Session 1B. - Hall 4. - Hall 4

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1 CONFERENCE PROGRAMME WEDNESDAY, 24 OCTOBER h00 18h00 Registration OFFICIAL MEETING COMMENCES 14h00 15h30 Session 1A Adolescent cases - Teen pregnancy and breast feeding (Julia Turner) - Previously on PrEP, now pregnant. What to do? (Tshidi Sebitloane) - Teen adherence (Juliet Houghton) - Breast abnormalities in adolescents receiving ART (Jackie Dunlop) Chair: Moherndran Archary 15h30 16h00 Refreshments, exhibition and posters 16h00 17h30 Session 2: Open Session Debate: Undetectable = Untransmittable - Yes (Annemarie Wensing) - No (Graeme Meintjes) Chair: Yunus Moosa and Moeketsi Mathe 17h40 19h00 Session 3: Opening Plenary Opening (Yunus Moosa) Welcome (Moeketsi Mathe) Official conference opening (Desmond Martin) Mechanism of resistance (Douglas Richman) HIV drug resistance: are we about to win the war? (John Mellors) Chair: Annemarie Wensing and Sipho Dlamini 19h00 21h00 Opening Cocktail Function Session 1B Adult cases (Michelle Venter, Kim Roberg, Eric Hefer) - Adherence, Mental health, STIs, Opportunistic Infections, TB, Drug Interactions Panel discussion (Gary Maartens, Yunus Moosa, Ebrahim Variava) Chair: Jeremy Nel Session 1C - Skills building - Nurse cases - Cases primary healthcare, rural doctors (Ndiviwe Mphothulo, Jenny Nash) - Cases nurses (Talitha Crowley, Gloria Mthombeni) - Panel discussion: Integration; Re-starting (Ndiviwe Mphothulo, Talitha Crowley, Gloria Mthombeni, Jenny Nash) Chair: Gloria Maimela Southern African HIV Clinicians Society Conference 2018 programme subject to change 2 P a g e

2 THURSDAY, 25 OCTOBER h30 08h20 Session 4A Stock outs and medicine availability - Introduction (Flora Bertizzolo) - Not deaf or dead! The seven-year journey of bedaquiline as a third choice for all South Africans with MDR-TB, as told by one fortunate MDR-TB survivor. (Arne von Delft) - Stop Stockouts Project and launch of the 4 th annual medicine availability survey (Tinne Gils) Chair: Anele Yawa 08h30 10h00 Session 5: Plenary Session Welcome (Mylan) - How are we doing with HIV self-screening? (Karin Hatzold) - How are we doing with Universal test and treat? (Francois Venter) - How are we doing with viral suppression? (Sergio Carmona) Chair: Ian Sanne 10h00 10h30 Refreshments, exhibition and posters 10h30 12h00 Session 6A Pharmacovigilance and registers - Pharmacovigilance (Karen Cohen) - Pregnancy register (Mukesh Dheda) - Registers and centralised reporting (Ruth Lancaster) Chair: Gary Maartens Session 4B Ethics and research - The informed consent process (Lucy Allais and Mary Carman) Session 6B - Skills building session Infant testing - Swallowing tablets (Melanie Collins) - Optimising formulations (Carol Ruffell) - The latest on infant testing, and how to access (Gayle Sherman) - Switching in children (Helena Rabie) - Weight and age (Helena Rabie) Chair: James Nuttall Session 6C Ethics and the Law - Whistle-blowing in the health-sector (Karessa Govender) - Mandatory testing (Wayne Ncube) - Ethics on how health budgets are split (Marije Versteeg-Mojanaga) - Q&A Chair: Lucy Allais Southern African HIV Clinicians Society Conference 2018 programme subject to change 3 P a g e

3 12h00 13h30 Lunch, exhibition and posters (Poster track: Paediatric and Adolescents) Satellite Session 7 GlaxoSmithKline / ViiV Healthcare session 13h30 15h00 Session 8A Cancer treatment models - Kaposi Sarcoma (Zainab Mohamed) - Lymphoma (Zainab Mohamed) - Priorities for cervical cancer prevention among HIV-infected women (Masangu Mulongo) - Update on cancer treatment (Adam Nosworthy) Chair: Moosa Patel 15h00 15h30 Refreshments, exhibition and posters 15h30 17h00 Session 9A An update on - NRTIs (Yunus Moosa) - NNRTIs (Michelle Moorhouse) - Protease Inhibitors (Sipho Dlamini) - Integrase inhibitors (Francois Venter) Session 8B Resistance - Viral resistance first-line and secondline (Graeme Meintjes) - At which detectable viral load should we switch? (Lucas Hermans) - Third-line treatment. Feedback on outcome of patients on national thirdline regimen (Michelle Moorhouse) - Transmitted drug resistance: surveillance, implications, future (Cloete van Vuuren) Chair: Theresa Rossouw Session 9B What s coming / What s missing in paediatrics - Integrase inhibitors (James Nuttall) - Protease Inhibitors (Leon Levin) - Drug interactions (Moherndran Archary) Chair: Nosisa Sipambo and Riana van Zyl Women and HIV: Challenges and solutions towards treatment optimization Session 8C Prevention - Non-biomedical approaches (Sue Goldstein) - Condoms (Mags Beksinska) - Update on trials of vaccines and monoclonals in SA; how PrEP could augment these approaches (Fatima Laher) - Voluntary medical male circumcision (Limakatso Lebina) - Treatment as prevention (Francois Venter) Chair: Fatima Laher Session 9C Modelling and scale-up - What are the numbers telling us (Andrew Boulle) - How the epidemic informs resource planning (Zukiswa Pinini) Southern African HIV Clinicians Society Conference 2018 programme subject to change 4 P a g e

