PRICELIST ANALYSES Last Update:

PRICELIST ANALYSES Last Update: 2016-05-27 DOG Genotype Blood H255 Genotype dog 12 MS (currently used for ASCA, ASCD) 20 39,15 H256 Genotype dog 22 MS (ISAG-Markerset) 20 41,65 H257 Genotype dog 22 MS (ISAG-Markerset) incl. sampling kit 20 44,63 H607 Factor IX Deficiency* 15 47,01 H435 Factor VII Deficiency * 15 47,01 H491 Haemophilia A (Factor VIII), partnerlaboratory * 25 47,01 H436 Haemophilia A (Factor VIII), patent owner * 25 106,51 H364 Hypocatalasia* 15 47,01 H450 P2RY12-defect, bleeding disorder * 15 47,01 H741 PKDef (Pyruvatkinase Deficiency) * 15 47,01 H454 PKDef2 (Pyruvatkinase Deficiency 2) * 15 47,01 H455 PKDef3 (Pyruvatkinase Deficiency 3) * 15 47,01 H438 Polycythemia * 15 47,01 H439 Prekallikrein Deficiency * 15 47,01 H440 Thrombasthenia * 15 47,01 H447 Thrombasthenia2 * 15 47,01 H441 Thrombocytopenia * 15 47,01 H442 Thrombopathy * 15 47,01 H448 Thrombopathy 2 * 15 47,01 H449 Thrombopathy 3 * 15 47,01 H642 Von Willbrand s disease 3 2 * 15 47,01 H677 Von Willebrand s disease type 1, partnerlaboratory * 25 47,01 Page 1 of 7

H742 Von-Willebrand s-disease Type 1, patent owner * 15 106,51 H743 Von-Willebrand s-disease Type 2 * 15 82,11 H744 Von-Willebrand s-disease Type 3 * 15 58,91 Brain / Nervous System H413 Cerebellar Abiotrophy * 15 47,01 H410 Cerebellar Ataxia * 15 47,01 H653 Cerebellar Ataxia 2 * 15 47,01 H411 Cerebellar Ataxia progressive, early onset * 15 47,01 H355 Cerebellar Hypoplasia resembling DWLM* 15 47,01 H425 CMS (congenital myasthenic syndrome) * 15 47,01 H673 DM (Degenerative Myelopathy), partnerlaboratory * 25 47,01 H806 DM (Degenerative Myelopathy), patent owner * 25 106,51 H308 DM2 (Degenerative Myelopathy 2)* 15 47,01 H674 EFS (Episodic Falling Syndrome), partnerlaboratory * 25 47,01 H883 EFS (Episodic Falling Syndrome), patent owner * 25 106,51 H486 Epilepsy, BFJ * 15 47,01 H736 Fucosidosis * 15 47,01 H737 Globoid Cell Leukodystrophy Krabbe s disease *l 15 47,01 H365 Hypomyelination* 15 47,01 H724 L2-HGA (L2-Hydroxyglutaraciduria) * 15 47,01 H723 MDR1 (Multidrug Resistance Type 1) * 15 68,43 H428 NAD (Neuroaxonal Dystrophy) * 15 47,01 H707 Narcolepsy 1 * 25 47,01 H697 Narcolepsy 2 * 20 47,01 H698 Narcolepsy 3 * 20 47,01 H494 NCL 1 (Neuronal Ceroid Lipofuscinosis) * 15 47,01 H499 NCL 2 (Neuronal Ceroid Lipofuscinosis 2) * 15 47,01 H804 NCL 4A (Neuronal Ceroid Lipofuscinosis 4A /"CA")* 15 47,01 H721 NCL 5 (Neuronal Ceroid Lipofuscinosis 5) * 15 47,01 H652 NCL 8 (Neuronal Ceroid Lipofuscinosis 8) * 15 47,01 H429 NCL 10 (Neuronal Ceroid Lipofuscinosis 10) * 15 47,01 H812 Neonatal Encephalopathy * 15 47,01 H872 Pituitary Dwarfism * 15 47,01 H914 Polyneuropathy 1 * 15 47,01 H495 Polyneuropathy 2 * 15 47,01 H303 Spinocerebellar ataxia* 15 47,01 H696 WARBM1 (Warburg Micro Syndrome) 10 47,01 H432 X-linked Tremor * 15 47,01 Page 2 of 7

