CALL FOR PROPOSALS Imprvement in tuberculsis screening, treatment and preventin Reference: AP-5PC 2018 03-RO THIS CALL FOR PROPOSALS WILL CLOSE ON 26/10/2018 AT 12:00 (UTC+1) 1. INTRODUCTION The 5% Initiative is the secnd mechanism fr France s cntributin t the Glbal Fund t Fight AIDS, Tuberculsis and Malaria (GF). The peratinal implementatin f this Initiative has been entrusted t Expertise France (the French Agency fr Internatinal Technical Expertise) under the supervisin f the Ministry fr Eurpe and Freign Affairs (MEAE). Its aim is t respnd t requests fr high-level technical expertise frm cuntries, especially French-speaking cuntries, and beneficiaries f GF grants t assist them and build their capacities fr the design, implementatin, mnitring-evaluatin and measurement f the impact f the grants allcated by the GF. The 5% Initiative is implemented in cmplementarity with GF prgrammes and aims t enhance their efficiency and health impact via tw means f interventin: sending technical expertise at the request f cuntries, financing lng-term prjects which aim t strengthen the impact f the Glbal Fund s actins. In 2018, the 5% Initiative is launching a Call fr Prjects which aims t finance specific peratinal research prjects t supprt Glbal Fund prgrammes. It will be implemented every year starting in 2018. 2. CONTEXT 1 Fllwing the glbal interministerial cnference Ending Tuberculsis in the cntext f the Sustainable Develpment Gal Era A Multisectral Respnse, 2 which was successfully held in Mscw in Nvember 2017, n 26 September 2018, the United Natins General Assembly will hld the 1 st high-level meeting with the aim f speeding up effrts t end tuberculsis. During this meeting, entitled United t end tuberculsis: An urgent glbal respnse t a glbal epidemic, Heads f States and Gvernment are expected t make an ambitius declaratin which will strengthen actins and investments t end tuberculsis at wrld level. 3 WHO estimates that 10.4 millin peple develped tuberculsis wrldwide in 2016. Amng them, 1 millin cases (10%) cncerned peple living with HIV and 1 millin children. The glbal ttal fr 2016 als cmprised 490,000 cases f multi-drug resistant tuberculsis and 100,000 cases f rifampicin-resistant tuberculsis. In the same year, tuberculsis caused 1.8 millin deaths, hitting in particular 390,000 HIV-psitive peple and sme 250,000 patients with multi-drug resistant tuberculsis r rifampicin-resistant tuberculsis, and 253,000 children. These figures make tuberculsis the mst fatal infectius disease in the wrld, causing a higher number f deaths than HIV/AIDS r malaria, and ne f the ten main causes f death in 2015. 1 Fr further infrmatin n the cntextual elements related t the strategy f the Glbal Fund fr 2017-2022, please refer t https://www.theglbalfund.rg/en/strategy/ and Appendix 8. 2 http://www.wh.int/cnferences/tb-glbal-ministerial-cnference/en/ 3 http://www.wh.int/news-rm/events/un-general-assembly-high-level-meeting-n-ending-tb 1
Despite the unquestinable prgress in cntrl prgrammes, with a decline in incidence and mrtality which allwed the achievement f the Millennium Develpment Gals in 2015, glbal effrts t fight against the disease remain insufficient t achieve the gals f the End Tuberculsis strategy adpted by the Wrld Health Assembly in 2014. The bjective fr 2030 is t reduce mrtality by 90%, reduce the incidence f the disease by 80% and achieve a zer rate f families affected by tuberculsis facing catastrphic csts. Ending the tuberculsis epidemic is ne f the targets f the Sustainable Develpment Gals, which requires cnducting a set f bimedical, sciecnmic, public health and cmmunity interventins, which ften extend beynd the health sectr, as well as decisive prgress in the field f research and innvatin t speed up the decline in glbal tuberculsis incidence rates. Majr difficulties remain in the fight against the epidemic, which include the number f mitted cases (nn-screened r nt ntified/reprted t natinal r supranatinal surveillance systems), estimated at ver 4 millin in 2016, the multi-drug resistant tuberculsis crisis, the inadequacy f the respnse t the cepidemic f tuberculsis and HIV infectin, the catastrphic csts fr TB patients, the slwness in adpting