New NICE guideline updates recommendations for diagnosing latent tuberculosis
|
|
- Dina Montgomery
- 5 years ago
- Views:
Transcription
1 Tel: Ref: 2011/053 PRESS RELEASE New NICE guideline updates recommendations for diagnosing latent tuberculosis The National Institute for Health and Clinical Excellence (NICE) has today (23 March) published its clinical guideline on the diagnosis and management of tuberculosis, and measures for its prevention and control. A partial update of NICE clinical guideline 33 (published in March 2006), the new recommendations focus on the diagnosis of latent TB using interferon-gamma tests (IGT). All the other advice remains largely unchanged from the original guideline. The guideline addresses which diagnostic strategy is most accurate in diagnosing latent TB in adults and children who are recent arrivals from countries where TB is highly prevalent; in adults and children who have been in close contact with patients with active TB; in adults and children who are immunocompromised; healthcare workers and hard to reach populations. TB is caused by a bacterium called Mycobacterium tuberculosis ( M. tuberculosis or M.Tb ). It is spread by one person inhaling the bacterium in droplets coughed or sneezed out by someone with infectious tuberculosis. In over 80% of people the immune system kills the bacteria and they are removed from the body. However, in a small number of cases the TB bacteria are not killed and lie dormant (latent TB). Up to 15% of adults with latent TB will go on to develop active TB at some point in their lives and the risk in children may be much higher. In people who are immunocompromised - for example, if they are HIV positive - the chance of developing active TB within five years of infection is up to 50%. Detection of latent TB is therefore important in controlling the disease.
2 New recommendations for diagnosing latent TB in the guideline include: To diagnose latent TB in: household contacts aged 5 years and older and non-household contacts of all people with active TB: o A Mantoux test should be performed. Those with positive results (or in whom Mantoux testing may be less reliable for example, people who have had the BCG vaccination) should then be considered for IGT. o If Mantoux testing is inconclusive, refer the person to a TB specialist. New entrants from high-incidence countries aged 5 15 years: o Offer a Mantoux test followed by IGT if positive. New entrants from high-incidence countries aged years: o Offer either IGT alone or a dual strategy. For people aged 35 years or older, consider the individual risks and benefits of likely subsequent treatment before offering testing. New entrants from high-incidence countries aged under 5 years: o Use Mantoux as the initial test. If positive, taking into account BCG history, refer to a TB specialist to exclude active disease and consider treatment of latent TB. People who are immunocompromised: o If latent TB is suspected in children and young people who are immunocompromised, refer to a TB specialist. o For people with HIV and CD4 counts (also called T-cells, these are types of cells that help protect the body from infection) of less than 200 cells/mm 3, perform an IGT and a concurrent Mantoux test. If either test is positive assess for active TB and consider treating for latent TB. o For people with HIV and CD4 counts of cells/mm 3, perform an IGT alone or an IGT with concurrent Mantoux test. If either test is positive, assess for active TB and consider treating for latent TB. Dr Fergus Macbeth, Director of the Centre for Clinical Practice at NICE, said: Contrary to popular belief TB is not one of those diseases which, like smallpox, has been all but eradicated from our shores. In fact, latest figures show it is on the increase, particularly in our major cities. It is therefore important that the strategies that are used to detect the disease before it has the opportunity to develop into fullblown TB are as robust as possible and based on the best available evidence. When the original guideline was published NICE recommended further research to compare
3 the latent TB diagnostic strategies of conventional skin test only, skin test then interferon gamma test if positive, and interferon gamma test only. Based on a detailed analysis of this further research, the independent Guideline Development Group has concluded that the relative benefit of IGT over the Mantoux test in determining the need for treatment of latent TB infection is not certain and in the case of younger children it feels that IGT may even perform less well. However, the GDG has made recommendations in populations where they considered IGT to be of clear benefit, especially in cases where IGT would reduce the uncertain diagnosis after Mantoux testing. NICE has produced a range of tools to help health professionals implement this guideline, including audit support, a costing tool and a slide set, all of which are available on the NICE website. Ends Notes to Editors About tuberculosis 1. Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, also known as 'the tubercle bacillus'. TB commonly affects the lungs, but can also affect other parts of the body. The symptoms of TB are varied and depend on the site of infection. General symptoms may include fever, loss of appetite, weight loss, night sweats and tiredness. 2. TB is usually spread by coughs, but prolonged close contact with a person with active TB is usually necessary for infection to be passed on. It can take many years for a person infected with M. Tuberculosis to develop active TB. 3. Latent TB is where the person has been exposed to the tubercle bacillus, which remains in the body, but where there are no symptoms of TB. 4. In the UK, although the introduction of the universal programme of BCG vaccination significantly reduced rates from around 50,000 cases in the 1950s, TB is still an important public health issue, with some 8500 cases each year. 5. There are marked differences in the incidence of tuberculosis in different parts of England and Wales, with most new cases occurring in cities. 6. In 2009 in the UK, 9040 cases of tuberculosis were reported, an increase of 4.2% in the rate of the disease compared with The majority of cases continue to occur in the non-uk-born population (73%) and those aged years (60%). From 2004 to 2009 the most common settings in which new cases of TB occurred were healthcare and education. 7. Although rates of the disease are now very low in some parts of the country, in other areas, mainly cities, rates of the disease are higher and, in some cases, increasing. For example, nearly two in every five cases of TB occur in London. Specific groups are disproportionately affected by TB, including the homeless and those in poor housing, new entrants, particularly those who come from areas that have a high prevalence of TB and those living in inner city areas.
