CURRICULUM VITAE. AFFILIATION: Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara,Turkey

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1 CURRICULUM VITAE NAME: Ozge Ulker DATE OF BIRTH: CURRENT POSITION: Research Assistant AFFILIATION: Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara,Turkey EDUCATION: PhD degree: Ankara University Faculty of Pharmacy Department of Toxicology, 2010, Estimation of Relative Contact Allergenic Potency of the Chemicals by Using Non- Radioactive Local Lymph Node Assay and Comparison with the Patch Test Results Supervisor: Prof. Dr. Asuman Karakaya Master s degree: Ankara University, Faculty of Pharmacy, Department of Toxicology, 2004, The Role of Pro-inflammatory Cytokines and Antioxidant Enzymes in Coal Workers Pneumoconiosis and Disease Clinical Severity, Supervisor: Prof. Dr. Asuman Karakaya Undergraduate degree:ankara University, Faculty of Pharmacy, 2001 AREAS OF INTEREST: Immunotoxicology, occupational toxicology, genetic toxicology, in vitro and alternative toxicity tests PROJECTS: The role of cytokines and cytokine gene polymorphism in development and progression of coal workers pneumoconiosis. Supported by Ankara University Research Fund, Project number: , Position: Researcher Investigation on incidence and levels of ochratoxin A (OTA) in human urine samples collected from different region of Turkey by immunoaffinity column clean-up and high performance liquid chromatography. Supported by The Scientific and Technological Research Council of Turkey, Project Number: 105S412 Position: Researcher

2 Estimation of Relative Contact Allergenic potency of the Chemicals by using Non- Radioactive Local Lymph Node Assay and Comparison with the Patch Test Results Supported by The Scientific and Technological Research Council of Turkey, Project Number: 107S365 (Doctorate Project) Position: Researcher Investigation of antioxidant effect of boric acid in some cell cultures in vitro. Supported by Ankara University Research Fund, Project number: 12B Position: Project manager Investigation of the TiO 2 solid nanoparticles safety for human health by using in vitro tests. Supported by The Scientific and Technological Research Council of Turkey, Project Number: 113S229 PUBLICATIONS 1. Yucesoy B., Cemiloglu O., Chronic lung diseases and cytokines. Sendrom, 15(10): , Ulker C.O., Yucesoy B., Durucu M., Karakaya A., Neopterin as a marker for immune system activation in coal workers pneumoconiosis, Toxicology and Industrial Health, 23 : , Ulker C.O., Ustundag A., Duydu Y., Yucesoy B., Karakaya A., Cytogenetic monitoring of coal workers and patients with coal workers pneumoconiosis in Turkey. Environmental molecular and mutagenesis, 49: , Ulker C.O., Yucesoy B., Demir O., Tekin I.O. & Karakaya A., Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers. Human and Experimental Toxicology, 27: , Akdemir C., Ulker O.C., Basaran A., Ozkaya S., Karakaya A., Estimation of ochratoxin A in some Turkish populations: an analysis in urine as a simple, sensitive and reliable biomarker. Food Chem Toxicol. 48(3):877-82, Epub 2010 Jan Ates I, Ulker OC, Akdemir C, Karakaya A. Correlation of Ochratoxin A exposure to urinary levels of 8-hydroxydeoxyguanosine and malondialdehyde in a Turkish population. Bull Environ Contam Toxicol Mar;86(3): Epub 2011 Feb Ulker OC, Atak A, Ates I, Karakaya A. Evaluation of auricular lymph node cell lymphocyte proliferation and cytokine production as non-radioactive endpoints during murine contact allergy.j Immunotoxicol Jun;8(2): Epub 2011 Jan Ulker OC, Ates I, Atak A, Karakaya A., Evaluation of Non-Radioactive Endpoints of Ex Vivo

