We Are Ready for Prime Time Invest Today! Joseph Tector MD PhD, University of Alabama Birmingham School of Medicine
|
|
|
- Jade Lyons
- 5 years ago
- Views:
Transcription
1 We Are Ready for Prime Time Invest Today! Joseph Tector MD PhD, University of Alabama Birmingham School of Medicine
2 Disclosure I have founded Xenobridge LLC and have applied for patents related to pig engineering and xenotransplantation Portions of this project were funded by United Therapeutics.
3 Where We Are With Regards to Clinical Xenotransplantation Greater than 1-year survival in preclinical life supporting renal pig-to-primate model Understanding of pathophysiology and graft failure Familiar paradigm for posttransplant success Greater than 2-year survival in heterotopic heart transplant model Donor pigs with a negative CDC and Flow crossmatch to patients on the waitlist Detailed understanding of histocompatibility testing for clinical xenotransplantation
4 Where We Are With Regards to Clinical Xenotransplantation Progress regarding Zoonotic viral concerns Viral testing for donor pigs Greater understanding of PERV risk Clinical grade pig facility Community ethics outreach program
5 Heterotopic survival exceeding 2 years
6 Greater than 1-Year Survival in Preclinical Life Supporting Renal Pigto-Primate Model
7 Experimental Design
8 Graft Survival
9 Experimental Design
10 Graft Survival and Function
11 Antibody Dominates the Pathology of Long-Term Survivors GTKO/hDAF Rhesus macaque: T cell depletion, anti- CD154, MMF/steroids Glomerulopathy and thrombotic microangiopathy Basement membrane thickening Immunoglobulin and C4d deposition
12 Paradigm for Initial Clinical Xenotransplantation Trials
13 Donor Pigs with a Negative CDC and Flow Crossmatch to Patients on the Waitlist Detailed Understanding of Histocompatibility Testing for Clinical Xenotransplantation
14 Histocompatibility Testing
15 Histocompatibility Testing in Humans Flow cytometric crossmatch >1,000 waitlisted patients screened 45-55% of patients have negative crossmatch
16 cpra > 80 HLA Class I SLA Cross Reactivity
17 Limitations of the Preclinical Model No Rhesus or Baboon has a negative crossmatch to a GGTA1/B4GALNT2 KO pig Crossmatch to GGTA1/CMAH/B4GALNT2 KO pig is worse than to GGTA1/B4GALNT2 KO pig Baboons and Rhesus express Neu5Gc because they have an active CMAH gene Significant AMR is expected and not reflective of a crossmatch negative transplant
18 Rhesus Antibody Binding Rhesus Macaque serum antibodies tested on: GGTA1 KO GGTA1/B4GalNT 2 KO IgG IgM No Rhesus has a negative crossmatch
19 NHP vs. Human Antigen Elimination Better Crossmatch In Humans
20 We Cannot Test the Pig We Intend to Use in Patients in Our Preclinical Model
21 Triple Knockout Pig GGTA1/CMAH/B4GALNT2 KO Has a negative crossmatch Genetic engineering relatively simple minimizing Risk to recipient Graft can participate in immune response (fight infection) Risk to pig Immune system intact Risk to public Minimize off target effects Healthy pigs
22 Crossmatch in Non-Human Primates is Not Reflective of Human Scenario
23 Progress Regarding Zoonotic Viral Concerns
24 Porcine Endogenous Retrovirus (PERV) Never caused disease in pig or human Never infected non-transformed human primary cell Multiple anti-viral drugs are effective against PERV
25 Infectious Disease Testing for Donor Pigs
26 Infectious Disease Testing for We engineered an assay system to evaluate serum specimens for 30 viruses that need to be excluded in donor Donor Pigs
27 Clinical Grade Pig Facility
28 Building A Gilt Acclimation and Gestation Unit Configuration
29 Procedural Areas Behind Barrier Operating Room Animal Prep Room
30
31 Local Outreach Program Preparing the community for first trial Religious and civic leaders State Board of health Hospital operations committee Tuskegee ethics committee
