Atenolol conversion to carvedilol Coreg is one of the few meds that does not give me any side effects and works great.". "Coreg was slowly killing me and I didn't know it. I kept passing out, broke my nose, broke my back along with other injuries from just dropping. My last horrible experience was Ischemic Colitis from very low blood pressure. I was in the hospital for six days and cardiology realized my very low dose of this was dropping my BP dangerously low along with my EF dropping 15%. They switched the Coreg to Metropolol. I am no longer coughing uncontrollably, wheezing, coughing up a lot of white mucous! This was all due to Coreg! Never again!". The actual relationship between depression and beta-blockers has not been definitively established. Atenolol; chlorthalidone should be used with caution in patients with major depression. Although theorized to be less common with hydrophilic drugs such as atenolol, the potential for CNS adverse effects can occur (e.g., mental depression, fatigue). We comply with the HONcode standard for trustworthy health information - verify here. Thiazides and related diuretics have been reported to cause pancreatitis. Atenolol; chlorthalidone should be used with caution in patients with a history of pancreatitis. Thiazide diuretics and beta-blockers may worsen hypertriglyceridemia and hypercholesterolemia. The clinical implications of these effects, relative to the cardiovascular benefits of therapy, are not known. Serum cholesterol and triglyceride concentrations should be monitored periodically in hypertensive patients receiving atenolol; chlorthalidone. "I have been taking this med for 2 months and I feel horrible. I have every side effect listed besides impotence. I am going to stop taking this med with or without the doctor's blessing. I am tired of having shortness of breath and being extremely tired ALL THE TIME. I have a small TEEN and I can't not keep up. I cannot walk to my car from my office about 200 yards away. I am not doing this to myself anymore.". "I have had always had low BP and am very active. After Mitral Valve surgery, my ejection fraction (EF) was 29. I could still play tennis and lift weights even though the doctor was not sure how. He put me on Coreg to strengthen my EF, but it has no effect because lowering low BP and whatever else it supposed to do does not work. If I had high BP, maybe it would help, but it has only gone sideways or slightly down since I have been on Coreg for 6 months. I still play tennis, etc. The medicine should not be prescribed for people with Low BP in my opinion, but was told it is what is indicated for low EF.". The doctors started me on coreg and it definitely worked. 100 mg/day PO atenolol and 25 mg/day PO chlorthalidone. Peripheral vascular disease, pheochromocytoma, Raynaud's phenomenon, vasospastic angina. Atenolol; chlorthalidone is generally not recommended for use in breast-feeding women because of the potential risk of hypotension and bradycardia in the nursing infant. Neonates whose mothers receive atenolol during breast-feeding have an increased risk of hypoglycemia. Premature infants or infants with impaired renal function may be more likely to develop adverse effects. Atenolol is excreted in human breast milk at a ratio of 1.5 to 6.8 when compared to the concentration in maternal plasma. Chlorthalidone is also excreted in human milk. The American Academy of Pediatrics lists atenolol as a beta-blocker which should be given to nursing mothers with caution due to the risk for fetal cyanosis and bradycardia. Other beta-blockers that the AAP regards as usually compatible with breast feeding include labetalol, metoprolol, and propranolol; these agents may represent preferable alternatives for some patients. In general, the use of bendroflumethiazide, chlorthalidone, chlorothiazide, and hydrochlorothiazide is considered
compatible with breast-feeding by the American Academy of Pediatrics, due to lack of noted adverse effects on the nursing infant. My blood Pressure can go to 235 over 110. I have A-Fib. A Mitral Valve leak and a 4.2 bulge in my ascending Aorta. "I have using atenolol and amlodpine for 6 months now and it works for me but because of the side effects my Dr change it to carveliol 12.5mg once daily it worked also my boyfriend still read 110/75 at times 122/82 but I'm still having the side effects of pains, shortness of breath, numbness little chest fluttering tired and my internal body will be shaking.". Needless to say I was annoyed. So I quit taking my medications and said screw it. And after having taken Carvedilol for three months, I started having terrible headache (back and both sides), upset stomach (feeling nauseous) issues. I plan to ask my doctor to approve me to stop