4/14/2016. Breaking News From the 2016 Conference on Retroviruses and Opportunistic Infections
|
|
- Jeffery McBride
- 5 years ago
- Views:
Transcription
1 Breaking News From the 2016 Conference on Retroviruses and Opportunistic Infections Jeffrey L. Lennox, MD Professor of Medicine Associate Dean for Clinical Research Emory University School of Medicine Medicine Chief of Service Grady Health Systems Atlanta, Georgia FINAL: 03/29/16 Atlanta, Georgia: April 8, 2016 Financial Relationships With Commercial Entities Dr Lennox has served as a consultant or advisor to Bristol-Myers Squibb and Merck & Co, Inc. (Updated 04/8/16) Slide 2 of 38 Learning Objectives After attending this presentation, participants will be able to describe the results of studies presented at CROI 2016, including on: Results of studies of new drugs, combinations, and formulations. Risks and possible treatments for antiretroviral therapy (ART)-associated bone loss Approaches to prevent HIV-infection. Slide 3 of 38 1
2 Populations and Outcomes Slide 4 of 38 Slide 5 of 38 HIV+ vs. HIV- Life Expectancy- Kaiser California Adults receiving care at Kaiser California, HIV- to HIV+ 10:1 match for those seen between ,768 HIV+, 257,600 HIV-, 91% male, ~25% white, ~35% ever smoked Marcus JL #54 Life Expectancy Much Improved, But Gaps Remain Slide 6 of 38 2
3 Effect of Race, Gender and Other Factors on Success on Initial ART A5257:1809 ARV naïve began TDF/FTC + RAL or DRV/r or ATV/r 24% women; 43% Black, 22% Hispanic Slide 7 of 38 Ribaudo H #476 Association of Sex and Race/Ethnicity with V.F. Adjusting for Other Factors Women did no worse than men, and Hispanics no worse than non-hispanic whites, after adjusting for race (Women) and income (Hispanics) Slide 8 of 38 Case 1 A 22 year old male, high-school drop out diagnosed 1 year ago, CD4 = 2 (1%). Has been hospitalized 5 times for wasting, PCP, diarrhea. Continues to use marijuana, crack and ETOH. Has never gone to clinic. Social work has referred him to a drug rehabilitation program. Slide 9 of 38 3
4 Which of these do you think will most effectively engage him in ART? 1. A healthcare navigator 2. A navigator plus cash incentives 3. Enroll in a trial of longacting injectable ART 4. Some other intervention 19% 53% 17% 11% Slide 10 of 38 Improving Substance Users ART Outcome CTN 0049 Hospitalized, viremic pts in 11 hospitals randomized to 11 sessions of patient navigation (PN), vs PN + $, vs usual care PN+$ pts can earn up to $1160 total- $180 for 4 clinic visits, $100 for VL<50 Metsch L #27 Slide 11 of 38 CTN 0049 Results- Pay me now and pay me later? Slide 12 of 38 Change in Viral Suppression % p = p = mo. 12 mo. At 6 months engagement in care was also improved Southern sites had much higher rates of virologic failure (p<0.0001)
5 Treatment Naïve Studies and New ARVs Slide 13 of 38 Oral Induction, Injection Maintenance- LATTE week 32 Cabotegravir is a new integrase inhibitor. Population- ART naïve patients with mean CD4 489, 18% with HIV RNA >100,000K Volume two 3mL injections q8 weeks or two 2mL injections q4 weeks Slide 14 of 38 Margolis DA # 31LB LATTE Results Rilpivirine did not achieve desired plasma levels until ~ week 16, methods to increase early levels being explored No new ART resistance detected Slide 15 of 38 5
6 Adverse Events and Labs Maintenance Period Number of subjects reporting ISRs decreased over time, from 86% (Day 1) to 33% (Week 32) 2/230 subjects (1%) withdrew as result of injection reactions (Q 8 Wk) Slide 16 of 38 Q 8Wk IM Q 4Wk IM Number of injections Number of ISRs Grades Grade (80%) 1021 (83%) Grade (19%) 197 (16%) Grade 3 Duration, days 12 (1%) 10 (<1%) Median Slide 17 of 38 Efficacy and Safety of ELV/c/TAF/FTC in Adolescents Open label, 48 week, single arm study of ELV/c/TAF/FTC Age yrs, CD4>100, Wt>35kg 48 Subjects followed to 48 wks 92% (48/50) HIV RNA <50c/mL at 48 wks In this small study there were no signs of renal tubular dysfunction Gaur #817 New NNRTI Doravirine vs. EFV- Week 48 Results Doravirine active in vitro against K103N, Y181C, G190A, E138K Metabolized by Cyp3A4, but not an inducer or inhibitor Continuation of 100mg from a dose ranging study, plus new 100mg pts, vs. EFV in treatment naïve; with TDF/FTC 92% male, CD4 ~400, VL>100,000 ~36% Slide 18 of 38 Gatell #470 6