Coat Eyes H353 Coat Colour Saddle tan vs. Black-and-tan* 15 47,01 H354 Coat Colour White Spotting* 15 47,01 H848 IC13 (Improper Coat) * 15 47,01 H820 Inheritance of coat colour in dog, A-locus * 25 86,28 H733 Inheritance of coat colour in dog, B-locus * 15 47,01 H847 Inheritance of coat colour in dog, D-locus, improved test (MLPH)* 15 47,01 H734 Inheritance of coat colour in dog, E-locus * 15 47,01 H818 Inheritance of coat colour in dog, Em-locus * 15 47,01 H930 Inheritance of coat colour in dog, Merle * 25 89,25 H921 Inheritance of curly coat * 15 47,01 H765 Inheritance of hairlength * 15 47,01 H913 CCS (Dry Eye Curly Coat Syndrome) * 15 47,01 H918 CD (cone degeneration) * 15 47,01 H710 CEA-CH (Collie Eye Anomaly) * 30 175,53 H306 CMR 31 (Multifocal Retinopathy 3)* 15 47,01 H307 CMR 32 (Multifocal Retinopathy 3)* 15 47,01 H871 CMR1 (Canine Multifocal Retinopathy) * 15 47,01 H730 CMR2 (Canine Multifocal Retinopathy) * 15 47,01 H357 crd 1 (Cone rod dystrophy)* 15 47,01 H358 crd 2 (Cone rod dystrophy) in AmStaff* 15 47,01 H856 CRD3 (Cone and Rod Degeneration 3) * 30 119,00 H728 CSNB (Congenital Stationary Night Blindness) * 15 47,01 H699 HSF4 (Hereditary cataract 2) * 15 47,01 H809 HSF4 (Hereditary cataract) * 15 47,01 H849 PLL (Primary Lens Luxation) * 15 47,01 H496 POAG (Glaucoma)* 15 47,01 H383 Primary Glaucoma* 15 47,01 H794 RD OSD1 (Okuloskelettal Dysplasia) * 15 47,01 H426 RD OSD2 (Okuloskelettal Dysplasia) * 30 157,68 Eyes (Progressive Retinaatrophy) H372 crd PRA 1* 15 47,01 H766 crd4-pra (previously cord1-pra )* 15 47,01 H739 dominant PRA * 15 47,01 H915 gpra * 15 47,01 H868 GR PRA 1 * 15 47,01 H305 PAP-PRA1 1* 15 47,01 Page 3 of 7

H301 PAP-PRA1 2* 15 47,01 H371 PRA (progressive Retina Atrophy, late onset)* 15 47,01 H382 PRA erd* 15 47,01 H373 PRA type 3* 15 47,01 H700 prcd-pra * 30 178,50 H768 rcd1 PRA * 15 47,01 H769 rcd1a PRA * 15 47,01 H801 rcd2 PRA * 30 223,13 H770 rcd3 PRA * 15 47,01 H511 rcd4 PRA * 15 47,01 H771 Type A PRA * 30 157,68 H772 XL-PRA 1 (X-Linked PRA) * 15 47,01 Immune System Muscles H412 C3-deficiency * 15 47,01 H709 CLAD (Canine Leukozyte Adhesion Deficiency) * 15 47,01 H484 CLAD Type III (C. Leukozyte Adh. Deficiency) * 15 47,01 H752 Grey Collie Syndrome (Canine cyclic Neutropenia) * 15 47,01 H423 SCID (Severe Combined Immune Deficiency) * 15 47,01 H456 SCID2 (Severe Combined Immune Deficiency 2) * 15 47,01 H787 TNS *(Trapped Neutrophil Syndrome) * 15 47,01 H745 X-SCID (X-chromosomal SCID) * 15 58,91 H749 CNM (also HMLR, Centronuclear Myopathy) * 15 47,01 H434 DCM (Dilative Cardiomyopathy) * 15 47,01 H419 DMD (Duchenne Muskeldystrophy) * 15 47,01 H672 EIC (Exercise Induced Collapse), partnerlaboratory * 25 47,01 H805 EIC (Exercise Induced Collapse), patent owner * 25 106,51 H747 GRMD (Golden Retriever Muscular Dystrophy) * 15 47,01 H359 MDM 2 (Muscular Dystrophy, Duchenne type 2)* 15 47,01 H746 MH (Malignant Hyperthermia) * 15 47,01 H427 MTM (Myotubular Myopathy) * 15 47,01 H493 Muscular Hypertrophy (double muscling) * 15 47,01 H368 Myopathy* 15 47,01 H738 Myotonia Congenita * 25 58,91 H498 Myotonia Congenita 2 * 15 47,01 H740 PDP1 (Pyruvat-Dehydrogenase-Phosphatase-Deficiency 1) * 15 47,01 H717 PFK (Phosphofructokinase Deficiency) * 15 47,01 Page 4 of 7

