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Global Heart Valve Devices Market: Analysis By Procedure (Replacement & Repair), Replacement Procedure By Technique (Mechanical, Bioprosthetic & TAVR), Repair Procedure By Technique (Surgical, Balloon Valvuloplasty & TMVR), By Region, By Country (2016-2021) Scope of the Study g Global Coverage Regional Coverage Country Coverage Segment Coverage By Procedure By Technique Region (North America, Europe, APAC and ROW) Country (U.S., Canada, Germany, France, U.K., China, India, Japan, Brazil and Saudi Arabia) Global Coverage Regional Coverage Country Coverage Company Coverage North America U.S. Edward Life Sciences Europe Canada Medtronic Asia Pacific Germany Boston Scientific Corporation Heart Valve Market By Value (2011-2021) Breakdown-By Procedure (2011-2021) & By Technique Heart Valve Replacement Market- By Value Mechanical Valve Bioprosthetic Valve ROW Heart Valve Market- By Value (2011-15) Heart Valve Market-By Value France U.K. China India Japan Brazil Saudi Arabia Abbott Laboratories St. Jude Medical CryoLife, Inc. LivaNova Neovasc Inc. TTK Healthcare Jena Valve Meril Life Sciences Pvt. Ltd. TAVR (Transcatheter Aortic Valve Replacement) Heart Valve Repair Market- By Value Surgical Valve Repair Devices Balloon Valvuloplasty Devices TMVR (Transcatheter Mitral Valve Repair) (2016-21) By Procedure- By Value (2011-2021) By Technique- By Value (2011-2021) Heart Valve Market : By Value & (2011-2021) Heart Valve Market : By Procedure: By Value (2011-2021) Pricing Analysis Product Benchmarking Sales Business Overview Product Launches & Recent Approvals Merger & Acquisition 2

Table of Content S.No Particulars Page 1. Research Methodology 21 2. Executive Summary 22 3. Strategic Recommendation 23 3.1 Increasing demand for Bioprosthetic Valve replacement techniques 24 3.2 Rapid transition towards Transcatheter Heart Valve therapies 25 3.3 Asia Pacific Region to witness the fastest growth in Heart Valve Devices Market in the forecast period 26 4. Heart Valve Devices Outlook 27 5. Global Heart Valve Devices Market: Growth and Forecast 33 5.1 By Value (2011-2015) 35 5.2 By Value (2016-2021) 36 6. Global Heart Valve Devices Market-By Procedure 43 6.1 Global Heart Valve Devices Market-By Procedure (Replacement and Repair) : Breakdown(%) 43 6.1.1 Global Heart Valve Devices Market Size, By Procedure, 2015 (%) 44 6.1.2 Global Heart Valve Devices Market Size, By Procedure, 2021 (%) 45 6.2 Global Heart Valve Replacement Devices Market 46 6.2.1 By Value (2011-2015) 46 6.2.2 By Value (2016-2021) 46 3

Table of Content S. No Particulars Page 6.3 Global Heart Valve Repair Devices Market 47 6.3.1 By Value (2011-2015) 47 6.3.2 By Value (2016-2021) 47 7. Global Heart Valve Replacement Devices: By Technique 48 7.1 Global Heart Valve Replacement Devices Market Size, By Technique, Breakdown (%) 49 7.2 Global Mechanical Valve Replacement Devices Market 50 7.2.1 By Value (2011-2015) 50 7.2.2 By Value (2016-2021) 50 7.3 Global Bioprosthetic Valve Replacement Devices Market 52 7.3.1 By Value (2011-2015) 52 7.3.2 By Value (2016-2021) 52 7.4 Global Transcatheter Aortic Valve Replacement Devices (TAVR) Market 54 7.4.1 By Value (2011-2015) 54 7.4.2 By Value (2016-2021) 54 7.5 Global Heart Valve Repair Devices: By Technique 56 7.6 Global Heart Valve Repair Devices Market Size, By Technique, Breakdown (%) 57 7.7 Global Surgical Valve Repair Devices Market 58 7.7.1 By Value (2011-2015) 58 7.7.2 By Value (2016-2021) 58 4