32 Patient Selection for Initial Trial Important to remember when talking about expectations from xenotransplant Many patients will not ever be transplanted Bar is not being transplanted not allotransplant Preclinical data is very reasonable > 6 months Cyclosporine Increased survival from 32 to 42 days v.s. Immuran as monotherapy Limitations of caring for primates Therapeutic drug monitoring Not treating rejection
33 Acknowledgements UAB: Matt Tector Jose Estrada Luz Reyes Zhang Yu Wang Greg Martens Joe Ladowski Devin Eckhoff Emory: Andrew Adams Steven Kim Mandy Ford Ken Newell
Xenotransplantation. Pig as an organ donor
Xenotransplantation Pig as an organ donor Xenotransplantation Transplantation of solid organs Heart, Kidney, Liver Transplantation of live animal cells Pig neuronal and pig pancreatic islet cells Use of
Copyright information:
Pre-transplant antibody screening and anti-cd154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model Laura Higginbotham, Emory University Dave Mathews,
DE-MYSTIFYING THE BLACK BOX OF TRANSPLANT IMMUNOLOGY
2016 DE-MYSTIFYING THE BLACK BOX OF TRANSPLANT IMMUNOLOGY James H Lan, MD, FRCP(C), D(ABHI) Clinical Assistant Professor, University of British Columbia Nephrology & Kidney Transplantation, Vancouver General
Serum samples from recipients were obtained within 48 hours before transplantation. Pre-transplant
SDC, Patients and Methods Complement-dependent lymphocytotoxic crossmatch test () Serum samples from recipients were obtained within 48 hours before transplantation. Pre-transplant donor-specific CXM was
HLA and Non-HLA Antibodies in Transplantation and their Management
HLA and Non-HLA Antibodies in Transplantation and their Management Luca Dello Strologo October 29 th, 2016 Hystory I 1960 donor specific antibodies (DSA): first suggestion for a possible role in deteriorating
Case Presentation Turki Al-Hussain, MD
Case Presentation Turki Al-Hussain, MD Director, Renal Pathology Chapter Saudi Society of Nephrology & Transplantation Consultant Nephropathologist & Urological Pathologist Department of Pathology & Laboratory
Review of Rituximab and renal transplantation. Dr.E Nemati. Professor of Nephrology
Review of Rituximab and renal transplantation Dr.E Nemati Professor of Nephrology Introductio n Rituximab is a chimeric anti-cd20 monoclonal antibody. The CD20 antigen is a transmembrane nonglycosylated
Trends in Hematopoietic Cell Transplantation. AAMAC Patient Education Day Oct 2014
Trends in Hematopoietic Cell Transplantation AAMAC Patient Education Day Oct 2014 Objectives Review the principles behind allogeneic stem cell transplantation Outline the process of transplant, some of
RENAL EVENING SPECIALTY CONFERENCE
RENAL EVENING SPECIALTY CONFERENCE Harsharan K. Singh, MD The University of North Carolina at Chapel Hill Disclosure of Relevant Financial Relationships No conflicts of interest to disclose. CLINICAL HISTORY
2017 BANFF-SCT Joint Scientific Meeting. BARCELONA March 2017
2017 BANFF-SCT Joint Scientific Meeting BARCELONA 27-31 March 2017 Adriana Zeevi PhD (D) ABHI Professor of Pathology, Surgery and Immunology Director of Histocompatibility Laboratory University of Pittsburgh
Solid Organ Transplant
Solid Organ Transplant Lee R. Goldberg, MD, MPH, FACC Associate Professor of Medicine Medical Director, Heart Failure and CardiacTransplant Program University of Pennsylvania Disclosures Thoratec Consulting
XM-ONE XM-ONE XM-ONE. References XMO_V4.0_100205_CE.EU
Transplantation Cross match Transplantation Cross match XMO_V4._125_CE.EU Manufactured by: ABSORBER AB Address: Drottninggatan 33 SE-13 95 Stockholm, Sweden E-mail: info-ssp@olerup.com Tel: +46 8 5 89
