Pilot Projects Funded 2002-Present. The Role of CRF and the Locus Coeruleus in Women s Increased Vulnerability to Relapse

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1 Pilot Projects Funded 2002-Present Principal Investigator Affiliate, Department Pilot Project Impact Gary Aston-Jones, Ph.D. and Endowed Chair Rutgers University, Neuroscience The Role of CRF and the Locus Coeruleus in Women s Increased Vulnerability to Relapse 1 R21 Awarded 1P50 Awarded 1 abstract Sudie Back, PhD Addiction and Stress: Decreasing Stress Reactivity 1 R21 submission 1 K Award 1 R01 awarded Howard Becker, PhD Heather Bimonte-Nelson, PhD, ASU, Psychiatry Nicotine Self-Administration in Female Mice R21 submission Estrogen Replacement Effects on Spatial Memory 4 journal articles 2 R03 applications 1 RO3 awarded Gender-specific work in MUSC Aging Center Heather Boger, PhD, Gender Differences in Response to a Genetic Reduction of GDNF on the Nigrostriatal Dopamine System and Motor Function 1 R00 Awarded 2 journal articles Elizabeth Burnett, PhD Postdoctoral Scholar The role of the rostromedial tegmental nucleus in sex-related differences in the negative effects of alcohol

2 Angie Cason, PhD, Sex Differences in Natural Reward-seeking: Role of Orexin 6 abstracts 1 K01 awarded 1 K02 submitted Matthew Carpenter, PhD Menstrual Phase Influences on Smoking Cessation 6 journal articles 1 K Award 2 RO1s awarded Eugene Chang, MD MUSC, Obstetrics-Gynecology Patricia Coker-Bolt, PhD MUSC, College of Health Professions Melissa Cunningham, MD, PhD MUSC, Rheumatology and Immunology Salim El-Amouri, PhD Research Fellow Cincinnati Children s Hospital, Experimental Hematology and Cancer Biology William Griffin, PhD Research Antioxidant Approaches to Treatment and Prevention of Preclampsia in an Animal Model Early Gender-related Motor Skills Differences in Female and Male Preterm Infants The Role of Estrogen Receptor Alpha in Systemic Lupus Erythematosus: Modulation of the Inflammatory Response in the Brain of Lupus-prone Mice Gender Differences, Ischemia, and Neprilysin The Influence of Food Restriction and Sex on Cocaine-Evoked Increases in Extracellular Dopamine in the Nucleus Accumbens of C57BL6 Mice 1 abstract submission 1 K Award submission 1 U01 submission 1 Small Business Innovation Research (SBIR) grant submitted 3 abstracts submitted 4 manuscripts submitted 5 abstracts under review 1 manuscript in progress R01 in preparation (Kindy)

3 Constance Guille, MD and Behavioral Sciences Frances Koch, MD MUSC, Pediatrics Identification of genetic variants in the HPA axis that increase the risk of depression among women under conditions of stress Gender Differences in Cerebral Blood Flow and Neurodevelopmental Outcome Following Chorioamnionitis in Infants 37 Weeks Gestation 1 U79 awarded 1 manuscript submitted 4 abstracts 3 conference presentations Chitra Lal, MD MUSC, Pulmonary, Critical Care, Allergy & Sleep Medicine Marcelo Lopez, PhD Research Michael McCart, PhD Megan Moran-Santa Maria, PhD Kimber Price, MSCR, PhD Scientific Publication Consultant Self-Employed Carmela Reichel, PhD MUSC, Department of Neuroscience Cognitive Impairment and Obstructive Sleep Apnea Syndrome in Postmenopausal women Sex-Related Differences in Ethanol Self-Administration and Reinstatement in C57BL/6J Mice Alcohol, Arousal and Women s Judgments of Acquaintance Victimization Exploring Gender Differences in the Stress and Cue Induced Substrates of Drug Craving Sex Differences in Attentional Bias and Cognitive Functioning in Response to Stress in Marijuana-dependent Individuals Methamphetamine Self Administration and Reinstatement in Female Rats: Impact of Access Period and Modafinil Alcohol Research Center genderfocused project 1 U01 awarded 1 R34 awarded 3 conference presentations 7 publications 2 book chapters 1 K01 submitted 1 R21 awarded 4 R01s submitted K12 Awarded K01 submission R21 submission 10 journal articles 1 manuscript submitted 16 abstracts submitted R21 submitted

4 1 R03 Awarded Kimberlei Richardson, PhD Howard University College of Medicine, Pharmacology Xiang-Dang Shi, MD, PhD Assistant Scientist Center for Substance Abuse Research, Temple University Sex and Estrous Cycle-Dependent Differences in Morphine Conditioned Place Preference and Its Influence on Orexin Neuronal Activation The Effect of Sex Differences on the Phosphorylation of Phospho-proteins Induced by Acute Cocaine Administration in the Striatum and Nucleus Accumbens of Rats 1 travel award 2 journal articles 1 K01 awarded 1 R03 in submitted Stefanka Spassieva, PhD Research MUSC, Hematology/Oncology Possible Role of Deoxysphingolipids in Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients 4 abstracts submitted 1 pilot project awarded 1 R21 in preparation Sade Spencer, PhD Postdoctoral Fellow Development of a rodent mode of THC self-administration Eve Spratt, MD MUSC, Pediatrics- Child Development Lynn Veatch, PhD MUSC, Library Sciences and Informatics Angela Waldrop, PhD UCSF, Psychiatry Staff Psychologist, PTSD Clinical Team, San Francisco VA Medical Center Gender Differences in Autism Impact of Sex and Hormonal Status on Ethanol Withdrawal Gender Differences in Impulsivity 1 R01 in progress

5 Maggie Wilkes, MS Fellow MUSC, Child Psychiatry Jingmei Zhang, MD Postdoctoral Scholar MUSC, Biochemistry & Molecular Biology Gender differences in response to adversity in children in kinship care N-Acetylcysteine Attenuates Fetal Brain Injury and Behavioral Dysfunction in a Localized Maternal Infection/Inflammation Cycle TOTAL IMPACT: 70 national presentations or abstracts submitted 78 manuscript submissions or publications 43 NIH applications submitted and 25 awarded