4 8. Almost all cases of clinical TB in the UK contract the disease by breathing in infected respiratory droplets from a person with infectious respiratory active TB disease. The initial infection may either be eliminated, remain latent, or progress to active TB over the following weeks or months. 9. In people with latent TB, 10 15% of adults will go on to develop active TB at some point in their lives and the risk in children may be much higher. However, in people who are immunocompromised (for example, if they are HIV positive), the chance of developing active TB within 5 years of infection is up to 50%. 10. There is no gold-standard test for latent tuberculosis. Diagnosis has in the past relied on the TST but this has poor specificity if there has been BCG vaccination or exposure to environmental (non-tuberculous) mycobacteria, which can lead to false positive results. The test results have to be interpreted within a certain timescale, and patients who do not return, or delay returning, will have either no result or a possibly inaccurate one. 11. Recently, selective immunological (interferon-gamma, or IGT) tests have been developed using two tuberculosis antigens, early secretion antigen target 6 (ESAT-6 ) and culture filtrate protein 10 (CFP-10), which are not present in BCG, and are found in only a few species of environmental mycobacteria. These tests can be done on either cells or cell products derived from whole blood. These tests aim to be more specific by removing false positive results, and to be better correlated with latent infection or dormant organisms. About the guideline 12. The guideline, together with implementation tools to help health professionals put it into practice, is available on the NICE website at The original NICE guidance published in 2006, recognised that there was a lack of good quality evidence to show whether interferon-gamma tests are acceptable to patients and are more effective than tuberculin skin tests for predicting subsequent development of active TB, or diagnosing or ruling out current active TB. NICE therefore recommended further research to compare the strategies of skin test only, skin test then interferon gamma test if positive, and interferon gamma test only. Concern was also raised about the appropriateness of IGT use in current clinical practice during the planned review process for the original NICE guideline on the diagnosis and management of TB. 14. NICE was asked by the Dept of Health to produce a short clinical guideline on interferongamma immunological testing for diagnosing latent TB (partial review of CG33) and make recommendations on: Which diagnostic strategy is most accurate in diagnosing latent tuberculosis in adults and children who are recent arrivals from highly prevalent countries? Which diagnostic strategy is most accurate in diagnosing latent tuberculosis in children? Which diagnostic strategy is most accurate in diagnosing latent tuberculosis in adults and children (children considered as a separate population) who have been in close contact with patients with active tuberculosis? Which diagnostic strategy is most accurate in diagnosing latent tuberculosis in immunocompromised patients? About NICE 15. The National Institute for Health and Clinical Excellence (NICE) is the independent organisation responsible for providing national guidance and standards on the promotion of good health and the prevention and treatment of ill health 16. NICE produces guidance in three areas of health:
5 public health guidance on the promotion of good health and the prevention of ill health for those working in the NHS, local authorities and the wider public and voluntary sector health technologies guidance on the use of new and existing medicines, treatments, medical technologies (including devices and diagnostics) and procedures within the NHS clinical practice guidance on the appropriate treatment and care of people with specific diseases and conditions within the NHS. 17. NICE produces standards for patient care: quality standards these reflect the very best in high quality patient care, to help healthcare practitioners and commissioners of care deliver excellent services Quality and Outcomes Framework NICE develops the clinical and health improvement indicators in the QOF, the Department of Health scheme which rewards GPs for how well they care for patients 18. NICE provides advice and support on putting NICE guidance and standards into practice through its implementation programme, and it collates and accredits high quality health guidance, research and information to help health professionals deliver the best patient care through NHS Evidence.
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE SCOPE
TB Partial Update Appendix 1 - Scope NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE 1 Guideline title SCOPE Tuberculosis: interferon gamma tests for the diagnosis of latent tuberculosis (partial
More informationNATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE SCOPE
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE 1 Guideline title SCOPE Tuberculosis: interferon gamma tests for the diagnosis of latent tuberculosis (partial update) 1.1 Short title Tuberculosis
More informationNew Entrant Screening and Latent TB Get screened and find out if you have TB infection before you develop TB disease!