Table of Content S. No Particulars Page 7.8 Global Balloon Valvuloplasty Devices Market 60 7.8.1 By Value (2011-2015) 60 7.8.2 By Value (2016-2021) 60 7.9 Global Transcatheter Mitral Valve Repair (TMVR) Devices Market 61 7.9.1 By Value (2011-2015) 61 7.9.2 By Value (2016-2021) 61 8. Global Heart Valve Devices Market: Regional Analysis 63 8.1 Global Heart Valve Devices Market, By Region: Breakdown (%) 64 8.1.1 Global Heart Valve Devices Market Size, By Region, 2015 (%) 64 8.1.2 Global Heart Valve Devices Market Size, By Region, 2021 (%) 65 8.2 North America Heart Valve Devices Market: An Analysis 66 8.2.1 By Value (2011-2015) 67 8.2.2 By Value (2016-2021) 68 8.3 North America Heart Valve Devices Market: By Procedure 71 8.3.1 North America Heart Valve Devices Market, By Procedure, By Value (2011-2015) 72 8.3.2 North America Heart Valve Devices Market, By Procedure, By Value (2016-2021) 73 8.4 North America Heart Valve Devices Market: By Technique 74 4

Table of Content S. No Particulars Page 8.4.1 North America Heart Valve Replacement Devices Market, By Technique, By Value (2011-2021) 75 8.4.2 North America Heart Valve Repair Devices Market, By Technique, By Value (2011-2021) 76 8.5 North America Heart Valve Devices Market: Country Analysis (U.S. and Canada) 77 8.5.1 North America Heart Valve Devices Market: Country Analysis, Breakdown (%) 78 8.5.2 U.S. Heart Valve Devices Market, By Value (2011-2021) 79 8.5.2.1 U.S. Heart Valve Devices Market, By Procedure, By Value (2011-2021) 83 8.5.3 Canada Heart Valve Devices Market, By Value (2011-2021) 84 8.5.3.1 Canada Heart Valve Devices Market, By Procedure, By Value (2011-2021) 85 8.6 Europe Heart Valve Devices Market: An Analysis 86 8.6.1 By Value (2011-2015) 87 8.6.2 By Value (2016-2021) 88 8.7 Europe Heart Valve Devices Market: By Procedure 92 8.7.1 Europe Heart Valve Devices Market, By Procedure, By Value, 2011-2015 93 8.7.2 Europe Heart Valve Devices Market, By Procedure, By Value, 2016-2021 94 8.8 Europe Heart Valve Devices Market: By Technique 95 8.8.1 Europe Heart Valve Replacement Devices Market, By Technique, By Value (2011-2021) 96 8.8.2 Europe Heart Valve Repair Devices Market, By Technique, By Value (2011-2021) 97 4

Table of Content S. No Particulars Page 8.9 Europe Heart Valve Devices Market: Country Analysis (Germany, France, U.K., & Rest of Europe) 98 8.9.1 Europe Heart Valve Devices Market: Country Analysis, Breakdown (%) 99 8.9.2 Germany Heart Valve Devices Market, By Value (2011-2021) 100 8.9.2.1 Germany Heart Valve Devices Market, By Procedure, By Value (2011-2021) 103 8.9.3 France Heart Valve Devices Market, By Value (2011-2021) 104 8.9.3.1 France Heart Valve Devices Market, By Procedure, By Value (2011-2021) 106 8.9.4 U.K. Heart Valve Devices Market, By Value (2011-2021) 107 8.9.4.1 U.K. Heart Valve Devices Market, By Procedure, By Value (2011-2021) 109 8.9.5 Rest of Europe Heart Valve Devices Market, By Value (2011-2021) 110 8.10 Asia Pacific Heart Valve Devices Market: An Analysis 111 8.10.1 By Value (2011-2015) 112 8.10.2 By Value (2016-2021) 113 8.11 APAC Heart Valve Devices Market: By Procedure 116 8.7.1 APAC Heart Valve Devices Market, By Procedure, By Value, 2011-2015 117 8.7.2 APAC Heart Valve Devices Market, By Procedure, By Value, 2016-2021 118 8.12 APAC Heart Valve Devices Market: By Technique 119 8.12.1 APAC Heart Valve Replacement Devices Market, By Technique, By Value (2011-2021) 120 8.12.2 APAC Heart Valve Repair Devices Market, By Technique, By Value (2011-2021) 121 5

