International Neuromodulation Society 14th World Congress May 25-30, 2019, Preliminary Scientific Program*

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Pre-Conference Days May 25-26 International Neuromodulation Society 14th World Congress May 25-30, 2019, Preliminary Scientific Program* *Subject to change May 25 - Pre-Conference: Noninvasive Brain Stimulation May 26 - Pre-Conference: Innovations in Neuromodulation. Disruptive Innovation: The Driving Force of Progress in Neuromodulation May 26-2019 NSANZ and INS Cadaver Workshop

18:00-19:30 Sunday, May 26 2019 INS Opening Reception in the Exhibition Area 08:00-11:30 Opening Plenary Session 08:00-08:30 08:30-08:50 08:50-09:15 09:15-09:40 Monday, May 27 2019 Welcome and INS Leadership Message Novel Model of Brain Function Non-Surgical Deep Brain Stimulation A Critical Analysis of Clinical Trials in Neuromodulation 09:40-10:00 Late Breaking Research 10:00-10:25 10:30-10:50 Late Breaking Research 10:50-11:10 Late Breaking Research 11:10-11:30 Late Breaking Research 11:30-12:20 Oral Poster Presentations Five Best Abstracts 11:30-11:40 1 11:40-11:50 2 11:50-12:00 3 12:00-12:10 4 12:10-12:20 5 12:30-14:30 Lunch, Posters & Exhibits Break, Posters & Exhibits Lunch Symposium (12.30-13:30)

14:30-16:00 14:30-14:45 14:45-15:00 15:00-15:15 15:15-15:30 15:30-15:45 Breakout 1 - Improving Delivery of Neuromodulation What is on the Horizon for Stimulation Patterning? Adding Objective Markers to Spinal Cord Stimulation Assessments Common Research Questions for SCS Research and How to Answer them Systematic Troubleshooting Intrathecal Delivery Systems: Emerging Tools Animal models of Paresthesia based-scs and Sub-perception- SCS and clinical correlates Breakout 2 - Brain Neuromodulation Adaptive Stimulation in Deep Brain Stimulation Rhythms of the Brain Monday, May 27 2019 Deep Brain Stimulation for Obesity Deep Brain Stimulation for Eating Disorders Deep Brain Stimulation for Addiction 15:45-16:00 Discussion Discussion Discussion 16:00-16:30 Break, Posters & Exhibits Breakout 3 - Cardiovascular Neuromodulation Overview of Outcomes of Neuromodulation in Cardiac Diseases Extra-Cardiac Stimulators: What do Physicians Need to Know? 3 Basic Mechanisms of Vagal Modulation in Cardiac Diseases Basic Mechanisms of Spinal Cord Stimulation in Cardiac Diseases Indications and Future of Neuromodulation for Cardiac and Vascular Disease

Monday, May 27 2019 16:30-18:20 Oral Poster Presentations Moderator: Moderator: Moderator: 16:30-16:40 1 1 1 16:40-16:50 2 2 2 16:50-17:00 3 3 3 17:00-17:10 4 4 4 17:10-17:20 5 5 5 17:20-17:30 6 6 6 17:30-17:40 7 7 7 17:40-17:50 8 8 8 17:50-18:00 9 9 9 18:00-18:10 10 10 10 18:10-18:20 11 11 11 18:20-18:30 18:30-19:30 Short Break to Change Halls Young Neuromodulators' Reception

Tuesday, May 28 2019 Breakfast Symposium 08:30-11:30 08:30-09:00 09:00-09:30 Plenary Session Neuromodulation Centers of Excellence Progress in Brain Machine Interface 09:30-10:00 Intraspinal Stimulation 10:00-10:25 Allied Health Workshop on Neuromodulation Nurses, psychologists, physiotherapists Break, Posters & Exhibits 10:30-11:00 11:00-11:30 11:50-12:30 12:30-14:30 Neuromodulation for Visceral Pain Perspectives of Gastrointestinal Neuromodulation INS General Assembly of Members Lunch, Posters & Exhibits Lunch Symposium (12:30-13:30)

