PROJECT BRIDGE: Differentiation of HIV Services for PWID in Harm Reduction Programs in Kazakhstan. Nabila El-Bassel, PhD Columbia University

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PROJECT BRIDGE: Differentiation of HIV Services for PWID in Harm Reduction Programs in Kazakhstan Nabila El-Bassel, PhD Columbia University CUGH Conference March 16-18, 2018 New York, NY @NabilaElBassel #CUGH2018

Today s presentation will cover: Scope of HIV epidemic among people who inject drugs (PWID) in Kazakhstan HIV Treatment cascade and access to harm reduction services in Kazakhstan Project BRIDGE: Hybrid type II implementation study on differentiation of HIV services for PWID in Syringe Exchange Programs in three cities in Kazakhstan

KAZAKHSTAN AND CENTRAL ASIA HAVE THE FASTEST GROWING HIV EPIDEMIC IN THE WORLD Globally, AIDS-related deaths were reduced by 32% between 2010 and 2016; however, death rates increased 38% in Eastern Europe and Central Asia

2017 LANCET PUBLICATION: GLOBALLY, 15.6 MILLION PEOPLE INJECT DRUGS; RATES ARE HIGHEST IN EASTERN EUROPE & CENTRAL ASIA 127,800 PWID in Kazakhstan Injection Drug use accounts for 54% of all HIV cases Sexual transmission accounts for 46% of all HIV cases HIV prevalence among PWID is 8.5% Global prevalence of injecting drug use and sociodemographic characteristics (Degenhardt, et. al, Lancet Glob Health, 2017)

TREATMENT CASCADE IN KAZAKHSTAN Republican AIDS Center, 2016 People living w/hiv Know Status On ART ART >1 Year Suppressed VL Total 19838 17958 9982 6031 3866 PWID 10160 5995 4611 2797 1624

ONLY 3% OF 374 REGISTERED PWID WERE RECEIVING METHADONE TREATMENT IN KAZAKHSTAN IN 2017

COMPARED TO OTHER DRUG PROGRAMS, SYRINGE EXCHANGE PROGRAMS HAVE THE HIGHEST PWID PARTICIPATION IN KAZAKHSTAN : 144 SEPs in Kazakhstan Yet less than 50% of PWID are in SEPs Criminalization of drug use, policing, and stigma are barriers to accessing SEPs and HIV care SEPs mainly distribute condoms and syringes Less than 50% of PWIDs who visit SEPs receive rapid HIV testing Source: The global state of harm reduction 2014. London: Harm Reduction International; 2014

SYRINGE EXCHANGE PROGRAMS ARE IDEAL SITES TO IMPROVE THE HIV CONTINUUM OF CARE 1 2 SEPs may be the only harm reduction or drug treatment program available for PWID SEPs are often located within the PWID communities

BARRIERS THAT LIMIT HIV SERVICES IN SEPS Nurses and Outreach Workers: Staffing Low salary for nurses and outreach workers, high staff turnover, high workload Gap in knowledge Recruitment strategies, client engagement in services (outreach workers), use of evidence-based HIV interventions and case management (nurses) Limited Role in HIV care HIV services not seen as part of a nurse s role; low HIV testing, low supply of rapid HIV tests SURVEY BY GHRCCA : 84-SEPS, NURSES, OUTREACH AND ADMINISTRATORS AND SIX FOCUS GROUPS WITH PWID (2017).

BARRIERS THAT LIMIT HIV SERVICES IN SEPS No peer recruitment SEP Operations: No differentiation in services Recruitment relies on overburdened outreach workers No service integration or collaboration and teamwork Lack of electronic resources Paper-based records, only 1/3 of staff use computers SURVEY BY GHRCCA : 84-SEPS, NURSES, OUTREACH AND ADMINISTRATORS AND SIX FOCUS GROUPS WITH PWID (2017).

Primary Aims Increase # of PWID who: Attend SEPs Are tested for HIV at the SEPs Are linked to HIV care (if HIV positive) Secondary Aims # retained in HIV care ( 1 visit per 6 months) Viral suppression Implementation Aims Address barriers: client, staff, agency, community, structural Assess the effectiveness of implementation strategies Examine cost-effectiveness on primary outcomes

INTEGRATED EVIDENCE-BASED INTERVENTIONS HIV + PWIDs SNS CTR ARTAS #2 HIV Rapid testing and re-referral #3 Case management: Antiretroviral treatment and access to services for HIV+ PWIDs #4 Involvement and retention in HIV care program for HIV+ PWIDs; Engagement in additional medical services VIRAL SUPPRESSION #1 Social network strategy Outreach workers train PWID to recruit PWID peers to attend SEPs Implementation Strategies Supervision Teamwork Community of Practice WhatsApp Technical Assistance

BRIDGE STUDY USED A STEPPED-WEDGE DESIGN 3 cities 24 SEPs In each city 8 SEPs 8 nurses 16 outreach workers 1 supervisor from the AIDS Center

TRIANGULATION OF DATA IS USED FOR DELIVERY OF SERVICES AND TRACKING AppSheet Google-based application ran on tablets as a data collection tool. Used by nurses at SEPs and HIV service Keychain Each SEP client is given a keychain with a unique QR code Used by SEP clients and the HIV Care Center

PRELIMINARY FINDINGS, AUG 2017 JAN 2018 ONE CITY PWID were trained by outreach workers as peer recruiters # 110 New PWID clients recruited by peer recruiters 599 HIV tests at SEPs HIV positive (total new and old cases) New HIV cases identified Received at least one session of ARTAS case management 723 38 19 26

900 800 # of clients who visited SEPs and Received HIV testing in Almaty, KZ, Pre and 6 Months Post Intervention 825 Increased over 2x 723 Increased over 2x 700 600 500 400 300 372 312 200 100 0 # visited SEP # received rapid test Pre-Implementation (Feb - Jul 2017) Post-Implementation (Aug 2017 - Jan 2018)

SIX-MONTH OUTCOMES: NEW HIV POSITIVE, PRE- AND POST- INTERVENTION 50 45 40 Pre-Implementation (Feb Jul 2017) 46 Newly detected HIV positives Post-Implementation Aug 2017 Jan 2018 38 35 30 25 20 15 8.7% new HIV cases 19 50% new HIV cases 10 5 4 0 Total # HIV Positive Total # New HIV Positive Total # HIV Positive Total # New HIV Positive

# of clients who received ARTAS and were linked to care at the AIDS Center in Almaty, KZ 40 38 35 30 25 26 68.4% 20 15 10 5 6 16.6% 0 # HIV-positive # received ARTAS # linked to AIDS Center Post-Implementation (Aug 2017 - Jan 2018)

PRELIMINARY OUTCOMES FROM ALMATY Increased recruitment of PWID and HIV testing in SEPs and linkage to HIV care SEPs may serve as an important location to identify new HIV positive cases in PWID and link them to HIV care Use of peer recruitment can reduce the burden placed on outreach workers and improve linkage and access to SEPs and HIV care for hard-to-reach PWID Technology and monitoring of services can be used in SEPs to improve HIV care linkage I've now gained a clearer understanding of my role in the project.

THANK YOU The Social Intervention Group (SIG) at Columbia University and The Global Health Center of Central Asia NIDA for supporting our research And to the people who participated in our studies Visit us: http://sig.columbia.edu @ColumbiaSIG