University of Groningen Towards strengthening memory immunity in the ageing population van der Heiden, Marieke IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2018 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van der Heiden, M. (2018). Towards strengthening memory immunity in the ageing population: Investigating the immunological fitness of middle-aged adults [Groningen]: Rijksuniversiteit Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 18-10-2018
TOWARDS STRENGTHENING MEMORY IMMUNITY IN THE AGEING POPULATION Investigating the immunological fitness of middle-aged adults MARIEKE VAN DER HEIDEN
Cover Lay-out Printing ISBN Mars58 123RF Stockfoto Nikki Vermeulen Ridderprint BV Ridderprint BV www.ridderprint.nl 978-94-034-0229-1 printed book 978-94-034-0228-4 e-book Printing of this thesis was kindly supported by: The Dutch National Institute of Public Health and the Environment (RIVM), The University of Groningen (RUG), and the Groningen University Institute for Drug Exploration (GUIDE). Copyright 2017 Marieke van der Heiden All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.
Towards strengthening memory immunity in the ageing population Investigating the immunological fitness of middle-aged adults Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 10 januari 2018 om 11.00 uur door Marieke van der Heiden geboren op 13 april 1989 te Nijmegen
Promotor Prof. dr. A.M.H. Boots Copromotores Dr. A.M. Buisman Dr. G.A.M. Berbers Beoordelingscommissie Prof. dr. W. van Eden Prof. dr. S.M. van Ham Prof. dr. A.L.W. Huckriede Paranimfen Lia de Rond Lianne Ossenkoppele
Voor mijn ouders
It always seems impossible until it s done Nelson Mandela
Table of contents Chapter 1 Introduction 9 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Differential effects of Cytomegalovirus carriage on the immune phenotype of middle-aged males and females Sci Rep. 2016; 6: 26892 Novel intervention in the ageing population: a primary meningococcal vaccine inducing protective IgM responses in middle-aged adults Front Immunol. 2017; 8: 817 Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: role of IgM Submitted Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults Vaccine. 2017.08.056 Age-dependent pre-vaccination immunity affects the immunogenicity of Varicella Zoster vaccination in middle-aged adults Submitted An explorative biomarkers study for vaccine responsiveness after primary meningococcal vaccination in middle-aged adults Submitted 27 57 85 103 121 145 Chapter 8 General discussion 169 Appendices Nederlandse samenvatting About the author Publication list Dankwoord 187 193 194 195