Gastrointestinal motility modulating drugs include all compounds which have pharmacological
|
|
- Winifred Preston
- 6 years ago
- Views:
Transcription
1 Pharmacotherapeutics Gastrointestinal Motility Modulating Drugs Oh Young Lee, MD Department of Internal Medicine, Hanyang University College of Medicine E - mail : leeoy@hanyang.ac.kr J Korean Med Assoc 2009; 52(9): Abstract Gastrointestinal motility modulating drugs include all compounds which have pharmacological activity of modulating (stimulating or inhibiting) gastrointestinal motility. They are mainly used for the treatment of functional gastrointestinal diseases. Gastrointestinal motility modulating drugs include 5HT receptor agonists, antagonists, and antidopaminergic agents. Many new gastrointestinal motility modulating drugs are currently under investigation. The aims of this article are to review the mechanism of action, efficacy and side effects of the gastrointestinal motility modulating drugs. Keywords: Motility modulating drugs; Pharmacotherapy; Prokinetics; Functional gastrointestinal diseases 920
2 Gastrointestinal Motility Modulating Drugs Table 1. Pharmacodynamic properties, gastrointestinal motor effects and side effects of gastrointestinal modulating drugs Classification and Target receptors Gastrointestinal motor effects Side effects name of drugs and actions Esophagus Stomach Colon Dopamine D 2 R AT Metoclopramide Dopamine D 2 R AT, contraction GET extrapyramidal Sx 5HT 4 AG, 5HT 3 AT hyperprolactemia associated Sx Domperidone Dopamine D 2 R AT LES pr GET hyperprolactemia associated Sx Itopride Dopamine D 2 R AT,? GET? rash, diarrhea, gliddiness, inhibition of galactorrhea acethylcholinesterase Levosulpiride Dopamine D 2 R AT,? GET hyperprolactemia associated Sx 5HT 4 AG, weak 5HT 3 AT 5HT 4 R AG Cisapride 5HT 4 R AG, contraction, GET CTT QT prolongation weak 5HT 3 R AT LES pr Mosapride 5HT 4 R AG, metabolite:? GET? weak 5HT 3 R AT Tegaserod 5HT 4 R AG? GET, GA CTT abdominal pain, headache, heart attack Prucalopride 5HT 4 R AG?? CTT abdominal pain Renzapride 5HT 4 R AG, 5HT 1,? GET CTT abdominal pain, headache 5HT 3 R AT Motilin R AG Erythromycin Motilin R AG LES pr GET, GA arrythmia, reversible deafness, abdominal pain, diarrhea 5HT 1A R AG Buspirone 5HT 1 A R AG GET, GA vertigo, headache, agitation 5HT 1B/D R AG Sumatriptan 5HT 1B/D R AG GET, GA palpitation, syncope, anemia, myalgia 5HT 3 R AT Alosetron 5HT 3 R AT CTT ischemic colitis Cilansetron 5HT 3 R AT CTT ischemic colitis Ondansetron 5HT 3 R AT CTT dizziness, headache SSRI Citalopram contractility fatigue, drowsiness, dry mouth, headache Paroxetine GA nausea, somnolence, dizziness, dry mouth GABA B receptor AG Baclofen GABA B R AG TLESR headache, dizziness, insomnia, nausea, constipation Phosphodiesterase-5 inhibitors Sildenafil Phosphodiesterase -5 GA headache, flushing, dyspepsia, inhibitors nasal congestion, photophobia Nitrate Nitroglycerin GA headache, painful urination, dizziness R: receptor, Sx: symptom, Pr: pressure, AG: agonist, AT: antagonist SSRI: selective serotonin reuptake inhibitor GET (gastric emptying time) : accelerate, :delay CTT (colon transit time) : accelerate, : delay LES: low esophageal sphincter TLESR : reduces transient low esophageal sphincter relaxation GA (gastric accomodation) : enhance, : decrease 921
3 Lee OY 922
4 Gastrointestinal Motility Modulating Drugs 923
5 Lee OY 924
6 Gastrointestinal Motility Modulating Drugs 925