7 Doravirine vs. EFV Results Doravirine 100mg QD had similar efficacy to EFV, both with TDF/FTC AEs % DOR EFV Nightmares Dizziness Grade 1 LDL > Grade 2 TG Gatell JM #470 Slide 19 of 38 Long Acting Nucleoside Analog Potential Once Weekly Dosing EFdA (MK-8591) in vitro is active against HIV, including K65R TDF resistant ¹ MK mg single dose in 6 ARV-naïve patients ² PBMC MK-8591-TP concentrations exceeded target at 7 days 6/6 pts developed headaches Slide 20 of 38 ¹ Michailidis E Retrovirology 2015 ² Friedman EJ #437LB Switch Study Slide 21 of 38 7
8 Case 2 A 28 year old Black female on chronic ART with ELV/c/TDF/FTC. Viral load is suppressed, egfr is normal. She heard through a friend that she should switch to a TAF-containing regimen. Slide 22 of There is not enough data on efficacy in this population, stay the course 2. Change TDF to TAF since it is effective and less toxic 3. Wait until we have more safety data on long-term, TAF treated patients What do you recommend? 7% 66% 27% Slide 23 of 38 Switching Patients From TDF/FTC to TAF/FTC Stable patients on ART entered a placebo-controlled study to change TDF to TAF, or remain on TDF TAF/FTC dosage differs: 200/10 mg with PI, 200/25 mg with non-pi Gallant J # 29 Slide 24 of 38 8
9 TAF Switch- Safety Tolerability and A/E similar Grade 3 or 4 LDL in 20 pts on TAF, 8 pts on TDF Emergent resistance in 1 pt (184V) on TAF Slide 25 of 38 End Organ Disease Slide 26 of 38 Body Composition Changes: RAL vs. TDF/FTC Neat 001study- DRV/r + TDF/FTC vs. DRV/r + RAL DEXA Substudy of 126 pts Week 96 DRV/r + RAL DRV/r + TDF/FTC Limb Fat Change +9.8% +4.9% 20% Limb Fat 10.4% 17.9% Body Fat Change +15.8% +6.0% 20% Trunk Fat 40.8% 35.7% Bernardino J #45 Slide 27 of 38 9
10 Bone Fractures and Osteonecrosis A Multi-National Risk Analysis EUROSIDA cohort of 11,820 patients with 86,118 PYFU since Jan New Fractures 619, rate 7.2/1,000 PYFU Osteonecrosis 89, rate 1.0/1,000 PYFU Patients who ever used TDF were more likely (IRR 1.40) to develop fractures, but Not osteoporotic fractures Slide 28 of 38 Borges AH #46 Slide 29 of 38 Maternal TDF Effect on Infant Bone? DXA substudy of PROMISE: Maternal ZDV + sdnvp vs ZDV/3TC + LPV/r vs TDF/FTC + LPV/r About 120 infants per arm DXA scanned after birth No difference in LS between arms. Whole body BMC was lower in both triple drug arms Siberry G #36 Stopping or Changing TDF Effect on Bone Follow on study of IPREX: 352 pts with DEXA at 24 weeks after D/C TDF/FTC PrEP ¹ Annualized BMD 1.13 hip, 1.81 spine TAF Switch Study TAF Quad Switch Substudy ² BMD spine and hip Slide 30 of 38 ¹ Grant R #48LB ² Gallant J #29 10
11 Bisphosphonate to Prevent ART-Associated Bone Loss ART naïve began TDF/FTC + ATV/r plus either Zoledronic acid 5mg IV or placebo IV single dose BMD at baseline, q 24 weeks 63 subjects completed 48 wks 79% male, 84% Black, CD4 ~ 125 CTx, a marker of bone resorption, was dramatically reduced in the ZA arm Ofotokun I #47 Slide 31 of 38 Single Dose Zoledronic Acid Preserves BMD Lumbar Spine Hip Femoral Neck Slide 32 of 38 Prevention Slide 33 of 38 11
12 Maraviroc as PrEP A5305/HPTN 069 Double-blind, randomized study where all pts got 3 pills daily ¹ 404 MSM/TGW enrolled and treated MVC MVC+FTC MVC+TDF TDF+FTC New HIV Of 5 newly HIV +, all had R5 HIV, 2/5 never had detectable drug levels and 3/5 had low levels Rectal biopsy tissue explants from MVC only patients more easily infected in vitro than tissues from patients in other arms ² Slide 34 of 38 ¹ Gulick R #103 ² McGowan #104 Cabotegravir as PrEP Phase 2A - Safety and PK (ECLAIR) Placebo-controlled, 4 week oral CAB 30mg or PBO; then Q/2 wk IM CAB 800mg or PBO 127 low risk MSM enrolled Slide 35 of 38 PBO CAB % I.S. pain % Grade 3 pain 0 10 # days pain PK showed higher peaks, lower trough than expected. 2 new HIV+, 1 PBO + 1 CAB. CAB pt had low PK levels despite I.M. injections. Markowitz M #106 Dapivirine Ring PrEP-Phase III Trials ¹ MTN 020 (Aspire) enrolled 2,629 women at 4 African sites. 1:1 randomization to DPV ring vs. control ring changed monthly Residual drug concentration of returned, used rings were measured ² IPM027 enrolled 1,959 African women 2:1 randomization Slide 36 of 38 ¹ Baeten JM #109LB ² Nel A #110LB 12
13 DPV Ring Efficacy Phase III Trials MTN 020 IPM 027 DPV PBO DPV PBO % Efficacy MTN / IPM Rate/100 Pt / 31 Rate, Age > / 37 Rate, Age <0 / 15 %NNRTI Resistance n/a Higher residual drug concentration in used rings correlated with decreased protection Slide 37 of 38 MTN 020 Adherence and Age Slide 38 of 38 Opportunistic Infections Slide 39 of 38 13
14 Operational Research for Cryptococcal Antigen Screening (ORCAS) Trial Test WHO recommended therapy for asymptomatic + CRAG 151 asymptomatic CRAG+ given Fluconazole 800mg QD x 2 wks Add ART 400mg QD x 8 wks ~25% risk for death and/or meningitis, risk greater if CD4<50 or CRAG>1:160 Slide 40 of 38 Morawski BM #
