sulphate with lamivudine Tab 600 mg with lamivudine 300 mg 36,458 $765,618 $21.0000 Aciclovir Inj 250 mg H 1% Inj 500 mg H 1% Inj 1,000 mg H 1% + 14

Aciclovir Tab 200 mg Tab 400 mg Tab 800 mg Dispersible tablets need to remain subsidised for patients who are unable to swallow tablets and the prescription is endorsed accordingly. Not currently listed on the Pharmaceutical Schedule. Dispersible tablets need to remain subsidised for patients who are unable to swallow tablets and the prescription is endorsed accordingly. Not currently listed on the Pharmaceutical Schedule. Dispersible tablets need to remain subsidised for patients who are unable to swallow tablets and the prescription is endorsed accordingly. Not currently listed on the Pharmaceutical Schedule. Tab dispersible 200 mg 815,115 $64,557 $0.0792 Tab dispersible 400 mg 3,046,791 $361,349 $0.1186 Tab dispersible 800 mg 497,147 $104,848 $0.2109 Amikacin Inj 5 mg per ml, 5 ml H 1% Inj 250 mg per ml, 2 ml H 1% Amoxycillin Grans for oral liq 125 mg per 5 ml 29,891,936 $298,919 $0.0100 Grans for oral liq 250 mg per 5 ml 22,765,928 $289,127 $0.0127 Sachets 3 g Amoxycillin Clavulanate Grans for oral liq amoxycillin 125 mg with potassium clavulanate 31.25 mg per 5 ml Grans for oral liq amoxycillin 250 mg with potassium clavulanate 62.5 mg per 5 ml 12,012,266 $330,337 $0.0275 15,612,478 $741,593 $0.0475 Azithromycin Tab 500 mg 93,956 $465,082 $4.9500 Caspofungin Inj 50 mg H 1% Inj 70 mg H 1% Cefazolin Sodium Liq Cephradine Liq 15

Chloroquine Oral liq Tab 200 mg - 250 mg Dicloxacillin Inj 500 mg C C Erythromycin Ethyl Succinate Tab 400 mg 4,664,291 $883,883 $0.1895 Flucloxacillin Sodium Cap 250 mg 1,289,694 $95,437 $0.0740 Cap 500 mg 7,610,215 $881,263 $0.1158 Grans for oral liq 125 mg per 5 ml 4,295,279 $88,053 $0.0205 Grans for oral liq 250 mg per 5 ml 5,616,300 $152,763 $0.0272 Fluconazole Inj 2 mg per ml, 50 ml H 1% Gentamicin Sulphate Inj 40 mg per ml, 2 ml 6,288 $2,867 $0.4560 Lamivudine Oral liq 5 mg per ml 240 $90 $0.3750 C Oral liq 10 mg per ml 83,825 $34,930 $0.4167 C Tab 100 mg 299,522 $1,529,689 $5.1071 C Tab 150 mg 80,464 $411,976 $5.1200 C Nevirapine Oral suspension 10 mg per ml 43,764 $24,534 $0.5606 Oral suspension 50 mg per 5 ml Tab 200 mg 123,184 $656,571 $5.3300 Pyrantel Embonate Oral suspension Tab $0.2950 * A variety of oral solid dose forms would be considered. Note this product has been discontinued. Roxithromycin Tab 150 mg 1,711,147 $325,118 $0.1900 Tab 300 mg 700,273 $252,098 $0.3600 Streptomycin Inj 1 g H 1% 16

