University of Groningen The tryptophan link to psychopathology Russo, Sascha IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2004 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Russo, S. (2004). The tryptophan link to psychopathology s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 20-10-2018
The tryptophan link to psychopathology
Met dank voor financiële ondersteuning bij het afdrukken van dit proefschrift: - Graduate School of Behavioral and Cognitive Neurosciences - ORGANON NEDERLAND BV
Rijksuniversiteit Groningen The tryptophan link to psychopathology Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, Prof. dr. F. Zwarts in het openbaar te verdedigen op woensdag 10 november 2004 om 16.15 uur door Sascha Russo geboren op 6 december 1969 te Dordrecht 3
Promotores: Prof. dr. J. Korf Prof. dr. E.G.E. de Vries Prof. dr. J.A. den Boer Copromotores: dr. I.P. Kema dr. P.H.B. Willemse Beoordelingscommissie: Prof. dr. J.P.J. Slaets Prof. dr. W. A. Nolen Prof. dr. M. Maes
Contents Chapter 1 Introduction and scope of the thesis 11 Chapter 2 Tryptophan as a link between psychopathology and somatic states 15 Sascha Russo, Ido P. Kema, M. Rebecca Fokkema, Jim C. Boon, Pax H.B. Willemse, Elisabeth G.E. de Vries, Johan A. den Boer and Jakob Korf. Psychosomatic Medicine, 2003; 65: 665-671 Chapter 3. Patients with carcinoid syndrome exhibit symptoms of aggressive impulse dysregulation 39 Sascha Russo, Jim C. Boon, Ido P. Kema, Pax H.B. Willemse, Johan A. den Boer, Jakob Korf, Elisabeth G.E. de Vries. Psychosomatic Medicine, in press Chapter 4. Neuropsychological investigation into the carcinoid syndrome 53 Sascha Russo, Marjan M.A. Nielen, Jim C. Boon, Ido P. Kema, Pax H.B. Willemse, Elisabeth G.E. de Vries, Jakob Korf, Johan A. den Boer. Psychopharmacology, 2003; 168: 324-328 5
Chapter 5. Irritability rather than depression during interferon treatment is linked to increased tryptophan catabolism 69 Sascha Russo, Ido P. Kema, Elizabeth B. Haagsma, Jim C. Boon, Pax H.B. Willemse, Johan A. den Boer, Elisabeth G.E. de Vries, Jakob Korf. Submitted Chapter 6. Mirtazapine for the treatment of interferon induced psychopathology 85 Sascha Russo, Jim C. Boon, Elisabeth B. Haagsma, Elizabeth G.E. de Vries, Johan A. den Boer, Jakob Korf. General Hospital Psychiatry, in press Chapter 7. Effects of endotoxin on tryptophan metabolism in pigs 89 Sascha Russo, Ido P. Kema, Frits A.M. Muskiet, M.Rebecca Fokkema, Sietse J. Koopmans, Elisabeth G.E. de Vries, Jakob Korf Chapter 8. Cytokine and tryptophan profile in healthy volunteers following inflammatory challenge 99 Sascha Russo, M.Rebecca Fokkema,Ido P. Kema, Jan G. Zijlstra, Elisabeth G.E. de Vries and Jakob Korf, submitted 6
Chapter 9. Tryptophan dependency of brain serotonin is evolutionary conserved and of functional significance 111 Sascha Russo, Ido P. Kema, Jan Haavik, Jakob Korf. Submitted Chapter 10. General discussion 135 Chapter 11. Samenvatting 147 Chapter 12. Dankwoord 151 7
8
List of abreviations TRP 5-HT BBB 5-HIAA 5-HTP CSF IDO NMDA CNS SSRI tryptophan 5-hydroxytryptamine = serotonin blood-brain-barrier 5-hydroxyindoleacetic acid 5-hydroxytryptophan cerebrospinal fluid indoleamine 2,3 di-oxygenase N-Methyl-D- Aspartate central nervous system serotonin specific reuptake inhibitor 9
10