Cardiometabolic Risk and Cardiomyopathies

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Cardiometabolic Risk and Cardiomyopathies April 19-21, 2018 Hotel Royal Continental, Via Partenope Napoli, Italy President of the meeting: Prof. Bruno Trimarco CONSORZIO FORMAZIONE MEDICA PROVIDER STANDARD NAZIONALE - ID33 With an unrestricted grant by

INTRO SPEECH I would like to extend my warm welcome to all faculty and participants to the International Symposiumon Cardiometabolic risk and cardiomyopathies. The fil rouge of the Symposium is the holistic approach to the patient at risk or with incident cardiomyopathies. Over the last decades we ve witnessed an exponential growth of what was initially not more than a sub-discipline of General Internal Medicine. Today, Cardiology stands alone encompassing multiple sub-disciplines that have referred the diagnosis and treatment of patients with cardiomyopathies to super-specialized professionals. Without dismissing the paramount achievements in Cardiology, I believe there comes a moment when we need to zoom out and gather a global appraisal of the wealth of information to ultimately treat the patient as a whole. This Symposium provides the unique opportunity to overview the latest clinical evidence, novel diagnostic strategies and cutting-edge therapies without loosing focus on patient s expectations in quality and quantity of life. In other words, by dwelling in the past, we might better enter the doors of the future. Prof. Bruno Trimarco

UNDER THE AUSPICES OF Società Italiana dell Ipertensione Arteriosa Lega Italiana contro l Ipertensione Arteriosa President of the Meeting: Prof. Bruno Trimarco Full Professor of Cardiology Chief of Department of Cardiovascular Emergencies, University FEDERICO II, Naples. Scientific & Organizing Secretariat Consorzio Formazione Medica P.zza San Camillo De Lellis,1 20124 Milano (Italy) Phone: +39 02 29534735 Fax: +39 02 29401674 E-mail: segreteriaecm@coformed.it Website: www.coformed.org With an Unrestricted Grant by Fondazione Internazionale Menarini Centro Direzionale Milanofiori 20089 Rozzano (Milan, Italy) Edificio L - Strada 6 Phone: +39 02 55308110 Fax: +39 02 55305739 E-mail: milan@fondazione-menarini.it Website: www.fondazione-menarini.it

Scientific Programme Thursday, April 19 th, 2018 13.30-14.15 Registration and entry test 14.15-14.30 Introductory notes 14.30-15.00 First Lecture Introduction: Luigi Frati (Rome, I) Massimo Volpe (Rome, I) The role of the renin-angiotensin system in the pathogenesis of cardiomyopathies and heart failure 15.00-15.30 Second Lecture Introduction: Domenico Bonaduce Marco Metra (Brescia, I) Direct-acting oral anticoagulants: a new frontier for prevention of cardiovascular events 15.30-16.00 Coffee Break 16.00-17.45 Session I Cardiomyopathy: from bench to bedside 16.00-16.05 Chairpersons: Giuseppe Lembo (Rome, I) Guido Iaccarino (Salerno, I) 16.05-16.25 Gianluigi Condorelli (Milan, I) Epigenetic mechanisms in cardiovascular diseases 16.25-16.45 Daniela Carnevale (Rome, I) Neuroimmune mechanisms in cardiovascular diseases 16.45-17.05 Tomasz Guzik (Glasgow, UK) Perivascular inflammation in hypertension and atherosclerosislocal or systemic phenomenon? 17.05-17.25 Jean Luc Balligand (Brussels, B) Not the usual business; adrenergic regulation of cardiac function through the NOS system 17.25-17.45 Discussion 17.45-18.45 Session II Metabolic Risk Factors and Cardiomyopathies 17.45-17.50 Chairpersons: Giuseppe Paolisso Paolo Calabrò 17.50-18.10 Claudio Ferri (L Aquila, I) Uric acid metabolism 18.10-18.30 Giovambattista Desideri (L Aquila, I) Uric acid as a prognostic marker 18.30-18.45 Discussion 18.45-19.00 Closing Remarks

April 19-21, 2018 Hotel Royal Continental Scientific Programme Friday, April 20 th, 2018 8.45-10.30 Session III Risk factors and co-morbidities: Holistic approach to the patient with cardiomyopathy 8.45-08.50 Chairpersons: Carmine Vecchione (Salerno, I) Carmine Morisco 8.50-9.10 Junichi Sadoshima (Newark, USA) Molecular mechanisms of diabetic cardiomyopathy 9.10-9.30 Silvia Priori (Pavia, I) Mechanisms and prognostic value of ventricular arrythmias in cardiomyopathy 9.30-9.50 Antonio Cittadini Endocrine homeostasis and cardiac function: role of the Growth Hormone in the failing heart 9.50-10.10 Gaetano Santulli Targeting intracellular calcium in clinical scenarios 10.10-10.30 Discussion 10.30-11.00 Coffee Break 11.00-11.30 Third Lecture Introduction: Pasquale Perrone Filardi Wolfram Zimmermann (Goettingen, D) Cardiac tissue engineering: back to the future 11.30-12.50 Session IV Non-invasive diagnostic cardiovascular imaging 11.30-11.35 Chairpersons: Maurizio Galderisi Nicola De Luca 11.35-11.55 Maria Lorenza Muiesan (Brescia, I) Cardiac target organ damage in arterial hypertension 11.55-12.15 Roland Asmar (Paris, F) Update on the technology for arterial evaluation 12.15-12.35 Juan Carlos Plana (Houston, USA) Cardiotoxicity cardiomyopathies in oncology patients 12.35-12.50 Discussion 12.50-14:00 Lunch Buffet 14.00-15.45 Session V Ischemic cardiomyopathy 14.00-14.05 Chairpersons: Emanuele Barbato Eugenio Stabile 14.05-14.25 William Wijns (Galway, IRL) Definition and management of chronic ischemic cardiomyopathy 14.25-14.45 Francesco Cosentino (Stockholm, S) Diabetic cardiomyopathy: the role of epigenetics