Tuesday, May 28 2019 14:30-16:00 Breakout 1 - Basal or Non-Basal: Intrathecal Regimens for 2019 Breakout 2 - Deep Brain Stimulation for Pain Breakout 3 - New Developments in Neuromodulation for Gastrointestinal Conditions 14:30-14:45 Tailoring Intrathecal Therapy to Match Your Patient's Needs Stimulation of the Accumbens Region New Methods and Applications Using the Science Underlying GI Neuromodulation: Low and High Resolution Mapping 14:45-15:00 Challenges for Bolus only Therapy Cingulate Stimulation New Approaches to Upper Gut Stimulation 15:00-15:15 15:15-15:30 Functional Improvement with Continuous Intrathecal Morphine Infusion in Chronic Non-Cancer pain Are Side Effects Associated with the Long-Term Usage of Intrathecal Drug Delivery so Frightful? Deep Brain Stimulation for Pain: Pro and Con Motor Cortex Stimulation for Pain and Related Conditions: Pro and Con Neuromodulation for Inflammatory Bowel Disease New Applications for Mid Gut Stimulation for Metabolic Disorders: GI Stimulation for Diabetes and Obesity 15:30-15:45 The Economics of Cancer Related Pain: New Data to Support use of New Neuromodulation Therapies for Colonic Disorders 15:45-16:00 Novel Intrathecal Analgesics in Cancer Pain Discussion Discussion 16:00-16:30 Break, Posters & Exhibits

16:30-18:20 16:30-16:40 1 1 1 16:40-16:50 2 2 2 16:50-17:00 3 3 3 17:00-17:10 4 4 4 17:10-17:20 5 5 5 17:20-17:30 6 6 6 17:30-17:40 7 7 7 17:40-17:50 8 8 8 17:50-18:00 9 9 9 18:00-18:10 10 10 10 18:10-18:20 11 11 11 18:20-18:30 18:30-19:30 Tuesday, May 28 2019 Oral Poster Presentations Short Break to Change Halls International Women in Neuromodulation Reception

08:00-08:30 Breakfast Symposium 08:30-11:30 08:30-09:00 09:00-09:30 Plenary Session Sources of Bias in Randomized Controlled Trials of Neuromodulation and Advice on Mitigation Current Concepts and Evidence in Neuromodulation for Headache Wednesday, May 29 2019 09:30-10:00 Prospective 12 Month Outcomes of Multi-Center Trials of 10 khz Spinal Cord Stimulation in the Treatment of Arm and Neck Pain (Australian & North American Centers) 10:00-10:25 Current State of Battery-Free 10:30-11:00 Systems 11:00-11:30 Late Breaking Research Giant of Neuromodulation Award Awarded to: Break, Posters & Exhibits 11:30-12:20 12:30-14:30 Michael Cousins, MD DSc FANZCA FFPMANZCA FAChPM(RACP) FAICD Richard North, MD Lunch, Posters & Exhibits Lunch Symposium (12:30-13:30)

Wednesday, May 29 2019 14:30-16:00 14:30-14:45 Breakout 1 - Neuromodulation for Pain: Sensing and Feedback What Should a Neuromodulation Device Measure? Breakout 2 - Neuromodulation for Neuro- Rehabilitation and Stroke Neuromodulation for Neurorehabilitation of Motor Disorders for Stroke and Spinal Cord Injury: An Overview Breakout 3 - Under the Hood: Mechanisms of Action Aspects Beyond the Gate 14:45-15:00 15:00-15:15 15:15-15:30 Using Wearable Sensors and Implantable Neuromodulation Devices to Measure Function Physiological Sensing in Deep Brain Stimulation Feedback Stimulation of the Dorsal Columns Noninvasive Brain Stimulation for Stroke Invasive Brain Stimulation for Stroke Spinal Cord Stimulation for Spinal Cord Injury Burst and High Frequency Stimulation: Mechanisms of Action Role of ECAPS in Understanding Spinal Cord Stimulation Action Microglial Modulation in Neural Stimulation 15:30-15:45 Long-term Outcomes from the Noninvasive Brain Stimulation for Avalon Study: A prospective Spinal Cord Injury Multicenter Study Evaluating Closed-Loop SCS in the Treatment of Chronic Back and Leg Pain Deep Brain Stimulation Mechanism of Action Review 15:45-16:00 Discussion Discussion Discussion 16:00-16:30 Break, Posters & Exhibits

