University of Groningen Hymenoptera venom allergy Vos, Byrthe IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Vos, B. (2017). Hymenoptera venom allergy: Challenges in diagnosis and treatment [Groningen]: Rijksuniversiteit Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 19-10-2018
Hymenoptera venom allergy Challenges in diagnosis and treatment Byrthe Jorga Petra Ruth Vos
Copyright 2017 by B.J.P.R. Vos, Zwolle, The Netherlands Cover design by Gautier Scientific Illustration Lay-out by Legatron Electronic Publishing Printed by IPSKAMP Drukkers Financial support for the publication of this thesis was provided by: HAL allergy, Pharming Group, Shire, Bausch + Lomb, ALK-Abelló, MEDA Pharma, Thermo Fisher Scientific, Junior Scientific Masterclass, Graduate School of Medical Sciences, University Medical Center Groningen. ISBN: 978-90-367-9547-0 (printed version) ISBN: 978-90-367-9546-3 (electronic version)
Hymenoptera venom allergy Challenges in diagnosis and treatment Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op maandag 13 maart 2017 om 09.00 uur door Byrthe Jorga Petra Ruth Vos geboren op 28 februari 1988 te Groningen
Promotores Prof. A.E.J. Dubois Prof. F. Ruëff Copromotor Dr. J.N.G. Oude Elberink Beoordelingscommissie Prof. H.M. Boezen Prof. R. Gerth van Wijk Prof. K. Brockow
Contents Chapter 1 Introduction and aims of the thesis 9 Chapter 2 Spiking venom with rves v 5 improves sensitivity of IgE detection in 29 patients with allergy to Vespula venom Journal of Allergy and Clinical Immunology 2013; 131: 1225-7. Chapter 3 Fatal anaphylaxis to yellow jacket stings in mastocytosis: options for 37 identification and treatment of at risk patients Journal of Allergy and Clinical Immunology in practice (manuscript in revision). Chapter 4 Diminished reliability of tryptase as risk indicator of mastocytosis in 53 older overweight subjects Journal of Allergy and Clinical Immunology. 2015; 135: 792-8. Chapter 5 Initiating yellow jacket venom immunotherapy with a 100-microgram 71 dose: a challenge? Journal of Allergy and Clinical Immunology in practice (manuscript in revision) Chapter 6 Predictors of clinical effectiveness of Hymenoptera venom immunotherapy 87 Clinical & Experimental Allergy, 2014;44:736 46. Chapter 7 Summary 109 Appendices Nederlandse samenvatting 119 Dankwoord Acknowledgements 127 Bibliography 131 Over de auteur 133
List of abbreviations ACE inhibitor Angiotensin-converting enzyme inhibitor AIC Akaike information criterion AUC Area under the curve BAT Basophil activation test BHRT Basophil histamine release test BMI Body mass index BsT Baseline serum tryptase BTC Baseline serum tryptase concentration CCD Cross-reactive carbohydrate determinant CI Confidence interval ELIFAB Enzyme-linked immunosorbent facilitated antigen binding HBV Honeybee venom HVA Hymenoptera venom allergy IL Interleukin IQR Interquartile range ISM Indolent systemic mastocytosis LRM Logistic regression model MC Mast cell MH Methylhistamine MIMA Methylimidazole acetic acid MIS Mastocytosis in the skin OPD Outpatient department rapi m 1 Recombinant Apis mellifera 1 rves v 1 Recombinant Vespula vulgaris antigen 1 rves v 5 Recombinant Vespula vulgaris antigen 5 ROC Receiver operating characteristic SC Sting challenge SD Standard deviation sige Specific immunoglobulin E sigg4 Specific immunoglobulin G4 SM Systemic mastocytosis TH2 T helper 2 cells TFH T follicular helper cells UP Urticaria pigmentosa Ves v 5 Vespula vulgaris antigen 5 VIT Venom immunotherapy WHO World health organization YJ Yellow jacket YJV Yellow jacket venom