New Entrant Screening and Latent TB Get screened and find out if you have TB infection before you develop TB disease! Screening and treatment for TB are free. What does this leaflet cover? What is Tuberculosis
More informationPrimary Care and TB Control Dr Helen Booth Consultant Thoracic Physician, UCLH Clinical Lead, Integrated TB NCL-Service
Primary Care and TB Control Dr Helen Booth Consultant Thoracic Physician, UCLH Clinical Lead, Integrated TB NCL-Service North Central London TB Service TBService@nhs.net After Action Review Could we have
More informationWhy need to havetb Clearance. To Control and Prevent Tuberculosis
Why need to havetb Clearance To Control and Prevent Tuberculosis How to ID Tuberculosis There are two kinds of tests that are used to determine if a person has been infected with TB bacteria: the tuberculin
More informationProposed Regs.pdf
Kansas Wesleyan University TB testing Policy In Compliance with Kansas Statue KSA 2009 Supp. 65-129, all Kansas Wesleyan University students who have traveled, resided in for more than three months, or
More informationFrequently asked questions about Tuberculosis (TB) screening & prevention
Frequently asked questions about Tuberculosis (TB) screening & prevention TB Nursing Service. Department of Respiratory Medicine Information for Patients i Telephone 0116 258 3767 Fax 0116 256 3766 Monday
More informationInterferon gamma release assays and the NICE 2011 guidelines on the diagnosis of latent tuberculosis
CLINICAL AUDIT Clinical Medicine 2013, Vol 13, No 4: 362 6 Interferon gamma release assays and the NICE 2011 guidelines on the diagnosis of latent tuberculosis Helen R Mujakperuo, Richard D Thompson and
More informationSymptoms Latent TB Active TB
1 Tuberculosis Tuberculosis (TB) is a disease that can spread through the air. It is caused by a bacterium called Mycobacterium tuberculosis. It usually affect the lungs. However, it can also affect other
More informationRespiratory Tuberculosis (TB)
Respiratory Tuberculosis (TB) Information Leaflet For Patients and Visitors Please follow this guidance from the Infection Prevention and Control Team What is Respiratory Tuberculosis (TB)? Pulmonary/respiratory
More informationTuberculosis Procedure ICPr016. Table of Contents
Tuberculosis Procedure ICPr016 Table of Contents Tuberculosis Procedure ICPr016... 1 What is Tuberculosis?... 2 Any required definitions/explanations... 2 NHFT... 2 Tuberculosis (TB)... 3 Latent TB...
More informationThorax Online First, published on December 8, 2009 as /thx
Thorax Online First, published on December 8, 2009 as 10.1136/thx.2009.119677 Title Page Cost effectiveness of the NICE guidelines for screening for latent tuberculosis infection: the Quantiferon-TB gold
More informationBarbara J Seaworth MD Medical Director, Heartland National TB Center Professor, Internal Medicine and Infectious Disease UT Health Northeast
Practical Aspects for Using the Interferon Gamma Release Assay (IGRA) Test Live Webinar July 14, 2017 Barbara J Seaworth MD Medical Director, Heartland National TB Center Professor, Internal Medicine and
More informationTUBERCULOSIS. What you need to know BECAUSE...CARING COMES NATURALLY TO US
TUBERCULOSIS What you need to know BECAUSE...CARING COMES NATURALLY TO US Are certain people more at risk of developing Tuberculosis Yes, while everyone exposed to the disease could develop TB, the following
More informationTuberculosis What you need to know. James Zoretic M.D., M.P.H. Regions 2 and 3 Director
Tuberculosis What you need to know James Zoretic M.D., M.P.H. Regions 2 and 3 Director What is Tuberculosis? Tuberculosis, (TB) is a communicable disease caused by the Mycobacterium tuberculosis bacillus
More informationTuberculosis (TB) Fundamentals for School Nurses
Tuberculosis (TB) Fundamentals for School Nurses June 9, 2015 Kristin Gall, RN, MSN/Pat Infield, RN-TB Program Manager Marsha Carlson, RN, BSN Two Rivers Public Health Department Nebraska Department of
More informationLet s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year
A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year Madhukar Pai, MD, PhD Author and Series Editor Camilla Rodrigues, MD co-author Abstract Most individuals who get exposed
More informationUnderstanding and Managing Latent TB Infection Arnold, Missouri October 5, 2010
Understanding and Managing Latent TB Infection Arnold, Missouri October 5, 2010 What is Latent TB Infection (LTBI)? Traci Hadley, RN October 5, 2010 LTBI or TB Disease? Presented by : Traci Hadley, RN