Table of Content S. No Particulars Page 8.13 APAC Heart Valve Devices Market: Country Analysis (China, India, Japan and Rest of Asia Pacific) 122 8.13.1 APAC Heart Valve Devices Market: Country Analysis, Breakdown (%) 123 8.13.2 China Heart Valve Devices Market, By Value (2011-2021) 124 8.13.2.1 China Heart Valve Devices Market, By Procedure, By Value (2011-2021) 127 8.13.3 India Heart Valve Devices Market, By Value (2011-2021) 128 8.10.3.1 India Heart Valve Devices Market, By Procedure, By Value (2011-2021) 133 8.13.4 Japan Heart Valve Devices Market, By Value (2011-2021) 134 8.13.4.1 Japan Heart Valve Devices Market, By Procedure, By Value (2011-2021) 136 8.13.4 Rest of Asia Pacific Heart Valve Devices Market, By Value (2011-2021) 137 8.14 Rest of the World Heart Valve Devices Market: An Analysis 138 8.14.1 By Value (2011-2015) 139 8.14.2 By Value (2016-2021) 140 8.15 RoW Heart Valve Devices Market: By Procedure 143 8.15.1 RoW Heart Valve Devices Market, By Procedure, By Value, 2011-2015 144 8.15.2 RoW Heart Valve Devices Market, By Procedure, By Value, 2016-2021 145 8.16 RoW Heart Valve Devices Market: By Technique 146 6

Table of Content S. No Particulars Page 8.16.1 RoW Heart Valve Replacement Devices Market, By Technique, By Value (2011-2021) 147 8.16.2 RoW Heart Valve Repair Devices Market, By Technique, By Value (2011-2021) 148 8.17 RoW Heart Valve Devices Market: Country Analysis (Brazil and Saudi Arabia) 149 8.17.1 RoW Heart Valve Devices Market: Country Analysis, Breakdown (%) 150 8.17.2 Brazil Heart Valve Devices Market, By Value (2011-2021) 151 8.17.2.1 Brazil Heart Valve Devices Market, By Procedure, By Value (2011-2021) 153 8.17.3 Saudi Arabia Heart Valve Devices Market, By Value (2011-2021) 154 8.17.3.1 Saudi Arabia Heart Valve Devices Market, By Procedure, By Value (2011-2021 ) 155 9. Market Dynamics 156 9.1 Global Heart Valve Devices Market Growth Drivers 157 9.2 Global Heart Valve Devices Market Restraints 162 10. Market Trends 164 11. Porter s Five Forces Analysis Heart Valve Devices Market 169 12. SWOT Analysis Heart Valve Devices Market 171 13. Supply Chain Analysis 173 14. Competitive Landscape 175 14.1 Global Heart Valve Devices Market- Country Pricing and Volume Analysis (U.S., Germany, France, India) 176 14.2 Global Heart Valve Devices Market- Company Share Analysis 177 14.3 Product Benchmarking of Key Industry Players, By Procedure 178 5

Table of Content S. No Particulars Page 14.4 Product Benchmarking of Key Industry Players in Heart Valve Replacement Devices, By Technique 181 15. Policy and Regulatory Landscape 183 16. Company Profiling 191 16.1 Edwards Lifesciences Corporation 192 16.2 Medtronic Plc 196 16.3 Boston Scientific Corporation 200 16.4 Abbott Laboratories 204 16.5 St. Jude Medical Inc. 208 16.6 CryoLife Inc. 210 16.7 LivaNova Plc 213 16.8 Neovasc Inc. 215 16.9 TTK Healthcare 217 16.10 JenaValve Technology Inc. 219 16.11 Meril Life Sciences Pvt. Ltd. 220 17. About Us 221 7

