C. Michael Wright, MD FACC DABCL_FNLA Biography March 2017

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C. Michael Wright, MD FACC DABCL_FNLA Biography March 2017 Address 13090 Caminito del Rocio Del Mar, CA 92014 Cell Phone 858-699-1958 Email cmichael.wright@gmail.com DEA FW3193113 California Medical License G58919 Board Certifications Board certification in Clinical Lipidology- 2005 Board certification in Cardiovascular Diseases- 1988 Board certification in Internal Medicine- 1985 1 P a g e

Current Positions 6/2012-present 10/2012-present 7/2012-present 7/2013-present 9/2013-present 10/2015-present 1/2012-present Cardiologist, private practice, Scripps Memorial Hospital, La Jolla, CA general cardiology, preventive cardiology, clinical lipidology, internal medicine Cardiologist, Scripps Center for Executive Health perform all carotid ultrasound studies and interpret for patients, perform treadmills, perform lead physician role and perform history and physicals Staff physician, Scripps Memorial Hospital, La Jolla, CA Voluntary Clinical Professor, UCSD, Department of Family and Preventive Medicine mentor post docs, assist with research papers on data collected at LifeScore Clinic (see below) Advisory Panel and Speaker Panel, LipoScience Consultant to Dr. Satchin Panda, Salk Institute, La Jolla, CA Expert Witness providing expert testimony in medical legal cases Hospital Privileges Scripps Memorial Hospital, La Jolla, CA Prior Positions 09/2007-05/2012 Cardiologist, Partner, Board Member The Cardiovascular Specialists, Hyannis, MA 09/2009-09/2012 Board Member National Lipid Association, North East Chapter 02/1999-09/2007 Founder, President, and Medical Director, The LifeScore Clinic, San Diego. Preventive cardiology, lipid clinic, general cardiology, cardiovascular CT 09/2001-09/2003 Adjunct Associate Professor, San Diego State University, Graduate School of Public Health 2 P a g e

09/2001-09/2007 Assistant Clinical Professor, University of California, San Diego, Division of Cardiovascular Disease 02/2003-09/2007 Staff physician, Scripps Memorial Hospital, La Jolla, CA 07/1994-02/1999 Cardiologist, Southern California Cardiology Medical Group 01/1992-06/1996 Founder, Chairman, CEO, HealthCap, Inc. 07/1989-06/1996 Founder, President, NOVA HealthCare Medical Group 08/1988-07/1994 Solo cardiology practice, La Mesa, California 06/1985-06/1986 Intensivist, Missouri Baptist Hospital, St. Louis, MO Education & Training 06/1986-06/1988 Fellowship in Cardiovascular Disease, University of California, San Diego 06/1982-06/1985 Internship & Residency, Internal Medicine, Washington University, St. Louis, MO 06/1981-06/1982 Internship in General Surgery, Washington University, St. Louis 06/1981 MD Degree, Mt. Sinai School of Medicine, New York, NY 06/1974 BS, Chemistry, Georgetown University, Washington, DC Physician Management Experience HealthCap- Founder and CEO. HealthCap. Managed large physician groups in San Diego, Palm Springs, Atlanta and St. Louis, in a fully capitated environment. Responsible for approximately 30,000 senior lives and 50,000 commercial lives. HealthCap was sold to a publicly-traded company in 1996. There were two rounds of private equity financing before the sale. 3 P a g e

The Cardiovascular Specialists. Partner, cardiologist and board member. Lead physician in transition to NexGen EHR. Helped modify the EHR for use in a 20 physician cardiology group Research Experience LifeScore Clinic- See publications below. Also participated in BELLES Study funded by Pfizer, and provided research imaging for the Rancho Bernardo Study. Pharmaceutical Speaker Experience Formerly speaker for GSK and Astra-Zeneca. Publications The LifeScore Clinic Database: From 1999 to 2007, over 15,000 clients were seen at the LifeScore Clinic. This lead to the creation of a comprehensive research database combining CT images from multiple vascular territories, CT images of abdominal fat, liver, and bone density, as well as lipid parameters, physiologic parameters, and pertinent past medical history. This database has been shared with the Department of Family and Preventive Medicine at UCSD. With the exception of item 2 below, the listed research papers have been derived from the LifeScore database. Unless otherwise specified, Dr. Wright is an author on the papers. The LifeScore database is the most comprehensive database available for the study of atherosclerosis in multiple arterial beds and its relationship to other risk factors. Longterm follow-ups using the National Death Index now allows the research team to explore mortality data as it relates to subclinical atherosclerosis in multiple arterial beds. Calcification of the splenic, iliac, and breast arteries and risk of all-cause and cardiovascular mortality. Atherosclerosis. http://dx.doi.org/10.1016/j.atherosclerosis.2017.01.029 0021-9150 Relationship of Coronary Calcium on Standard Chest CT Scans With Mortality. JACC Cardiovasc Imaging. 2016 Feb;9(2):152-9. doi: 10.1016/j.jcmg.2015.06.030. Epub 2016 Jan 6. 4 P a g e

