Session 1B. - Hall 4. 15h30 16h00 Refreshments, exhibition and posters - Hall 5 16h00 17h30 Session 2: Open Session. - Hall 4

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1 CONFERENCE PROGRAMME WEDNESDAY, 24 OCTOBER h00 18h00 Registration OFFICIAL MEETING COMMENCES 14h00 15h30 Session 1A Adolescent cases - Teen pregnancy and breast feeding (Julia Turner) - Previously on PrEP, now pregnant. What to do? (Tshidi Sebitloane) - Teen adherence (Juliet Houghton) - Breast abnormalities in adolescents receiving ART (Jackie Dunlop) Chair: Moherndran Archary 15h30 16h00 Refreshments, exhibition and posters 16h00 17h30 Session 2: Open Session Debate: Undetectable = Untransmittable - Yes (Annemarie Wensing) - No (Graeme Meintjes) Chair: Yunus Moosa and Moeketsi Mathe 17h40 19h00 Session 3: Opening Plenary Welcome (Moeketsi Mathe) Official conference opening (Desmond Martin) Mechanism of resistance (Douglas Richman) HIV drug resistance: are we about to win the war? (John Mellors) Chair: Annemarie Wensing Session 1B Adult cases (Michelle Venter, Kim Roberg, Eric Hefer) - Adherence - Mental health - STIs - Opportunistic Infections - TB - Drug Interactions Panel discussion (Gary Maartens, Yunus Moosa) Chair: Jeremy Nel Session 1C - Skills building - Nurse cases - Cases primary healthcare, rural doctors (Ndiviwe Mphothulo, Jenny Nash) - Cases nurses (Talitha Crowley, Gloria Mthombeni) - Panel discussion: Integration; Re-starting (Ndiviwe Mphothulo, Talitha Crowley, Gloria Mthombeni, Jenny Nash) Chair: Gloria Maimela Southern African HIV Clinicians Society Conference 2018 programme subject to change 2 P a g e

2 19h00 21h00 Opening Cocktail Function THURSDAY, 25 OCTOBER h30 08h15 Session 4A Stock outs and medicine availability - Stop Stockouts Project - Essential medicines to add to the formulary (Tinne Gils) - Not deaf or dead! The seven-year journey of bedaquiline as a third choice for all South Africans with MDR-TB, as told by one fortunate MDR-TB survivor. (Arne von Delft) Chair: Anele Yawa 08h20 10h15 Session 5: Plenary Session How are we doing with HIV self-screening? (Francois Venter) - How are we doing with Universal test and treat? - How are we doing with viral suppression? (Sergio Carmona) Chair: 10h15 10h30 Refreshments, exhibition and posters 10h30 12h00 Session 6A Session 6B Pharmacovigilance and registers - Pharmacovigilance (Karen Cohen) - Pregnancy register (Mukesh Dheda) - Registers and centralised reporting (Ruth Lancaster) Chair: Gary Maartens - Skills building session Infant testing - Swallowing tablets (Melanie Collins) - Optimising formulations (Carol Ruffell) - The latest on infant testing, and how to access (Gayle Sherman) Session 4B Ethics and research - The informed consent process (Lucy Allais and Mary Carman) Session 6C Ethics and the Law - Whistle-blowing in the health-sector (Mark Heywood) - Mandatory testing (Wayne Ncube) - Ethics on how health budgets are split (Marije Versteeg-Mojanaga) - Q&A Chair: Lucy Allais Southern African HIV Clinicians Society Conference 2018 programme subject to change 3 P a g e

3 - Switching in children (Helena Rabie) - Weight and age (Helena Rabie) Chair: James Nuttall 12h00 13h30 Lunch, exhibition and posters (Poster track: Paediatric and Adolescents) Satellite Session 7 GlaxoSmithKline session 13h30 15h00 Session 8A Cancer treatment models - Kaposi Sarcoma (Zainab Mohamed) - Lymphoma (Zainab Mohamed) - Priorities for cervical cancer prevention among HIV-infected women (Masangu Mulongo) - Update on cancer treatment (Adam Nosworthy) Chair: Moosa Patel 15h00 15h30 Refreshments, exhibition and posters Hall 5 15h30 17h00 Session 9A An update on - NRTIs (Yunus Moosa) - NNRTIs (Michelle Moorhouse) - Protease Inhibitors (Sipho Dlamini) Session 8B Resistance - Viral resistance first-line and second-line (Graeme Meintjes) - At which detectable viral load should we switch? (Lucas Hermans) - Third-line treatment. Feedback on outcome of patients on national third-line regimen (Michelle Moorhouse) - Transmitted drug resistance: surveillance, implications, future (Cloete van Vuuren) Chair: Theresa Rossouw Session 9B What s coming / What s missing in paediatrics - Integrase inhibitors (James Nuttall) - Protease Inhibitors (Leon Levin) Session 8C Prevention - Non-biomedical approaches (Sue Goldstein) - Condoms (Mags Beksinska) - Update on trials of vaccines and monoclonals in SA; how PrEP could augment these approaches (Fatima Laher) - Voluntary medical male circumcision (Limakatso Lebina) - Treatment as prevention (Francois Venter) Chair: Fatima Laher Session 9C Modelling and scale-up - What are the numbers telling us - How the epidemic informs resource planning Southern African HIV Clinicians Society Conference 2018 programme subject to change 4 P a g e