More information(b) Describe the role of antigen presentation in the body s specific immune response to infection by viruses. (4)
1 The human body responds to infection by viruses in a number of ways. The non-specific response involves interferon. The specific immune response requires antigen presentation to the cells of the immune
More informationAll you need to know about Tuberculosis
All you need to know about Tuberculosis What is tuberculosis? Tuberculosis is an infectious disease that usually affects the lungs. Doctors make a distinction between two kinds of tuberculosis infection:
More informationCommunity pharmacy-based tuberculosis skin testing
Community pharmacy-based tuberculosis skin testing Shanna K. O Connor, PharmD ISU KDHS Spring CE Seminar 2018 In support of improving patient care, Idaho State University Kasiska Division of Health Sciences
More informationTrust Guideline for the Prevention of Tuberculosis and Management of Tuberculosis Exposure in Health Care Workers
A Clinical Guideline For Use in: By: For: Division responsible for document: Key words: Name and job title of document author: Name and job title of document author s Line Manager: Supported by: Assessed
More information2014 TUBERCULOSIS FACT SHEET A Profile of Mecklenburg County Reported Cases
OVERVIEW T uberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. TB usually affects the lungs, but it can also affect other parts of the body. TB is spread through the air
More informationPRESS RELEASE. New NICE guidance will improve diagnosis and treatment of chronic heart failure
Tel: 0845 003 7782 www.nice.org.uk Ref: 2010/118 ISSUED: WEDNESDAY, 25 AUGUST 2010 PRESS RELEASE New NICE guidance will improve diagnosis and treatment of chronic heart failure The National Institute for
More informationTuberculosis Tools: A Clinical Update
Tuberculosis Tools: A Clinical Update CAPA Conference 2014 JoAnn Deasy, PA-C. MPH, DFAAPA jadeasy@sbcglobal.net Adjunct Faculty Touro PA Program Learning Objectives Outline the pathogenesis of active pulmonary
More informationLatent Tuberculosis Infection (LTBI) Questions and Answers for Health Care Providers
Latent Tuberculosis Infection (LTBI) Questions and Answers for Health Care Providers Who Should Be Screened for Latent Tuberculosis Infection (LTBI)?... 2 What tests are used to screen for LTBI?... 2 How
More informationTB Intensive San Antonio, Texas November 11 14, 2014
TB Intensive San Antonio, Texas November 11 14, 2014 Interferon Gamma Release Assays Lisa Armitige, MD, PhD November 12, 2014 Lisa Armitige, MD, PhD has the following disclosures to make: No conflict of
More informationWhat is tuberculosis? What causes tuberculosis?
What is tuberculosis? What causes tuberculosis? Last updated: Thursday 4 September 2014 Tuberculosis Infectious Diseases / Bacteria / Viruses Respiratory / Asthma Some may see Tuberculosis as a historical
More informationNHS SHETLAND TUBERCULOSIS ANNUAL REPORT
NHS SHETLAND TUBERCULOSIS ANNUAL REPORT 2014-2015 Prepared by Wendy Hatrick October 2015 NHS Shetland Tuberculosis Annual Report 2013-14 Acronyms and Abbreviations AIDS Acquired Immuno-Deficiency Syndrome
More informationTargeted Testing and the Diagnosis of. Latent Tuberculosis. Infection and Tuberculosis Disease
Self-Study Study Modules on Tuberculosis Targeted Testing and the Diagnosis of Latent Tuberculosis Infection and Tuberculosis Disease 1 Module 3: Objectives At completion of this module, learners will
More informationTB Intensive Tyler, Texas December 2-4, 2008
TB Intensive Tyler, Texas December 2-4, 2008 Interferon Gamma Releasing Assays: Diagnosing TB in the 21 st Century Peter Barnes, MD December 2, 2008 TOPICS Use of interferon-gamma release assays (IGRAs)
More informationTB and Respiratory Protection
Slide 1 TB and Respiratory Protection Tuberculosis (TB) is a disease present throughout the United States. Lehigh Valley Health Network is concerned about your health and needs your help to prevent the
More informationContracts Carla Chee, MHS May 8, 2012
Moving Past the Basics of Tuberculosis Phoenix, Arizona May 8-10, 2012 Contracts Carla Chee, MHS May 8, 2012 Carla Chee, MHS has the following disclosures to make: No conflict of interests No relevant
More informationPeggy Leslie-Smith, RN
Peggy Leslie-Smith, RN EMPLOYEE HEALTH DIRECTOR - AVERA TRAINING CONTENT 1. South Dakota Regulations 2. Iowa Regulations 3. Minnesota Regulations 4. Interferon Gamma Release Assay (IGRA)Testing 1 SOUTH
More informationTuberculosis. Clinical diagnosis and management of tuberculosis, and measures for its prevention and control