Tetracycline Hydrochloride Cap 250 mg Ticarcillin Inj 1 g Inj 3 g H 1% H 1% Zidovudine (AZT) with Lamivudine Tab 300 mg with lamivudine 150 mg 363,685 $4,044,177 $11.1200 C Musculo-Skeletal System Baclofen Inj 10 mg Oral liq 5 mg per 5 ml Pharmaceuticcal Schedule Tab 10 mg Tab 20 mg Dantrolene Sodium Cap 25 mg 130,888 $43,141 $0.3296 Cap 50 mg 53,732 $27,779 $0.5170 Inj 1 mg per ml, 20 ml H 1% Diclofenac Sodium Cap long-acting 100 mg Tab 50 mg dispersible 813,172 $60,988 $0.0750 Tab EC 25 mg 498,946 $17,513 $0.0351 Tab EC 50 mg 3,827,691 $198,121 $0.0518 Tab long-acting 75 mg 21,240,802 $967,731 $0.0456 Tab long-acting 100 mg 4,444,439 $305,066 $0.0686 Leflunomide Tab 10 mg 163,670 $432,471 $2.6423 Tab 20 mg 388,518 $1,406,435 $3.6200 Tab 100 mg 25 $454 $18.1467 Naproxen Tab 250 mg 1,138,443 $47,815 $0.0420 Tab 500 mg 2,585,347 $185,628 $0.0718 Quinine Sulphate Tab 200 mg 1,894,387 $120,862 $0.0638 Tab 300 mg 3,544,411 $246,337 $0.0695 17

Raloxifene Tab 60 mg. Tender Agreement may be subject to an endorsement or Special Authority restriction Rasburicase Inj 1.5 mg H 1% Nervous System Apomorphine Hydrochloride Inj 10 mg per ml, 1 ml 8,036 $81,051 $10.0860 Atracurium Besylate Inj 10 mg per ml, 2.5 ml H 1% Inj 10 mg per ml, 5 ml H 1% Bupivacaine hydrochloride Inf 0.125%, 100 ml H 1% Inf 0.125%, 200 ml H 1% Inf 0.25%, 100 ml H 1% Inj 0.25%, 20 ml H 1% Inj 0.375%, 20 ml H 1% Inj 0.5%, 4 ml theatre pack H 1% Inj 0.5%, 10 ml H 1% Inj 0.5%, 10 ml Theatre pack H 1% Inj 0.5%, 20 ml H 1% Inj 0.5%, 20 ml Theatre pack H 1% Bupivacaine Hydrochloride with Adrenaline Inj 0.25% with 1:400,000 of adrenaline, 10 ml H 1% Inj 0.25% with 1:400,000 of adrenaline, 10 ml theatre pack H 1% Inj 0.25% with 1:400,000 of adrenaline, 20 ml H 1% Inj 0.25% with 1:400,000 of adrenaline, 20 ml theatre pack H 1% Inj 0.5% with 1:200,000 of adrenaline, 10 ml H 1% Inj 0.5% with 1:200,000 of adrenaline, 10 ml theatre pack H 1% Inj 0.5% with 1:200,000 of adrenaline, 20 ml H 1% Inj 0.5% with 1:200,000 of adrenaline, 20 ml theatre pack H 1% Cocaine Soln 4%, 2 ml BP H 1% 18

Cyclizine Hydrochloride Tab 50 mg 677,078 $134,739 $0.1990 Cyclizine Lactate Inj 50 mg per ml, 1 ml 56,899 $170,128 $2.9900 Diazepam Rectal tubes 5 mg 11,015 $61,309 $5.5660 Rectal tubes 10 mg 15,928 $246,151 $15.4540 Dopamine Inj 40 mg per ml, 5 ml H 1% Entacapone Tab 200 mg 391,751 $505,359 $1.2900 Ephedrine Sulphate Inj 30 mg per ml, 1 ml H PCT 1% Ergotamine Tartrate with Caffeine Tab 1 mg with caffeine 100 mg 462,764 $143,457 $0.3100 Fentanyl Inj 50 mcg per ml, 2 ml Inj 50 mcg per ml, 5 ml Inj 50 mcg per ml, 10 ml Inj 50 mcg per ml, 20 ml Gabapentin Cap 100 mg 895,270 $118,713 $0.1326 C H 5% Tender Agreement may be subject to an endorsement or Special Authority restriction. Currently two different subsidies. Unit Subsidy reflects the lower of the two. Cap 300 mg 6,568,959 $2,613,789 $0.3979 C H 5% Tender Agreement may be subject to an endorsement or Special Authority restriction. Currently two different subsidies. Unit Subsidy reflects the lower of the two. Cap 400 mg 814,273 $431,646 $0.5301 C H 5% Tender Agreement may be subject to an endorsement or Special Authority restriction. Currently two different subsidies. Unit Subsidy reflects the lower of the two. Tab 600 mg 43,134 $34,417 $0.7979 C H 5% Tender Agreement may be subject to an endorsement or Special Authority restriction. Currently two different subsidies. Unit Subsidy reflects the lower of the two. 19