the new tls, and the majr shrtcmings cncerning service prvisin and the scaling up f the technlgical innvatins f the past ten years, as well as the lw number f cmmunity actrs. In terms f peratinal research, the pririty is t help cuntries implement innvative strategies t imprve access t and the prvisin f TB diagnsis, treatment and preventin services, and prmte the scaling up and use f new tls, in relatin t the glbal plicy fr universal health cverage. In this cntext, in rder t make the best pssible cntributin t strengthening the activities cnducted by the Glbal Fund fr pverty-related diseases, and in line with the bjectives f France s Glbal Health Strategy: 2017-2021, 4 this Call fr Prjects by the 5% Initiative will finance peratinal research prjects which aim t enhance the effectiveness f the fight against tuberculsis, in the fields f screening, treatment and preventin. As with all its ther activities, this Call fr Prpsals launched by the 5% Initiative is intended t be cmplementary t the investments made by the Glbal Fund and will finance prjects cncerning pririty thematic areas in the cntext f the fight against pulmnary tuberculsis. The ttal cumulative amunt f the Call fr Prpsals AP-5PC-2018-03-RO stands at apprximately EUR 4 millin. 4 https://www.diplmatie.guv.fr/img/pdf/fiche_reperes_sante_mndiale_cle89ea7b.pdf 2
3. PURPOSE OF THIS CALL FOR PROPOSALS This Call fr Prpsals is being launched with the bjective f selecting peratinal research prjects that aim t strengthen the fight against tuberculsis in the cntext f Glbal Fund grants in the fllwing fields: Imprvement in tuberculsis screening and treatment (all frms) in the general ppulatin and risk grups, including the ptimal use f new tls fr the diagnsis and setting up f a curse f treatment; Optimisatin f the setting up and use f shrt-term multi-drug resistant tuberculsis regimens; Definitin f the best strategies fr screening latent tuberculsis infectin in the families f TB patients and risk grups (children, peple living with HIV) by linking them t a cmplete and effective curse f prphylaxis; In the general cntext f health services, the develpment f innvative strategies aiming at imprving the integratin f early screening, tuberculsis treatment and preventin in HIV/AIDS prgrammes and maternal, child and adlescent health prgrammes. It shuld be nted that the chice f this thematic area in 2018 is nt an indicatr f the future and that the Steering Cmmittee encurages peratinal research prjects designed t identify and test innvative strategies t imprve the quality f integrated services fr early screening, and HIV/AIDS and tuberculsis care and preventin in mther and child care. DEFINITIONS FOR THIS CALL FOR PROPOSALS: Definitin f peratinal research: Accrding t the guide prepared by WHO, TDR and the Glbal Fund, Any research prducing practicallyusable knwledge (evidence, findings, infrmatin, etc.) which can imprve prgram implementatin (e.g., effectiveness, efficiency, quality, access, scale-up, sustainability) regardless f the type f research (design, methdlgy, apprach) falls within the bundaries f peratins research. 5 Generally speaking, peratinal research (OR) is cnducted with the aim f: 1) Imprving the quality and perfrmance f prgrammes by using scientifically valid methds; 2) Assessing the feasibility, efficiency and impact f new strategies r peratins in the ppulatin; and 3) Prducing, cllecting and analysing the data required fr the develpment f public health recmmendatins n the use f a given peratin. In all cases, the capacity required t cnduct OR prjects will need t take int accunt the brader cntext f cuntries which may lack resurces, as well as technical structures able t cnduct a cncerted research strategy, r t prepare requests fr OR assistance in the cntext f the Glbal Fund grant (including the cnsultatin and crdinatin mechanisms f the scientific cmmunity n the identificatin f research pririties). TYPES OF ELIGIBLE PROJECTS: Varius types f prjects may be submitted: 5 Framewrk fr Operatins and Implementatin Research in Health and Disease Cntrl Prgrams. http://www.wh.int/hiv/pub/peratinal/r_framewrk.pdf 3