Issue date: March 2011 Tuberculosis Clinical diagnosis and management of tuberculosis, and measures for its prevention and control This is the full version of NICE clinical guideline 117. It contains details
More informationFundamentals of Tuberculosis (TB)
TB in the United States Fundamentals of Tuberculosis (TB) From 1953 to 1984, reported cases decreased by approximately 5.6% each year From 1985 to 1992, reported cases increased by 20% 25,313 cases reported
More informationCHILDHOOD TUBERCULOSIS: NEW WRINKLES IN AN OLD DISEASE [FOR THE NON-TB EXPERT]
CHILDHOOD TUBERCULOSIS: NEW WRINKLES IN AN OLD DISEASE [FOR THE NON-TB EXPERT] QUESTION: : Which children in the United States should get a tuberculin skin test? Do questionnaires really work? Jeffrey
More informationSelf-Study Modules on Tuberculosis
Self-Study Modules on Tuberculosis Targe te d Te s ting and the Diagnosis of Latent Tuberculosis Infection and Tuberculosis Disease U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control
More informationTUBERCULOSIS. Presented By: Public Health Madison & Dane County
TUBERCULOSIS Presented By: Public Health Madison & Dane County What is Tuberculosis? Tuberculosis, or TB, is a disease caused by a bacteria called Mycobacterium tuberculosis. The bacteria can attack any
More informationStop TB Poster (laminated copies are available from TB Control: )
Tuberculosis Prevention and Control Recommendations For Homeless Shelters in Maine Tool Kit What Your Shelter Can Do to Prevent TB Assessing Your Shelter Guests Risk for TB Cough Alert Policy Think TB
More informationCHAPTER 3: DEFINITION OF TERMS
CHAPTER 3: DEFINITION OF TERMS NOTE: TB bacteria is used in place of Mycobacterium tuberculosis and Mycobacterium tuberculosis complex in most of the definitions presented here. 3.1 Acid-fast bacteria
More informationTB Nurse Case Management San Antonio, Texas July 18 20, 2012
TB Nurse Case Management San Antonio, Texas July 18 20, 2012 IGRA s and Their Use in TB Nurse NCM Lisa Armitige, MD, PhD July 18, 2012 Lisa Armitige, MD, PhD has the following disclosures to make: No conflict
More informationTB Intensive Houston, Texas October 15-17, 2013
TB Intensive Houston, Texas October 15-17, 2013 Interferon Gamma Release Assays (IGRA s) Lisa Armitige, MD, PhD October 16, 2013 Lisa Armitige, MD, PhD has the following disclosures to make: No conflict
More information"GUARDING AGAINST TUBERCULOSIS IN INSTITUTIONAL FACILITIES"
MAJOR PROGRAM POINTS "GUARDING AGAINST TUBERCULOSIS IN INSTITUTIONAL FACILITIES" Training For THE CDC "TUBERCULOSIS PREVENTION GUIDELINES" "Quality Safety and Health Products, for Today...and Tomorrow"
More informationTB facts & figures Microbiology of TB Transmission of TB Infection control in health care settings Special cases Resistant TB Masks
1 TB facts & figures Microbiology of TB Transmission of TB Infection control in health care settings Special cases Resistant TB Masks 2 Page 1 4 NHS Lothian Infection Prevention and Control Study Day On
More informationTUBERCULOSIS IN HEALTHCARE SETTINGS Diana M. Nilsen, MD, FCCP Director of Medical Affairs, Bureau of Tuberculosis Control New York City Department of
TUBERCULOSIS IN HEALTHCARE SETTINGS Diana M. Nilsen, MD, FCCP Director of Medical Affairs, Bureau of Tuberculosis Control New York City Department of Health and Mental Hygiene TODAY S PRESENTATION Epidemiology
More informationLATENT TUBERCULOSIS. Robert F. Tyree, MD
LATENT TUBERCULOSIS Robert F. Tyree, MD 1 YK TB OFFICERS Ron Bowerman Elizabeth Roll Mien Chyi (Pediatrics) Cindi Mondesir (Pediatrics) The new guys: Philip Johnson Robert Tyree 2009 CDC TB CASE DEFINITION
More informationTB Prevention Who and How to Screen
TB Prevention Who and How to Screen 4.8.07. IUATLD 1st Asia Pacific Region Conference 2007 Dr Cynthia Chee Dept of Respiratory Medicine / TB Control Unit Tan Tock Seng Hospital, Singapore Cycle of Infection
More informationTB in Corrections Phoenix, Arizona
TB in Corrections Phoenix, Arizona March 24, 2011 Treatment of Latent TB Infection Renuka Khurana MD, MPH March 24, 2011 Renuka Khurana, MD, MPH has the following disclosures to make: No conflict of interests
More informationESCMID Online Lecture Library. by author
Tuberculosis prevention in immunodepressed patients M. Carmen Fariñas Álvarez Infectious Diseases.H.U.Marqués de Valdecilla University of Cantabria, Spain DISCLOSURES I have no potential conflicts with
More information#114 - Tuberculosis Update [1]
Published on Excellence In Learning (https://excellenceinlearning.net) Home > #114 - Tuberculosis Update #114 - Tuberculosis Update [1] Please login [2] or register [3] to take this course. $8.00 Course