Carvedilol.". "Started on carvedilol 6.25mg 3 weeks ago. Have had serious issues with dizziness, nausea and severe pressure in the back of my head and neck. When I am laying down the pressure is not as bad but if I am trying to read anything, the pressure gets severe.". Abrupt discontinuation of any beta-adrenergic blocking agent, including atenolol, can result in the development of myocardial ischemia, myocardial infarction, ventricular arrhythmias, or severe hypertension, particularly in patients with preexisting cardiac disease. Even in hypertensive patients without overt coronary artery disease (CAD), it is prudent to taper the dosage of atenolol; chlorthalidone since CAD is common and frequently unrecognized. "Started taking carvedilol the first week of May. My EF is at 33%. In the first week I already felt a difference. Prior symptoms were chest pressure, shortness if breathe, extreme fatigue. I would say these symptoms are 80% gone now. I feel it's time to start my cardio workouts again! In two months I will have another echocariogram. Hopefully I see some improvements. Also I would like to add that in some reviews I read of people combining CoQ10 with this medicine and I am now taking it as well. I feel more energized and I feel it makes side effect of carvedilol dissipate with it.". Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Sep 4th, 2018), Cerner Multum (updated Sep 4th, 2018), Wolters Kluwer (updated Sep 3rd, 2018) and others. To view content sources and attributions, please refer to our editorial policy. AV block, bradycardia, cardiogenic shock, heart failure, pulmonary edema, sick sinus syndrome, ventricular dysfunction. Reviews for Carvedilol to treat High Blood Pressure. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Sep 4th, 2018), Cerner Multum (updated Sep 4th, 2018), Wolters Kluwer (updated Sep 3rd, 2018) and others. To view content sources and attributions, please refer to our editorial policy. I have been on coreg since that time to treat my blood pressure problems and my EF has been normal since. "Taking carvedilol for 8 weeks now. Started off fine and seemed like was the answer. Now extreme tiredness, dizzy spells, nausea and episodes of low blood pressure and heart rate. Depression is just an added bonus side effect. Ready to throw all meds in the garbage and roll the dice. 68 yrs old.". Electrolyte imbalance, hypercalcemia, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, metabolic alkalosis. I will always be on high blood pressure pills because even with a weight loss of 90 lbs since 2002, I still have high BP. "i was on atenolol for a year 25 mg prn for palpitations. Then i felt like crap without it. Started experiencing more palpitations, doc put me on it twice a day. after a bout with ED, I asked to be put on something else, doc didn't budge. I was diagnosed with mild aortic valve regurg. new doc, reluctantly switched me to coreg 12.5 2xday. No longer ED, but it makes my heart rate go from 72 w/bp 126/69 at rest to 50 with bp raised to 149/78 with that low a pulse. Horrible bouts of light-headedness, subdermal rashes that won't go
away, 50 pounds gained with even more exercise and closely monitored diet than before, and blood pressure that will not stay regulated. Never had high bp before getting on beta blockers. stay away unless absolutely necessary!!!!". "I was put on Carvedilol after a spontaneous coronary artery dissection (SCAD) as a way to lower my NEW hypertension. I had HYPOTENSION for 63 yrs now suddenly it's high. They started out on 6.25mg. I immediately had fatigue & nausea. My BP stayed up so they doubled the dose..worsening both the fatigue & the nausea as in I felt like I was pregnant nausea 24/7 and fatigue to where I could barely get out of bed and then moved to the sofa. YES!!!! I complained to my PCP & Cardiology md they DOUBLED THE DOSE again to 25mg BID. At 12 weeks I said ENOUGH. I chose quality of my life VS quantity if that was to happen&stopped the Carvedilol. Within the week I felt 100% better + my BP came down to 100/60 where I normally 'live'. AWFUL DRUG!". Because beta-blockers depress conduction through the AV node, atenolol is contraindicated in patients with severe bradycardia or advanced AV block (second or third-degree AV block) unless a functioning pacemaker is present. Betablockers should also be avoided in patients with sick sinus syndrome unless a functioning pacemaker is present. In general, atenolol should be avoided in patients with acute pulmonary edema and is contraindicated in patients with cardiogenic shock or decompensated heart failure due to systolic dysfunction. Although some beta-blockers have been used as adjunctive therapy in patients with compensated congestive heart failure, beta-blockers should