1. Discuss the basic pathophysiology of end-stage liver and kidney failure.
TRANSPLANT SURGERY ROTATION (PGY1, 2) A. Medical Knowledge Goal: The resident will achieve a detailed knowledge of the evaluation and treatment of a variety of disease processes. The resident will be exposed
FIT Board Review Corner March 2016
FIT Board Review Corner March 2016 Welcome to the FIT Board Review Corner, prepared by Sarah Spriet, DO, and Tammy Peng, MD, senior and junior representatives of ACAAI's Fellows-In-Training (FITs) to the
A POTENTIAL EXPANSION OF THERAPEUTIC APHERESIS UTILIZATION
THE NEW KIDNEY ALLOCATION SYSTEM: A POTENTIAL EXPANSION OF THERAPEUTIC APHERESIS UTILIZATION Paul Warner, PhD, D(ABHI) Director, HLA/Immunogenetics Laboratory Bloodworks Northwest Seattle, Washington Disclosure
APHERESIS FOR DESENSITIZATION OF NON-RENAL TRANSPLANTS
APHERESIS FOR DESENSITIZATION OF NON-RENAL TRANSPLANTS GOW AREPALLY, MD MEDICAL DIRECTOR DUKE THERAPEUTIC APHERESIS SERVICE ASSOCIATE PROFESSOR, MEDICINE AMERICAN SOCIETY FOR APHERESIS MAY 25 TH 2013 OVERVIEW
Transplantation. Immunology Unit College of Medicine King Saud University
Transplantation Immunology Unit College of Medicine King Saud University Objectives To understand the diversity among human leukocyte antigens (HLA) or major histocompatibility complex (MHC) To know the
Eculizumab chez les receveurs de greffe rénal à haut risque immunologique. Mark D. Stegall Mayo Clinic, Rochester, MN
Eculizumab chez les receveurs de greffe rénal à haut risque immunologique Mark D. Stegall Mayo Clinic, Rochester, MN Disclosure. Dr Mark Stegall. Institution : Mayo Clinic, Rochester. Research contracts
Why so Sensitive? Desensitizing Protocols for Living Donor Kidney Transplantation
Why so Sensitive? Desensitizing Protocols for Living Donor Kidney Transplantation Stephen J Tomlanovich MD Objectives of this Talk Define the sensitized patient Describe the scope of the problem for a
IMMUNOBIOLOGY OF TRANSPLANTATION. Wasim Dar
IMMUNOBIOLOGY OF TRANSPLANTATION Wasim Dar Immunobiology of Transplantation Overview Transplantation: A complex immunologic process Contributions Innate Immunity Adaptive immunity T Cells B Cells HLA Consequences
Living Kidney Donation. Dr. Joseph Keith Melancon
Living Kidney Donation Dr. Joseph Keith Melancon Thanks to our speaker! Keith Melancon, MD Chief Transplant Institute And Division Of Transplant Surgery; Medical Director GW/ Ron And Joy Paul Kidney Center
HHS Public Access Author manuscript Transplantation. Author manuscript; available in PMC 2017 March 01.
Silencing porcine CMAH and GGTA1 genes significantly reduces xenogeneic consumption of human platelets by porcine livers James R. Butler, Leela L. Paris, Ross L. Blankenship, Richard A. Sidner, Gregory
Organ transplantation in Bulgaria
Cell Tissue Banking (28) 9:337 342 DOI 1.17/s1561-7-935-2 Organ transplantation in Bulgaria Elissaveta Naumova Æ Petar Panchev Æ Pencho J. Simeonov Æ Anastassia Mihaylova Æ Kalina Penkova Æ Petia Boneva
Donor-Specific HLA Class I and CREG Antibodies in Complement-Dependent Cytotoxicity-Negative Renal Transplants
Available online at www.annclinlabsci.org 330 Annals of Clinical & Laboratory Science, vol. 40, no. 4, 2010 Donor-Specific HLA Class I and CREG Antibodies in Complement-Dependent Cytotoxicity-Negative
3/6/2017. Prevention of Complement Activation and Antibody Development: Results from the Duet Trial
Prevention of Complement Activation and Antibody Development: Results from the Duet Trial Jignesh Patel MD PhD FACC FRCP Medical Director, Heart Transplant Cedars-Sinai Heart Institute Disclosures Name:
Management of Rejection
Management of Rejection I have no disclosures Disclosures (relevant or otherwise) Deborah B Adey, MD Professor of Medicine University of California, San Francisco Kidney and Pancreas Transplant Center
Innovation In Transplantation:
Innovation In Transplantation: Improving outcomes Thomas C. Pearson Department of Surgery Emory Transplant Center CHOA Symposium October 22, 2016 Disclosures Belatacept preclinical and clinical trial were
Glossary. Anesthesiologist A doctor who puts you or parts of your body to sleep during surgery.
1-Glossary Glossary Acute rejection A type of rejection that occurs when immune cells from your body attack the transplanted organ(s). Acute rejection may occur at any time after a transplant. But it usually
Oxford Transplant Centre. Live donor kidney transplantation what if we are not a match?