More informationTuberculosis Facts. TB is not spread by: Sharing food and drink Shaking someone s hand Touching bed lines or toilet seats
Tuberculosis Facts Below are frequently asked questions about TB, and their answers. If you have additional questions you may contact the City of Ennis Department of Health Services at 972-875-1234 or
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationEvaluation and Treatment of TB Contacts Tyler, Texas April 11, 2014
Evaluation and Treatment of TB Contacts Tyler, Texas April 11, 2014 Interferon Gamma Release Assays: Understanding the Test David Griffith, BA, MD April 11, 2014 David Griffith, BA, MD has the following
More informationClinical Practice Guideline
ITBS LTBI ITBS Management 1 of 6 ITBS Contact ITBS Oversight ITBS Disease Professional Advisory 1.0 PURPOSE: 1.1 Provide clinical practice and operational guidance to Public Health Nurses to ensure consistency
More informationApproaches to LTBI Diagnosis
Approaches to LTBI Diagnosis Focus on LTBI October 8 th, 2018 Michelle Haas, M.D. Associate Director Denver Metro Tuberculosis Program Denver Public Health DISCLOSURES I have no disclosures or conflicts
More information"GUARDING AGAINST TUBERCULOSIS IN HEALTHCARE FACILITIES"
MAJOR PROGRAM POINTS "GUARDING AGAINST TUBERCULOSIS IN HEALTHCARE FACILITIES" Training For THE CDC "TUBERCULOSIS PREVENTION GUIDELINES" "Quality Safety and Health Products, for Today...and Tomorrow" Outline
More informationChapter 7 Tuberculosis (TB)
Chapter 7 Tuberculosis (TB) TB infection vs. TB disease Information about TB TB skin testing Active TB disease TB risk factors Role of Peel Public Health in TB prevention and control Environmental and
More informationTuberculosis. Impact of TB. Infectious Disease Epidemiology BMTRY 713 (A. Selassie, DrPH)
Infectious Disease Epidemiology BMTRY 713 (A. Selassie, DrPH) Lecture 20 Tuberculosis Learning Objectives 1. Describe the biologic characteristics of the agent 2. Determine the epidemiologic characteristics
More informationTB, BCG and other things. Chris Conlon Infectious Diseases Oxford
TB, BCG and other things Chris Conlon Infectious Diseases Oxford Epidemiology Latent TB IGRA BCG >50/100000
More information"GUARDING AGAINST TUBERCULOSIS AS A FIRST RESPONDER"
MAJOR PROGRAM POINTS "GUARDING AGAINST TUBERCULOSIS AS A FIRST RESPONDER" Training For THE CDC "TUBERCULOSIS PREVENTION GUIDELINES" "Quality Safety and Health Products, for Today...and Tomorrow" Outline
More informationClinical diagnosis and management of tuberculosis, and measures for its prevention and control
Quick reference guide Issue date: March 2006 Clinical diagnosis and management of tuberculosis, and measures for its prevention and control Clinical Guideline 33 Developed by the National Collaborating
More informationTesting for Tuberculosis Infection and Disease: The Expanding Role of Blood-based Assays
Complimentary CME Testing for Tuberculosis Infection and Disease: The Expanding Role of Blood-based Assays POWERED BY Program Description Screening and testing guidelines are an important component in
More informationTuberculosis and Diabetes Mellitus. Lana Kay Tyer, RN MSN WA State Department of Health TB Nurse Consultant
Tuberculosis and Diabetes Mellitus Lana Kay Tyer, RN MSN WA State Department of Health TB Nurse Consultant Learning Objectives Understand the impact of uncontrolled diabetes mellitus (DM) on TB infection
More informationBCG in Tower Hamlets. Luise Dawson Public Health Nurse
BCG in Tower Hamlets Luise Dawson Public Health Nurse Coverage levels of BCG for infants under 1 year 100% 90.9% 95.5% 95.0% 98.7% 90% 81% 82% 80% 70% 60% 50% 40% 30% 20% 10% 0% March 0708 March 0809 March
More information2017/2018 Annual Volunteer Tuberculosis Notice
Lewis Center for Educational Research Academy for Academic Excellence Norton Science and Language Academy Business Offices 17500 Mana Road Apple Valley, CA 92307 E-mail: hr@lcer.org 760-946-5414 Fax 760-946-9193
More informationCommunicable Disease Control Manual Chapter 4: Tuberculosis
Provincial TB Services 655 West 12th Avenue Vancouver, BC V5Z 4R4 www.bccdc.ca Communicable Disease Control Manual Definitions Page 1 2.0 DEFINITIONS Many of the definitions that follow are taken from
More informationTB the disease, its treatment. Tuberculosis. and prevention
TB the disease, its treatment Tuberculosis and prevention TUBERCULOSIS TB (tuberculosis) is an infectious disease that usually affects the lungs, although it can affect any part of the body. About 150