Organs Skeleton H416 CHG 1 (Congenital Hypothyroidism 1) * 15 47,01 H485 CHG 2 (Congenital Hypothyroidism 2) * 15 47,01 H488 CHG 3 (Congenital Hypothyroidism 3) * 15 47,01 H701 Coppertoxicosis * 15 47,01 H703 Cystenuria, type I - A - 1 * 15 47,01 H643 Cystinuria, Type II A 1 * 15 47,01 H644 Cystinuria, Type II A * 15 47,01 H645 Cystinuria, Type II B * 15 47,01 H676 FN (Familiar Nephropathia), partnerlaboratory * 25 47,01 H729 FN (Familiar Nephropathia), patent owner * 15 130,90 H360 Gallbladder Mucocele* 15 47,01 H361 GM 2 B (Gangliosidosis 2, type I, variant B)* 15 47,01 H702 GM1 (Gangliosidosis I) * 15 47,01 H490 GM2 (Gangliosidosis II) * 15 47,01 H415 GSD I (Glycogen Storage Disease) * 15 47,01 H813 GSD IIIa (Glycogen Storage Disease Type III a) * 25 52,96 H811 HUU (Hyperurikaemia) 15 47,01 H370 Nephritis* 15 47,01 H414 PCD (Primary Ciliar Dyskinesia) * 15 47,01 H509 PKD1 (Polycystic Kidney Disease) * 15 47,01 H374 Primary Hyperoxaluria* 15 47,01 H487 Brachyury (Bobtail)* 15 47,01 H356 Chondrodysplasia* 15 47,01 H919 Hip Laxity 1 * 15 47,01 H421 Hip Laxity 2 * 15 47,01 H418 Mucopolysaccharidosis Type IIIa * 15 47,01 H451 Mucopolysaccharidosis Type VII 2 * 15 47,01 H748 Mucopolysaccharidosis Type VII * 15 47,01 H430 Osteogenesis imperfecta ("brittle bone disease") * 15 47,01 H431 Osteogenesis imperfecta 2 ("brittle bone disease") * 15 47,01 H510 SD 2 (skeletal dysplasia) * 15 47,01 H377 Spinal Dysraphism* 15 47,01 H433 Vitamin D-Deficiency, Rickets Type II * 15 47,01 Skin H375 ED (Ectodermal Dysplasia / Skin Fragility Syndrome)* 15 47,01 H675 HPNK (Hereditary Nasal Parakeratosis), partnerlaboratory * 25 47,01 Page 5 of 7

H443 HPNK (Hereditary Nasal Parakeratosis), patent owner * 25 130,31 H363 Hyperkeratosis, epidermolytic* 15 47,01 H492 Hyperkeratosis, palmoplantar * 15 47,01 H873 Ichthyosis Type 2 * 15 47,01 H304 Ichthyosis Type 3 * 15 47,01 H424 MLS (Musladin-Lueke syndrome) * 15 47,01 H489 RCND (Dermatofibrosis)* 15 47,01 H497 RDEB (Epidermolysis bullosa, dystrophic) * 15 47,01 other H351 Amelogenesis imperfecta* 15 47,01 H691 Breed Identification Mixed Breed 25 94,61 H692 CanineHD Whole-Genome Genotyping 15 auf Anfrage H366 IGS 1 (selective Cobalamin malabsorption)* 15 47,01 H367 IGS 2 (selective Cobalamin malabsorption)* 15 47,01 Packs H474 CombiBreed FCI Group 01 * 15 65,45 H475 CombiBreed FCI Group 02 * 15 65,45 H476 CombiBreed FCI Group 03 * 15 65,45 H477 CombiBreed FCI Group 04 * 15 65,45 H478 CombiBreed FCI Group 05 * 15 65,45 H479 CombiBreed FCI Group 06 * 15 65,45 H480 CombiBreed FCI Group 07 * 15 65,45 H481 CombiBreed FCI Group 08 * 15 65,45 H482 CombiBreed FCI Group 09 * 15 65,45 H483 CombiBreed FCI Group 10 * 15 65,45 H469 Combination Pack Coat Variation (7 Marker) * 15 65,45 H398 Combination Package Partnerlab* 25 94,61 Page 6 of 7

Required sample material: 2 5ml EDTA-blood or 20 30 Hair with roots or 1 buccal swab (Genotek or else) Please note: - All previous pricelists are herewith invalid. - All prices are given including the statutory VAT (19%). - The given prices refer to single samples, gliding scale prices depending on order volumes and special rebates for resellers and breeding organisations are individually negotiable. - The given processing time in working days ( Time ) varies depending on general workload at the lab and sample quality. - By agreement and depending on the capacity of the laboratory, several analyses can be performed partly within 48 h. If required please ask for your special offer. - In case that the submitted sample material does not meet our specifications for a perfect analysability, it will be decided after consulting the client, whether the sample is to be analysed. In this case the cost for the analysis have to be born anyway, also in case of failed analyses. - *: This analysis is performed through our sister-lab. - Errors excepted. - Our general conditions apply. Accredited Laboratory (DIN EN ISO/IEC 17025) Certagen GmbH Marie-Curie-Straße 1 D-53359 Rheinbach T 02226 871600 F 02226 871604 labor@certagen.de www.certagen.de Page 7 of 7