Oxford Transplant Centre Live donor kidney transplantation what if we are not a match? page 2 You will already have been provided with information about different types of kidney transplant and the tests
Mucosal Immune System
Exam Format 100 points - 60 pts mandatory; 40 points where 4, 10 point questions will be chosen Some open-ended questions, some short answer. Kuby question Cytokines Terminology How do cytokines achieve
Transplant Applications of Solid phase Immunoassays Anti HLA antibody testing in solid organ transplantation
AACC Professional Course BETH ISRAEL DEACONESS MEDICAL CENTER HARVARD MEDICAL SCHOOL Transplant Applications of Solid phase Immunoassays Anti HLA antibody testing in solid organ transplantation J. Ryan
HLA Part II: My Patient Has DSA, Now What?
2017 CST-Astellas Canadian Transplant Fellows Symposium HLA Part II: My Patient Has DSA, Now What? James Lan, MD, FRCPC, D(ABHI) Dr. Lan completed his nephrology training at the University of British Columbia.
OPTN/UNOS Policy Notice Review of HLA Tables (2016)
Review of HLA Tables (2016) Sponsoring Committee: Policy/Bylaws Affected: Histocompatibility Policy 4.10 (Reference Tables of HLA Antigen Values and Split Equivalences) Public Comment: July 31, 2017 October
Highly Sensitized Patient Registry: Update and Successes
Highly Sensitized Patient Registry: Update and Successes Dr. Olwyn Johnston Medical Director Kidney and Pancreas Transplant Program Vancouver General Hospital Conflict of Interest Transplant Nephrologist
Peritubular capillaries C4d deposits in renal allograft biopsies and anti HLA I/II alloantibodies screening Incidence and clinical importance
ORIGINAL ARTICLE Port J Nephrol Hypert 2008; 22(1): 37-42 Peritubular capillaries C4d deposits in renal allograft biopsies and anti HLA I/II alloantibodies screening Incidence and clinical importance Helena
PUO in the Immunocompromised Host: CMV and beyond
PUO in the Immunocompromised Host: CMV and beyond PUO in the immunocompromised host: role of viral infections Nature of host defect T cell defects Underlying disease Treatment Nature of clinical presentation
The Lecture s topics
The Lecture s topics Blood groups -ABO system *Transfusion reaction -Rhesus factor *Hemolytic disease of newborn Blood transfusion and Tissue transplant The ABO System Discovered in 1901 by Dr. Karl Landsteiner
Quantifying HLA-specific antibodies in patients undergoing desensitization Andrea Zachary a and Nancy L. Reinsmoen b
Quantifying HLA-specific antibodies in patients undergoing desensitization Andrea Zachary a and Nancy L. Reinsmoen b a John Hopkins University, Immunogenetics Laboratory, Baltimore, Maryland and b Cedars-Sinai
Is it safe to transplant against HLA DSA in cardiothoracic patients? development and implementation of national Guidelines
Is it safe to transplant against HLA DSA in cardiothoracic patients? development and implementation of national Guidelines Dr Martin Howell. Laboratory Director. Department of H&I, NHS Blood and Transplant,
Transplantation in highly sensitised patients treated with intravenous immunoglobulin and Rituximab
ORIGINAL ARTICLE Advance Access publication 1 February 2010 Transplantation in highly sensitised patients treated with intravenous immunoglobulin and Rituximab Ana Carina Ferreira 1, Sandra Brum 1, Vasco
Mary Keogan, on Mary behalf Keogan of all in NHISSOT On behalf of all in NHISSOT. 4th April 2014
Solid Organ Transplantation How the Lab Contributes to Improved Patient Outcomes Mary Keogan, on Mary behalf Keogan of all in NHISSOT On behalf of all in NHISSOT 4th April 2014 Solid Organ Transplantation
Evaluation of Two New Antibody Detection Techniques in Kidney Transplantation. Doctoral Thesis. Dr. Petra Gombos
Evaluation of Two New Antibody Detection Techniques in Kidney Transplantation Doctoral Thesis Dr. Petra Gombos Semmelweis University Doctoral School of Pathology Supervisor: Dr. Róbert Langer, Ph.D. Consultant:
[Some people are Rh positive and some are Rh negative whether they have the D antigen on the surface of their cells or not].