Imipramine Hydrochloride Tab 10 mg 480,347 $84,541 $0.1760 Tab 25 mg 1,637,443 $179,464 $0.1096 Ketamine Inj 100 mg per ml, 2 ml H 1% Levodopa with Benserazide Cap 50 mg with benserazide 12.5 mg 1,017,949 $81,436 $0.0800 Cap 100 mg with benserazide 25 mg 1,218,285 $152,286 $0.1250 Cap long-acting 100 mg with benserazide 25 mg 654,911 $111,335 $0.1700 Cap 200 mg with benserazide 50 mg 153,844 $38,461 $0.2500 Tab dispersible 50 mg with benserazide 12.5 mg 580,338 $58,034 $0.1000 Lignocaine Gel 2% H 1% Lorazepam Tab 1 mg 4,401,220 $110,559 $0.0251 Tab 2.5 mg 256,674 $10,575 $0.0412 Maprotiline Hydrochloride Tab 25 mg 92,569 $23,198 $0.2506 Tab 75 mg 16,952 $11,871 $0.7003 Methadone Hydrochloride Oral liq 2 mg per ml 2,398,374 $78,547 $0.0328 Oral liq 5 mg per ml 20,903,093 $681,441 $0.0326 Oral liq 10 mg per ml 2,995,585 $142,290 $0.0475 Methylphenidate Hydrochloride Tab immediate-release 5 mg 102,380 $10,924 $0.1067 Tab immediate-release 20 mg 34,071 $8,916 $0.2617 Tab immediate-release 10 mg 2,350,074 $336,061 $0.1430 Tab sustained-release 20 mg 2,445,000 $892,425 $0.3650 Excludes long-acting or extended-release products Metoclopramide Hydrochloride with Paracetamol Tab 5 mg with paracetamol 500 mg 1,304,831 $70,670 $0.0542 C Midazolam Inj 1 mg per ml, 5 ml H 1% Inj 5 mg per ml, 3 ml H 1% Moclobemide Tab 150 mg 1,491,347 $147,494 $0.0989 Tab 300 mg 356,795 $93,159 $0.2611 20

Morphine Hydrochloride Oral liq 1 mg per ml 5,435,380 $219,046 $0.0403 Oral liq 2 mg per ml 714,066 $30,562 $0.0428 Oral liq 5 mg per ml 1,004,181 $48,251 $0.0481 Oral liq 10 mg per ml 585,791 $36,788 $0.0628 Morphine Sulphate Cap long-acting 10 mg 2,944,101 $529,938 $0.1800 Cap long-acting 30 mg 1,014,236 $267,758 $0.2640 Cap long-acting 60 mg 407,958 $293,730 $0.7200 Cap long-acting 100 mg 299,552 $235,148 $0.7850 Inj 5 mg per ml, 1 ml 22,986 $23,768 $1.0340 Inj 15 mg per ml, 1 ml 11,669 $10,969 $0.9400 Tab immediate release 10 mg 1,289,061 $340,312 $0.2640 Tab immediate release 20 mg 659,111 $336,147 $0.5100 Tab long-acting 10 mg 772,937 $139,129 $0.1800 Tab long-acting 30 mg 388,234 $139,764 $0.3600 Tab long-acting 60 mg 185,167 $133,320 $0.7200 Tab long-acting 100 mg 253,839 $215,763 $0.8500 Morphine Tartrate Inj 80 mg per ml, 1.5 ml 23,383 $94,467 $4.0400 Inj 80 mg per ml, 5 ml 1,793 $24,159 $13.4740 Oxycodone Hydrochloride Cap 5 mg 512,539 $72,524 $0.1415 Cap 10 mg 346,876 $96,778 $0.2790 Cap 20 mg 233,842 $114,232 $0.4885 Tab controlled-release 5 mg 345,357 $129,682 $0.3755 Tab controlled-release 10 mg 709,346 $395,106 $0.5570 Tab controlled-release 20 mg 524,147 $496,105 $0.9465 Tab controlled-release 40 mg 173,489 $288,772 $1.6645 Tab controlled-release 80 mg 112,353 $325,992 $2.9015 Pancuronium bromide Inj 2 mg per ml, 2 ml H 1% Paracetamol Suppos 125 mg 69,308 $22,560 $0.3255 Suppos 250 mg 62,963 $39,415 $0.6260 Tab modified-release 665 mg C 21