Didactic Series. CROI New Antiretroviral Therapies. Daniel Lee, MD Clinical Professor of Medicine UCSD Medical Center Owen Clinic July 14, 2016
Didactic Series CROI 2016 - New Antiretroviral Therapies Daniel Lee, MD Clinical Professor of Medicine UCSD Medical Center Owen Clinic July 14, 2016 This project is supported by the Health Resources and
More informationCROI 2016 Update NEAETC, March 21, Sigal Yawetz, MD Brigham and Women s Hospital Harvard Medical School
CROI 2016 Update NEAETC, March 21, 2016 Sigal Yawetz, MD Brigham and Women s Hospital Harvard Medical School CROI 2016 Update NEAETC, March 21, 2016 UNITED STATES EPIDEMIOLOGY Estimating the lifetime risk
More information11/7/2016. Jeanne M. Marrazzo, MD, MPH Professor of Medicine University of Alabama at Birmingham Birmingham, Alabama
HIV Preexposure Prophylaxis: Pills, Rings, Injectables, and Gels Oh My! Jeanne M. Marrazzo, MD, MPH Professor of Medicine University of Alabama at Birmingham Birmingham, Alabama FORMATTED: 10/17/16 Financial
More informationHIV IS NOT OVER. Update From the Conference on Retroviruses and Opportunistic Infections (CROI) Learning Objectives
Update From the Conference on Retroviruses and Opportunistic Infections (CROI) Davey M. Smith, MD, MAS Professor of Medicine University of California San Diego San Diego, California Learning Objectives
More informationCabotegravir Long-Acting (LA) Injectable Nanosuspension Bill Spreen, for ViiV Healthcare & GSK Development Team. 17 th HIV-HEPPK June 2016
Cabotegravir Long-Acting (LA) Injectable Nanosuspension Bill Spreen, for ViiV Healthcare & GSK Development Team RPV CAB CAB RPV 1 June 2016 Cabotegravir Long-Acting Nanosuspension CAB is an investigational
More informationOral Versus Injectable Delivery, Impact on Adherence/Tolerability
Oral Versus Injectable Delivery, Impact on Adherence/Tolerability 2 nd European HIV Forum Ian McGowan MD DPhil FRCP University of Pittsburgh, PA, USA Glasgow, 22 nd October, 2016 Overview Why do we need
More informationLong-Acting Antiretrovirals for HIV
Long-Acting Antiretrovirals for HIV R.M. Gulick, MD, MPH Rochelle Belfer Professor in Medicine Chief, Division of Infectious Diseases Weill Cornell Medicine New York City Disclosures None Single Tablet
More information23 rd CROI Report Back AETC/Community Consortium Harry W. Lampiris, MD Professor of Clinical Medicine, UCSF Chief, ID Section, Medical Service,
23 rd CROI Report Back AETC/Community Consortium Harry W. Lampiris, MD Professor of Clinical Medicine, UCSF Chief, ID Section, Medical Service, SFVAMC March 23, 2016 Boston, MA, February 22-25, 2016 Disclosures
More informationProfessor Jeffery Lennox
BHIVA AUTUMN CONFERENCE 2014 Including CHIVA Parallel Sessions Professor Jeffery Lennox Emory University School of Medicine Atlanta, Georgia, USA 9-10 October 2014, Queen Elizabeth II Conference Centre,
More informationLong Acting ART for Treatment and PrEP
Long Acting ART for Treatment and PrEP Anton Pozniak MD FRCP Consultant Physician Disclosures I have received honoraria, travel sponsorship and research grants from: Gilead Sciences Janssen MSD ViiV Healthcare
More informationHIV Treatment Evolution. Kimberly Y. Smith MD MPH Vice President and Head, Global Research and Medical Strategy Viiv Healthcare
HIV Treatment Evolution Kimberly Y. Smith MD MPH Vice President and Head, Global Research and Medical Strategy Viiv Healthcare Overview of the Evolution of Antiretroviral Therapy Early Treatment 1987
More informationRoy M. Gulick, MD, MPH Rochelle Belfer Professor in Medicine Weill Cornell Medicine New York, New York
Antiretroviral Therapy: Investigational New Drugs and New Strategies Roy M. Gulick, MD, MPH Rochelle Belfer Professor in Medicine Weill Cornell Medicine New York, New York FORMATTED: MM/DD/YY Antiretroviral
More informationDidactic Series. CROI 2014 Update. March 27, 2014
Didactic Series CROI 2014 Update Christian Ramers, MD, MPH Family Health Centers of San Diego Ciaccio Memorial Clinic Jacqueline Peterson Tulsky, MD UCSF Positive Health Program at SFGH Medical Director,
More informationEpidemiology. Update From the 2019 Conference on Retroviruses and Opportunistic Infections. Learning Objectives
Slide 1 of 51 Update From the 2019 Conference on Retroviruses and Opportunistic Infections Jeffrey L. Lennox, MD Professor of Medicine Associate Dean for Clinical Research Emory University Atlanta, Georgia