1. Imprvement in tuberculsis screening and treatment (all frms) in the general ppulatin and risk grups, including the ptimal use f new tls fr the diagnsis and setting up f a curse f treatment. In this cntext, it is prpsed t supprt peratinal research prjects that aim t test innvative, decentralised and practical strategies which are apprpriate fr scaling up and cst-efficient, in rder t screen and identify patients suffering frm all frms f tuberculsis (including children and PLWHIV), at all levels f the health system, and place them under apprpriate treatment. Pririty will be given t prjects that integrate and ptimise the link between diagnsis and treatment. Prjects t imprve tuberculsis screening and treatment may, fr example, target: The identificatin and validatin f the best algrithms integrating existing tests and innvative tests t imprve the diagnsis f the varius frms f tuberculsis depending n the tests available at the varius levels f the health system (micrscpy, sputum culture, Xpert MTB/RIF test, rapid mlecular tests, radigraphy, including cmputer-aided diagnsis). The develpment f strategies facilitating access t diagnsis tests fr any persn with signs r symptms f tuberculsis r at risk f develping tuberculsis (children, PLWHIV, cntacts f TB patients, prisners, migrants), taking natinal cntexts int accunt and encuraging cmmunity participatin and the cmmitment f the private sectr and assciatins. The investigatin f the effectiveness f the varius frms f peratins aiming at imprving cmpliance with the treatment, particularly the mst effective peratins t supprt the patient and supervise the treatment and best suited t ppulatins in lw r middle-incme cuntries, including the new digital health methds. 2. Optimisatin f the setting up and use f shrt-term multi-drug resistant tuberculsis regimens. Since 2016, WHO has recmmended fr patients with multi-drug resistant tuberculsis r rifampicinresistant tuberculsis the pssibility f using a treatment regimen f 9 t 12 mnths (the shrt treatment regimen) prvided they d nt have a resistance t ther secnd-line anti-tuberculsis agents (flurquinlnes and/r injectables agents) r d nt meet ther exclusin criteria. In these cases, a lng treatment regimen (individualised) f at least 20 mnths, cmprising at least five effective anti-tuberculsis agents during the intensive phase and fur anti-tuberculsis agents during the maintenance phase, is recmmended. At least 35 cuntries have intrduced shrt treatment regimens fr the treatment f multidrug resistant tuberculsis. With regard t peratinal research, it is imprtant t imprve strategies fr the integratin and scaling up f the prgrammatic management f multi-drug resistant TB, including these shrt treatments. Prjects may, fr example, target: The develpment f strategies t set up and mnitr shrt-term multi-drug resistant tuberculsis regimens and their integratin int prgrammes t treat multi-drug resistant tuberculsis alngside ther treatment regimes, including the use f new drug resistance tests; A study n the cst-effectiveness rati and impact f these regimens n the expansin f multi-drug resistant TB treatment, the number f patients treated and the quality f life f treated patients; An assessment f the efficiency and security f the shrt-term multi-drug resistant tuberculsis treatment in grups f specific patients fr example, children, PLWHIV and patients with extrapulmnary TB and in places where there is a high level f prfund resistance t drugs ther than flurquinlnes and injectable agents (fr example, pyrazinamide, ethinamide r high-level resistance t isniazid); An investigatin f the pssibilities f mdifying the shrt-term treatment f multi-drug resistant TB in rder t imprve its effectiveness and security, fr example, by replacing injectable drugs with 4