7 Lee OY 11. Karamanolis G, Tack J. Promotility medication-now and in the future. Dig Dis 2006; 24: Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza GR, De Ponti F. Clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther 2004; 19: Tack J. Prokinetics and fundic relaxants in upper functional GI disorders. Curr Opin Pharmacol : Kindt S, Tack J. Mechanisms of serotonergic agents for treatment of gastrointestinal motility and functional bowel 926
8 Gastrointestinal Motility Modulating Drugs disorders. Neuogastroenterol Motility 2007; 19: Costedio MM, Hyman N, Mawe GM. Serotonin and its role in colonic function and in gastrointestinal disorders. Dis Colon Rectum 2007; 50: Peer Reviewers Commentary 927
MANAGEMENT OF CHRONIC CONSTIPATION BEYOND LAXATIVES
Enrique Rey Professor of Medicine Head. Department of Digestive Diseases Hospital Clínico San Carlos Complutense University Madrid, Spain MANAGEMENT OF CHRONIC CONSTIPATION BEYOND LAXATIVES CONSTIPATION:
More informationNumber of studies. Endoscopic finding. Number of subjects. Pooled prevalence 95% CI
Clinical Approach to the Patient t with Dyspepsia William D. Chey, MD, FACG Professor of Medicine University of Michigan Prevalence of Endoscopic Findings in Individuals with Dyspepsia Systematic Review
More informationDOMPERIDONE BNF 4.6. Domperidone is a dopamine type 2-receptor antagonist. It is structurally related to the
DOMPERIDONE BNF 4.6 Class: Prokinetic anti-emetic. Indications: Nausea and vomiting, dysmotility dyspepsia, gastro-oesophageal reflux. Pharmacology Domperidone is a dopamine type 2-receptor antagonist.
More informationThe Opportunity: c-ibs and pain relief with confidence YKP10811
The Opportunity: c-ibs and pain relief with confidence YKP10811 1 TABLE OF CONTENTS Profile Summary Clinical Data Mode of Action Pharmacologic Profile Safety and Toxicity Profile ADME Overview vs. Competitors
More informationOutline. Definition (s) Epidemiology Pathophysiology Management With an emphasis on recent developments
Chronic Dyspepsia Eamonn M M Quigley MD FRCP FACP MACG FRCPI Lynda K and David M Underwood Center for Digestive Disorders Houston Methodist Hospital Houston, Texas Outline Definition (s) Epidemiology Pathophysiology
More informationEffect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro
Yonsei Med J 49(3):472-478, 2008 DOI 10.3349/ymj.2008.49.3.472 Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro Hyun Chul Lim, 1 Young Gyun Kim, 1 Jung Hyun Lim,
More informationGastroparesis. - Recent advances in the pathophysiology and treatment -
ICDM 2015 Gastroparesis - Recent advances in the pathophysiology and treatment - Department of Internal Medicine, College of Medicine, St. Paul s hospital, The Catholic University of Korea, Seoul, Korea
More informationPRUCAPLA Tablets (Prucalopride)
Published on: 2 May 2018 PRUCAPLA Tablets (Prucalopride) Composition PRUCAPLA 1 mg Each film coated tablet contains: Prucalopride succinate equivalent to Prucalopride 1 mg Excipients. q. s. Color: Titanium
More informationpissn: eissn: Journal of Neurogastroenterology and Motility
JNM J Neurogastroenterol Motil, Vol. 21 No. 3 July, 2015 pissn: 2093-0879 eissn: 2093-0887 http://dx.doi.org/10.5056/jnm15094 Review Prokinetics in the Management of Functional Gastrointestinal Disorders
More informationDr. Patsy Smyth, FNP-BC
Dr. Patsy Smyth, FNP-BC Gastroparesis literally translated means stomach paralysis. Gastroparesis is a syndrome characterized by delayed gastric emptying in absence of mechanical obstruction of the stomach.