More informationCROI 2017 Highlights What s New in Antiretrovirals (Part 2)
Mountain West AIDS Education and Training Center CROI 2017 Highlights What s New in Antiretrovirals (Part 2) Ann Collier, MD This presentation is intended for educational use only, and does not in any
More informationID Week 2016: HIV Update
Mountain West AIDS Education and Training Center ID Week 2016: HIV Update Robert Harrington, M.D. This presentation is intended for educational use only, and does not in any way constitute medical consultation
More informationDRUGS IN PIPELINE. Pr JC YOMBI UCL-AIDS REFERENCE CENTRE BREACH Sept 27, 2015
DRUGS IN PIPELINE Pr JC YOMBI UCL-AIDS REFERENCE CENTRE BREACH Sept 27, 2015 N(t)RTI The Development of TAF TAF Delivers the High Potency of TDF While Minimizing Off- Target Kidney and Bone Side Effects
More informationDisclosures (last 12 months)
HIV Research What s in the Pipeline? Samir K. Gupta, MD, MS Division of Infectious Diseases Indiana University School of Medicine Disclosures (last 12 months) Independent research grant funding by NIH/NHLBI,
More informationAre the current doses of ARV correct. Richard Elion MD Associate Adjunct Clinical Professor of Medicine Johns Hopkins School of Medicine
Are the current doses of ARV correct Richard Elion MD Associate Adjunct Clinical Professor of Medicine Johns Hopkins School of Medicine Can we lower doses of HIV meds safely? Consensus Panel in Alexandria
More informationThe injectables: a new silver bullet?
The injectables: a new silver bullet? Geneva October 6 Francois Venter Wits Reproductive Health and HIV Institute Thanks Clinical Care Options, Helen Rees, Joe Eron, Wits RHI sex worker team Disclosures
More informationThe Science behind Preexposure Prophylaxis (PrEP) Yunus Moosa Department of Infectious Diseases UKZN
The Science behind Preexposure Prophylaxis (PrEP) Yunus Moosa Department of Infectious Diseases UKZN 1 Ongoing HIV transmission despite expanding access to ART SA 18 16 14 12 10 8 6 4 2 0 Treatment exposure
More informationPrEP Dosing Strategies
PrEP Dosing Strategies Outline o Background PrEP absorption and tissue penetration o Oral versus topical o Lead in and lead out dosing Time to protection o Cycling on and off PrEP o Balancing toxicity
More informationHIV and Bone Disease: Through Thick and Thin! Pablo Tebas, MD
HIV and Bone Disease: Through Thick and Thin! Pablo Tebas, MD April 30 th, 2016 Disclosures I serve in an adjudication panel in a VZV vaccine study (Glaxo) I consult for Merck My research is supported
More informationCROI 2016: Top Ten for Clinicians
Hynes Convention Center. Boston, MA; US. Feb 22-25, 2016 CROI 2016: Top Ten for Clinicians Josep M Llibre Hospital Universitari Germans Trias i Pujol Fundació Lluita contra la SIDA Badalona, Barcelona
More informationSwitching ARV Regimens: Managing Toxicity and Improving Tolerability; Switches & Class-Sparing Approaches
Switching ARV Regimens: Managing Toxicity and Improving Tolerability; Switches & Class-Sparing Approaches Harry W. Lampiris, MD Chief, Infectious Disease Section, San Francisco VA Medical Center Professor
More informationSTRIBILD (aka. The Quad Pill)
NORTHWEST AIDS EDUCATION AND TRAINING CENTER STRIBILD (aka. The Quad Pill) Brian R. Wood, MD Medical Director, NW AETC ECHO Assistant Professor of Medicine, University of Washington Presentation prepared
More informationWhat s in the Biomedical Prevention Pipeline
What s in the Biomedical Prevention Pipeline HIV Endgame: Closing Gaps in the Care Cascade Toronto, 24 th October 2016 Ian McGowan MD DPhil FRCP University of Pittsburgh Pittsburgh, PA, USA Presenter Disclosure
More informationAntiretroviral Treatment Strategies: Clinical Case Presentation
Antiretroviral Treatment Strategies: Clinical Case Presentation Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan Chia-Jui, Yang M.D Disclosure No conflicts of interests.
More informationWHEN TO START? CROI 2015: Focus on ART
CROI 215: Focus on ART FORMATTED: 4-1-15 Washington, DC: May 13, 215 Roy M. Gulick, MD, MPH Gladys and Roland Harriman Professor of Medicine Chief, Division of Infectious Diseases Weill Cornell Medical
More informationRajesh T. Gandhi, M.D.
HIV Treatment Guidelines: 2010 Rajesh T. Gandhi, M.D. Case 29 yo M with 8 weeks of cough and fever. Diagnosed with smear-positive pulmonary TB. HIV-1 antibody positive. CD4 count 361. HIV-1 RNA 23,000
More informationCrafting an ART Regimen for Initiation or Salvage: Are NRTI s Necessary?