List of Figures Figure Figure Title Page Figure 1: Heart Valve Problems and Disease Flowchart 29 Figure 2: Heart Valve Treatment Procedure Flowchart 32 Figure 3: Global Healthcare Landscape 34 Figure 4: Global Heart Valve Devices Market Size, By Value, 2011-2015 (USD Million) 35 Figure 5: Global Heart Valve Devices Market Size, By Value, Forecast, 2016-2021(USD Million) 36 Figure 6: Global Population Ages 65 and Above, 2011-2015 (% of Total) 37 Figure 7: Global Diabetic Population, By Region, 2015 (Million) 37 Figure 8: Global Health Expenditure, 2011-2014 (% of GDP) 38 Figure 9: Medical Tourism Index, By Region and Top Destinations 39 Figure 10: Medical Tourism Market Drivers 39 Figure 11: Global Heart Valve Devices Market Size, By Procedure, 2015 (%) 44 Figure 12: Global Heart Valve Devices Market Size, By Procedure, 2021 (%) 45 Figure 13: Global Heart Valve Replacement Devices Market, By Value, 2011-2015 (USD Million) 46 Figure 14: Global Heart Valve Replacement Devices Market, By Value, Forecast, 2016-2021(USD Million) 46 Figure 15: Global Heart Valve Repair Devices Market, By Value, 2011-2015 (USD Million) 47 Figure 16: Global Heart Valve Repair Devices Market, By Value, Forecast, 2016-2021(USD Million) 47 Figure 17: Global Heart Valve Replacement Devices Market Size, By Technique, 2015 (%) 49 Figure 18: Global Heart Valve Replacement Devices Market Size, By Technique, 2021 (%) 49 Figure 19: Global Mechanical Valve Replacement Devices Market, By Value, 2011-2015 (USD Million) 50 11

List of Figures Figure Figure Title Page Figure 20: Global Mechanical Valve Replacement Devices Market, By Value, Forecast, 2016-2021(USD Million) 50 Figure 21: Global Population Age Structure Breakdown, 2011-2015 (% of Total) 51 Figure 22: Global Bioprosthetic Valve Replacement Devices Market, By Value, 2011-2015 (USD Million) 52 Figure 23: Global Bioprosthetic Valve Replacement Devices Market, By Value, Forecast, 2016-2021(USD Million) 52 Figure 24: Global Transcatheter Aortic Valve Replacement Devices Market, By Value, 2011-2015 (USD Million) 54 Figure 25: Global Transcatheter Aortic Valve Replacement Devices Market, By Value, Forecast, 2016-2021(USD Million) 54 Figure 26: Global Heart Valve Repair Devices Market Size, By Technique, 2015 (%) 57 Figure 27: Global Heart Valve Repair Devices Market Size, By Technique, 2021 (%) 57 Figure 28: Global Surgical Valve Repair Devices Market, By Value, 2011-2015 (USD Million) 58 Figure 29: Global Surgical Valve Repair Devices Market, By Value, Forecast, 2016-2021(USD Million) 58 Figure 30: Global Balloon Valvuloplasty Devices Market, By Value, 2011-2015 (USD Million) 60 Figure 31: Global Balloon Valvuloplasty Devices Market, By Value, Forecast, 2016-2021(USD Million) 60 Figure 32: Global Transcatheter Mitral Valve Repair Devices Market, By Value, 2011-2015 (USD Million) 61 Figure 33: Global Transcatheter Mitral Valve Repair Devices Market, By Value, Forecast, 2016-2021(USD Million) 61 Figure 34: Global Heart Valve Devices Market Size, By Region, 2015 (%) 64 Figure 35: Global Heart Valve Devices Market Size, By Region, 2021 (%) 65 Figure 36: North America Heart Valve Devices Market, By Value, 2011-2015 (USD Million) 67 Figure 37: North America Heart Valve Devices Market, By Value, Forecast, 2016-2021 (USD Million) 68 Figure 38: North America GDP, 2011-2015 (USD Trillion) 69 Figure 39: North America Healthcare Expenditure, 2011-2014 (% of GDP) 69 12