ther less txic and mre effective drugs. 3. Definitin f the best strategies fr screening latent tuberculsis infectin in the families f TB patients and risk grups (children, peple living with HIV) by linking them t a cmplete and effective curse f prphylaxis. Ensuring universal access t the preventin f the disease fr vulnerable peple, r thse expsed t the infectin r the disease, is a key cmpnent f the strategies prpsed at wrld level t end HIV/AIDS and tuberculsis. In additin t the peple cnventinally designated at risk and in need f a chemprphylaxis f tuberculsis, 6 the new WHO guidelines (2018) recmmend extending the screening and treatment f latent tuberculsis infectin (LTBI) t all persns ver the age f 5 in dmestic cntact with a persn with pulmnary tuberculsis, wh have nt been fund t have active tuberculsis, as well as t the cntacts f patients with multi-drug resistant tuberculsis under certain cnditins. 7 The standard treatment is 6 mnths f isniazid mntherapy. The new WHO guidelines als recmmend the weekly cmbinatin f rifapentine + isniazid fr 3 mnths as a preventive treatment fr adults and children in cuntries where there is a high incidence f tuberculsis. In prgrammatic terms, it is imprtant t manage adverse events, prvide assistance t ensure there is better cmpliance with treatment, and set up mnitring and evaluatin systems based n standardised indicatrs. Tls t supprt the mnitring and evaluatin are encuraged (WHO has develped a mbile phne applicatin t supprt the prgrammatic management f LTBI). The prjects may, fr example, target: The definitin f the best algrithms t rule ut the diagnsis f active TB befre giving a preventive treatment. The perfrmance and feasibility f the algrithms prpsed in the WHO guidelines need t be assessed, particularly in children and pregnant wmen; An imprvement in the perfrmance f LTBI diagnsis tests in ppulatins at risk, with a fcus n the best way f using the available tls fr example, a cmbined r sequential use f the tuberculin test and tests t detect gamma interfern prductin (IGRA); The determinatin f the best strategies fcused n the patient and their family t identify peple wh are expsed t tuberculsis and need t have preventive chemtherapy, in rder t prmte the setting up f and adherence t treatments and their cmprehensive mnitring; The prductin f reliable data n the efficiency f peratins t imprve cmpliance with treatment, which are specific and adapted t the epidemilgical and prgrammatic cntext, including risk grups and taking int accunt the health system infrastructure; The definitin f the best service prvisin mdels t ensure that peple in need f chemprphylaxis are apprpriately and fully managed in husehlds (cntacts) and in the cmmunity (PLWHIV), thrugh apprpriate targeted peratins (including mnitring and evaluatin) under prgramme cnditins. 6 Peple living with HIV and children under the age f five wh are dmestic cntacts r cntacts clse t peple with tuberculsis and fr which it is determined, fllwing an apprpriate clinical examinatin, that they d nt have active tuberculsis but a latent tuberculsis infectin (LTBI). 7 Latent tuberculsis infectin: updated and cnslidated guidelines fr prgrammatic management. Geneva: Wrld Health Organizatin; 2018 (WHO/CDS/TB/2018.4) (http://apps.wh.int/iris/bitstream/handle/10665/260233/9789241550239-eng.pdf;jsessinid=9a5133f378d 172D22981BCC52A9E7EB1?sequence=1) 5
4. In the general cntext f health services, the develpment f innvative strategies aiming at imprving the integratin f early screening, tuberculsis treatment and preventin in HIV/AIDS prgrammes and maternal, child and adlescent health prgrammes. Integrated service delivery has the ptential f imprving the availability, quality and effectiveness f the health system and can be a key enabler fr imprving the health f ppulatins affected by HIV and tuberculsis. Pregnant wmen, the newbrn and children under the age f 5 are a risk grup fr these diseases. The effective delivery f integrated services t ppulatins at risk may be difficult and cmplex t evaluate in rder t establish standards and use explitable data t imprve the quality and results f integrated services. Supprt fr integrated service delivery has s far been limited and the relatinship between the integratin and quality f these services is perhaps even mre limited. Innvative strategic guidelines are required t imprve the quality f preventin prgrammes and integrated health services fcused n the mther and child in the cntext f the fight against HIV and tuberculsis. The prjects may, fr example, target: The determinatin and evaluatin f the best family-centred strategies t identify the children wh have been expsed t tuberculsis, diagnse cnfirmed cases, and prvide