More informationGastroparesis and other upper GI problems DR ANDREW DAVIES
Gastroparesis and other upper GI problems DR ANDREW DAVIES Outline Gastroparesis Hiccoughs Gastroparesis Gastroparesis Definition: A syndrome of objectively delayed gastric emptying in the absence of mechanical
More informationEmerging Treatments for IBS-C and Clinical Trial Endpoints
Emerging Treatments for IBS-C and Clinical Trial Endpoints Lin Chang, M.D. Oppenheimer Family Center for Neurobiology of Stress David Geffen School of Medicine at UCLA Learning Objectives Describe current
More informationGI Pharmacology -4 Irritable Bowel Syndrome and Antiemetics. Dr. Alia Shatanawi
GI Pharmacology -4 Irritable Bowel Syndrome and Antiemetics Dr. Alia Shatanawi 11-04-2018 Drugs used in Irritable Bowel Syndrome Idiopathic, chronic, relapsing disorder characterized by abdominal discomfort
More informationGASTROPARESIS. C. Prakash Gyawali, MD Professor of Medicine Washington University in St. Louis
GASTROPARESIS C. Prakash Gyawali, MD Professor of Medicine Washington University in St. Louis Symptom Definitions Nausea: a subjective feeling of wanting to vomit Vomiting: forceful expulsion of gastroduodenal
More informationCore Safety Profile. Pharmaceutical form(s)/strength: Tablets and Oral lyophilisates (wafers) 5 and 10 mg NL/H/PSUR/0002/001 Date of FAR:
Core Safety Profile Active substance: Rizatriptan Pharmaceutical form(s)/strength: Tablets and Oral lyophilisates (wafers) 5 and 10 mg P RMS: NL/H/PSUR/0002/001 Date of FAR: 23.05.2011 4.3 Contraindications
More informationJNM Journal of Neurogastroenterology and Motility
JNM Journal of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 20 No. 4 October, 2014 pissn: 2093-0879 eissn: 2093-0887 http://dx.doi.org/10.5056/jnm14010 Original Article Effects of
More informationPathophysiology/Etiology As with most diseases in the veterinary
VETTALK Volume 15, Number 04 American College of Veterinary Pharmacists THE HARD TRUTH ABOUT PROKINETIC MEDICATION USE IN PETS Introduction The moving topic of this Vet Talk newsletter will be prokinetic
More informationThe Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders
GASTROENTEROLOGY 2007;132:397 414 REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders MICHAEL D. GERSHON*
More informationManagement of Gastroparesis
Management of Gastroparesis Bible Class Jan Hendrik Niess As published in Am J Gastroenterol. 2013 Jan;108(1):18-37 What is the definition of gastroparesis? What are cardinal symptoms of gastroparesis?
More informationLong term pharmacotherapy for Alcohol Dependence: Anti Craving agents
Long term pharmacotherapy for Alcohol Dependence: Anti Craving agents Myth or Reality? Complete Recovery means a medication-free state True or False? Treatment of Alcoholism Assessment Motivation Alcohol
More informationVomiting Approach to diagnosis
Vomiting Approach to diagnosis By Dr. Sahar El-Gharabawy Associate professor of internal medicine Hepato-gastroenterology Unit )SMH ) Mansoura University Definitions: Nausea: Feeling "sick to the stomach",
More informationICCR rotation February 7, The efficacy, safety and tolerability of tegaserod in celiac disease patients
The efficacy, safety and tolerability of tegaserod in celiac disease patients A. Study Purpose and Rationale: Celiac disease is an autoimmune inflammatory disease of the small intestine induced by the
More informationThe influence of early postoperative enteral feeding and promotility drugs on upper GI tract and gallbladder motility in the critical care setting
The influence of early postoperative enteral feeding and promotility drugs on upper GI tract and gallbladder motility in the critical care setting Alan Šustić, MD, PhD Dept. of Anesthesiology and ICU Univ.
More informationPropulsion and mixing of food in the alimentary tract Chapter 63
Propulsion and mixing of food in the alimentary tract Chapter 63 Types of GI movements: Propulsive movement-peristalsis Propulsion: controlled movement of ingested foods, liquids, GI secretions, and sloughed
More informationPatient Interview Form
Page 1 of 5 Physicians: D.F. Jackson, III, MD William D. McLaughlin, MD Robert P. Albares, MD Jeffrey J. Crittenden, MD Physicians: Samuel J. Tarwater, MD Travis J. Rutland, MD Ashwani Kapoor, MD Pathologist:
More informationAmyloidosis & the GI Tract
Amyloidosis & the GI Tract John O. Clarke, M.D. Director, Esophageal Program Clinical Associate Professor of Medicine Stanford University john.clarke@stanford.edu 2017 Topics to cover 1) Patterns of GI
More informationWhy does my stomach hurt? Exploring irritable bowel syndrome
Why does my stomach hurt? Exploring irritable bowel syndrome By Flavio M. Habal, MD, PhD, FRCPC Case In this article: 1. What is IBS? A 45-year-old female is referred to your office with recurrent 2. How
More informationBuspirone, a new drug for the management of patients with ineffective esophageal motility?