See no evil, editorial by Dr. Harvey Hecht on above publication http://dx.doi.org/10.1016/j.jcmg.2015.08.020 Relationship of Coronary Artery Calcium on Standard Chest Computed Tomography Scans with Mortality. J Am Coll Cardiol Img. 2016;9(2):152-159. doi:10.1016/j.jcmg.2015.06.030 Comparison of ordinal versus Agatson coronary calcification scoring for cardiovascular disease mortality in community-living individuals Int J Cardiovasc Imaging. 2014 Apr;30(4):813-8 Biographical Notes on Ancel Keys and Salim Yusuf: Origins and significance of the Seven Countries Study and the INTERHEART Study. Journal of Clinical Lipidology. 2011; 5: 434-40 Kidney Function and Progression of Coronary Artery Calcium in Community Dwelling Older Adults (from the Rancho Bernardo Study). American Journal of Cardiology 2012; 110:1425-1433 (LifeScore database. Not listed as author) Calcified Atherosclerosis in Different Vascular Beds and Risk of Mortality. Arteriosclerosis, Thrombosis and Vascular Biology. 2012; 32:140-146 Health Behavior Modification After Electron Beam Computed Tomography and Physician Consultation. J. Behav. Med 2011; 34(2):148-55 Blood Pressure and Vascular Calcification. Hypertension. 2010; 55:990-97 The Associations Between Visceral Fat and Calcified Atherosclerosis are Stronger in Women Than Men. Atherosclerosis. 2010; 208: 531 536 Heart Disease Risk Factors in Midlife Predict Subclinical Coronary Atherosclerosis More Than 25 Years Later in Survivors Without Clinical Heart Disease: the Rancho Bernardo Study. Journal of the American Geriatrics Society. 2009; 57(6):1041-1044 The Epidemiology of Abdominal Aortic Aneurysm. J. Vasc. Surg. 2008; 48: 121-127. Renal Artery Calcium is Independently Associated with Hypertension. J. Am. Coll. Cardiol. 2007; 50(16): 1578-1583 Renal Artery Calcium: Relationship to Systemic Calcified Atherosclerosis. Vascular Medicine. 2006; 11: 232-238 5 P a g e

Renal Artery Calcium, Blood Pressure and Hypertension. Selected as one of the five finalists for the Sandra Daugherty Award for Excellence in Cardiovascular Disease or Hypertension Epidemiology, 46 th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, March 2-5, 2006 in Phoenix, Arizona. Mitral and Aortic Annular Calcification are Highly Associated with Systemic Calcified Atherosclerosis. Circulation. 2006. 113(6):861-866 The Differential Associations Between HDL, non-hdl and Total Cholesterols and Atherosclerotic Calcium Deposits in Multiple Vascular Beds. Atherosclerosis 2007 194(2): 87-94 Association Between Systemic Calcified Atherosclerosis and Bone Density. Calcified Tissue Journal. 2007 (80): 301-306 Atherosclerotic Calcification and Intimal Medial Thickness of the Carotid Arteries. International Journal of Cardiology 103. 2005: 98 104 A Comparison of HDL and LDL Cholesterol for Prevalent Coronary Calcification. International Journal of Cardiology. 95. 2004: 55-60 Patterns and Risk Factors for Systemic Calcified Atherosclerosis. Arteriosclerotic Thrombosis and Vascular Biology. 24. 2004: 1-6 Body Morphology Differentially Predicts Coronary Calcium. International Journal of Obesity. 2004; 28: 396-401 Age and Gender are the Strongest Clinical Correlates of Prevalent Coronary Calcification. International Journal of Cardiology. 2005; 98: 325-330 The Predictive Power of Low Density Lipoprotein Cholesterol for Coronary Calcification. International Journal of Cardiology. 2003; 90: 281-2 Associations and other positions Fellow, American College of Cardiology Member, Clinical Cardiology Council, American Heart Association Fellow, National Lipid Association Board of Directors, Northeast Chapter, National Lipid Association 2010-2013 Advisory Board, Aegerion Pharmaceuticals 2012-2015 Advisory Board, Voluware 2012-2016 6 P a g e

Clinical Educator, Viridian Health Management 2013-2014 Advisory Panel and Speaker Panel, LipoScience 2010-2014 7 P a g e