a prphylactic treatment t disease-free children wh are in cntact with subjects wh have tuberculsis r are HIV-psitive, including actrs in the fight against HIV and Maternal and Child Health Prgrammes, particularly cmmunity actrs. The identificatin f the specific needs and difficulties f adlescents; test, assess and deply the ptimal mdalities t fight against tuberculsis and TB/HIV cinfectin in adlescents, as well as strategies t prvide a respnse t their specific needs and the scial and cultural determinants f this vulnerable grup. Recmmendatins t bidders: Fr all these activities, the use f new technlgies and innvatins will be highly appreciated. Prjects may use all the tls that allw a sund management f prgrammes t screen and treat peple with tuberculsis and prevent it in peple with latent tuberculsis infectin. This als includes the varius mdalities f digital health and the cmputerisatin f patient files and the tls that allw health wrkers t take infrmed decisins. Gender inequalities will need t be analysed and taken int accunt in the peratin and the activities will need t be gender-sensitive. The cmplementarity f prjects with Glbal Fund prgrammes in beneficiary cuntries is a key aspect f this Call fr Prpsals. Partnerships with research structures in the Suth, gvernmental actrs, civil sciety rganisatins and cmmunities in the preparatin, implementatin and mnitring f OR prjects is strngly encuraged. Finally, prjects cmbining varied and multidisciplinary appraches are strngly encuraged. 4. ELIGIBILITY CRITERIA Prjects that d nt meet all the eligibility criteria will be deemed ineligible and will be rejected. Expertise France will verify that each prject submitted meets all the fllwing eligibility criteria: 4.1 Duratin The duratin f prjects shall nt exceed 36 mnths. 6
4.2 Amunt requested and gegraphical cverage The ttal amunt f the grant financed by the 5% Initiative will cver between 50% and 100% f the ttal prject budget and may nt exceed EUR 1,000,000. It is cmpulsry t include cfinancing 8 in the prject budget fr structures whse annual budget exceeds EUR 5 millin. 9 The inclusin f cfinancing will be cnsidered favurably fr the ther structures. The prjects will be implemented in ne r several cuntries. Hwever, the prjects may nt exceed 5 cuntries f implementatin, except if they are backed t an existing sub-reginal netwrk r rganisatin. The reginal ratinale will need t be clearly justified and will be the subject f particular attentin by the evaluatrs if the prject is eligible. 4.3 Status and partnerships T be eligible fr a grant, the bidder must: Be a legal persn whse headquarters is in an eligible cuntry r in France (i.e. have statutes registered in an eligible cuntry r in France) and Implement the prject in partnership (several structures invlved) and Include at least ne partner frm each beneficiary cuntry and Nt have statutry prvisins that wuld nt authrise Expertise France r any external auditr appinted by Expertise France t cnduct n-the-spt cntrls and verificatins and have an apprpriate right f access t the sites and premises where the prject will be cnducted, including their cmputer systems, as well as t all the cmputerised dcuments and data cncerning the technical and financial management f the prject. Lcal rganisatins in eligible cuntries (see the list in paragraph 4.4) may submit a prject as principal bidders. Internatinal Organisatins 10 may participate as prviders f expertise, but may nt be the prject leader r receive funds. This prvisin des nt apply t Reginal Organisatins. Fr this Call fr Prpsals, each rganisatin may nly apply nce as principal bidder (lead rganisatin). Hwever, an rganisatin can participate in several prjects as a partner. The implementatin f a prject in partnership requires the partners f the principal bidder t be invlved in the prject design and given respnsibility fr the implementatin f activities and fr this rle t be accmpanied by a budgetary delegatin. 4.4 Cuntries The cuntries eligible fr this Call fr Prpsals are as fllws: 11 8 Frm wn funds r external (ther dnr). 9 The annual budget will be established n the basis f the last validated financial year (2016 r 2017). It is the annual budget realised set ut in the bidder s financial statement which will be taken int accunt. 10 The term Internatinal Organisatin refers here t a legal persn gverned by public law established by an internatinal treaty between States r between internatinal rganisatins (United Natins agencies, etc.). 11 Member r bserver cuntries f the Internatinal Organisatin f La Francphnie and eligible fr Glbal Fund grants, pririty cuntries fr Official Develpment Assistance. 7