3 Local Lymph Node Assay-BrdU to Investigate Select Contact Sensitizers.J Immunotoxicol : Ulker OC, Kaymak Y., Karakaya A., Allergenicity evaluation of fragrance mix and its ingredients bu using ex vivo local lymph node assay-brdu endpoints. Food Chem Toxicol : Ulker OC, Kaymak Y, Karakaya A., Investigation of allergenicity of some cosmetic mixtures by using ex vivo local lymph node assay-brdu endpoints. Int Arch Allergy Immunol. 2014;164(4): Arancioglu S, Ulker OC, Karakaya A. Utilization of the ex vivo LLNA: BrdU-ELISA to distinguish the sensitizers from irritants in respect of 3 end points-lymphocyte proliferation, ear swelling, and cytokine profiles. Int J Toxicol Jan;34(1): Ustundag A., Yılmaz S, Ulker O.C., Duydu Y., Protective Effect of Boric ac on oxidative DNA Damage in Chinese Hamster Lung Fibroblast V79 Cell Lines. Cell journal, 17, Charehsaz M., Sipahi H., Celep E., Üstündag A., Ülker OC, Duydu Y, Aydin A, Yesilada E.The fruit extract of Berberis crataegina DC. exerts potent antioxidant activity and protects DNA integrity, DARU Journal of Pharmaceutical Sciences. PARTICIPATING CONGRESS 1. 8 th International Symposium on Pharmaceutical Sciences (ISOPS-8), June 13-16, 2006, Ankara, Turkey. Ulker C.O., Yucesoy B., Tekin O.I., Karakaya A., Neopterin as a marker for immune system activation in coal miners pneumoconiosis rd Congress of the European Societies of Toxicology (EUROTOX), 6 th Congress of Toxicology in Developing Countries, September 20-24, 2006, Dubrovnik/Cavtat, Croatia. Ulker O.C., Ustundag A., Duydu Y., Yucesoy B., Karakaya A., Possible genotoxic risk in coal workers pneumoconiosis (Oral Presentation) 3. 6 th International Congress of Turkish Society of Toxicology, November 2-5, 2006, Antalya, Turkey. Ulker O. C., Yucesoy B., Demir O., Karakaya A, Serum and BALF cytokine levels at different stages of pneumoconiosis in coal workers 4. 6 th International Congress of Turkish Society of Toxicology, November 2-5, 2006, Antalya, Turkey. Karakaya A., Ulker O.C., Yucesoy B., Durucu M., Neopterin: A novel marker for immune activation in patients with CWP 5. 5 th International Congress on Environmental Mutagens in Human Populations, May 20-24, 2007, Antalya, Turkey. Ulker O.C., Ustundag A., Duydu Y., Yucesoy B., Karakaya A., SCE

4 and MN frequencies in coal workers and coal workers pneumoconiosis patients 6. The 3 th Euro-Asian Conference on Hazardous Waste & Human Health, March 27-30, 2008, Istanbul, Turkey. Ulker O.C., Yucesoy B., Demir O., Tekin I.O., Karakaya A., Serum and BAL antioxidant enzyme levels as markers of effect in CWP patients th Annual Meeting of the Society of Toxicology, March 16-20, 2008, Seattle, USA. Karakaya A., Akdemir C., Basaran A., Ulker O.C., Ozkaya S., Estimation of ochratoxin A in Turkish population: An analysis in urine as a simple, sensitive and reliable biomarker 8. The 3 th Euro-Asian Conference on Hazardous Waste & Human Health, March 27-30, 2008, Istanbul, Turkey. Karakaya A., Ulker O.C., Yucesoy B., Demir O., Tekin I.O., Serum and BAL cytokine levels as markers at different stages in CWP patients 9. The 45 th Congress of the European Societies of Toxicology, October 5-8, 2008, Rhodes, Greece. Ulker O.C., Yucesoy B., Demir O., Tekin I.O., Karakaya A., Evaluation of antioxidant enzyme levels as biological markers at different stages of pneumoconiosis in coal workers 10.The 45 th Congress of the European Societies of Toxicology, October 5-8, 2008, Rhodes, Greece, Karakaya A., Ulker O.C., Yucesoy B., Demir O., Tekin I.O., Relationship of inflammatory cytokines with disease severity in CWP patients 11.The 48 th Annual Meeting of the Society of Toxicology, March 15-19, 2009, Baltimore, USA, Karakaya A., Ulker O.C., Ates I., The murine local lymph node assay with non-radioactive alternative endpoints 12.The 9 th International Symposium on Pharmaceutical Sciences (ISOPS-9), June , Ankara, Turkey. Ulker O.C., Ates I., Karakaya A., The murine local lymph node assay with nonradioactive alternative endpoints 13.The 46 th Congress of the European Societies of Toxicology, September , Dresden, Germany, Ulker O.C., Karakaya A., Evaluation of alternative endpoints for nonradioactive local lymph node assay by using two strong sensitizers 14.7 th Congress of Toxicology in Developing Countries (CTDC), September , Sun City, South Africa, Karakaya A., Akdemir C., Ulker O.C., Başaran A., Ozkaya S., Estimation of ochratoxin A in some Turkish population: An analysis in urine as a simple, sensitive and reliable biomarker 15.The 47 th Congress of the European Societies of Toxicology, XII International Congress of Toxicology, July , Barcelona, Spain Karakaya A., Ulker O.C., Evaluation of cytokine production in auricular lymph nodes as an alternative endpoint during murine contact allergy