![[Some people are Rh positive and some are Rh negative whether they have the D antigen on the surface of their cells or not].](/thumbs/95/122584877.jpg "[Some people are Rh positive and some are Rh negative whether they have the D antigen on the surface of their cells or not].")
Few things to add to agglutination subject: When you agglutinate red blood cells (hemagglutination) you cross link the antigens that are present on two adjacent red blood cells, and of course red blood
Strategies for Desensitization
Strategies for Desensitization Olwyn Johnston MB, MRCPI, MD, MHSc BC Nephrology Day October 8 th 2010 Pre-transplant crossmatch (CMX) with donor lymphocytes has been standard of practice Positive CDC CXM
Virtual Crossmatch in Kidney Transplantation
Virtual Crossmatch in Kidney Transplantation Shiva Samavat Associate Professor of Nephrology Labbafinejad Hospital SBMU 2018.11.21 All transplant candidates are screened to determine the degree of humoral
ACCME/Disclosure. Case #1. Case History. Dr. Bracamonte has nothing to disclose
Case #1 ACCME/Disclosure Dr. Erika Bracamonte Associate Professor of Pathology University of Arizona, College of Medicine Banner University Medical Center, Tucson Dr. Bracamonte has nothing to disclose
The Generation of Specific Immunity
The Generation of Specific Immunity Antibody structure! Antibodies classified by specificity (antigen, binding site) and class (general structure, function)! Differences in variable regions produce different
Chapter 40 Section 2 The Immune System
Chapter 40 Section 2 The Immune System Science Standard 10a What is the role of the skin in providing nonspecific defenses against infection? What is the function of the immune system? The immune system
Living Donor Paired Exchange (LDPE)
Living Donor Paired Exchange (LDPE) Why do we need Living Donation? 3,796 patients waiting for an organ transplant 2,679 (71%) waiting for a kidney transplant 249 people died while waiting for an organ
Desensitization in Kidney Transplant. James Cooper, MD Assistant Professor, Kidney and Pancreas Transplant Program, Renal Division, UC Denver
Desensitization in Kidney Transplant James Cooper, MD Assistant Professor, Kidney and Pancreas Transplant Program, Renal Division, UC Denver Organ Shortage Currently there are >90,000 patients on the kidney
Belatacept: An Opportunity to Personalize Immunosuppression? Andrew Adams MD/PhD Emory Transplant Center
Belatacept: An Opportunity to Personalize Immunosuppression? Andrew Adams MD/PhD Emory Transplant Center Disclosure Research Funding from BMS. Learning Objectives -Define belatacept-resistant rejection
The Acceptable Mismatch program of Eurotransplant.
The Acceptable Mismatch program of Eurotransplant. Frans Claas Leiden University Medical Center Eurotransplant Reference Laboratory Leiden, the Netherlands. Hinterzarten, December 7, 2013 Main problem
Renal Pathology- Transplantation. Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic
Renal Pathology- Transplantation Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic eva.honsova@ikem.cz Kidney has a limited number of tissue reactions by which the kidney
Getting a New Kidney UHN. Information for patients and families. Is a kidney transplant right for me? Read this booklet to learn:
Getting a New Kidney UHN Information for patients and families Read this booklet to learn: about kidney transplants who can be donors how to start the transplant process how long the process might take
Clinical Study Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients
BioMed Research International Volume 2013, Article ID 738404, 5 pages http://dx.doi.org/10.1155/2013/738404 Clinical Study Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly
Clinical impact of de-novo HLA antibodies in pancreas and islet transplantation
Clinical impact of de-novo HLA antibodies in pancreas and islet transplantation David Turner, PhD, FRCPath Lead for H&I Services, Scottish National Blood Transfusion Service Treatment of Type I DM Insulin
Blood transfusion. Dr. J. Potgieter Dept. of Haematology NHLS - TAD
Blood transfusion Dr. J. Potgieter Dept. of Haematology NHLS - TAD General Blood is collected from volunteer donors >90% is separated into individual components and plasma Donors should be: healthy, have
Autoimmunity & Transplantation. Dr. Aws Alshamsan Department of Pharmaceu5cs Office: AA87 Tel:
Autoimmunity & Transplantation Dr. Aws Alshamsan Department of Pharmaceu5cs Office: AA87 Tel: 4677363 aalshamsan@ksu.edu.sa Learning Objectives By the end of this lecture you will be able to: 1 Recognize
Infectious Disease Issues in Xenotransplantation
CLINICAL MICROBIOLOGY REVIEWS, Jan. 2001, p. 1 14 Vol. 14, No. 1 0893-8512/01/$04.00 0 DOI: 10.1128/CMR.14.1.1 14.2001 Infectious Disease Issues in Xenotransplantation ROUMIANA S. BONEVA,* THOMAS M. FOLKS,
6/19/2012. Who is in the room today? What is your level of understanding of Donor Antigens and Candidate Unacceptables in KPD?