Afghanistan Albania Armenia Benin Bulgaria Burma Burkina Fas Burundi Cambdia Camern Cape Verde Central African Republic Chad Cmrs Csta-Rica Côte d Ivire Demcratic Republic f Cng Djibuti Dminica Dminican Republic Egypt Equatrial Guinea Ethipia Gabn Gambia Gergia Ghana Guinea Guinea-Bissau Haiti Ksv Las Lebann Liberia Madagascar Mali Mauritania Mldavia Mntenegr Mrcc Mzambique Niger Palestinian Territries Republic f the Cng Republic f Mauritius Rmania Rwanda Sã Tmé and Príncipe Saint Lucia Senegal Serbia Thailand Tg Tunisia Ukraine Vanuatu Vietnam 4.5 Management capacities The principal submitting rganisatin has sufficient management capacities t manage the budget requested. This management capacity will in particular be established n the basis f the submissin by the rganisatin f its last validated financial year, the last validated audit reprt, its prvisinal budget fr 2018, and the descriptin f the team currently respnsible fr the administrative and financial management f the rganisatin. The average annual cst f the prject shall nt exceed 70% f the annual budget 12 f the principal submitting rganisatin. Fr example, fr an rganisatin whse annual budget is equal t EUR 400,000 12 The annual budget will be established n the basis f the last validated financial year (2016 r 2017) submitted in Appendix 6. It is the annual budget realised set ut in the bidder s financial statement which will be taken int accunt. 8
eurs, the ttal prject amunt shall nt exceed an annual average f EUR 280,000, i.e. a ttal f EUR 840,000 if the duratin is 36 mnths. 4.6 Cmpleteness The bids submitted shall cmprise all the dcuments and infrmatin requested in Sectin 8. Any incmplete bid will be autmatically rejected. The missing dcuments will nt be requested frm bidders a psteriri. Only prjects meeting all these eligibility criteria will be cnsidered eligible and prceed t the next stage. 5. ELIGIBILITY OF COSTS The fllwing direct csts f the principal bidder and its partners are eligible. The csts are financed n the basis f the actual csts incurred by the prject partners (n flat-rate fee will be accepted in the budget): The csts f staff assigned t the prject, crrespnding t the actual salaries (grss) plus emplyers charges and ther csts included in the remuneratin. They shall nt exceed the salaries and csts usually brne by the Beneficiary r, where applicable, its partners, unless there is an a priri justificatin indicating that the surpluses are essential fr carrying ut the prject. The travel and subsistence expenses f staff and ther peple participating in the prject, prvided that the selected ptin is financially sund and ecnmically advantageus. Fr the per diems: the amunt f the per diem per night shall be n higher than the rate set by the French Ministry f Ecnmy and Finance, with the exceptin f the per diems f the natinal staff and participants, which are set in agreement with Expertise France. The current rates set by the French Ministry f Ecnmy and Finance can be accessed n the Internet at the fllwing link: http://www.ecnmie.guv.fr/dgfip/missin_taux_chancellerie/frais Fr transprt: travel shall be in ecnmy class, unless there is specific prir authrisatin in writing frm Expertise France. The csts f purchasing r hiring equipment and supplies (new r secnd-hand) specifically fr the needs f the Prject, prvided that these csts crrespnd t thse f the cntract and cmply with the cmpetitive bidding prcedures. The csts f prviding services, prvided that they crrespnd t thse f the cntract and that they are justified in relatin t the needs f the Prject. The csts f cnsumable gds. The csts directly resulting frm the requirements fr the prper implementatin f the prject (fr example, disseminatin f infrmatin, translatins, reprductins, insurance...), including the charges fr financial services (ntably the cst f transfers and financial guarantees) prvided fr in the budget. A budget fr a mid-term external scientific review (nly fr prjects exceeding EUR 500,000 and 24 mnths). The cst f the final evaluatin will be brne by Expertise France/5% Initiative. The budget may prvide fr a line fr cntingencies up t a maximum f 5% and may prvide fr a line fr management fees f up t 7%. Only the medical inputs required fr the peratinal research activities. The fllwing are nt eligible: The salaries f civil servants; 9