be used cautiously in this patient population. In the setting of congestive heart failure due to left ventricular dysfunction, sympathetic stimulation is a vital component supporting circulatory function. The negative inotropic effects of beta-blockade may result in further depression of myocardial contractility and precipitate decompensated heart failure in these patients; however, stable patients with heart failure benefit from beta-blocker therapy. Several low dose beta-blockers (e.g., bisoprolol, carvedilol, metoprolol) have shown benefit in the treatment of hypertrophic cardiomyopathy, dilated cardiomyopathy, or Class II-IV heart failure. If atenolol; chlorthalidone is used in a patient with coexisting heart failure, low initial doses should be used and increases in dosage should be made gradually. orthostatic hypotension / Delayed / 2.0-2.0 depression / Delayed / 0.6-0.6 dyspnea / Early / 0.6-0.6 impotence (erectile dysfunction) / Delayed / Incidence not known hypoglycemia / Early / Incidence not known hyperglycemia / Delayed / Incidence not known glycosuria / Early / Incidence not known diabetes mellitus / Delayed / Incidence not known hypotension / Rapid / Incidence not known wheezing / Rapid / Incidence not known hypercholesterolemia / Delayed / Incidence Acute bronchospasm, asthma, bronchitis, chronic obstructive pulmonary disease (COPD), emphysema, pulmonary disease. Then came the tongue movements and facial movements. I was flailing my arms all over the place. Went to my Neurologist and then a second Neurologist. Both tried to tell me I had Conversion Disorder. Idiopathec they said to me. "I had dizzy spells, blepharospasms, ocular migraine and some other eye problem that made my eyes close. "While being care giver for my dying husband I rarely remembered to take BP meds. One day I felt terrible and checked my BP. It was 120/111. Trip to doc. Put on increasing doses of Carvedilol, up to 25mg twice a day with zero results. Lowest BP 147/89 usually 190/86. Do not feel this is working and have asked doctor to try something else. Problem is systolic is much higher but diastolic is not. Doctor says my heart is good and lungs clear despite having the flu. I am 82 years old. Had a stress test two years ago, which was perfect. What next? Compare all 327 medications used in the treatment of High Blood Pressure. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Atenolol; chlorthalidone should be used with caution in patients with thyroid disease because beta-blockers can mask the tachycardia that can otherwise be a useful monitoring parameter in evaluating hyperthyroidism. In addition,
rapid discontinuation of beta-blocking therapy can precipitate thyroid storm in patients with hyperthyroidism or thyrotoxicosis. However, beta-blockers are generally useful in the symptomatic treatment of hyperthyroid-related states. "I am taking generic Carvedilol for 3 days now, perhaps I should wait a week or two before I can make a fair assessment of this medication, but I felt I should start by saying that I am only on 6.25 once a day due to hypertension. Never had high blood pressure in my life even when I was pregnant and gained 105 lbs after being only 115 lbs before I got pregnant. The only things I feel as for side effects are pain in my right knee, ringing in my ears and gas. I must say that my 175/110 bp went down to 130/ 75 but does jump up during the afternoon. I am one of those people who is paradoxical meaning I get the opposite effect of every side effect. I am going to write another review after 2 weeks, but for now pretty good.". The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and ios devices. "Fine a bit of nausea and headache to start im on the lowest dose. nothing else. made my bp optimal.". Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List. 1 Clinical Research Manager, Research and Development Pharmaceuticals, UK. Summary (text) Abstract (text) MEDLINE XML PMID List CSV. J Cardiovasc Pharmacol. 1992;19 Suppl 1:S82-5. A comparison of carvedilol with atenolol in the treatment of mild-to-moderate essential hypertension. INT-CAR- 07 (U.K.) Study Group. 301.7 Antisocial p/d 301.9 Personality d/o NOS 298.9 Psychotic d/o NOS 314.0 ADHD Axis II 301.7 Antisocial p/d 301.83 Borderline p/d 301.9 Personality d/o NOS 317 Mild mental retardation. endstream endobj 6 0 obj endobj xref 0 83 0000000000 65535 f 0000025281 00000 n 0000025626 00000 n 0000026590 00000 n 0000027871 00000 n 0000027928 00000 n 0000029378 00000 n 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer. xref 21 52 0000000016 00000 n 0000001692 00000 n 0000001755 00000 n 0000002027 00000 n 0000002070 00000 n 0000002113 00000 n 0000002232 00000 n 0000002263 00000 n 0000009243 00000 n 0000009726 00000 n 0000010252 00000 n 0000010294 00000 n 0000011112 00000 n 0000011930 00000 n 0000013263 00000 n 0000018430 00000 n 0000018917 00000 n 0000019306 00000 n 0000020753 00000 n 0000022049 00000 n 0000023327 00000 n 0000024620 00000 n 0000025903 00000 n 0000027113 00000 n 0000047544 00000 n 0000067813 00000 n 0000068794 00000 n 0000074424 00000 n 0000074761 00000 n 0000074847 00000 n