More informationNICE guideline Published: 13 January 2016 nice.org.uk/guidance/ng33
Tuberculosis NICE guideline Published: 13 January 2016 nice.org.uk/guidance/ng33 NICE 2017. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationDiagnosis Latent Tuberculosis. Disclosures. Case
Diagnosis Latent Tuberculosis Neha Shah MD MPH Field Medical Officer Tuberculosis Control Branch California Department of Public Health Centers for Disease Control and Prevention September 2016 1 Disclosures
More informationStudent Health Requirements Master of Arts, Biomedical Sciences Program
Student Health Requirements Master of Arts, Biomedical Sciences Program All students in medically related programs, just as physicians in practice, are required to be current with required immunizations
More informationInterferon Gamma Release Assay Testing for Latent Tuberculosis Infection: Physician Guidelines
Interferon Gamma Release Assay Testing for Latent Tuberculosis Infection: Physician Guidelines Historically, Latent Tuberculosis Infection (LTBI) diagnosis was based on risk assessment, chest x-ray (CXR)
More informationSummary of Key Points WHO Position Paper on BCG Vaccine, February 2018
Summary of Key Points WHO Position Paper on BCG Vaccine, February 2018 1 Introduction This position paper replaces the 2004 WHO position paper on Bacille Calmette-Guérin (BCG) vaccine and the 2007 WHO
More informationNorthwestern Polytechnic University
Clinical Tuberculosis Assessment by Health Care Provider Clinicians should review and verify the information in the Tuberculosis (TB) Screening Questionnaire (attached). Persons answering YES to any questions
More informationInfection Prevention and Control Annual Education Authored by: Infection Prevention and Control Department
Infection Prevention and Control Annual Education 2017 Authored by: Infection Prevention and Control Department Objectives After you complete this Computer-Based Learning (CBL) module, you should be able
More informationTesting for TB. Bart Van Berckelaer Territory Manager Benelux. Subtitle
Testing for TB Bart Van Berckelaer Territory Manager Benelux Subtitle Agenda TB infection pathway TB immunisation Testing options Pre lab considerations of the whole blood ELISA test The T-SPOT.TB test
More informationThese recommendations will remain in effect until the national shortage of PPD solution has abated.
Maryland Recommendations Regarding the National Shortage of Purified Protein Derivative (PPD) Solution; Attachment to Health Officer Memorandum National Shortages of Tubersol and Aplisol for TB Skin Testing;
More informationTB Skin Test Practicum Houston, Texas Region 6/5 South September 23, 2014
TB Skin Test Practicum Houston, Texas Region 6/5 South September 23, 2014 Catalina Navarro, BSN, RN has the following disclosures to make: No conflict of interests No relevant financial relationships with
More informationInterventions to improve screening for latent TB: effectiveness and outcomes
Interventions to improve screening for latent TB: effectiveness and outcomes Fotinie Ntziora, Thushan DeSilva, Natasha Baker, Debbie Talbot, Louise Byrne, Karen Sherry, Sandra Booth, Janice Hobson, Karen
More informationTB Transmission, Pathogenesis & Infection Control
TB Transmission, Pathogenesis & Infection Control Bradley Allen, MD, PhD, FACP, FIDSA. 2014 MFMER slide-1 Disclosures Medical Consultant, TB Control Program Indiana State Department of Health Past clinical
More informationCore Curriculum on Tuberculosis: What the Clinician Should Know
Core Curriculum on Tuberculosis: What the Clinician Should Know Sixth Edition 2013 National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination 1 Chapters
More informationLatent tuberculosis infection
EXECUTIVE SUMMARY Latent tuberculosis infection Updated and consolidated guidelines for programmatic management Executive summary Latent tuberculosis infection (LTBI) is defined as a state of persistent
More informationVaccine Preventable Respiratory Infections and Tuberculosis
Vaccine Preventable Respiratory Infections and Tuberculosis Infection Prevention Essentials in Long-Term Care Spring 2019 Teri Hulett, RN, BSN, CIC, FAPIC Leading infection prevention education across
More informationTuberculosis & Refugees in Philadelphia
Tuberculosis & Refugees in Philadelphia Philadelphia TB Control Program Daniel P. Dohony, MPH Philadelphia TB Control Program Health Information Portal Website: hip.phila.gov Contains Information On» Disease
More informationInfections What is new and what is important?
