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Strategy and Analysis G4-1 CEO statement: relevance of sustainability to the company www.amgen.com (Responsibility/2016 Responsibility Highlights Report) Organizational Profile G4-3 Name of the organization Amgen G4-4 Primary brands, products and services www.amgen.com (Product websites) G4-5 Location of headquarters Thousand Oaks, CA G4-6 Number of countries of operation www.amgen.com (Amgen Fact Sheet) G4-7 Nature of ownership and legal form www.amgen.com (Amgen Fact Sheet) G4-8 Markets served www.amgen.com (Amgen Fact Sheet) G4-9 Scale of organization (number of staff, number of operations, net sales, debt/equity, quantity of products provided) www.amgen.com (Amgen Fact Sheet) G4-10 Staff information: number, region, gender, etc. www.amgen.com (Amgen Fact Sheet) G4-13 Any changes during reporting period Amgen facilities in Washington and Colorado were scheduled to close at the end of 2015. While two facilities did close, our Bothell, Washington, and Longmont, Colorado, facilities remained in operation in 2016. 1

Identified Material Aspects and Boundaries G4-17 Entities covered by the report Amgen facilities within the scope of this report are as follows: United States: Thousand Oaks, California; Cambridge, Massachusetts; Woburn, Massachusetts; West Greenwich, Rhode Island; Louisville, Kentucky; South San Francisco, California; Longmont, Colorado; Juncos, Puerto Rico; Bothell, Washington; Field Sales U.S. Fleet Canada: Burnaby, British Columbia Europe: Breda, Netherlands; Uxbridge, Abingdon and Cambridge, United Kingdom; Dun Laoghaire, Ireland Brazil: Sao Paulo Turkey: Yenibosna and Sekerpinar Singapore: Tuas G4-18 Process for defining report content and determining boundaries for aspects www.amgen.com (Responsibility/2016 Responsibility Highlights Report) www.amgen.com (Responsibility/Environment/Commitment) G4-19 List all material aspects www.amgen.com (Responsibility/Environment/Commitment) G4-22 Effects of any restatements from information provided in previous reports None G4-23 Significant changes from previous reports in scope or aspect boundaries Data from our facility in Singapore is now included in the 2016 report. Stakeholder Engagement G4-24 Stakeholder groups engaged by the organization www.amgen.com (Responsibility/2016 Responsibility Highlights Report) www.amgen.com (Responsibility/Environment/Commitment) 2

Report Profile G4-28 Reporting period January 1, 2016, to December 31, 2016 G4-29 Date of most previous report May 2016 G4-30 Reporting cycle Annual G4-31 Contact for questions regarding report responsibility@amgen.com G4-32 GRI content index www.amgen.com (Responsibility/Reporting and Metrics) G4-33 Scope and basis of external assurance www.amgen.com (Responsibility/Reporting and Metrics) Governance G4-34 Governance structure of the organization www.amgen.com (About/How We Operate/Corporate Governance) Ethics and Integrity G4-56 Organization s values, principles, standards and norms of behavior www.amgen.com (About/Mission and Values) Economic G4-EC1 Direct economic value generated and distributed www.amgen.com (2016 Annual Report and Financial Summary) G4-EC2 Financial implications and other risks and opportunities for the organization s activities due to climate change We re actively working to conserve energy and reduce greenhouse gas emissions that result from our operations. We have also considered potential risks to our business associated with climate change, such as extreme weather events and increasing regulation. Financial impact is considered as part of our risk management processes. Having plans in place to mitigate these risks increases the overall sustainability of the business. G4-EC8 Significant indirect economic impacts, including the extent of impacts www.amgen.com (Responsibility/Amgen Foundation) 3

Environmental G4-EN3 Energy consumption within the organization www.amgen.com (Responsibility/Environment/Energy Performance) G4-EN4 Energy consumption outside the organization www.amgen.com (Responsibility/Environment/Energy Performance) G4-EN6 Reduction of energy consumption www.amgen.com (Responsibility/Environment/Energy Performance) G4-EN8 Total water withdrawal by source www.amgen.com (Responsibility/Environment/Water Approach) G4-EN10 Percentage and total volume of water recycled and reused www.amgen.com (Responsibility/Environment/Water Approach) G4-EN15 Direct Greenhouse Gas Emissions (Scope 1) www.amgen.com (Responsibility/Environment/Carbon Performance, Summary of Data) G4-EN16 Energy Indirect Greenhouse Gas Emissions (Scope 2) www.amgen.com (Responsibility/Environment/Carbon Performance, Summary of Data) G4-EN17 Other Indirect Greenhouse Gas Emissions (Scope 3) www.amgen.com (Responsibility/Environment/Summary of Data) G4-EN19 Reduction of Greenhouse Gas Emissions www.amgen.com (Responsibility/Environment/Carbon Performance and Approach) G4-EN23 Total weight of waste by type and disposal method www.amgen.com (Responsibility/Environment/Summary of Data) G4-EN24 Total number and volume of significant spills There were no significant spills in 2016. G4-EN27 Extent of impact mitigation of environmental impacts of products and services www.amgen.com (Responsibility/Environment/Product Sustainability) G4-EN28 Percentage of products sold and their packaging materials that are reclaimed by category www.amgen.com (Responsibility/Environment/Product Sustainability) G4-EN29 G4-EN30 Monetary value of significant fines and total number of non-monetary sanctions for non-compliance with environmental laws and regulations Significant environmental impacts of transporting products and other goods and materials for the organization's operations and transporting members of the workforce $1,000 USD One Notice of Violation in 2016 www.amgen.com (Responsibility/Environment/Summary of Data) 4

Social G4-LA6 G4-LA10 G4-LA12 Type of injury and rates of injury, occupational diseases, lost days, and absenteeism, and total number of work-related fatalities, by region and by gender Programs for skills management and lifelong learning that support the continued employability of employees and assist them in managing career endings Composition of governance bodies and breakdown of employees per employee category according to gender, age group, minority group membership and other indications of diversity www.amgen.com (Responsibility/Safety and Wellness) www.amgen.com (Careers/Training and Development) www.amgen.com (Careers/Diversity) G4-SO4 Communication and training on anti-corruption policies and procedures www.amgen.com (Corporate Compliance Policies) G4-SO6 Total value of political contributions by country and recipient/beneficiary www.amgen.com (Political Contributions) G4-PR1 Percentage of significant product and service categories for which health and safety impacts are assessed for improvement www.amgen.com (Medicine Safety) 5