Pethidine Hydrochloride Inj 50 mg per ml, 1 ml 33,594 $25,196 $0.7500 Inj 50 mg per ml, 1.5 ml 201 $175 $0.8700 Inj 50 mg per ml, 2 ml 71,687 $59,930 $0.8360 Rocuronium Inj 10 mg per ml, 5 ml H 1% Inj 10 mg per ml, 10 ml H 1% Selegiline Hydrochloride Tab 5 mg 179,760 $28,869 $0.1606 C Tetrabenazine Tab 25 mg 111,640 $242,219 $2.1696 C Tropisetron Cap 5 mg 8,623 $133,501 $15.4820 Inj 1 mg per ml, 2 ml Vecuronium Inj 4 mg H 1% Inj 10 mg H 1% Zuclopenthixol Hydrochloride Tab 2 mg Tab 10 mg Tab 25 mg Tab 40 mg Oncology Agents and Immunosuppressants Amsacrine Inj 50 mg per 1 ml H 1% Bleomycin sulphate Inj 15,000 iu H PCT 1% Capecitabine Tab 150 mg 613,071 $3,601,792 $5.8750 Tab 500 mg 117,595 $225,394 $1.9167 Carboplatin Inj 10 mg per ml, 5 ml H PCT 1% Inj 10 mg per ml, 10 ml H PCT 1% Inj 10 mg per ml, 15 ml H PCT 1% Inj 10 mg per ml, 45 ml H PCT 1% 22

Carboplatin Inj 10 mg per ml, 100 ml H PCT 1% Carmustine Inj 100 mg, 3 ml H PCT 1% Cyclosporin Inf 50 mg per ml, 5 ml H 1% Dacarbazine Inj 200 mg H PCT 1% Daclizumab Inj 25 mg per 5 ml H 1% Doxorubicin Inj 10 mg H PCT 1% Inj 20 mg H PCT 1% Inj 50 mg H PCT 1% Inj 100 mg H PCT 1% Inj 200 mg H PCT 1% Epirubicin Inj 1 mg per ml, 5 ml H PCT 1% Inj 2 mg per ml, 2 ml H PCT 1% Inj 2 mg per ml, 5 ml H PCT 1% Inj 2 mg per ml, 10 ml H PCT 1% Inj 2 mg per ml, 25 ml H PCT 1% Inj 2 mg per ml, 50 ml H PCT 1% Inj 2 mg per ml, 100 ml H PCT 1% Etoposide Cap 50 mg 6,196 $105,558 $17.0365 C H PCT 1% Cap 100 mg 1,059 $36,083 $34.0730 C H PCT 1% Inj 20 mg per ml, 20 ml H PCT 1% Inj 20 mg per ml, 50 ml H PCT 1% Idarubicin hydrochloride Cap 5 mg H PCT 1% Cap 10 mg H PCT 1% Inj 5 mg H PCT 1% Inj 10 mg H PCT 1% Irinotecan Inj 20 mg per ml, 2 ml H PCT 1% Inj 20 mg per ml, 5 ml H PCT 1% 23