Infections What is new and what is important? 2 What am I going to talk about? Imported infections Meningitis changes Flu vaccine issues TB NICE guidance changes 3 Imported infections - Zika Transmitted
More informationScreening for Tuberculosis Infection. Harlingen, TX. Linda Dooley, MD has the following disclosures to make:
TB Infection Diagnosis Recommendations Talk Developed by Lisa Y. Armitige, MD, PhD Medical Consultant, Heartland National TB Center Associate Professor Internal Medicine/Pediatrics/Infectious Disease UT
More informationMaking the Diagnosis of Tuberculosis
Making the Diagnosis of Tuberculosis Alfred Lardizabal, MD NJMS Global Tuberculosis Institute Testing for TB Infection Targeted Testing: Key Points Test only if plan for ensuring treatment De-emphasizes
More informationINTENSIFIED TB CASE FINDING
INTENSIFIED TB CASE FINDING My friends call me Intensified Case Finding (ICF) I undertake regularly screening all people with, or at high risk of HIV, for symptoms of TB in health care facilities, communities
More informationTB, BCG vaccine and your baby
TB, BCG vaccine and your baby This leaflet is about the BCG (Bacillus Calmette-Guérin) vaccination that is being offered to protect your baby against tuberculosis (TB). What is BCG vaccine? BCG vaccine
More informationNHS public health functions agreement
NHS public health functions agreement 2016-17 Service specification No.7 Hib/MenC vaccination programme NHS England INFORMATION READER BOX Directorate Medical Commissioning Operations Patients and Information
More informationTUBERCULOSIS. Pathogenesis and Transmission
TUBERCULOSIS Pathogenesis and Transmission TUBERCULOSIS Pathogenesis and Transmission Infection to Disease Diagnostic & Isolation Updates Treatment Updates Pathogenesis Droplet nuclei of 5µm or less are
More informationTB 2015 burden, challenges, response. Dr Mario RAVIGLIONE Director
TB 2015 burden, challenges, response Dr Mario RAVIGLIONE Director Addis Ababa, Ethiopia 11-13 November 2015 Overview TB basics TB burden & challenges Response: End TB Strategy DAY 1 What is TB? Definition
More informationTuberculosis (TB) and Infection Control PICNET Conference April 12, 2013
Tuberculosis (TB) and Infection Control PICNET Conference April 12, 2013 Michelle Mesaros RN BScN Nash Dhalla RN BScN BC Center for Disease Control TB and Infection Control WHAT IS TB? TB Statistics (2011)
More informationInfectious Diseases and Sexual Health in Southwark
Chapter 7 Infectious Diseases and Sexual Health in Southwark Introduction 7.1 The JSNA 2008 did not reflect the problems of infectious diseases and this chapter redresses this gap. Infectious diseases
More informationNHS public health functions agreement Service specification No.6 Meningococcal C (MenC) containing vaccine immunisation programme
NHS public health functions agreement 2018-19 Service specification No.6 Meningococcal C (MenC) containing vaccine immunisation programme 1 NHS public health functions agreement 2018-19 Service specification
More informationNATIONAL INSTITUTE FOR CLINICAL EXCELLENCE SCOPE. Dementia: the management of dementia, including the use of antipsychotic medication in older people
NATIONAL INSTITUTE FOR CLINICAL EXCELLENCE 1 Guideline title SCOPE Dementia: the management of dementia, including the use of antipsychotic medication in older people 1.1 Short title Dementia 2 Background
More informationflu vaccination DRAFT The WINTER 2018/19 Who should have it and why Includes information for children and pregnant women mmunisation
flu vaccination Who should have it and why The WINTER 2018/19 Includes information for children and pregnant women The flu vaccination 1 Winter 2018/19 Flu mmunisation Helping to protect everyone, every
More informationNew Approaches to the Diagnosis and Management of Tuberculosis Infection in Children and Adolescents
New Approaches to the Diagnosis and Management of Tuberculosis Infection in Children and Adolescents Jeffrey R. Starke, M.D. Professor of Pediatrics Baylor College of Medicine [With great thanks to Andrea
More informationWhat Drug Treatment Centers Can do to Prevent Tuberculosis
What Drug Treatment Centers Can do to Prevent Tuberculosis Tuberculosis (TB) is alive and well Learn what you can do to prevent TB among your clients and protect yourself! Transmission TB is spread through
More information