NORTHWEST AIDS EDUCATION AND TRAINING CENTER Crafting an ART Regimen for Initiation or Salvage: Are NRTI s Necessary? Brian R. Wood, MD Assistant Professor of Medicine, University of Washington Medical
More informationTim Horn Deputy Executive Director, HIV & HCV Programs Treatment Action Group NASTAD Prevention and Care Technical Assistance Meeting Washington, DC
Tim Horn Deputy Executive Director, HIV & HCV Programs Treatment Action Group NASTAD Prevention and Care Technical Assistance Meeting Washington, DC July 19, 2017 Pipeline is robust! Several drugs, coformulations,
More informationACTHIV 2018: A State-of-the-Science Conference for Frontline Health Professionals
ACTHIV 2018: A State-of-the-Science Conference for Frontline Health Professionals ACTHIV 2018: A State-of-the-Science Conference for Frontline Health Professionals Are You Ready? New Drugs Are on the Way!
More informationARVs in Development: Where do they fit?
The picture can't be displayed. ARVs in Development: Where do they fit? Daniel R. Kuritzkes, M.D. Division of Infectious Diseases Brigham and Women s Hospital Harvard Medical School Disclosures The speaker
More informationNext Generation PrEP? Injectable & Implantable ARVs
Next Generation PrEP? Injectable & Implantable ARVs Craig W. Hendrix, MD Wellcome Professor & Director, Clinical Pharmacology Johns Hopkins University Objectives Describe alternative formulations to improve
More informationAntiretroviral Therapy in 2016
Antiretroviral Therapy in 2016 Joel Gallant, MD, MPH Southwest CARE Center Santa Fe, NM University of New Mexico School of Medicine Johns Hopkins University School of Medicine Disclosures Consulting, Advisory
More informationFuture Perspectives for Delivery of Antiretroviral Drugs
Future Perspectives for Delivery of Antiretroviral Drugs David Back University of Liverpool UK David Back University of Liverpool Disclosures Honoraria received for advisory boards and lectures from AbbVie,
More informationThe role of Integrase Inhibitors during HIV prevention
The role of Integrase Inhibitors during HIV prevention Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint 2nd Global HIV Clinical Forum: Integrase Inhibitors Paris July 22th
More informationThe next generation of ART regimens
The next generation of ART regimens By Gary Maartens Presented by Dirk Hagemeister Division of Clinical Pharmacology UNIVERSITY OF CAPE TOWN IYUNIVESITHI YASEKAPA UNIVERSITEIT VAN KAAPSTAD Current state
More informationhiv treatmen + bulletin (e) march-april 2016 htb(e): volume 17 number 3/4 Published by HIV i-base C O N T E N T S ISSN
ISSN 1472-4863 htb(e): volume 17 number 3/4 hiv treatmen + bulletin (e) march-april 2016 C O N T E N T S EDITORIAL 2 CONFERENCE REPORTS 2 23rd Conference on Retroviruses and Opportunistic Infections (CROI
More informationVirological suppression and PIs. Diego Ripamonti Malattie Infettive - Bergamo
Virological suppression and PIs Diego Ripamonti Malattie Infettive - Bergamo Ritonavir-boosted PIs Boosted PIs: 3 drugs in one The intrinsic antiretroviral activity Viral suppression and high baseline
More informationTreating HIV in 2018 Interactive Cases From the Clinic(ians)
Slide 1 of 51 Treating HIV in 2018 Interactive Cases From the Clinic(ians) Michael S. Saag, MD Professor of Medicine Associate Dean for Global Health Jim Straley Chair in AIDS Research University of Alabama
More informationTaking a shot at HIV with longacting injectable ARVs for treatment and prevention
Taking a shot at HIV with longacting injectable ARVs for treatment and prevention Martin Markowitz M.D. Clinical Director and Staff Investigator Aaron Diamond AIDS Research Center Aaron Diamond Professor
More information11/8/2016. Moving Beyond Truvada: The (Current) Future Pipeline for PrEP. Prevention Modalities
Moving Beyond Truvada: The (Current) Future Pipeline for PrEP Raphael J. Landovitz, MD MSc Associate Professor of Medicine UCLA Center for Clinical AIDS Research & Education November 18, 2016 2 Million
More informationAntiretroviral Treatment: What's in the Pipeline
Antiretroviral Treatment: What's in the Pipeline Joseph P. McGowan, MD, FACP, FIDSA Professor of Medicine Hofstra North Shore-LIJ School of Medicine October 14, 2015 Which describes best how HIV Maturation
More informationThe pipeline: Long-acting agents and new drugs. Charles Flexner, MD Johns Hopkins University
The pipeline: Long-acting agents and new drugs Charles Flexner, MD Johns Hopkins University Do we still need an ARV pipeline? How close are we to having a universal antiretroviral regimen? A universal
More informationCases from the Clinic(ians): Case-Based Panel Discussion
Cases from the Clinic(ians): Case-Based Panel Discussion Michael S. Saag, MD Professor of Medicine The University of Alabama at Birmingham EDITED: 03-12-14 Learning Objectives After attending this presentation,
More informationCabotegravir + Rilpivirine as Long-Acting Maintenance Therapy: LATTE-2 Week 32 Results
Slide 1 Cabotegravir + Rilpivirine as Long-Acting Maintenance Therapy: LATTE-2 Week 32 Results David A. Margolis, 1 Juan Gonzalez-Garcia, 2 Hans-Jürgen Stellbrink, 3 Joe Eron, 4 Yazdan Yazdanpanah, 5 Sandy
More informationTreating HIV: When the Guidelines Don t Fit. Joel Gallant, MD, MPH. Southwest CARE Center Santa Fe, New Mexico
Treating HIV: When the Guidelines Don t Fit Joel Gallant, MD, MPH Southwest CARE Center Santa Fe, New Mexico Johns Hopkins University School of Medicine University of New Mexico School of Medicine Disclosures
More informationSimplifying HIV Treatment Now and in the Future
Simplifying HIV Treatment Now and in the Future David M. Hachey, Pharm.D., AAHIVP Professor Idaho State University Department of Family Medicine Nothing Disclosure 1 Objectives List current first line
More informationMedical Challenges of HIV/AIDS pandemic: The WHO perspective. SOLTHIS HIV Forum
Medical Challenges of HIV/AIDS pandemic: The WHO perspective SOLTHIS HIV Forum Marco Vitoria HIV/AIDS Department World Health Organization September 2013 Topic 2002 2003 2006 2010 2013 When to start 1
More informationMore Options, Some Opinions Initial Therapies for HIV Judith S. Currier, MD
More Options, Some Opinions Initial Therapies for HIV Judith S. Currier, MD More Options, Some Opinions: Initial Therapies for HIV Judith S. Currier, MD University of California Los Angeles Los Angeles,
More informationBiomedical Prevention Update Thomas C. Quinn, M.D.