16:30-18:20 Wednesday, May 29 2019 Oral Poster Presentations 16:30-16:40 1 1 1 16:40-16:50 2 2 2 16:50-17:00 3 3 3 17:00-17:10 4 4 4 17:10-17:20 5 5 5 17:20-17:30 6 6 6 17:30-17:40 7 7 7 17:40-17:50 8 8 8 17:50-18:00 9 9 9 18:00-18:10 10 10 10 18:10-18:20 11 11 11

08:00-10:00 Pyrmont Theatre Meeting Room C4.4 Meeting Room C4.5 Meeting Room C2.3 Breakout 1 - New Targets, New Diseases Thursday, May 30 2019 Breakout 2 - Advances in Neuromodulation for Refractory Epilepsy Breakout 3 - Neuromodulation for Pelvic Organ Motility Disorders Special Session Neuromodulation in Asia 08:00-08:15 The Case for Cordotomy vs. Neuromodulation for Cancer Pain Neurobiology of Neuromodulation of Epilepsy Complications Associated with Sacral Neuromodulation 08:15-08:30 08:30-08:45 08:45-09:00 09:00-09:15 09:15-09:30 Sphenopalatine Ganglion Stimulation Therapy: Procedural Challenges Treatment of Refractory Chronic Migraine: Results from a Feasibility Study The Approaches in Peripheral Nerve Stimulation of Brachial Mechanisms of Action of Dorsal Root Ganglion Stimulation for Pain State of the Art Review of Dorsal Root Ganglion Stimulation Neuro-Anatomy Relevant to Neuromodulation for Epilepsy Responsive Vagal Nerve Stimulation Responsive Deep Brain Stimulation Hippocampal Deep Brain Stimulation Targeting in Deep Brain Stimulation for Epilepsy Sacral Neuromodulation for the Treatment of Urinary Bladder Dysfunction: Mechanism of Action and Future Directions Standardization in Sacral Neuromodulation Technique Designing the Ideal Study in Sacral Neuromodulation Sacral Neuromodulation for Pelvic Pain and Pelvic Organ Dysfunction Updates in Percutaneous Tibial Neuromodulation 09:30-09:45 New Indications for Dorsal Root Experience of Deep Brain Pudendal Stimulation Ganglion Stimulation Stimulation for Epilepsy 09:45-10:00 Discussion Discussion Discussion Discussion 10:00-10:25 Break, Posters & Exhibits

Thursday, May 30 2019 Pyrmont Theatre Meeting Room C4.4 Meeting Room C4.5 Meeting Room C2.3 10:30-11:20 Oral Poster Presentations Special Session Neuromodulation in Asia 10:30-10:40 1 1 1 10:40-10: 50 2 2 2 10:50-11:00 3 3 3 11:00-11:10 4 4 4 11:10-11:20 5 5 5 Discussion 11:20-11:30 Short Break to Change Halls 11:30-13:20 11:30-12:00 12:00-12:30 12:30-13:00 13:00-13:30 Closing Plenary Session: The Future? Why Optimizing your Vagal Nerve will Become Routine Big Data Use in Neuromodulation Transcranial Stimulation for a Smarter You Imagining the Artificial Intelligence- Enhanced Human 13:30 Congress Adjourns