Editorial Buspirone, a new drug for the management of patients with ineffective esophageal motility? United European Gastroenterology Journal 2015, Vol. 3(3) 261 265! Author(s) 2015 Reprints and permissions:
More informationEDUCATION PRACTICE. Management of Delayed Gastric Emptying. Clinical Scenario. The Problem. Management Strategies and Supporting Evidence
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2005;3:642 646 EDUCATION PRACTICE Management of Delayed Gastric Emptying FRANK K. FRIEDENBERG and HENRY P. PARKMAN Temple University Hospital, Philadelphia, Pennsylvania
More informationMigraine and Gallbladder Motility
Migraine and Gallbladder Motility Georgescu Doina, MD, PhD Ancusa Oana, MD, PhD Ist Department of Internal Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara Georgescu Liviu-Andrei,
More informationSymptom Management. Thomas McKain, MD, ABFM, ABHPM Medical Director
Symptom Management Nausea & Vomiting Thomas McKain, MD, ABFM, ABHPM Medical Director Mr. Jones has nausea and vomiting. May I initiate Compazine from the Comfort Pak? Objectives 1. Delineate the Differential
More information2. QUALITATIVE AND QUANTITATIVE COMPOSITION
Summary of Product Characteristics 1. NAME OF THE MEDICINAL PRODUCT {To be completed nationally} 2. QUALITATIVE AND QUANTITATIVE COMPOSITION 1 mg tablets: each tablet contains 1 mg granisetron (as hydrochloride).
More informationPrimary Management of Irritable Bowel Syndrome
Primary Management of Irritable Bowel Syndrome Jasmine Zia, MD Acting Instructor, Division of Gastroenterology Current Concepts in Drug Therapy CME Course April 23, 2015 Irritable Bowel Syndrome (IBS)
More informationANTI-DEPRESSANT MEDICATIONS
ANTI-DEPRESSANT MEDICATIONS This information is not intended to be a substitute for medical advice. It s purpose is solely informative. If your client or yourself are taking antidepressants, do not change
More informationDementia Medications Acetylcholinesterase Inhibitors (AChEIs) and Glutamate (NMDA) Receptor Antagonist
Dementia Medications Acetylcholinesterase Inhibitors (AChEIs) and Glutamate (NMDA) Receptor Antagonist Medication Dosage Indication for Use Aricept (donepezil) Exelon (rivastigmine) 5mg 23mg* ODT 5mg Solution
More informationSANDOMIGRAN (pizotifen malate)
SANDOMIGRAN (pizotifen malate) S N CH 3 Pizotifen. COOH CH OH CH 2 COOH MALATE DESCRIPTION Pizotifen is a cycloheptathiophene derivative structurally related to cyproheptadine and the tricyclic antidepressants.
More informationThe Use of Antidepressants in the Treatment of Irritable Bowel Syndrome and Other Functional GI Disorders What are functional GI disorders?
The Use of Antidepressants in the Treatment of Irritable Bowel Syndrome and Other Functional GI Disorders Christine B. Dalton, PA-C Douglas A. Drossman, MD and Kellie Bunn, PA-C What are functional GI
More informationDRUGS THAT ACT IN THE CNS
DRUGS THAT ACT IN THE CNS Anxiolytic and Hypnotic Drugs Dr Karamallah S. Mahmood PhD Clinical Pharmacology 1 OTHER ANXIOLYTIC AGENTS/ A. Antidepressants Many antidepressants are effective in the treatment
More informationPatient Interview Form
Page 1 of 5 Gastroenterologists: D.F. Jackson, III, MD William D. McLaughlin, MD Robert P. Albares, MD Jeffrey J. Crittenden, MD Samuel J. Tarwater, MD Travis J. Rutland, MD Gastroenterologists: Marc L.