6/19/212 KPD Webinar Series: Part 3 Demystifying the OPTN Kidney Paired Donation Pilot Program Unacceptable HLA antigens: The key to finding a compatible donor for your patient M. Sue Leffell, Ph.D. J.
ABO. ABO ABO ABO ABO ABO ABO ABO ABO. Key words ABO. Alexandre ABO ABO. double filtration plasmapheresis, DFPP. antibody-mediated rejection, AMR
ABO ABO ABO ABO ABO ABO ABO ABO ABO ABO.. ABO ABO. ABO. ABO ABO Key words ABO ABO A B antibody-mediated rejection, AMR Alexandre ABO double filtration plasmapheresis, DFPP ABO ABO n ABO n p-value R.....
Islet Xenotransplantation: Are We Really Ready for Clinical Trials?
American Journal of Transplantation 2006; 6: 1269 1274 Blackwell Munksgaard Personal Viewpoint C 2006 The Authors Journal compilation C 2006 The American Society of Transplantation and the American Society
- Transplantation: removing an organ from donor and gives it to a recipient. - Graft: transplanted organ.
Immunology Lecture num. (21) Transplantation - Transplantation: removing an organ from donor and gives it to a recipient. - Graft: transplanted organ. Types of Graft (4 types): Auto Graft - From a person
23/10/2017. Panel Reactive Antibodies and Crossmatch by Flow Cytometry. Antibodies against. Renal transplantation. Antibody mediated rejection (AMR)
Renal transplantation Panel Reactive Antibodies and Crossmatch by Flow Cytometry Katherina Psarra Immunology Histocompatibility Dept Evangelismos Hospital Athens, Greece In spite of the enormous progress
DISCLOSURES LESS OR NONE? SAFE OR SORRY? Consulting EARLY VERSUS LATE OUTCOMES AFTER LIVER TRANSPLANTATION
IS IT EVER SAFE TO DISCONTINUE IMMUNOSUPPRESSION AFTER PEDIATRIC LIVER TRANSPLANTATION? LESS OR NONE? SAFE OR SORRY? Sandy Feng, MD, PhD University of California San Francisco NASPGHAN Washington DC October
Transplant Success in Sensitized Patients Receiving a Standardized Desensitization Therapy: 3 Year Outcomes
Transplant Success in Sensitized Patients Receiving a Standardized Desensitization Therapy: 3 Year Outcomes INTRODUCTION In patients awaiting a transplant, having antibodies reactive to HLA antigens present
Biological Basis for Increased Risk of Graft Loss in African American (AA)-APOL1 and Beyond
Biological Basis for Increased Risk of Graft Loss in African American (AA)-APOL1 and Beyond Jonah Odim, MBA, MD, PhD Chief, Clinical Transplantation Division of Allergy, Immunology, and Transplantation
The Banff Classification for Diagnosis of Renal Allograft Rejection: Updates from the 2017 Banff Conference
The Banff Classification for Diagnosis of Renal Allograft Rejection: Updates from the 2017 Banff Conference Mark Haas Cedars-Sinai Medical Center Los Angeles, California, USA Statement of Disclosure Mark
The New Kidney Allocation System (KAS) Frequently Asked Questions
The New Kidney Allocation System (KAS) Frequently Asked Questions Contents General: The Need for the New System and Key Implementation Details... 4 Why was the newly revised KAS necessary?... 4 What were
Cases: CMV, HCV, BKV and Kidney Transplantation. Simin Goral, MD University of Pennsylvania Medical Center
Cases: CMV, HCV, BKV and Kidney Transplantation Simin Goral, MD University of Pennsylvania Medical Center Disclosures Grant support: Otsuka Pharmaceuticals, Astellas Pharma, Angion, AstraZeneca, and Kadmon
ABSTRACT AJCP /ORIGINAL ARTICLE. Downloaded from by guest on 07 January 2019
Correlation of Circulating Complement-Fixing Donor-Specific Antibodies Identified by the C1q Assay and Presence of C4d in Endomyocardial Biopsy Specimens Renee Frank, MD, 1 Priti Lal, MD, 1 Jane Kearns,
Preliminary Program Outline
Saturday, June 2, 2018 1:00 pm 5:30 pm Pre-Meeting Symposia Advanced Immunology Basic Science for the Clinician The Immunology of Kidney Transplantation Transplant Center QAPI and Advanced Leadership:
Immunology. Anas Abu-Humaidan M.D. Ph.D. Transplant immunology+ Secondary immune deficiency
Immunology Anas Abu-Humaidan M.D. Ph.D. Transplant immunology+ Secondary immune deficiency Transplant Immunology Transplantation is the process of moving cells, tissues or organs from one site to another
Recurrent Idiopathic Membranous Glomerulonephritis After Kidney Transplantation and Successful Treatment With Rituximab
TRANSPLANTATION Recurrent Idiopathic Membranous Glomerulonephritis After Kidney Transplantation and Successful Treatment With Rituximab Khadijeh Makhdoomi, 1,2 Saeed Abkhiz, 1,2 Farahnaz Noroozinia, 1,3
Hong Kong Journal Nephrol of 2000;(2): Nephrology 2000;2(2): BR HAWKINS ORIGINAL A R T I C L E A point score system for allocating cadaver
Hong Kong Journal Nephrol of 2000;(2):79-83. Nephrology 2000;2(2):79-83. ORIGINAL A R T I C L E A point score system for allocating cadaveric kidneys for transplantation based on patient age, waiting time
Antibody-Mediated Rejection in the Lung Allograft. Gerald J Berry, MD Dept of Pathology Stanford University Stanford, CA 94305
Antibody-Mediated Rejection in the Lung Allograft Gerald J Berry, MD Dept of Pathology Stanford University Stanford, CA 94305 Gerald J Berry, MD Professor of Pathology Stanford University, Stanford, CA
Immunology: an overview Lecture
Slide #2: Immunology is sometimes regarded as part of microbiology department because it started there as an investigation of ways used to prevent against infectious agents (e.g. microorganisms ). However
Blood Component Testing and Labeling
Blood Component Testing and Labeling Each donor unite must be tested and properly labeled before its release for transfusion. Required Tests: In most blood banks, pretransfusion testing involves determining
Steroid Minimization: Great Idea or Silly Move?
Steroid Minimization: Great Idea or Silly Move? Disclosures I have financial relationship(s) within the last 12 months relevant to my presentation with: Astellas Grants ** Bristol Myers Squibb Grants,
BLAZING TRAILS IN TRANSPLANTATION. Danielle Fritze, MD
BLAZING TRAILS IN TRANSPLANTATION Danielle Fritze, MD BETTER TODAY THAN YESTERDAY BETTER TOMORROW THAN TODAY. Jim Harbaugh,via Twitter (and others) Transplant s Joseph Murray Legacy The Herrick Twins NPR,
Islet Cell Allo-Transplantation. Disclosure. Objectives
Islet Cell Allo-Transplantation Gregory P. Forlenza, MD MCR Assistant Professor Barbara Davis Center University of Colorado Denver Special thanks to Melena Bellin, MD at The University of Minnesota who
The new Banff vision of the role of HLA antibodies in organ transplantation: Improving diagnostic system and design of clinical trials
The new Banff vision of the role of HLA antibodies in organ transplantation: Improving diagnostic system and design of clinical trials Carmen Lefaucheur 1 2 Banff 2015: Integration of HLA-Ab for improving
Access and Outcomes Among Minority Transplant Patients, , with a Focus on Determinants of Kidney Graft Survival
American Journal of Transplantation 2010; 10 (Part 2): 1090 1107 Wiley Periodicals Inc. Special Feature No claim to original US government works Journal compilation C 2010 The American Society of Transplantation
Transplantation and Cancer
Transplantation and Cancer Immunology Bởi: OpenStaxCollege The immune responses to transplanted organs and to cancer cells are both important medical issues. With the use of tissue typing and anti-rejection
Desensitization for solid organ and hematopoietic stem cell transplantation
Andrea A. Zachary Mary S. Leffell Desensitization for solid organ and hematopoietic stem cell transplantation Authors address Andrea A. 1 Zachary, Mary S. Leffell 1 1 Department of Medicine, Division of