4 - Integrase inhibitors (Francois Venter) - Drug-drug interaction (Gary Maartens) Chair: Karen Cohen 17h10 18h40 Session 10A Skills building session Resistance - Third-line (Leon Levin) - Paediatric third-line (Moherndran Archary) - Stanford database - how to interpret resistance test results (Robert Shafer) Chair: Cloete van Vuuren - Drug interactions (Moherndran Archary) Chair: Nosisa Sipambo Session 10B - Skills building session Counselling - How to deliver HIV risk reduction counselling in 2018 (Janan Dietrich) - Integrating HIV prevention with other services (Natasha Davies) - How to tell a teenager they have HIV: A practical approach (Julia Turner) - Uptake and yield of a 24/7 HIV testing service across four Eastern Cape hospital Emergency departments (Dave Stead) Chair: Pierre Brouard 18h50 20h20 Session 11: Debate (Open Session) Hall 4 Implications of scarcer resources for 90:90:90 (Gloria Maimela) - Panel: Elliot Raizes, Annemarie Wensing, Jean Nachega, Francois Venter Chair: FRIDAY, 26 OCTOBER h30 08h15 Southern African HIV Clinicians Society AGM 08h30 10h00 Session 12: Plenary Our current understanding of antibodies (Nono Mhkize) Cost effectiveness of TLD versus TEE (Gesine Meyer-Rath) Chair: Richard Borain Session 10C National Health Insurance - Keynote: Mark Heywood Southern African HIV Clinicians Society Conference 2018 programme subject to change 5 P a g e

5 Why do we need cure (John Mellors) How do you measure cure (Monique Nijhuis) Management of patients with advanced HIV (Graeme Meintjes) 10h00 10h30 Refreshments, exhibition and posters 10h30 12h00 Session 13A Session 13B Opportunistic infections - An approach to intracranial mass lesions in HIV patients (Dave Stead) - Pneumocystis pneumonia (Michelle Wong) - Endemic mycoses in HIV patients (Jade Mogambery) - An approach to chronic diarrhoea (Sipho Dlamini) Chair: Colin Menezes HIV and TB in children and adults - Paediatric TB diagnosis and management (Ashendri Pillay) - TB in children and HIV-TB coinfection (Fiona Kritzinger) - TB in adults and HIV-TB coinfection (Ndiviwe Mphothulo) - TB and HIV co-infection including IRIS (Richard Lessells) Chair: Kogieleum Naidoo 12h00 13h30 Lunch, exhibition and posters (Poster tracks: Antiretroviral Treatment; Primary Health Care and Nursing; Basic Science; Opportunistic Infections and Malignancies; HIV Treatment Failure and Drug Resistance) 13h30 15h00 Session 15: Plenary Botswana Dolutegravir experience (Ava Avalos) Could good point-of-care testing revolutionise issues in the region? (Peter Manyike) Balancing politicians, ministries of health, communities and donors (Paula Munderi) Chair: 15h00 15h30 Refreshments, exhibition and posters 15h30 17h00 Session 16A Session 16B Session 13C Key populations and mobile populations - Injecting drug users in the region (Andrew Scheibe) - Sex workers including satellite clinics; peer support (Naomi Hill) - Engaging in care (Naomi Hill) - Testing in taxi ranks (Thandeka Khoza) Chair: Kholi Buthelezi Satellite Session 14 GILEAD session Session 16C Southern African HIV Clinicians Society Conference 2018 programme subject to change 6 P a g e