More informationM0BCore Safety Profile. Pharmaceutical form(s)/strength: ordispersible tablet SE/H/PSUR/0022/002 Date of FAR:
M0BCore Safety Profile Active substance: Zolmitriptan Pharmaceutical form(s)/strength: ordispersible tablet P-RMS: SE/H/PSUR/0022/002 Date of FAR: 15.03.2014 4.3 Contraindications Zolmitriptan is contraindicated
More informationIBS Irritable Bowel syndrome Therapeutics II PHCL 430
Salman Bin AbdulAziz University College Of Pharmacy IBS Irritable Bowel syndrome Therapeutics II PHCL 430 Email:- ahmedadel.pharmd@gmail.com Ahmed A AlAmer PharmD R.S is 32-year-old woman experiences intermittent
More informationIBS current status Peter Laszlo Lakatos
IBS current status Peter Laszlo Lakatos Semmelweis University 1st Department of Medicine Functional gastrointestinal disorders Chronic or fluctuating functional gastrointestinal symptoms that can not be
More informationThe PPI Doesn t Work, Now What? PPI Non-responsive Dyspepsia. Disclosures
The PPI Doesn t Work, Now What? PPI Non-responsive Dyspepsia Lana Bistritz MD FRCPC Royal Alexandra Hospital GI Update 2016 Disclosures I have no relevant financial disclosures I will be discussing off
More informationDiagnosis and Treatment of Irritable Bowel Syndrome
Special Issue Diagnosis and Treatment of Irritable Bowel Syndrome Myung Gyu Choi, M.D. Department of Internal Medicine The Catholic University of Korea, College of Medicine Kangnam St. Mary's Hospital
More informationApproach to Nausea & Vomi2ng
Approach to Nausea & Vomi2ng Med 3 Seminar 2017 Dr. Robin Grant Division of Pallia2ve Medicine robin.grant@nshealth.ca Why nausea and vomi2ng? Pain 80-90+ % Fa2gue / asthenia 75-90% Cons2pa2on 70% Dyspnea
More informationUse of Prokinetic Agents in Intensive Care Medicine - What is Evidence Based? Dr Martin Sterba PhD EDIC CICM TWH ICU, NSW, Australia
Use of Prokinetic Agents in Intensive Care Medicine - What is Evidence Based? Dr Martin Sterba PhD EDIC CICM TWH ICU, NSW, Australia Ostrava Ostrava Wollongong Wollongong Wollongong Prokinetics and EBM
More informationThis initial discovery led to the creation of two classes of first generation antidepressants:
Antidepressants - TCAs, MAOIs, SSRIs & SNRIs First generation antidepressants TCAs and MAOIs The discovery of antidepressants could be described as a lucky accident. During the 1950s, while carrying out
More informationSTRATEGIES TO IMPROVE ENTERAL FEEDING TOLERANCE. IS IT WORTH IT? ENGELA FRANCIS RD(SA)
STRATEGIES TO IMPROVE ENTERAL FEEDING TOLERANCE. IS IT WORTH IT? ENGELA FRANCIS RD(SA) DEFINITION OF ENTERAL FEEDING INTOLERANCE Gastrointestinal feeding intolerance are usually defined as: High gastric
More informationTegaserod in the treatment of constipation-predominant functional gastrointestinal disorders
DRUG PROFILE Tegaserod in the treatment of constipation-predominant functional gastrointestinal disorders Anurag Agrawal & Peter Whorwell Author for correspondence ERC Building, First Floor, Wythenshawe
More informationNausea & Vomiting. Dr Eve Lyn TAN Liverpool Hospital NSW, AUSTRALIA
Nausea & Vomiting Dr Eve Lyn TAN Liverpool Hospital NSW, AUSTRALIA Prevalence prevalence varies *, systemic review 2007 : overall prevalence : nausea 30%, vomiting 20% in last 1-2 weeks of life : nausea
More informationNausea and Vomiting in Palliative Care
Nausea and Vomiting in Palliative Care Definitions Nausea - an unpleasant feeling of the need to vomit Vomiting - the expulsion of gastric contents through the mouth, caused by forceful and sustained contraction
More informationConstipation An Overview. Definition Physiology of GI tract Etiology Assessment Treatment
CONSTIPATION Constipation An Overview Definition Physiology of GI tract Etiology Assessment Treatment Definition Constipation = the infrequent passage of hard feces Definition of Infrequent The meaning
More informationPRAMIN PRODUCT INFORMATION
PRAMIN PRODUCT INFORMATION 1. NAME OF THE MEDICINAL PRODUCT Pramin Tablets Pramin Injection Pramin Suppositories 5 mg 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Pramin Tablets: Each tablet contains: Metoclopramide
More informationCoastal Digestive Diseases, P.C. MA New Pt Ht
Coastal Digestive Diseases, P.C. MA New Pt Ht Interview Form Limited Use Only Estab Pt Wt Name Nickname DOB Address Occupation Social Security # Married Single Email Address: Divorced Widowed Check Contact
More informationMirtazapine in diarrhea-predominant irritable bowel syndrome: an openlabel
Research Article http://www.alliedacademies.org/gastroenterology-and-digestive-diseases/ Mirtazapine in diarrhea-predominant irritable bowel syndrome: an openlabel study. Sanagapalli S 1,2*, Kim E 1, Zarate-Lopez