Cardiometabolic Risk and Cardiomyopathies 14.45-15.05 Alberto Cuocolo Imaging assisted management of patients with ischemic severe left ventricle dysfunction 15.05-15.25 Raffaele Piccolo Revascularization strategies in patients with ischemic left ventricular systolic dysfunction 15.25-15.45 Discussion 15.45-16.15 Coffee break 16.15-17.15 Lectures Introduction: Francesco Rossi, Claudio Borghi (Bologna, I) 16.15-16.45 Fourth Lecture Joseph A. Hill (Dallas, TX, USA) Heart failure with preserved ejection fraction: an expanding epidemic 16.45-17.15 Fifth Lecture Giuseppe Mancia (Milan, I) One Step Below: New Blood Pressure Targets in the Guidelines for High Blood Pressure Management 17.15-18.15 Session V Contemporary trends in valvular heart disease treatment Chairpersons: Giovanni Esposito Plinio Cirillo 17.15-17.45 Sixth Lecture Francesco Romeo (Rome, I) Pathophysiology, classification and epidemiology of heart valve disease 17.45-18.15 Seventh Lecture Robert O. Bonow (Chicago - IL, USA) Guidelines recommendations for management of aortic stenosis 18.15-18.35 Roberto Di Bartolomeo (Bologna, I) Present and future of valve surgery and surgeons 18.35-18.55 Giuseppe Tarantini (Padua, I) Trans-catheter heart valve therapy: from innovation strategy to mainstream therapy 18.55-19.05 Discussion 19.05-19.15 Closing Remarks

April 19-21, 2018 Hotel Royal Continental Scientific Programme Saturday, April 21 st, 2018 8.30-10.30 Session VI Perspectives in Cardiomyopathies 8.30-08.35 Chairpersons: Cinzia Perrino Antonio Rapacciuolo 8.35-8.55 Renato Pietro Ricci (Rome, I) Heart failure management: emerging role of remote control of implantable devices 8.55-9.15 Daniele Catalucci (Milan, I) Nanotechnology applications in cardiomyopathies 9.15-10.00 Discussion 10.00-11.30 Lectures Introduction: Giovanni De Simone Paolo Golino 10.00-10.30 Eight Lecture Giuseppe Ambrosio (Perugia, I) Oxidative stress to regulate cardiac function 10.30-11.00 Ninth Lecture Gianni Marone The Resurrection of Mast Cells in Cardiovascular Diseases 11.00-11.30 Tenth lecture James Thomas (Chicago, USA) Advanced echocardiography: The role of strain imaging 11.30-12.15 Discussion 12.15-12.45 Coffee Break 12.45-13.45 Lectures Introduction: Cinzia Perrino Raffaella Lombardi 12.45-13.15 Eleventh lecture Vera Regitz-Zagrosek (Berlin, D) Translational aspects of sex differences in cardiomyopathies 13.15-13.45 Twelfth lecture Ali J Marian (Houston - TX, USA) Genetics and genomics of cardiomyopathies 13.45-14.30 Discussion 14.30-15.00 Closing Remarks 15.00-15.15 CME Questionnaire

GENERAL INFORMATION Meeting venue The venue for the Meeting will be HOTEL ROYAL CONTINENTAL Via Partenope 38-44 Napoli (Italy) Secretariat during the Meeting The Secretariat will be open at the following times: Thursday, April 19 2018, from 13:00 a.m. to 19.30 p.m. Friday, April 20 2018, from 8:00 a.m. to 20.00 p.m. Saturday, April 21 2018, from 8.00 a.m. to 14:00 p.m. Official language The official language of the Meeting will be English. Simultaneous translation will be provided. Registration The Meeting is free to attend. Please confirm the participation to the Organizing Secretariat Provider ECM e Segreteria Organizzativa CONSORZIO FORMAZIONE MEDICA PROVIDER STANDARD NAZIONALE - ID33 Provider with E.C.M. Standard Accreditation No 33 Training event No 33-220199 Registration for training credits (No 12,6) is limited to a number of 180 participants. At the time of registration participants must provide personal tax code and fill in the registration form. The actual participation to the training event will be electronically detected by badge(at the entrance, during and at the end of each of the two days of the course). This CME event will be held in Naples from the 19 th to 21 th of April 2018. The event will be reserved to the following disciplines: Cardiology, Diabetology, Endocrinology & Metabolism, Family Practice (GP s), Geriatric Medicine, Internal Medicine, Nephrology. No registration fee is required. Technical facilities Facilities will be available for computer presentations and overhead projections. A business center with PC (Powerpoint for Windows) will be available for check and preview of presentations. It is essential that speakers take their presentation to the business center at least one hour before the session starts. The center will be open at the following times: Thursday April 19 2018, from 12:00 a.m. to 19.30 p.m. Friday April 20, from 8:00 a.m. to 20.00 p.m. Saturday, March 3rd 2018, from 8.00 a.m. to 14:00 p.m. Lunches and coffee breaks Lunches and coffee breaks will be served in the Meeting area. Menarini Foundation Simposia n 384