6 Skills building Clinical skills building (Henry Sunpath, Yunus Moosa) Should the private sector be treating TB? Yes No Chair: Kogieleum Naidoo Update on PMTCT - Where are we with PMTCT, including epidemiology (Landon Myer) - Transmission of HIV in breastfeeding (Ameena Goga) - Pregnant women on ART programmatic issues (Coceka Mnyani) - Contraception, clinical issues, MPTs and new technologies (Helen Rees) Chair: Tshidi Sebitloane 17h10 18h40 Session 17 Hall 4 Dolutegravir in pregnancy - Overview (Landon Myer) - DolPHIN-1: Randomised controlled trial of dolutegravir (DTG)- versus efavirenz (EFV)-based therapy in mothers initiating antiretroviral treatment in late pregnancy (Catherine Orrell) - Dolutegravir rollout (Steven Smith) - Debate: Treatment for children Dolutegravir versus Raltegravir Chair: Landon Myer 19h00 22h30 Celebratory Dinner (RSVP only additional fee applies) SATURDAY, 27 OCTOBER h30 08h15 Session 18 Auditorium Meet the Professor / Clinician How did I start my academic / research career? (Dave Spencer; Francois Venter; Michelle Moorhouse; Yunus Moosa; Gary Maartens) 08h30 10h00 Session 19: Plenary Vaccinations - Overview (Benjamin Kagina) Southern African HIV Clinicians Society Conference 2018 programme subject to change 7 P a g e

7 - Influenza vaccines (Shabir Madhi) - HIV vaccines - SAHCS vaccination guidelines (Sipho Dlamini) Chair: Rudzani Muloiwa 10h00 10h30 Refreshments, exhibition and posters 10h30 12h00 Session 20A Session 20B Noncommunicable diseases - Inflammation (Dave Spencer) - Hypertension - Obesity (Denasha Reddy) - Mental health (John Joska) - Injection drug use, HIV and hepatitis (Moeketsi Mathe) Chair: Marlin McKay Ethics and technology - Electronic medical records (Sandile Mhlongo) - Digital database and the PoPI act (Siraaj Adams) - Ethico-legal framework for biobank research in SA (Safia Mahomed) - EMGuidance (Mohammed Dalwai) Chair: Funeka Bango 12h00 13h30 Lunch, exhibition and posters (Poster tracks: Operations Research; Prevention; TB; Women s Health; Key Populations; Non-Communicable Diseases; Clinical Skills Building) 13h30 15h00 Session 22A - Advanced HIV Management - Care of aging patients (Marlin McKay) - Cryptococcal meningitis (Charlotte Sriruttan) - Palliative care (Dave Spencer) Chair: Dave Spencer Session 22B Treatment optimisation - (Polly Clayden, Francois Venter, Gary Maartens, Michelle Moorhouse, Graeme Meintjes, Landon Myer) Chair: Polly Clayden Session 20C Sexually transmitted infections - Strategies to achieve STI control in South Africa (Remco Peters) - Hepatitis C (Andrew Scheibe) - Update on vaginal microbiome and HIV - In context of PrEP (Danielle Travill) - Management of STIs in HIV+ population case-based (Ranmini Kuluratne) Chair: Helen Rees Satellite Session 21 Johnson & Johnson session - Optimising treatment for life-long management of HIV Session 22C Best abstracts session - Constructing TB cascades to inform TB programme improvement (Kate Rees) - HIV drug resistance profiles in patients failing integrase strand transfer inhibitors in the South African public sector (Kim Steegen) Southern African HIV Clinicians Society Conference 2018 programme subject to change 8 P a g e

8 15h10 16h40 Session 23A Skills building Guidelines: all new (Sipho Dlamini, James Nuttall, Dave Spencer, Natasha Davies, Michelle Moorhouse) Session 23B Adherence - Adherence (Catherine Orrell) - Adherence clubs (MSF) - Continued Use of PrEP among Sex Workers in Six Sites in South Africa (Cara O Connor) - Linking paediatric, adolescent and adult patients to care through the implementation of clinic navigators in high volume facilities (Chantal Smith) - Perceptions of HIV-Self Screening (Nthabiseng Koloane) - Viral load suppression among pregnant women presenting on ART in antenatal care; Chiredzi District Zimbabwe (Talent Maphosa) - Evaluation of the new Option B+ PMTCT program for HIV at hospital facilities: case study at the Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa (Melanie Bisnauth) - Triple-NRTI regimens while on TB treatment in a resource constrained setting a paediatric cohort analysis (Jennifer Minnaar) - Youth Care Clubs: Optimising clinic time, fostering peer support, improving adherence (Moira Beery) Session 23C - Quality Improvement - The Aurum Institute (Lauren de Kock, Winnet Chiningwenya) Southern African HIV Clinicians Society Conference 2018 programme subject to change 9 P a g e

9 - Virological monitoring how it relates to adherence (Henry Sunpath) Chair: Maria Sibanyoni 16h50 18h15 Session 24: Closing Plenary Big challenges in public health Big challenges in TB drug resistance (Richard Lessells) Big challenges in introducing and scaling up new prevention technologies (Helen Rees) Chair: Gary Maartens 18h15 18h20 Conference closing Moeketsi Mathe Southern African HIV Clinicians Society Conference 2018 programme subject to change 10 P a g e