More informationIrritable bowel syndrome: An overview of diagnosis and pharmacologic treatment
REVIEW KEVIN W. OLDEN, MD Associate Professor of Medicine, Division of Gastroenterology, Mayo Clinic Scottsdale, Scottsdale, Ariz. Irritable bowel syndrome: An overview of diagnosis and pharmacologic treatment
More informationChapter 41. Media Directory. Lower Digestive Tract. Constipation (continued) Constipation
Chapter 41 Drugs for Bowel Disorders and Other Gastrointestinal Conditions Slide 43 Media Directory Tegaserod Animation Upper Saddle River, New Jersey 07458 All rights reserved. Lower Digestive Tract Figure
More informationPatient Interview Form
Page 1 of 5 Patient Interview Form Patient Information First Name: MRN: Last Name: Date Of Birth: Contact Preference Email Telephone call- Work Telephone call - Home Email Please check one as your preferred
More informationHealth History Questionaire
Patient DOB: Patient Name: Date: Health History Questionaire Who referred your consultation? If no one referred you, how did you hear about us? Who is your primary care physician? Have you ever seen a
More informationIs one of the most common chronic disorders. causing patients to seek medical treatment.
ILOs After this lecture you should be able to : Define IBS Identify causes and risk factors of IBS Determine the appropriate therapeutic options for IBS Is one of the most common chronic disorders causing
More informationOur evidence. Your expertise. SmartPill : The data you need to evaluate motility disorders.
Our evidence. Your expertise. SmartPill : The data you need to evaluate motility disorders. SmartPill benefits your practice: Convenient performed right in your office Test standardization Provides direct
More informationManagement of Functional Dyspepsia (FD)
Management of Functional Dyspepsia (FD) Amy S. Oxentenko, MD, FACG Program Director and Associate Chair, IM Associate Professor of Medicine Mayo Clinic, Rochester Outline Define functional dyspepsia (FD)
More informationA SLP s Guide to Medication Therapy and Management. Sarah Luby, PharmD, BCPS KSHA 2017
A SLP s Guide to Medication Therapy and Management Sarah Luby, PharmD, BCPS KSHA 2017 Objectives Identify the appropriate route of administration for medications and proper formulations for use Understand
More informationFunctional Dyspepsia
Functional Dyspepsia American College of Gastroenterology Boston Massachusetts, June 2015 Brian E. Lacy, PhD, MD, FACG Professor of Medicine Geisel School of Medicine at Dartmouth Chief, Section of Gastroenterology
More informationNew Tests and Treatments for Dyspepsia and Irritable Bowel Syndrome
New Tests and Treatments for Dyspepsia and Irritable Bowel Syndrome Soojong Hong Chae, MD Clinical Assistant Professor Digestive Diseases and Nutrition University of South Florida ROME III Functional dyspepsia
More informationKEY MESSAGES. It is often under-recognised and 30-50% of MDD cases in primary care and medical settings are not detected.
KEY MESSAGES Major depressive disorder (MDD) is a significant mental health problem that disrupts a person s mood and affects his psychosocial and occupational functioning. It is often under-recognised
More informationCYCLIC VOMITING SYNDROME. C. Prakash Gyawali, MD Professor of Medicine Washington University in St. Louis
CYCLIC VOMITING SYNDROME C. Prakash Gyawali, MD Professor of Medicine Washington University in St. Louis Case 26 year old male Symptoms began at age 19 yr 5-6 day episodes of recurrent, severe vomiting
More informationMigraleve, Migraleve Pink and Migraleve Yellow Product Information
Migraleve, Migraleve Pink and Migraleve Yellow Product Information Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard Adverse events should also
More informationGI Complications in heds and HSD
GI Complications in heds and HSD Qasim Aziz PhD, FRCP Professor in Neurogastroenterology Neurogastroenterology Group GUT = Gastrointestinal (GI) tract Oesophagus / gullet Gastro-oesophageal junction Stomach
More informationMANAGEMENT OF VISCERAL PAIN
MANAGEMENT OF VISCERAL PAIN William D. Chey, MD, FACG Professor of Medicine University of Michigan 52 year old female with abdominal pain 5 year history of persistent right sided burning/sharp abdominal
More informationGuidelines MANAGEMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
MANAGEMENT OF MAJOR DEPRESSIVE DISORDER (MDD) Guidelines CH Lim, B Baizury, on behalf of Development Group Clinical Practice Guidelines Management of Major Depressive Disorder A. Introduction Major depressive
More informationF A M N O P R S ! D !