Figure List of Figures Figure Title Page Figure 40: North America Diabetic Population Growth (Million) 70 Figure 41: North America Population Ages 65 and above, 2011-2015 (% of Total) 70 Figure 42: North America Heart Valve Devices Market: By Procedure, By Value, 2011-2015 (USD Million) 72 Figure 43: North America Heart Valve Devices Market: By Procedure, By Value, 2016-2021 (USD Million) 73 Figure 44: North America Heart Valve Replacement Devices Market: By Technique, By Value, 2011-2021 (USD Million) 75 Figure 45: North America Heart Valve Repair Devices Market: By Technique, By Value, 2011-2021 (USD Million) 76 Figure 46: North America Heart Valve Devices Market, Country Share, 2011-2015(% of Total) 78 Figure 47: North America Heart Valve Devices Market, Country Share, 2016-2021 (% of Total) 78 Figure 48: U.S. Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 79 Figure 49: U.S. Health Expenditure, 2011-2015 (% of GDP) 80 Figure 50: U.S. Population Ages 65 and above, 2014 and Forecast (Million) 80 Figure 51: U.S Health Spending by Type of Service or Product, 2015 (%) 81 Figure 52: U.S. Age Structure Breakdown, (%) 81 Figure 53: Major U.S. Players in Heart Valve Devices Industry 82 Figure 54: U.S. Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 83 Figure 55: Canada Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 84 Figure 56: Canada Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 85 Figure 57: Europe Heart Valve Devices Market, By Value, 2011-2015 (USD Million) 87 Figure 58: Europe Heart Valve Devices Market, By Value, Forecast, 2016-2021 (USD Million) 88 Figure 59: Europe Diabetes Prevalence, By Country, 2015 (% of Population Aged 20 to 79) 89 Figure 60: EU Health Expenditure Per Capita, 2011-2014 (USD) 90 13

List of Figures Figure Figure Title Page Figure 61: Breakdown of Total Health Expenditure in Europe (%) 90 Figure 62: Global Medical Technology Market Based on Manufacturer Prices, By Region (%) 91 Figure 63: European Medical Technology Market Based on Manufacturer Prices, By Country (%) 91 Figure 64: Europe Heart Valve Devices Market: By Procedure, By Value, 2011-2015 (USD Million) 93 Figure 65: Europe Heart Valve Devices Market: By Procedure, By Value, 2016-2021 (USD Million) 94 Figure 66: Europe Heart Valve Replacement Devices Market: By Technique, By Value, 2011-2021 (USD Million) 96 Figure 67: Europe Heart Valve Repair Devices Market: By Technique, By Value, 2011-2021 (USD Million) 97 Figure 68: Europe Heart Valve Devices Market, Country Share, 2011-2015(% of Total) 99 Figure 69: Europe Heart Valve Devices Market, Country Share, 2016-2021(% of Total) 99 Figure 70: Germany Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 100 Figure 71: Germany GDP Per Capita, PPP, 2011-2015 (USD) 101 Figure 72: Germany Age Structure Breakdown, (%) 102 Figure 73: Germany Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 103 Figure 74: France Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 104 Figure 75: France GDP Per Capita, PPP 2011-2015 (USD) 105 Figure 76: France Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 106 Figure 77: U.K. Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 107 Figure 78: U.K. Health Expenditure Per Capita, 2011-2014 (USD) 108 Figure 79: U.K. Age Structure Breakdown, (%) 108 Figure 80: U.K. Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 109 14

List of Figure Figure Figure Title Page Figure 81: Rest of Europe Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 110 Figure 82: Asia Pacific Heart Valve Devices Market, By Value, 2011-2015 (USD Million) 112 Figure 83: Asia Pacific Heart Valve Devices Market, By Value, Forecast, 2016-2021 (USD Million) 113 Figure 84: APAC Healthcare Expenditure Per Capita, 2011-2014 (% of GDP) 114 Figure 85: Asia Pacific Diabetes Prevalence, By Country, 2015 (% of Population Age 20 to 79) 115 Figure 86: Asia Pacific Heart Valve Devices Market: By Procedure, By Value, 2011-2015 (USD Million) 117 Figure 87: Asia Pacific Heart Valve Devices Market: By Procedure, By Value, 2016-2021 (USD Million) 118 Figure 88: Asia Pacific Heart Valve Replacement Devices Market: By Technique, By Value, 2011-2021 (USD Million) 120 Figure 89: Asia Pacific Heart Valve Repair Devices Market: By Technique, By Value, 2011-2021 (USD Million) 121 Figure 90: Asia Pacific Heart Valve Devices Market, Country Share, 2011-2015(% of Total) 123 Figure 91: Asia Pacific Heart Valve Devices Market, Country Share, 2016-2021(% of Total) 123 Figure 92: China Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 124 Figure 93: China GDP Per Capita, 2011-2015 (USD) 125 Figure 94: China Population Aged 65 and Above, 2011-2015 (% of Total) 126 Figure 95: China Healthcare Expenditure Outlook (%) 126 Figure 96: China Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 127 Figure 97: India Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 128 Figure 98: Major Factors affecting the Indian Medical Device Industry 129 Figure 99: India Age Structure Breakdown, (%) 130 Figure 100: India Population Aged 65 and Above, 2011-2015 (% of Total) 130 15