The salaries f peple already financed by ther prgrammes, including thse f the Glbal Fund; The perating csts f the CCM; Expenditure fr the cnstructin f buildings, excluding reasnable csts fr wrks fr refurbishment r upgrading t standards required fr the implementatin f specific activities; The purchase f vehicles, excluding reasnable csts fr vehicles indispensable fr the implementatin f activities that are essential t the prper functining f the prject; The structure fees (ther than the 7% maximum management fees as indicated in the previus sectin). Prjects which will primarily invlve financing the perating csts f the submitting structures will be cnsidered ineligible and will nt be assessed. All the submitting rganisatins shuld take nte f the 3.1 Budgetary Ntice tab in Appendix 3. 6. EVALUATION CRITERIA Only eligible prjects will be assessed. The fllwing pints will be decisive in the chice f the prjects selected fr financing (details f these pints will be given t the preselected bidders fllwing phase 1 and are prvided here n an indicative basis): The bjectives f the prject cmply with the purpse f the Call fr Prpsals; The prjects must imperatively attach a letter f supprt frm the CCM t their bid. An apprval letter frm the ethics cmmittee shall be submitted prir t the signing f the agreement (in the event f the apprval f the bid). The frmulatin f the prject shall respect a prtcl as set ut in Appendix 6. The prjects are based n a ratinale f strengthening and cmplementarity with Glbal Fund grants. They shall be based n a clear and reasned analysis f the cntext and needs fr the relevant Glbal Fund grants. All the prjects shall demnstrate a strng assciatin and invlvement f partners and beneficiaries f the prject based in the beneficiary cuntry/cuntries. Each submitting rganisatin shall ensure and demnstrate that there is an active participatin f the target ppulatins in the definitin f needs and the prgramming and implementatin f the prject. All the capacity building prjects shall demnstrate that they meet the needs f the beneficiary. Furthermre, special attentin will be paid t the authenticity and lng-term nature f the partnerships. All prjects shall integrate, describe and budget a capitalisatin prcess and shall ensure that this prcess is systematised frm the utset f and thrughut the prject. All prjects shall demnstrate t what extent they will have an impact n the management f the prblem identified and n the public health plicy in the relevant cuntry/cuntries. Prjects integrating a gender-sensitive apprach will be judged favurably. This includes the taking int accunt f the specific needs f wmen and men, the reductin f gender inequalities, and the transfrmatin f the gender rles assigned by sciety which increase vulnerability t pandemics and access t care. The inclusin f technical expertise, with the aim f building the rganisatinal and/r technical capacities f the principal submitting rganisatin and/r the partner rganisatins, will be judged favurably, when the needs identified are described and justified in the prject prpsal. Prject initiatrs are encuraged t use existing methdlgies fr the identificatin f capacity building needs. 10
