EMPOWER Clubs for Young Women using oral PrEP as part of an HIV prevention package: What we ve learned so far
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1 EMPOWER Clubs for Young Women using oral PrEP as part of an HIV prevention package: What we ve learned so far Lethabo Ramskin, Deborah Baron, Keolepile Makgamathe, Jennifer Schutzman, Anne Stangl, Kirsty Sievwright, Nomhle Khoza, Fiona Scorgie, Charlotte Watts & Sinead Delany-Moretlwe Adherence to HIV Prevention and Treatment Harare, Zimbabwe 26 April 2018
2 Potential Conflicts and Financial Disclosures I have no actual or potential conflicts to declare in relation to this programme and presentation Grant/Research support: DFID through STRIVE, EHPSA, Mott MacDonald
3 Introduction In trials with 80% adherence, PrEP reduced risk of infection by 70% but efficacy was lower in populations <25 yrs, owing to poor adherence* Hence the need for interventions to tackle factors likely to impact negatively on adherence: Gender Based Violence (GBV) Lack of partner support Gender inequality in sexual relationships *Marrazzo, J.M., et al., Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women. New England Journal of Medicine, (6): p
4 EMPOWER Study Objectives To evaluate the feasibility, acceptability and safety of: integrating screening and linkage-to-care for GBV & stigma within HIV counselling and testing for AGYW. supporting PrEP acceptance, effective use & retention in care through adherence clubs. Two sites: Wits RHI Johannesburg, South Africa; Mwanza Intervention Trials Unit (MITU), Tanzania 4
5 Randomisation EMPOWER Study Design HCT+ GBV screening AGYW age years HIV positive and/or risk of immediate harm - refer Enrol HIV negative Accept oral PrEP (N=500) Standard of Care N=250 Empowerment clubs + standard adherence support (N=250) Standard of Care Decline oral PrEP Empowerment clubs + standard adherence support
6 Data collection & analysis Computer Assisted Self-Interview (CASI) Baseline and follow-up all participants Process data on attendance Analysis pending trial completion Johannesburg site: In-depth interviews with AGYW (n = 25) Waiting room and club observations Data analysed for this presentation Field notes = Sep 2016 Dec 2017
7 Club format Sessions were sequentially structured Non-clinic venue Led by a trained facilitator One session per month; duration 2 hours Weekday afternoon and Saturday mornings Planned 20 members per club
8 Club curriculum development Literature review Adaption of materials from existing programmes Pilot testing during training of facilitators Session 1: Gender Roles & Social Norms Session 2: Power and Control Session 3: Sexual Reproductive Health Session 4: Empowerment
9 Participatory learning activities Practising negotiation skills Participants form small groups. Each group is given a roleplay scenario note card, asked to choose 2 actors and create a short skit based on their role-play scenario. Pose the following questions to the group and discuss: What if you want something during sex, but your partner does not? Can you negotiate?
10 Findings
11 Clubs create a safe space for young women To discuss relationship problems one participant shared her problem with her boyfriend like he d want to know where is she, what is she doing, and with who she used to panic about that until we gave her advice that she should tell him to stop it [IDI participant]
12 Clubs create a safe space for young women To practice self-confidence I was not able to talk in front of a group of people, but here I can do that [Notes from club observations] since I have started to come to the clubs my self-confidence has improved [Notes from club observations] To disclose personal experiences of GBV he beats me up then he can even cry when he apologise - [Notes from club observations]
13 Adherence To hear first-hand from other young women how they have handled PrEP side-effects and stigma everyone used to open up about their different situations we give each other advice, we laugh, there was no one judgemental or anything [IDI participant]
14 Clubs are not for everyone Inconvenient club times Afternoon and Saturday sessions Two visits per month is burdensome Align clinic visit with club sessions
15 Implementation lessons Content is acceptable Important niche in addressing the social and structural context of AGYWs vulnerability to HIV Additional support on transitioning into adulthood is needed Best way to deliver Sequential sessions may not be the best format Young people have busy lives and want fast, easy services Merge club sessions with clinic visits to reduce time burden Mixed age range works well Supporting Adherence Young women report honestly about adherence (share tips and tricks to overcome side-effects) Clubs are potentially a valuable source of peer support Creating networks beyond trial participation
16 Acknowledgements Participants YCAB EMPOWER team Funders: EHPSA, STRIVE, Mott MacDonald
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