Dictionary of Organ Donation and Transplantation Terms
Dictionary of Organ Donation and Transplantation Terms Acute Rejection: The body s attempt to destroy the transplanted organ. Acute rejection usually occurs in the first year after transplant. Adverse
Posttransplant Human Leukocyte Antigen Antibodies in Stable Kidney Transplant Recipients
Trends in Transplant. 2014;8:3-9 Gregor Bartel, Georg A. Böhmig: Alloantibodies and Graft Function Posttransplant Human Leukocyte Antigen Antibodies in Stable Kidney Transplant Recipients Gregor Bartel
TRANSPLANT IMMUNOLOGY. Shiv Pillai Ragon Institute of MGH, MIT and Harvard
TRANSPLANT IMMUNOLOGY Shiv Pillai Ragon Institute of MGH, MIT and Harvard Outline MHC / HLA Direct vs indirect allorecognition Alloreactive cells: where do they come from? Rejection and Immunosuppression
Cellular Pathology of immunological disorders
Cellular Pathology of immunological disorders SCBM344 Cellular and Molecular Pathology Witchuda Payuhakrit, Ph.D (Pathobiology) witchuda.pay@mahidol.ac.th Objectives Describe the etiology of immunological
Transplantation in Australia and New Zealand
Transplantation in Australia and New Zealand Matthew D. Jose MBBS (Adel), FRACP, FASN, PhD (Monash), AFRACMA Professor of Medicine, UTAS Renal Physician, Royal Hobart Hospital Overview CKD in Australia
HLA Antibody Complement Based Assays. Howard M. Gebel, PhD, D(ABHI) Robert A. Bray, PhD, D(ABHI) Emory University Hospital Atlanta, GA
HLA Antibody Complement Based Assays Howard M. Gebel, PhD, D(ABHI) Robert A. Bray, PhD, D(ABHI) Emory University Hospital Atlanta, GA Disclosure Neither presenter has any financial relationships related
Barriers to Transplantation
Barriers to Transplantation Ruth McCarrell RN BSN CNeph(C) Clinical Nurse Leader Kidney transplant Program St. Paul s Hospital Email: rmccarrell@providencehealth.bc.ca Overview Transplant Basics Living
Transfusion support in Transplantation
Transfusion support in Transplantation Patricia Campbell University of Alberta Hospitals University of Alberta Objectives UofA transplant programs What we do and why? HLA and ABO incompatible transplants
Immunity. Acquired immunity differs from innate immunity in specificity & memory from 1 st exposure
Immunity (1) Non specific (innate) immunity (2) Specific (acquired) immunity Characters: (1) Non specific: does not need special recognition of the foreign cell. (2) Innate: does not need previous exposure.
Dr. Yi-chi M. Kong August 8, 2001 Benjamini. Ch. 19, Pgs Page 1 of 10 TRANSPLANTATION
Benjamini. Ch. 19, Pgs 379-399 Page 1 of 10 TRANSPLANTATION I. KINDS OF GRAFTS II. RELATIONSHIPS BETWEEN DONOR AND RECIPIENT Benjamini. Ch. 19, Pgs 379-399 Page 2 of 10 II.GRAFT REJECTION IS IMMUNOLOGIC
Definitions. You & Your New Transplant ` 38
Definitions Acute Short, relatively severe Analgesic Pain medicine Anemia A low number of red blood cells Anesthetic Medication that dulls sensation in order to reduce pain Acute Tubular Necrosis (ATN)
Antibody Mediated Rejection (AMR) in LUNG TRANSPLANT Recipients
Antibody Mediated Rejection (AMR) in LUNG TRANSPLANT Recipients Lorriana Leard, MD UCSF Transplant Pulmonologist Associate Professor of Clinical Medicine Vice Chief of Clinical Activities Pulmonary, Critical
Statement of Disclosure
Statement of Disclosure Mark Haas serves as a paid consultant on pathology adjudication committees for two industry-sponsored clinical trials: Shire ViroPharma Treatment of Acute ABMR AstraZeneca Treatment
Mazen Animal Health. Jennifer Filbey, Ph.D. CEO March 2017
Mazen Animal Health Jennifer Filbey, Ph.D. CEO March 2017 Revolutionary Way to Prevent Disease and Save the Producer Money 2 The Strategic Opportunity NOVEL VACCINE production platform in maize enables