5 16.The 50 th Annual Meeting of the Society of Toxicology, March Washington DC, USA Karakaya A, Ulker O.C., Ateş I., Atak A.,Evaluation of the non-radioactive endpoints of LLNA by applying moderate and weak sensitizers, 17. The 48 th Congress of European Societies of Toxicology, June Stockholm, Sweden Ulker O.C., Ates I., Atak A., Karakaya A., Investigation of sensitizing potency of some cosmetic mixtures 18. The 10 th International Symposium on Pharmaceutical Sciences (ISOPS -10), June 26-29, 2012, Ankara, Turkey. Ulker O.C., Ates I., Atak A., Karakaya A., Investigation of the utility of the non-radioactive endpoints of ex vivo LLNA-BrdU method by using some cosmetic mixtures 19. The 8th Congresses on Toxicology in Developing Countries (8 th CTDC), September 10-13, 2012 Bankgog, Tailand, Karakaya A., Ulker O.C, Ates I, Atak A., Evaluation of contact sensitizing potential of fragrance mix and balsam of peru by using the ex vivo LLNA-BrdU method 20. The 8 th International Congress of Toxicology, June 30-July 4, 2013 Seoul, Korea., Karakaya A., Ulker O.C, Kaymak Y., Comparative Investigation of Contact Sensitization Potency of Fragrance mix ingredients by using ex vivo LLNA-BrdU 21. Yılmaz S., Üstündağ A., Ulker OC., Duydu Y., 50. Congress of the European Societies of Toxicology (EUROTOX) Investigation of antioxidant activity of boric acid in V79 cell cultures. ULUSAL 1. 7 th Congress of the Turkish Society of Toxicology with International Participation, 30 May-1 June 2009, Ankara, Turkey. Ulker O.C., Karakaya A., Ates I., Investigation of allergy and irritancy potency of DNCB and paraphenylenediamine bu using nonradioactive LLNA (Oral presentation) 2. 7 th Congress of the Turkish Society of Toxicology with International Participation, 30 May-1 June 2009, Ankara, Turkey Akdemir C., Ulker O.C., Basaran A., Ozkaya S., Karakaya A., Estimating ochratoxin A levels in urinary in Turkish population as a sensitive biomarker 3. 8 th Congress of the Turkish Society of Toxicology with International Participation, November 15-18, 2012, Antalya, Turkey. Ulker O., Kaymak Y., Karakaya A., Investigation of contact sensitization potency of fragrance mix and fragrance mix ingredients by using ex vivo nonradioactive local lymph node assay (Oral presentation) 4. 8 th Congress of the Turkish Society of Toxicology with International Participation, November 15-

6 18, 2012, Antalya, Turkey. Karakaya A., Ulker O., Ates I., Atak A., Investigation of the dermal sensitization potential of cosmetic materials by using the ex vivo local lymph node assay-brdu 5. Türk Toksikoloji Derneği II.Bölgesel Toksikoloji Sempozyumu, 3-4 Mayıs, 2013, Ülker Ö.C., Karakaya A., Ateş İ.,Eskişehir, Türkiye, Fragrans Karışımı ve Peru balsamının temas allerjik kontakt dermatit oluşturma potansiyellerinin ex vivo LLNA-BrdU yöntemi ile araştırılması. PARTICIPATING COURSES AND WORKSHOPS Workshop on Alternative Methods Reduction, Refinement, Replacement to Animal Tests, November 12-13, Ankara, Turkey CASCADE course in Regulatory Toxicology, August 25-29, 2008, Kuopio, Finland (course fellowship) Safe Handling of cytotoxic/hazardous drugs and Laminar flow and biosafety cabinet technology course, September 29, 2011, Ankara, Turkey. Developments in Risk Assessment: Basic Concepts and International Frameworks for Evaluating Toxicity Data for Human Health Risk Assessment, November 14, 2012, Antalya, Turkey. Chemicals regulation in EU. REACH and CLP- Legislation and Consequences, November 15, 2012, Antalya, Turkey. MEMBERSHIPS OF SCIENTIFIC AND PROFESSIONAL COMMUNITIES: IUTOX (International Union of Toxicology), EUROTOX (Federation of European Toxicologists and European Societies of Toxicology), Turkish Society of Toxicology VISITING SCHOLAR: Johns Hopkins University, School of Public Health, Center for Alternatives to Animal Testing (CAAT), 22 May February (TUBİTAK-2219 Fellowship) ADRESS: Ankara University, Faculty of Pharmacy, Depertment of Toxicology, 06510, Ankara, Turkey Tel: + 90 (312) oulker@pharmacy.ankara.edu.tr