Lipoatrophy and Fat Accumulation in HIV-Infected Adults
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1 Switch to a PI-Containing/NRTI-Sparing regimen (LPVr/EFV) increases appendicular fat content and serum lipid levels without affecting glucose metabolism or bone mineral density. The results of a prospective randomized trial. ACTG 5125 P Tebas*, J Zhang, K Yarasheski, S Evans, MA Fischl, A Shevitz, J Feinberg, A Collier, C Shikuma, B Brizz, F Sattler, and the Adult AIDS Clinical Trials Group (AACTG)
2 Lipoatrophy and Fat Accumulation in HIV-Infected Adults Lipoatrophy and fat accumulation are frequent complications of HIV or its treatment Grinspoon, S. et al. N Engl J Med 25;352:48-62
3 The initiation of ART ACTG 55. Changes in body composition according to NRTI assignment in ACTG Limb fat D4T+ DDI AZT+3TC Trunk fat % change from baseline Weeks Weeks
4 Lipoatrophy effects Negative impact on physical and psychosocial well-being Social stigmatization and easy identification as HIV+ Increased risk of depression Decreased self-esteem, daily performance, and sexual and social functioning Increases the risk of non adherence Increases the cost of treatment Probable metabolic consequences
5 Treatment options for lipoatrophy Things that work: Things that do not work: Switching NRTIs D4T to abacavir or ZDV (TARHEEL, McComsey, G. CID 24;38:263-27) D4T or ZDV to abacavir (MITOX. A. Martin et al. AIDS 24;18: Switching PIs (Tebas P. AIDS Res Hum Retroviruses. 24;6:589-94). Rosiglitazone (Carr A. Lancet, 24; 363(947):429-38) Poly-L-lactic acid.(sculptra ) AIDS. 23;17:
6 Do regimens without NRTIs increase appendicular fat?
7 ACTG 5125s Naïve HIV + nadir CD4 2 or HIV RNA 8, 2NRTI + IDV 2NRTI + IDV +NFV 2NRTI + IDV + EFV VL undetectable (<2 c/ml) 18 months of HAART 2NRTI +EFV LPV/r+EFV
8 ACTG 5125s. Schema Variable time DEXAs DEXAs extension DEXAs w 24w 48w q16w Median 14w 2 NRTIs + EFV LPV/r+EFV Power Within arm 86%.4 kg (n=32, α=.5, SD=.65) Between arms >9%.6 kg (n1=n2=32, α=.5, SD1=SD2=.65)
9 Objectives Primary Objective Examine changes in appendicular fat at 48 weeks Secondary Objectives Examine changes in Lipids (HDL, LDL cholesterol, total cholesterol, triglycerides, and free fatty acids) Fasting glucose, insulin, and HOMA Regional bone mineral density (BMD) Bone metabolic markers in serum Examine the relationship between changes in regional fat and measures of fasting lipids and insulin sensitivity. Explore the association between prior antiretroviral therapy and changes in BMD and regional fat distribution as measured by DEXA
10 Inclusion/Exclusion criteria Inclusion Enrollment in A5116 Signed informed consent document specific to this substudy No need for clinical lipoatrophy Exclusion Uncontrolled hypogonadism. Receipt during the last 6 months: Growth hormone (Serostim ) Megestrol acetate (Megace ) Anticytokine agents Ketoconazole (Nizoral ) Systemic glucocorticoids Treatment for osteoporosis Cushing s syndrome and American Diabetes Association (ADA)- defined diabetes mellitus.