4 - Drug-drug interaction (Gary Maartens) Chair: Karen Cohen 17h10 18h40 Session 10A Skills building session Resistance - Third-line (Leon Levin) - Paediatric third-line (Moherndran Archary) - Stanford database - how to interpret resistance test results (Robert Shafer) Chair: Cloete van Vuuren Session 10B - Skills building session Counselling - How to deliver HIV risk reduction counselling in 2018 (Janan Dietrich) - Integrating HIV prevention with other services (Natasha Davies) - How to tell a teenager they have HIV: A practical approach (Julia Turner) - Uptake and yield of a 24/7 HIV testing service across four Eastern Cape hospital Emergency departments (Dave Stead) Chair: Pierre Brouard 18h50 20h20 Session 11: Debate (Open Session) Hall 4 Implications of scarcer resources for 90:90:90 (Gloria Maimela) - Panel: Elliot Raizes, Annemarie Wensing, Jean Nachega, Francois Venter Chair: Zukiswa Pinini FRIDAY, 26 OCTOBER h30 08h15 Southern African HIV Clinicians Society AGM Cost effectiveness of TLD versus TEE (Gesine Meyer-Rath) Chair: Richard Borain Session 10C National Health Insurance - Keynote: Sasha Stevenson 08h30 10h00 Session 12: Plenary Our current understanding of antibodies (Nono Mkhize) Why do we need cure (John Mellors) How do you measure cure (Monique Nijhuis) Southern African HIV Clinicians Society Conference 2018 programme subject to change 5 P a g e

5 Management of patients with advanced HIV (Graeme Meintjes) 10h00 10h30 Refreshments, exhibition and posters 10h30 12h00 Session 13A Session 13B Opportunistic infections - An approach to intracranial mass lesions in HIV patients (Dave Stead) - Pneumocystis pneumonia (Michelle Wong) - Endemic mycoses in HIV patients (Jade Mogambery) - An approach to chronic diarrhoea (Sipho Dlamini) Chair: Colin Menezes HIV and TB in children and adults - Paediatric TB diagnosis and management (Ashendri Pillay) - TB in children and HIV-TB co-infection (Fiona Kritzinger) - TB in adults and HIV-TB co-infection (Ndiviwe Mphothulo) - TB and HIV co-infection including IRIS (Richard Lessells) Chair: Kogieleum Naidoo 12h00 13h30 Lunch, exhibition and posters (Poster tracks: Antiretroviral Treatment; Primary Health Care and Nursing; Basic Science; Opportunistic Infections and Malignancies; HIV Treatment Failure and Drug Resistance) 13h30 15h00 Session 15: Plenary Botswana Dolutegravir experience (Ava Avalos) Could good point-of-care testing revolutionise issues in the region? (Peter Manyike) Balancing politicians, ministries of health, communities and donors (Paula Munderi) Chairs: (Ebrahim Variava and Muhangwi Mulaudzi) 15h00 15h30 Refreshments, exhibition and posters 15h30 17h00 Session 16A Session 16B Skills building Clinical skills building Should the private sector be treating TB? Yes (Moeketsi Mathe) Session 13C Key populations and mobile populations - Injecting drug users in the region (Andrew Scheibe) - Sex workers including satellite clinics; peer support (Naomi Hill) - Engaging in care (Naomi Hill) - Testing in taxi ranks (Thandeka Khoza) Chair: Kholi Buthelezi Satellite Session 14 GILEAD session Session 16C Update on PMTCT Southern African HIV Clinicians Society Conference 2018 programme subject to change 6 P a g e