Biomedical Prevention Update Thomas C. Quinn, M.D. Associate Director of International Research National Institute of Allergy and Infectious Diseases Director, Johns Hopkins Center for Global Health Global
More informationPanelists Melanie Thompson Jeffrey Lennox Wendy Armstrong Jonathan Li
Slide 1 of 51 Interactive ART Cases From the Clinic(ians): Case-Based Panel Discussion Michael S. Saag, MD Professor of Medicine Associate Dean for Global Health Jim Straley Chair in AIDS Research University
More information11/7/2016. Antiretroviral Therapy Strategies. Learning Objectives. After attending this presentation, participants will be able to:
Antiretroviral Therapy Strategies FORMATTED: 1/14/16 Joel E. Gallant, MD, MPH Medical Director of Specialty Services Southwest CARE Center Santa Fe, New Mexico Adjunct Professor of Medicine The Johns Hopkins
More informationSusan L. Koletar, MD
HIV/AIDS Susan L. Koletar, MD Division Director, Infectious Diseases Professor of Internal Medicine Department of Internal Medicine The Ohio State University Wexner Medical Center HIV through the Decades
More informationReduced Drug Regimens
Dr. Jose R Arribas @jrarribas Financial disclosures JOSE R ARRIBAS Research Support: Speaker s Bureau: Viiv, Janssen, Abbvie, BMS, Gilead, MSD Board Member/Advisory Panel: Merck, Gilead Stock/Shareholder:
More informationCROI 2013: New Drugs for Treatment and PrEP
NORTHWEST AIDS EDUCATION AND TRAINING CENTER CROI 2013: New Drugs for Treatment and PrEP Brian R. Wood, MD Medical Director, NW AETC Project ECHO Assistant Professor of Medicine, University of Washington
More information10/05/2016. Long-Acting Antiretroviral Agents For Prevention. Dr Paul Benn MB ChB FRCP
Long-Acting Antiretroviral Agents For Prevention Dr Paul Benn MB ChB FRCP 1 Disclosures Paul Benn is a full time employee of ViiV Healthcare and an honorary HIV Consultant at the Mortimer Market Centre,
More informationInvestigational Approaches to Antiretroviral Therapy
Investigational Approaches to Antiretroviral Therapy Rajesh T. Gandhi, MD Massachusetts General Hospital Professor of Medicine Harvard Medical School Boston, Massachusetts Learning Objectives After attending
More informationHIV in in Women Women
HIV in Women Susan L. Koletar, MD The Ohio State University How Many of These Women Have HIV? Answer: I don t really know Google Search: Photos of Groups of Women Pub Med Search: HIV and Women 22,732
More informationBHIVA Best of CROI Feedback Meetings. London Birmingham North West England Cardiff Gateshead Edinburgh
BHIVA Best of CROI Feedback Meetings London Birmingham North West England Cardiff Gateshead Edinburgh BHIVA Best of CROI Feedback Meetings 2010 COMPLICATIONS OF HIV DISEASE AND TREATMENT Overview Cardiovascular
More informationUpdate on Biomedical Prevention. Thomas C. Quinn, MD, MSc
Update on Biomedical Prevention Thomas C. Quinn, MD, MSc Associate Director of International Research National Institute of Allergy and Infectious Diseases Director, Johns Hopkins Center for Global Health
More informationClinical support for reduced drug regimens. David A Cooper The University of New South Wales Sydney, Australia
Clinical support for reduced drug regimens David A Cooper The University of New South Wales Sydney, Australia Clinical support for reduced drug regimens First line optimisation Virological failure New
More informationInvestigational Approaches to Antiretroviral Therapy
Investigational Approaches to Antiretroviral Therapy Rajesh T. Gandhi, MD Massachusetts General Hospital Professor of Medicine Harvard Medical School Boston, Massachusetts Learning Objectives After attending
More informationHIV Treatment Update. Anton Pozniak Consultant Physician, Director of HIV Services Chelsea and Westminster Hospital, London
HIV Treatment Update Anton Pozniak Consultant Physician, Director of HIV Services Chelsea and Westminster Hospital, London Guidelines Nuke sparing Nukes Efavirenz placement as the gold standard ARV Role
More informationWhat are the most promising opportunities for dose optimisation?