A B C D E F A M N O P Q G H I J R S T U V 595 W http://www.encognitive.com/images/digestive-system-2.jpg K L M A N B C O P D E F G D Q R H S I J K http://apbrwww5.apsu.edu/thompsonj/anatomy%20&%20physiology/2020/2020%20exam%20reviews/exam%203/colon%20diagram.jpgd
More informationTreatments for migraine
Treatments for migraine Information for patients and carers Department of Neurology Aberdeen Royal Infirmary Contents Page About this leaflet Abortive medication for migraine Painkillers Antisickness medication
More informationThe effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study
Aliment Pharmacol Ther 2005; 22: 381 385. doi: 10.1111/j.1365-2036.2005.02566.x The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled
More informationManagement of SSRI Induced Sexual Dysfunction. Serotonin Reuptake Inhibitors*
Management of SSRI Induced Sexual Dysfunction John J. Miller, M.D. Medical Director, Center for Health and WellBeing Exeter, NH Serotonin Reuptake Inhibitors* fluoxetine clomipramine sertraline paroxetine
More informationIndex. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Achalasia, barium esophagography for, 57 58 Acid pocket, 18 19 Acid-sensing ion, 20 Acupuncture, 128 Adiponectin, in obesity, 166 ADX10059 metabotropic
More informationGI Pharmacology. Dr. Alia Shatanawi 5/4/2018
GI Pharmacology Dr. Alia Shatanawi 5/4/2018 Z Gastroenterol. 1983 Mar;21 Suppl:111-6. [Effect of antacids on intestinal motility]. [Article in German] Wienbeck M, Erckenbrecht J, Strohmeyer G. Abstract
More informationBend Surgical Associates. Michael J. Mastrangelo, MD, FACS. Medication Name Dosage Frequency Medication Name Dosage Frequency
Bend Surgical Associates Michael J. Mastrangelo, MD, FACS PATIENT NAME: DATE F BIRTH: MEDICATINS Please list all of your current prescription, non-prescription medications, vitamins, minerals, and supplements.
More informationPrevalence of IBS Diagnosis
Irritable Bowel Syndrome: Past, Present, and Future G. Nicholas Verne, M.D. Professor and Division Director Division of Gastroenterology, Hepatology, Nutrition Department of Internal Medicine Ohio State
More information2 QUALITATIVE AND QUANTITATIVE COMPOSITION
1 PRODUCT NAME TROPISETRON-AFT tropisetron hydrochloride (equivalent to 2 mg or 5 mg tropisetron) per ampoule. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml contains 1 mg of tropisetron 1 2 ml ampoule
More informationGut involvement in PoTS an overview
Gut involvement in PoTS an overview Qasim Aziz, PhD, FRCP Centre for Neuroscience and Trauma Wingate Institute of Neurogastroenterology Case Hx * 28 year old lady presents with a long hx of constipation
More informationLevocetirizine dihydrochloride
INSERT TEXT UAP Levocetirizine dihydrochloride Allerzet 5 mg Tablet Antihistamine FORMULATION Each film-coated tablet contains: Levocetirizine dihydrochloride.. 5 mg PRODUCT DESCRIPTION Levocetirine 5
More informationREAD THIS FOR SAFE AND EFFECTIVE USE OF YOUR MEDICINE PATIENT MEDICATION INFORMATION. linezolid tablets
READ THIS FOR SAFE AND EFFECTIVE USE OF YOUR MEDICINE PATIENT MEDICATION INFORMATION Pr ZYVOXAM linezolid tablets Read this carefully before you start taking ZYVOXAM and each time you get a refill. This
More informationGastrointestinal Physiology. Intensive Care Training Program Radboud University Nijmegen Medical Centre
Gastrointestinal Physiology Intensive Care Training Program Radboud University Nijmegen Medical Centre Content Gastrointestinal blood flow Portal hypertension Motility disorders Specific metabolic disorders
More informationAUTOCOIDS. Mr. D.Raju, M.pharm, Lecturer
AUTOCOIDS Mr. D.Raju, M.pharm, Lecturer DEFINITION An organic substance, such as a hormone, produced in one part of organism and transported by the blood or lymph to another part of the organism where