List of Figure Figure Figure Title Page Figure 101: Medical Tourist Arrival in India, By Country, 2015 (%) 131 Figure 102: Share of Indian States in Foreign Tourist Arrival (%) 131 Figure 103: India Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 133 Figure 104: Japan Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 134 Figure 105: Japan Population Aged 65 and Above, 2011-2015 (% of Total) 135 Figure 106: Japan Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 136 Figure 107: Rest of Asia Pacific Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 137 Figure 108: Rest of the World Heart Valve Devices Market, By Value, 2011-2015 (USD Million) 139 Figure 109: Rest of the World Heart Valve Devices Market, By Value, Forecast, 2016-2021 (USD Million) 140 Figure 110: Middle East and North Africa Healthcare Expenditure, 2011-2014 (% of GDP) 141 Figure 111: Latin America Healthcare Expenditure, 2011-2014 (% of GDP) 141 Figure 112: Latin America Healthcare Expenditure, By Country 2014 (% of GDP) 142 Figure 113: ROW Heart Valve Devices Market: By Procedure, By Value, 2011-2015 (USD Million) 144 Figure 114: ROW Heart Valve Devices Market: By Procedure, By Value, 2016-2021 (USD Million) 145 Figure 115: ROW Heart Valve Replacement Devices Market: By Technique, By Value, 2011-2021 (USD Million) 147 Figure 116: ROW Heart Valve Repair Devices Market: By Technique, By Value, 2011-2021 (USD Million) 148 Figure 117: Rest of World Heart Valve Devices Market, Country Share, 2011-2015(% of Total) 150 Figure 118: Rest of World Heart Valve Devices Market, Country Share, 2011-2015(% of Total) 150 Figure 119: Brazil Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 151 Figure 120: Brazil Health Expenditure, 2011-2014 (% of GDP) 152 16

List of Figure Figure Figure Title Page Figure 121: Brazil Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 153 Figure 122: Saudi Arabia Heart Valve Devices Market Size, By Value, 2011-2021 (USD Million) 154 Figure 123: Saudi Arabia Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) 155 Figure 124: Global Heart Valve Devices Market Size, By Company Share, 2015 (%) 179 Figure 125: Edwards Lifesciences Growth Strategy 180 Figure 126: Classes of Medical Devices 186 Figure 127: Edwards Lifesciences Corporation Sales, 2011-2015 (USD Billion) 193 Figure 128: Edwards Lifesciences Corporation Sales, By Product Group, 2015 (%) 193 Figure 129: Edwards Lifesciences Corporation Sales, By Region, 2015 (%) 193 Figure 130: Edwards Lifesciences Corporation Product Group Sales Trend, 2013-2015 (USD Billion) 194 Figure 131: Medtronic Plc Sales, 2011-2015 (USD Billion) 197 Figure 132: Medtronic Plc Sales, By Business Group, 2015 (%) 197 Figure 133: Medtronic Plc Sales, By Region, 2015 (%) 197 Figure 134: Medtronic Plc Cardiac & Vascular Business Group Sales Trend, By Business Division 2014-2016 (USD Billion) 198 Figure 135: Medtronic Plc Cardiac & Vascular Business Group Sales, By Division 2016 (%) 198 Figure 136: Boston Scientific Corporation Sales, 2011-2015 (USD Billion) 201 Figure 137: Boston Scientific Corporation Sales, By Business Group, 2015 (%) 201 Figure 138: Boston Scientific Corporation Sales, By Region, 2015 (%) 201 Figure 139: Boston Scientific Corporation Cardiovascular Business Segment Sales Trend, By Division 2013-2015 (USD Billion) 202 Figure 140: Boston Scientific Corporation Cardiovascular Business Segment Sales, By Division 2015 (%) 202 17