What are the most promising opportunities for dose optimisation? Andrew Hill Liverpool University, UK Global Financial Crisis How can we afford to treat 15-30 million people with HIV in the future? Lowering
More informationDr Marta Boffito Chelsea and Westminster Hospital, London
Dr Marta Boffito Chelsea and Westminster Hospital, London Speaker Name Statement Dr Marta Boffito has received travel and research grants from and has been an advisor for Janssen, Roche, Pfizer, ViiV,
More informationChronic complications of HIV infection. An update Pablo Tebas, MD
Activity Code TM809 Chronic complications of HIV infection. An update 2014 Pablo Tebas, MD Learning Objectives Upon completion of this presentation, learners should be better able to: Identify and update
More informationSwitching antiretroviral therapy to safer strategies based on integrase inhibitors. Pedro Cahn
Switching antiretroviral therapy to safer strategies based on integrase inhibitors Pedro Cahn Disclosures Research Grants: Abbvie-Merck-Richmond-ViiV Advisory boards: Merck-Sandoz-ViiV Switching in Virologically
More informationFat redistribution on ARVs: dogma versus data
Fat redistribution on ARVs: dogma versus data Gary Maartens Division of Clinical Pharmacology UNIVERSITY OF CAPE TOWN IYUNIVESITHI YASEKAPA UNIVERSITEIT VAN KAAPSTAD Half of what we are going to teach
More informationPharmacologic Characteristics and Delivery Options for Integrase Inhibitors
Pharmacologic Characteristics and Delivery Options for Integrase Inhibitors Courtney V. Fletcher, Pharm.D. Dean, College of Pharmacy Professor, Department of Pharmacy Practice and Division of Infectious
More informationPediatric HIV Update NORTHWEST AIDS EDUCATION AND TRAINING CENTER
NORTHWEST AIDS EDUCATION AND TRAINING CENTER Pediatric HIV Update Christian B. Ramers, MD, MPH Assistant Medical Director, Family Health Centers of San Diego HIV/HCV Distance Education Specialist - NWAETC,
More informationCADO/PADO: Update on 2015 WHO Consolidated guidelines Towards Treat All in the context of SDGs
CADO/PADO: Update on 2015 WHO Consolidated guidelines Towards Treat All in the context of SDGs Meg Doherty, Treatment and Care Coordinator WHO HQ Outline What s new in ARV Guidelines Drug optimisation
More informationLong Acting HIV Drugs for Prevention: what are the data? Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint
Long Acting HIV Drugs for Prevention: what are the data? Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint DISCLOSURES I have received a research grant from Gilead Sciences
More informationHIV Clinical Management: Antiretroviral Therapy and Drug Resistance
HIV Clinical Management: Antiretroviral Therapy and Drug Resistance Judith S. Currier, MD, MSc Professor of Medicine University of California, Los Angeles Disclosures: Research Grant from Theratechnologies
More informationCase 1 continued. Case 1 (cont) 12/8/16. MMAH Debate Panel Thursday, December 8, Case 1
MMAH Debate Panel Thursday, December 8, 2016 Case 1 HPI 55 yo man with newly diagnosed HIV initiates care in your clinic. His CD4+ cell count is 600, with HIV VL=90,000 copies/ml. He is asymptomatic at
More informationTwo Drug Regimens Pros and Cons. Jürgen Rockstroh Department of Medicine I University Hospital Bonn, Bonn, Germany
Two Drug Regimens Pros and Cons Jürgen Rockstroh Department of Medicine I University Hospital Bonn, Bonn, Germany HIV Clinical Forum, Moscow, Russia, Friday 23 rd November 2018 Conflict of Interest: JKR
More informationInvestigational Approaches to Antiretroviral Therapy: New Strategies and Novel Agents
Investigational Approaches to Antiretroviral Therapy: New Strategies and Novel Agents Joseph J. Eron MD Professor of Medicine University of North Carolina Chapel Hill, North Carolina Learning Objectives
More informationBHIVA Best of CROI Feedback Meetings. London Birmingham North West England Cardiff Gateshead Edinburgh
BHIVA Best of CROI Feedback Meetings London Birmingham North West England Cardiff Gateshead Edinburgh BHIVA Best of CROI Feedback Meetings 2010 ANTIRETROVIRAL TREATMENT STRATEGIES AND NEW DRUGS A5202:
More informationPrima linea: dovremmo evitare i PI nella terapia di prima linea per i loro effetti non desiderati? Giuseppina Liuzzi
6 th INFECtivology TOday Paestum 15-16 -17 maggio 2014 Prima linea: dovremmo evitare i PI nella terapia di prima linea per i loro effetti non desiderati? Giuseppina Liuzzi Istituto Nazionale per le Malattie
More informationSecond and third line paediatric ART strategies
Second and third line paediatric ART strategies Dr. Marape Marape Assistant Professor Ohio University School of Health Professions Gaborone, Botswana Marape Marape MB, BCh, BAO, MPH, PhD Assistant Professor
More informationTDF containing ART: Efficacy and Safety. Dr Lloyd B. Mulenga Adult Infectious Diseases Centre University Teaching Hospital Lusaka, Zambia