More informationThe GI tract in PD: From Beginning to End Lauren Seeberger, MD Associate Professor, Neurology University of Colorado, Denver
The GI tract in PD: From Beginning to End Lauren Seeberger, MD Associate Professor, Neurology University of Colorado, Denver The Problems Introduc
More informationDisorders in which symptoms cannot be explained by the presence of structural or tissue abnormalities Irritable bowel syndrome Functional heartburn Functional dyspepsia Functional constipation Functional
More informationJune By: Reza Gholami
ACG/CAG guideline on Management of Dyspepsia June 2017 By: Reza Gholami DEFINITION OF DYSPEPSIA AND SCOPE OF THE GUIDELINE Dyspepsia was originally defined as any symptoms referable to the upper gastrointestinal
More information) and serotonin Type 2 (5-HT 2A
Latuda (lurasidone HCl) Fact Sheet Schizophrenia FREQUENTLY ASKED QUESTIONS What type of patient with schizophrenia is appropriate for LATUDA? LATUDA is an atypical antipsychotic agent indicated for the
More informationWEIGHT LOSS/MANAGEMENT IS IT JUST ANOTHER PIPE DREAM?
WEIGHT LOSS/MANAGEMENT IS IT JUST ANOTHER PIPE DREAM? THE OBESITY MEDICINE ASSOCIATION S DEFINITION OF OBESITY Obesity is defined as a chronic, relapsing, multi-factorial, neurobehavioral disease, wherein
More informationFecal incontinence causes 196 epidemiology 8 treatment 196
Subject Index Achalasia course 93 differential diagnosis 93 esophageal dysphagia 92 95 etiology 92, 93 treatment 93 95 work-up 93 Aminosalicylates, pharmacokinetics and aging effects 36 Antibiotics diarrhea
More informationClinical Trial Results Summary Study EN3409-BUP-305
Title of Study: A 52-Week, Open-Label, Long-Term Treatment Evaluation of the Safety and Efficacy of BEMA Buprenorphine in Subjects with Moderate to Severe Chronic Pain Coordinating Investigator: Martin
More informationDefense Technical Information Center Compilation Part Notice
UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADPO 11045 TITLE: Gastrointestinal Drugs in Aircrew DISTRIBUTION: Approved for public release, distribution unlimited This paper
More informationSUMMARY OF PRODUCT CHARACTERISTICS
MUTUAL RECOGNITION PROCEDURE Page 1 of 5 SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT, syrup 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml of syrup contains 1 mg loratadine.
More informationWhen Diet and Exercise Aren t Enough: Pharmacologic Management of Obesity
When Diet and Exercise Aren t Enough: Pharmacologic Management of Obesity Casey Bonaquist, DO Saturday, April 30 th, 2016 17 th Annual Primary Care & Cardiovascular Symposium Learning Objectives After
More informationAntidepressant Pharmacology An Overview
Figure 1. Antidepressant Pharmacology An Overview Source: NEJM 2005;353:1819-34 Figure 2. 1 Figure 3: Antidepressant Pharmacology pictures: Weak inhibition Bupropion NOTE: CYP enzymes noted are those inhibited
More informationLa tasca acida nella MRGE: aspetti patogenetici e terapeutici
La tasca acida nella MRGE: aspetti patogenetici e terapeutici Prof. VINCENZO SAVARINO Professore Ordinario di Gastroenterologia, Università degli Studi di Genova Direttore della Clinica Gastroenterologica
More informationDisclosures. Objectives. Gastroparesis: Are We Moving On? Gastroparesis: Clinical Overview
Gastroparesis: Are We Moving On? Anthony Lembo, M.D. Associate Professor of Medicine Harvard Medical School Beth Israel Deaconess Medical Center Boston, MA Disclosures Consultant Alkermes, Allergan, Forest,
More informationDavid Leff, DO. April 13, Disclosure. I have the following financial relationships to disclosure:
David Leff, DO AOMA 94 th Annual Convention April 13, 2016 Disclosure I have the following financial relationships to disclosure: Speaker s Bureau: Allergan Labs, Takeda Pharmaceutical, Valeant Pharmaceutical
More information