Letrozole Tab 2.5 mg 403,568 $1,970,219 $4.8820 Methotrexate Tab 2.5 mg 1,816,012 $351,096 $0.1933 C H PCT 1% Tab 10 mg 254,883 $208,647 $0.8186 C H PCT 1% Mycophenolate Mofetil Cap 250 mg 255,891 $528,824 $2.0666 Inj 500 mg H 1% Powder for oral liq 1 g per 5 ml 9,177 $15,851 $1.7273 Tab 500 mg 446,759 $1,846,544 $4.1332 Oxaliplatin Inj 50 mg H PCT 1% Inj 100 mg H PCT 1% Vincristine Sulphate Inj 1 mg per ml, 1 ml H PCT 1% Inj 1 mg per ml, 2 ml H PCT 1% Vinorelbine Inj 10 mg per ml, 1 ml H PCT 1% Inj 10 mg per ml, 5 ml H PCT 1% Beclomethasone Dipropionate Respiratory System and Allergies Metered aqueous nasal spray, 50 mcg per dose 11,712,396 $137,621 $0.0118 Metered aqueous nasal spray, 100 mcg per dose 44,054,856 $541,875 $0.0123 Beractant Inj 25 mg per ml, 8 ml H 1% Budesonide Metered aqueous nasal spray, 50 mcg per dose 5,253,314 $61,726 $0.0118 * Metered aqueous nasal spray, 100 mcg per dose 29,732,447 $388,008 $0.0131 * Nebuliser soln, 500 mcg per ml, 2 ml H 1% Nebuliser soln, 1 mg per ml, 2 ml H 1% Chlorpheniramine Maleate Cap long-acting 12 mg Not currently subsidised on the Pharmaceutical Schedule Salbutamol Nebuliser soln, 1 mg per ml, 2.5 ml 441,581 $81,692 $0.1850 Nebuliser soln, 2 mg per ml, 2.5 ml 1,052,618 $202,629 $0.1925 24

Salbutamol with Ipratropium Bromide Nebuliser soln, 2.5 mg with ipratropium bromide 0.5 mg per vial, 2.5 ml 1,256,489 $332,970 $0.2650 Sodium Cromoglycate Nasal spray, 4% 49,813 $30,567 $0.6136 C Acetylcholine Sensory Organs Inj 10 mg per ml, 2 ml H 1% Betaxolol Hydrochloride Eye drops 0.25% 65,418 $154,386 $2.3600 C Eye drops 0.5% 9,179 $13,769 $1.5000 C Bimatoprost Eye Drops 0.03% 115,766 $752,479 $6.5000 C Chloramphenicol Eye drops 0.5% 1,671,053 $233,947 $0.1400 Single dose presentation would not be a DV Pharmaceutical Eye oint 1% 451,236 $279,766 $0.6200 Dorzolamide Hydrochloride Eye drops 2% 27,856 $54,431 $1.9540 * C Dorzolamide hydrochloride with timolol maleate Eye drops 2% with timolol maleate 0.5% 323,288 $1,196,166 $3.7000 Fluorometholone Eye drops 0.1% 64,020 $55,057 $0.8600 Sodium Cromoglycate Eye drops 2% 442,865 $174,932 $0.3950 C Sodium Hyaluronate Inj 3% with 4% chondroitin sulphate, 0.35 ml H 1% Inj 3% with 4% chondroitin sulphate, 0.5 ml H 1% Ophthalmic inj 14 mg per ml H 1% Ophthalmic soln 10 mg per ml H 1% Sodium Hyaluronidate Inj 14 mg per ml H 1% Travoprost Eye drops 0.004% 94,418 $736,460 $7.8000 C Triamcinolone acetonide with gramicidin, neomycin and nystatin Ear drops 1 mg with nystatin 100,000 u, neomycin sulphate 2.5 mg and gramicidin 250 mcg per g 176,287 $78,742 $0.4467 Special Foods + 25

Oral Feed 1.5 KCal per ml Liq 774,764,134 $4,338,679 $0.0056 * Sole supply could be awarded for a range of flavours from only one supplier. This line item describes oral feed listed under the "Adult Products Standard" therapeutic subgroup in the. Liq with fibre 73,903,400 $413,859 $0.0056 Sole supply could be awarded for a range of flavours from only one supplier. This line item describes oral feed listed under the "Adult Products Standard" therapeutic subgroup in the. 26