List of Figure Figure Figure Title Page Figure 141: Abbott Laboratories Sales, 2011-2015 (USD Billion) 205 Figure 142: Abbott Laboratories Sales, By Business Segment, 2015 (%) 205 Figure 143: Abbott Laboratories Sales, By Region, 2015 (%) 205 Figure 144: Abbott Laboratories Medical Devices Business Segment Sales Trend, By Division 2013-2015 (USD Billion) 206 Figure 145: Abbott Laboratories Medical Devices Business Segment Sales, By Division 2015 (%) 206 Figure 146: St. Jude Medical Inc. Sales, 2011-2015 (USD Billion) 209 Figure 147: St. Jude Medical Inc. Sales, By Product Segment, 2015 (%) 209 Figure 148: St. Jude Medical Inc. Sales, By Region, 2015 (%) 209 Figure 149: CryoLife Inc. Sales, 2011-2015 (USD Billion) 211 Figure 150: CryoLife Inc. Sales, By Business Segments, 2015 (%) 211 Figure 151: CryoLife Inc. Sales, By Region, 2015 (%) 211 Figure 152: LivaNova Plc Sales, By Business Group, 2015 (%) 214 Figure 153: LivaNova Plc Sales, By Region, 2015 (%) 214 Figure 154: Neovasc Inc. Sales, 2011-2015 (USD Million) 216 Figure 155: Neovasc Inc. Sales, By Region, 2015 (%) 216 Figure 156: TTK Healthcare Sales, 2011-2015 (USD Million) 218 Figure 157: TTK Healthcare Sales, By Business Segments, 2015 (%) 218 18

List of Tables Table Table Title Page Table A: Common Heart Valve Diseases, Symptoms and Causes 30 Table B: Medical Tourism Prices for Heart Valve Replacement Procedure, By Country (USD) 40 Table C: Recent Company Acquisitions In Heart Valve Devices Industry 42 Table D: Germany Healthcare Related Statistics 101 Table E: France Healthcare Related Statistics 105 Table F: Comparative Rates of Heart Valve Treatment in Various Countries (USD) 132 Table G: Cost Competitiveness Chart (% savings in other countries vs. United States) 132 Table H: Facts & Figure for Diabetes in Brazil, 2015 152 Table I: Pricing Analysis of Heart Valve Devices or Procedure in the U.S. 176 Table J: Pricing Analysis of Heart Valve Devices or Procedure in Germany and France 177 Table K: Pricing Analysis of Heart Valve Devices or Procedure in India 178 Table L: Product Benchmarking of Key Industry Players, By Procedure 181 Table M: Product Benchmarking of Key Industry Players in Heart Valve Replacement Devices, By Technique 182 Table N: Heart Valve Related Company Product Approval 195 Table O: Recent Merger, Acquisitions and Joint Venture 198 Table P: Heart Valve Related Company Product Approval 199 Table Q: Recent Merger, Acquisitions and Joint Venture Related to Heart Valve Systems 199 19

List of Tables Table Table Title Page Table R: Recent Heart Valve Related Company Product Approval 203 Table S: Recent Merger, Acquisitions and Joint Venture Related to Heart Valve Systems 203 Table T: Recent Heart Valve Related Company Product Approval 207 Table U: Recent Merger, Acquisitions and Joint Venture Related to Heart Valve Systems 207 Table V: Recent Heart Valve Related Company Product Approval 212 Table W: Recent Merger, Acquisitions and Joint Venture Related to Heart Valve Systems 212 Table X: Recent Heart Valve Related Company Product Approval 214 20

Research Methodology Research Definition Global Heart Valve Device Market Report comprises of the study of various aspects of Heart Valve Market and forecast until 2021. Global Heart Valve Devices Market has been segmented on basis of Procedure (Replacement and Repair); Replacement Procedure By Technique (Mechanical, Bioprosthetic, Transcatheter Aortic Valve Replacement (TAVR)), Repair By Technique (Surgical Devices, Balloon Valvuloplasty, Transcatheter Mitral Valve Repair (TMVR)), By Region (North America, Europe, APAC and ROW) and By Country (U.S., Canada, Germany, France, U.K., China, India, Japan, Brazil and Saudi Arabia) Data Analysis and Interpretation Our historic market trend has been figured out by various paid databases which was further triangulated with inputs and insights from industry experts, companies and stakeholders, through primary research (manufacturers, marketing managers, others). Back-of-the-Envelope calculation for the market estimation has been made through proper understanding of the market as well as future business strategies of the companies operating in the market. Azoth Analytics has conducted quantitative as well as qualitative research to gather market insights such as market sizing, market segmentation, recent trends and developments and competitive landscape. Our team has conducted extensive primary surveys by reaching out industry experts across the value chain of the global orthopeadic market. For Forecasting purpose we have accessed some of the paid databases such as Bloomberg, Reuters, Factiva, Hoovers etc. Companies Contacted: Medtronic, Edwards Lifesciences 21