TDF containing ART: Efficacy and Safety Dr Lloyd B. Mulenga Adult Infectious Diseases Centre University Teaching Hospital Lusaka, Zambia 1 Indications Treatment of HIV-1 in combination with other antiretroviral
More informationInfertility Treatment and HIV
Infertility Treatment and HIV Infertility Treatment by IVF Or Intra-cytoplasmic Sperm Injections (ICSC) In Chronic HIV-1 Sero- discordant Couples (Poster 670) Retrospective study of outcome of IVF or ICSC
More informationHIV 101. Applications of Antiretroviral Therapy
HIV 101. Applications of Antiretroviral Therapy Michael S. Saag, MD Professor of Medicine Associate Dean for Global Health Jim Straley Chair in AIDS Research University of Alabama at Birmingham Birmingham,
More informationThe impact of antiretroviral drugs on renal function
The impact of antiretroviral drugs on renal function Professor Bruce Hendry Renal Medicine King s College London King s College Hospital NHS Foundation Trust 1 DISCLOSURES: BRUCE HENDRY I have received
More informationCLINICAL PEARLS OF NEW HIV MEDICATIONS PHARMACIST OBJECTIVES TECHNICIAN OBJECTIVES. At the end of this presentation pharmacists will be able to:
CLINICAL PEARLS OF NEW HIV MEDICATIONS Cindy Lou Zoellner, PharmD, BCPS Added Qualifications in Infectious Diseases Senior Clinical Pharmacy Specialist in HIV Parkland Health & Hospital System Volunteer
More informationCROI 2015: Treatment and Cure Highlights
NORTHWEST AIDS EDUCATION AND TRAINING CENTER CROI 2015: Treatment and Cure Highlights Shireesha Dhanireddy Robert Harrington March 17, 2014 No financial conflicts of interest Outline Treatment Studies
More informationHIV Update. On The Cutting Edge A Chronic Disease. Rhett M Shirley, MD
HIV Update On The Cutting Edge A Chronic Disease Rhett M Shirley, MD CDC Mid-point life expectancy estimates at age 20 years in three calendar periods, overall and by sociodemographic characteristics,
More informationHIV Treatment: New and Veteran Drugs Classes
HIV Treatment: New and Veteran Drugs Classes Jonathan M Schapiro, MD National Hemophilia Center Stanford University School of Medicine Rome, March 2013 Overview Many excellent antiretroviral agents are
More informationQué anuncian los nuevos trials?
Qué anuncian los nuevos trials? XVII Curso Nacional VIH/SIDA Sociedad Chilena de Infectología Agosto 2014 Dr. Carlos Beltrán Hospital Barros Luco Trudeau Universidad de Santiago Grupo SidaChile El presente
More informationART and Prevention: What do we know?
ART and Prevention: What do we know? Biomedical Issues Trip Gulick, MD, MPH Chief, Division of Infectious Diseases Professor of Medicine Weill Cornell Medical College New York City ART for Prevention:
More informationHistory (August 2010) Therapy for Experienced Patients. History (September 2010) History (November 2010) 12/2/11
(August 2010) Therapy for Experienced Patients Hiroyu Hatano, MD, MHS Assistant Professor of Medicine University of California San Francisco Medical Management of AIDS December 2011 42M HIV (CD4=450, VL=6250,
More informationPharmacological considerations on the use of ARVs in pregnancy
Pharmacological considerations on the use of ARVs in pregnancy 11 th Residential Course on Clinical Pharmacology of Antiretrovirals Torino, 20-22 January 2016 Prof. David Burger, PharmD, PhD david.burger@radboudumc.nl
More informationExisting and most needed paediatric ARV formulations
Existing and most needed paediatric ARV formulations Martina Penazzato Paediatric HIV advisor WHO HIV Department, Geneva Mach 7th 2016 Paediatric coverage still lags behind 45 40 35 30 25 20 15 10 5 0
More informationWhat is the Virologic Support for Two-Drug Regimens?
What is the Virologic Support for Two-Drug Regimens? Daniel R. Kuritzkes, M.D. Division of Infectious Diseases Brigham and Women s Hospital Harvard Medical School Disclosures The speaker has received consulting
More informationHepatitis C in HIV Coinfection. Annie Luetkemeyer, MD Division of HIV, ID and Global Medicine ZSFG, UCSF
Hepatitis C in HIV Coinfection Annie Luetkemeyer, MD Division of HIV, ID and Global Medicine ZSFG, UCSF Disclosures I have received research grant support to UCSF related to HCV from the following: Abbvie
More informationv Dr Anton Pozniak Chelsea and Westminster Hospital, London Injectable ARVs a S.W.O.T Analysis
18 th Annual Resistance and Antiviral Therapy Meeting v Dr Anton Pozniak Chelsea and Westminster Hospital, London Thursday 18 September 2014, Royal College of Physicians, London Injectable ARVs a S.W.O.T
More informationNUEVOS ENFOQUES TERAPEUTICOS
NUEVOS ENFOQUES TERAPEUTICOS -11ºC Daniel Podzamczer Unidad VIH. S Enf. Infecciosas Hospital Universitari de Bellvitge L Hospitalet. Barcelona AGENDA ART simplification QD regimen: RAL Bitherapy: DRVr/RAL
More informationCROI 2018 Report Back
CROI 2018 Report Back Monika Roy, MD MAS Assistant Professor Division of HIV, Infectious Diseases, and Global Medicine bayareaaetc.org 1 Disclosures and Conflicts of Interest Nothing to report bayareaaetc.org
More information