6 (Yunus Moosa, Richard Lessells, Farai Russell Sigauke) No (Ebrahim Variava) Chair: Kogieleum Naidoo - Where are we with PMTCT, including epidemiology (Landon Myer) - Transmission of HIV in breastfeeding (Ameena Goga) - Pregnant women on ART programmatic issues (Coceka Mnyani) - Contraception, clinical issues, MPTs and new technologies (Helen Rees) Chair: Tshidi Sebitloane 17h10 18h40 Session 17 Hall 4 Dolutegravir in pregnancy - Overview (Landon Myer) - DolPHIN-1: Randomised controlled trial of dolutegravir (DTG)- versus efavirenz (EFV)-based therapy in mothers initiating antiretroviral treatment in late pregnancy (Catherine Orrell) - Dolutegravir rollout (Steven Smith) Chair: Sipho Dlamini and Francois Venter 19h00 22h30 Celebratory Dinner (RSVP only additional fee applies) Entertainment provided The Veldt SATURDAY, 27 OCTOBER h30 08h15 Session 18 Auditorium Meet the Professor / Clinician How did I start my academic / research career? (Dave Spencer; Francois Venter; Michelle Moorhouse; Yunus Moosa; Gary Maartens; Chris Jack) 08h30 10h00 Session 19: Plenary Vaccinations - Overview (Benjamin Kagina) - Influenza vaccines (Marta Nunes) Southern African HIV Clinicians Society Conference 2018 programme subject to change 7 P a g e

7 - HIV vaccines (Nivashnee Naicker) - SAHCS vaccination guidelines (Sipho Dlamini) Chair: Rudzani Muloiwa 10h00 10h30 Refreshments, exhibition and posters 10h30 12h00 Session 20A Session 20B Noncommunicable diseases - Inflammation (Dave Spencer) - Hypertension (Ebrahim Variava) - Obesity (Denasha Reddy) - Mental health (John Joska) - Injection drug use, HIV and hepatitis (Moeketsi Mathe) Chair: Marlin McKay Ethics and technology - Digital database and the PoPI act (Siraaj Adams) - Ethico-legal framework for biobank research in SA (Safia Mahomed) - EMGuidance (Mohammed Dalwai) Chair: Funeka Bango 12h00 13h30 Lunch, exhibition and posters (Poster tracks: Operations Research; Prevention; TB; Women s Health; Key Populations; Non-Communicable Diseases; Clinical Skills Building) Session 20C Sexually transmitted infections - Strategies to achieve STI control in South Africa (Remco Peters) - Hepatitis C (Andrew Scheibe) - In context of PrEP (Danielle Travill) - Management of STIs in HIV+ population (Ranmini Kuluratne) Chair: Helen Rees Satellite Session 21 Johnson & Johnson session - Optimising treatment for life-long management of HIV 13h30 15h00 Session 22A - Advanced HIV Management - Care of aging patients (Marlin McKay) - Cryptococcal meningitis (Charlotte Sriruttan) - Palliative care (Dave Spencer) Chair: Dave Spencer Session 22B Treatment optimisation - Overview of all medications currently available (Landon Myer) - Can we use dolutegravir second-line? (Graeme Meintjes) - New ARVs and surveillance (Michelle Moorhouse) - Low-dose darunavir (Francois Venter) Chair: Polly Clayden Session 22C Best abstracts session - Constructing TB cascades to inform TB programme improvement (Kate Rees) - HIV drug resistance profiles in patients failing integrase strand transfer inhibitors in the South African public sector (Kim Steegen) Southern African HIV Clinicians Society Conference 2018 programme subject to change 8 P a g e

8 15h10 16h40 Session 23A Skills building Guidelines - Vaccination guidelines (Sipho Dlamini) - Safer conception guidelines (Natasha Davies) Session 23B Adherence - What is new in adherence (Catherine Orrell) - Virological monitoring how it relates to adherence (Richard Lessells) - Continued Use of PrEP among Sex Workers in Six Sites in South Africa (Cara O Connor) - Linking paediatric, adolescent and adult patients to care through the implementation of clinic navigators in high volume facilities (Chantal Smith) - Perceptions of HIV-Self Screening (Nthabiseng Koloane) - Viral load suppression among pregnant women presenting on ART in antenatal care; Chiredzi District Zimbabwe (Talent Maphosa) - Evaluation of the new Option B+ PMTCT program for HIV at hospital facilities: case study at the Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa (Melanie Bisnauth) - Triple-NRTI regimens while on TB treatment in a resource constrained setting a paediatric cohort analysis (Jennifer Minnaar) - Youth Care Clubs: Optimising clinic time, fostering peer support, improving adherence (Moira Beery) Session 23C - Quality Improvement The Aurum Institute (Lauren de Kock, Winnet Chiningwenya) Southern African HIV Clinicians Society Conference 2018 programme subject to change 9 P a g e

9 - Adult antiretroviral therapy guidelines (Michelle Moorhouse) - Palliative care guidelines (Dave Spencer) - Self screening (Naleni Rhagnath) - Adherence and the related science (Nithendra Manickchund) Chair: Maria Sibanyoni 16h50 18h15 Session 24: Closing Plenary Big challenges in TB drug resistance (Richard Lessells) Big challenges in introducing and scaling up new prevention technologies (Helen Rees) Big challenges in public health with essential medicine availability (Anele Yawa) Chair: Gary Maartens 18h15 18h20 Conference closing Moeketsi Mathe Southern African HIV Clinicians Society Conference 2018 programme subject to change 10 P a g e