0000075335 00000 n 0000080151 00000 n 0000080604 00000 n 0000081174 00000 n 0000083842 00000 n 0000089794 00000 n 0000089993 00000 n 0000090121 00000 n 0000090313 00000 n 0000100327 00000 n 0000100527 00000 n 0000100694 00000 n 0000100950 00000 n 0000101150 00000 n 0000107981 00000 n 0000108364 00000 n 0000108655 00000 n 0000111383 00000 n 0000111843 00000 n 0000112156 00000 n 0000112364 00000 n 0000001336 00000 n trailer. xref 83 44 0000000016 00000 n 0000001585 00000 n 0000001727 00000 n 0000002179 00000 n 0000002594 00000 n 0000003139 00000 n 0000003326 00000 n 0000003596 00000 n 0000004032 00000 n 0000004302 00000 n 0000004914 00000 n 0000004999 00000 n 0000005111 00000 n 0000005840 00000 n 0000005975 00000 n 0000006599 00000 n 0000007224 00000 n 0000007397 00000 n 0000007951 00000 n 0000008544 00000 n 0000009003 00000 n 0000009314 00000 n 0000009807 00000 n 0000010395 00000 n 0000011019 00000 n 0000013388 00000 n 0000017385 00000 n 0000017838 00000 n 0000018093 00000 n 0000018162 00000 n 0000018314 00000 n 0000018340 00000 n 0000018644 00000 n 0000019152 00000 n 0000019413 00000 n 0000019710 00000 n 0000019802 00000 n 0000020790 00000 n 0000021073 00000 n 0000021423 00000 n 0000024487 00000 n 0000024770 00000 n 0000001417 00000 n 0000001176 00000 n trailer. Generate a file for use with external citation management software. endstream endobj xref 6 1 0000031524 00000 n 84 1 0000031787 00000 n 127 3 0000031931 00000 n 0000032292 00000 n 0000000000 65535 f trailer. Content is in draft form, not peer reviewed. endstream endobj xref 84 1 0000037401 00000 n 130 3 0000037546 00000 n 0000037933 00000 n 0000000000 65535 f trailer. The NCBI web site requires JavaScript to function. The efficacy and safety of carvedilol, a beta-blocker with vasodilating properties, were compared at a dosage of 25 to 50 mg once daily with those of atenolol at a dosage of 50-100 mg once daily in a double-blind, randomized, parallel-group, multicenter study. After a single-blind placebo phase of 3 to 6 weeks, 47 patients (median age, 59 years) were randomized to receive carvedilol and 52 patients (median age, 57 years) were randomized to receive atenolol for an 8-week study period. Patients on carvedilol received 12.5 mg for the first 2 days and then 25 mg as a once-daily dosage. The initial dosage of atenolol was 50 mg once daily. The dosage of each treatment could be doubled (to 50 and 100 mg once daily, respectively) at week 4 if the response was inadequate. Sitting and standing blood pressures and heart rates were recorded 24 h after the dose at weeks 4 and 8. Data from 90 of 98 patients who completed the study were eligible for per-protocol analysis. Approximately one-third of the patients in each group required upward dose titration at week 4 because of inadequate response. At week 8, 84% patients receiving carvedilol and 91% receiving atenolol had sitting diastolic blood pressure less than or equal to 90 mm Hg or decreased their blood pressure by greater than or equal to 10 mm Hg (95% confidence intervals for difference between carvedilol and atenolol, +7% and -21%). Safety profiles were similar between treatments. One patient withdrew; a skin rash developed during the fourth week of treatment with atenolol.(abstract TRUNCATED AT 250 WORDS). carvedilol 12.5mg BID acebutolol 100mg BID metoprolol 50mg BID propranolol 40mg BID atenolol 50mg daily metoprolol SR 100mg daily propranolol LA (ER) 80mg daily - FDA daily max is 640mg bisoprolol 5mg daily nadolol 80mg daily - FDA daily max is 320 sotalol 80mg BID labetolol 100mg BID pindolol 5mg BID timolol 5mg BID. All Databases Assembly Biocollections BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbgap dbvar EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene Identical Protein Groups MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed PubMed Health SNP Sparcle SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBookgh UniGene. 296.2 Major Dep, single ep 296.3 Major Dep, recurrent 311.0
Depression, NOS 296.89 Bipolar II d/o 296.4 Bipolar, Manic 296.5 Bipolar, Dep 296.7 Bipolar, unspec 300.01 Panic d/o, no agora 300.02 Generalized anx d/o 300.21 Agoraphob w/ panic 300.23 Social Phobia 300.3 OCD 303 Alcohol dependence 305.0 Alcohol abuse 307.1 Anorexia 307.51 Bulimia 307.41 Insomnia, transient 308.3 Situational stress 309.81 PTSD 295.30 Schizophren, paran 295.70 Schizoaffective d/o.