Heart Valve Devices Outlook Figure 1: Heart Valve Problems and Disease Flowchart Heart Valves Types of Heart Valves Heart Valve Diseases Tricuspid Pulmonary Mitral Aortic Stenosis Mitral Valve Prolapse Heart Valve Regurgitation Aortic Aortic Mitral Mitral Tricuspid Tricuspid Pulmonary Pulmonary Source: American Heart Association 22

Global Heart Valve Devices Market Overview Global Heart Valve Devices Market boosted by the rising healthcare awareness, growing aging population and increased expenditure in healthcare sector. Figure 4: Global Heart Valve Devices Market Size, By Value, 2011-2015 (USD Million) CAGR 2011-2015 x % 2011 2012 2013 2014 2015 Source: Azoth Analytics Estimates xx 23

Global Global Heart Heart Valve Valve Replacement Replacement Devices Devices Market, Market By Value Figure13: Global Heart Valve Replacement Devices Market, By Value, 2011-2015 (USD Million) Figure14: Global Heart Valve Replacement Devices Market, By Value, Forecast, 2016-2021(USD Million) CAGR 2011-2015 x% CAGR 2016-2021 x% 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 Source: Azoth Analytics Estimates xx 24

Global Global Heart Heart Valve Valve Repair Repair Devices Devices Market, Market By Value Figure15: Global Heart Valve Repair Devices Market, By Value, 2011-2015 (USD Million) CAGR 2011-2015 x% Figure16: Global Heart Valve Repair Devices Market, By Value, Forecast, 2016-2021(USD Million) CAGR 2016-2021 x % 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 Source: Azoth Analytics Estimates. xx 25

Global Heart Valve Replacement Devices Market- By Technique Figure 17 : Global Heart Valve Replacement Devices Market Size, By Technique, 2015 (%) Figure 18 : Global Heart Valve Replacement Devices Market Size, By Technique, 2021 (%) Mechanical Valve Mechanical Valve Bioprosthetic Valve Bioprosthetic Valve TAVR TAVR xx 26

Germany Heart Valve Devices Market, By Procedure Figure 73: Germany Heart Valve Devices Market: By Procedure, By Value, 2011-2021 (USD Million) CAGR 2011-2015 Heart Valve Replacement Devices: x% Heart Valve Repair Devices: x% CAGR 2016-2021 Heart Valve Replacement Devices: x% Heart Valve Repair Devices: x% 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 Heart Valve Replacement Devices Heart Valve Repair Devices Source: Azoth Analytics Estimates xx 27

About Azoth Analytics Pvt Ltd. Azoth Analytics is a business research and analytics firm that creates in-depth research reports and provides customized research solutions and consultancy services. Verticals in which Azoth Analytics specializes include healthcare and pharmaceutical, oil and gas, retail, chemicals, automotive, FMCG, food & beverages and technology. Azoth creates comprehensive and in-depth research reports by recording, interpreting and analyzing information. Strategic market sizing and data dredging techniques include secondary research, and primary research (interviews with management personnel and industry experts). Related Reports: Global Biomaterials Market (By Type, By Application, By Region): Opportunities and Forecasts (2016-2021) - (By Material Type Polymer, Ceramic, Metal; By Application - Orthopaedic, Cardiovascular, Plastic Surgery, Wound Care); By Region-North America, Europe, APAC, ROW; By Country US, UK, Germany, Italy, Japan, China, India; Key Players Strategy, Financial Performance) Disclaimer: Azoth Analytics report information is based mainly on interviews and therefore, is subject to fluctuation. Azoth Analytics therefore, takes no responsibility for any incorrect information supplied to us by industry experts, manufacturers or users. Azoth does not warranty the completeness of the information and data. Also, analysis provided in the report are meant for customers internal use only and not for general publication or disclosure to third parties. 28