11 Status 62 patients enrolled, 31 in each arm 9 confirmed patients did not complete the study: 7 in the LPV/r + EFV arm (1 death, 5 withdrew consent, 1 other) 2 in the NRTI+EFV arm (1 lost to follow up, 1 other)
12 Baseline characteristics Male % Caucasian % Hx IVDU % Age y (median) CD4/ml (median) % HIV RNA < 2 c/ml LPV/r + EFV (n=31) NRTI + EFV (n=31) p value NS NS NS NS NS NS No significant differences at baseline between arms: Glucose metabolism Lipids Fat distribution BMD % on D4T (n) 19 (6) 25 (8) NS
13 Appendicular fat change median (IQR) ITT analysis Fat change (g) NRTI + EFV LPV/r + EFV Baseline=6 kg 48 Last Time (weeks) p=.86 * p=.5 p=.2 Between arm * Within arm * p=.7 * p=.7 NRTI + EFV LPV/r + EFV
14 Is D4T driving the fat loss in the NRTI arm? Fat change (g) 15 D4T (n=6) 125 No D4T (n=19) Median NRTI+EFV arm Median LPV/r+EFV arm Baseline=6Kg 48 Last Time (weeks) Probably not Caveat: we were not powered to detect differences within the NRTI groups
15 Trunk fat change median (IQR) Fat change (g) No significant differences between or within arms -15 Baseline= 1.3 kg Last Time (weeks) NRTI + EFV LPV/r + EFV
16 Glucose/Insulin median (IQR) Glucose Insulin Change mg/dl 3 2NRTIs + EFV 25 LPV/r + EFV Change (microu) Weeks No significant changes from baseline within or between arms NRTI+EFV LPV/r +EFV
17 1 Cholesterol median (IQR) 2NRTIs + EFV LPV/r + EFV 2 Triglycerides median (IQR) Change (mg/dl) p=<.1 mixed model repeated measures ANOVA Weeks LPV/r + EFV had higher cholesterol and TG levels over time NRTI+EFV LPV/r +EFV
18 Non HDL-Cholesterol median (IQR) HDL cholesterol median (IQR) 1 2NRTIs + EFV LPV/r + EFV 2 Change (mg) p=<.1 mixed model repeated measures ANOVA Weeks NRTI+EFV LPV/r +EFV LPV/r + EFV had higher non HDL cholesterol and both arms moderately increased HDL levels over time
19 Changes in BMD median (IQR) % change Total body BMD NRTI + EFV LPV/r + EFV % change Lumbar spine BMD 35% of the patients had osteopenia or osteoporosis (lumbar) at baseline No significant changes overtime in whole body or regional BMD -5 NRTI + EFV LPV/r + EFV 48 Last Time (weeks) Last Time (weeks) No significant changes on osteocalcin and NTx
20 Baseline predictors of appendicular fat change We evaluated the correlation between baseline predictors and changes in appendicular fat overtime: Baseline appendicular fat Gender Age Race CD4 D4T use No evidence that baseline variables were associated with changes in peripheral fat
21 Conclusions The switch to a non-nrti containing combination of LPV/r+EFV was associated with significant improvement in appendicular fat (p=.8 at 48 weeks and p=.2 at last observation, median 14 weeks) significant increases in serum lipids stable glucose metabolism stable whole body and regional BMD
22 Conclusions These results provide additional evidence that NRTIs are important in progressive appendicular fat loss that characterizes HIV-lipoatrophy The switch to a NRTI-sparing regimen LPV/r + EFV may represent a therapeutic option for patients with lipoatrophy. This option has to be balanced with the increased lipids and the trend to increase virologic failure of the LPV/r + EFV regimen Please see the presentation of A5116 on Friday (Margaret Fischl Session 37 #162 at 11:3 am)
23 Acknowledgments Team members Abby Helen Shevitz, M.D., M.P.H. Kevin Yarasheski, Ph.D Marjorie Dehlinger, D.N.Sc. Barbara Brizz, B.S.N., M.H.S.Ed. Scott Evans, Ph.D. Jiameng Zhang, Ph.D.* Margaret A. Fischl, M.D Judith Feinberg, M.D. Cecelia Shikuma, M.D. Anne Kmack, B.S. Marlene Cooper, M.S. Pablo Tebas, M.D. Fred Richard Sattler, M.D. Study team A5116 Participants Sites Quest Diagnostics Bill Meyer Tufts University (central reading) Jodi Forand Abby Shevitz Pharmaceutical Partners Abbott Kevin Garren BMS GlaxoSmithKline Charles Lancaster * p<.1
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