All the prjects shall include an analysis f the ptential impact f the prject n the envirnment. The integratin f envirnmental appraches and sustainable slutins in peratins, such as supply and inventry management, the management f materials and waste management, will be judged favurably. A mid-term external scientific review shall be budgeted fr prjects that exceed EUR 500,000 and 24 mnths. 7. SELECTION OF PROJECTS The timetable fr this Call fr Prpsals is set ut belw: 3 August: publicatin f the Call fr Prpsals 26 Octber: deadline fr the receptin f prpsals 17 December: selectin and validatin f prjects 31 December: cnfirmatin f the lifting f the cnditins f prjects and sending f the final ntificatins t the initiatrs The Selectin Cmmittee 13 is cmpsed f members representing the fllwing rganisatins: Ministry fr Eurpe and Freign Affairs (MEAE) Ministry f Slidarity and Health (MASS) Agence Française de Dévelppement (AFD) Life Sciences and Healthcare Alliance (AVIESAN) French Red Crss Representatives f the Health Cmmittee f Crdinatin Sud (French civil sciety) The Glbal Fund t Fight AIDS, Tuberculsis and Malaria is als invited t participate in the Selectin Cmmittee as an bserver member. The grant agreement fr each prject selected by the 5% Initiative Selectin Cmmittee shall be signed and the implementatin f the prject shall start within 12 mnths frm the ntificatin date f the selectin. The financing f prjects that d nt meet these cnditins shall be decmmitted. 8. PROPOSALS: DOCUMENTS TO BE PROVIDED The mdels referred t belw are available in French and English n the 5% Initiative website: http://www.initiative5pur100.fr/partenariats-et-expertise/les-appels-a-prjets/. The prpsals shall be drafted in French r English and shall include the dcuments belw: 1. The respnse frm (Appendix 1) 2. The simplified budget (Appendix 3) 3. A cpy f the statutes f the principal submitting rganisatin 4. The last financial year validated (2016 r 2017) 5. The prvisinal budget f the principal submitting rganisatin fr 2018 13 The cmpsitin f this cmmittee may be subject t change. 11
6. The last annual activity reprt 7. The last validated audit reprt 8. The cmmitment letters f each f the partner rganisatins invlved in the implementatin f the prject 9. MODALITIES FOR THE SUBMISSION OF PROPOSALS The cmplete prpsals shall be upladed t the Clud f Expertise France by 26/10/2018 at 12:00 (Paris time - UTC+1) (attested by the date and time f the uplad). Submitting rganisatins will need t request an access link fr the Clud between XXX and XXX by sending an e-mail entitled link request + number f call fr prjects t the fllwing address: i7pc.ap2018@gmail.cm. An e-mail cntaining the link and access cdes will be sent in reply, withut delay. This link will allw each bidder t access an individual space n the Clud, which nly the bidder and administratrs f the 5% Initiative will have access t, and dwnlad prpsal dcuments frm it. Requests fr an access link sent after XXX may be refused. A single access link will be created and sent t the bidder fr each prject, and n request nly. The Clud will be pen fr the dwnlading f the prpsal dcuments f AP-5PC 2018 03-RO at 12:00 (UTC+1). It is strngly recmmended t start dwnlading the prpsal dcuments n the Clud as early as pssible befre the deadline f XXX 2018 at 12:00 in rder t take int accunt the time needed fr the dwnlading, which may vary depending n the size f the dcuments and the quality f the Internet cnnectin. The upladed dcuments must imperatively respect the fllwing nmenclature: Budget_call number_ initials f the submitting rganisatin Administrative frm_call number_ initials f the submitting rganisatin Statutes_ call number_ initials f the submitting rganisatin Financial year (insert 2016 r 2017)_ call number_ initials f the submitting rganisatin 2018 budget_ call number _ initials f the submitting rganisatin Activity reprt (insert year)_ call number_ initials f the submitting rganisatin Audit reprt (insert year)_ call number_ initials f the submitting rganisatin Partner letter (insert name f partner)_call number_ initials f the submitting rganisatin (If several dcuments, number 9a. 9b. 9c. etc.) 10. QUESTIONS All questins related t this call fr prjects shuld be sent t the address: i7pc.ap2018@gmail.cm, by e-mail nly, by XXX 2018 at 12:00 (UTC+1) at the latest. Answers t the questins received within the time limit will be psted nline n the 5% Initiative website http://www.initiative5pur100.fr/partenariats-et-expertise/les-appels-a-prjets/ as sn as they have been prepared. It will be up t the rganisatins t keep infrmed f the answers when they are psted n the 5% Initiative website. 12