Sources of ADRs - Recorded from in Tamil Nadu State, India

Transcription

1 Dr. G. SARATH CHANDRA, Ph.D

2 Sources of ADRs - Recorded from in Tamil Nadu State, India 6% % 9% 36% Antibiotics/Antimicrobial s Antiparasitics NSAIDs 1% 7% 19% Antihistamines Vitamins Vaccines Miscellaneous

3 Antibiotics / Antimicrobials Associated with ADRs 14 of ADR reported Number

4 10 Antiparasitic Drugs Associated with ADRs 9 8 Number of AD DR reported Levamisole Tetramisole Deltamethrin Ivermectin Berenil

5 6 NSAIDs Associated with ADRs 5 Number of ADR reported Nimesulide Metamizole Paracetamol

6 Vitamins Associated with ADRs Number of ADR reported Vitamin E & Selenium Vitamin A B-Complex B-Complex + Liver extract Multivitamins Iron+Folic acid -1

7 3 Miscellaneous Drugs Associated with ADRs Calcium borogluconate Number of ADR repo orted Phosphorus Sodium bicarbonate Atropine Triamcinolone Oxytocin Livodex 0

8 Adverse Drug Reactions Reported - Antibiotics/Antimicrobials Antibiotics / Antimicrobials Class of Drugs Species Adverse Drug Reactions No. of ADR Reported Oxytetracycline Cattle & Goat Pain, swelling, staggering gait, giddiness, sudden fell down, urination, respiratory distress-asphysia. i.m, preparation - but given through i.v route, 90ml along with DS, after 30 minutes animal collapsed 1 Tetracycline Cattle Edema at injection site 1 Streptopenicillin Cattle Salivation, Anaphylaxis, exaggerated allergic skin reactions, giddiness, allergic swelling over the body, death Streptomycin Cattle Death 1 Enrofloxacin Dog Giddiness 1 Cattle Allergic reactions, salivation, mydriasis Calf Collapsed after i.v injection 1 Ciprofloxacin Cattle Shivering, tremor, abdominal coughing 1 Chloramphenicol Goat Abortion 1 Procaine penicillin Cattle Urticaria, tremor Cattle Death 1 Penicillin Goat Allergic reactions 1 Amoxycillin Cattle Hyperactivity, Allergic reaction 1 Ceftrioxone Cattle Anaphylactic reaction, ocular edema, Skin rashes Sulfadiazine Cattle Skin eruptions 1 Sulfa+ Trimethoprime Cattle Bradycardia, Suddenly fell down, Urticaria, Salivation, Kicking of legs 7

9 Adverse Drug Reactions Reported - Antiparasitics Class of Drugs Species Adverse Drug Reactions No. of ADR Reported Levamisole Dog Salivation, Nervous signs, Tremor, Death Goat Nervous symptoms, Sudden fall down, Death Cattle Tremor, enteritis 1 Butox Dog Extensive salivation 1 (Deltamethrin) Goat Off feed 1 1 Tetramisole Sheep & Goat Excessive salivation, Anorexia, shivering, extended head, collapsed Tetramisole Cattle Salivation, nervous symptoms, staggering gait, shock Ivermectin Dog Tremor, severe convulsion Berenil Cattle Colic, frequent falling down, shivering, Cyanosis of mucous membranes, Salivation, Allergic reactions 4

10 Class of Drugs Adverse Drug Reactions Reported - NSAIDS Species Adverse Drug Reactions Nimesulide Cattle Muscular Tremor, Abortion Sheep & Goat No. of ADR Reported Paraplegia 1 Dog Severe pain 1 3 Analgin (Metamizole) Cattle Tremor 1 Paracetamol Cattle Nervous symptoms 1

11 Adverse Drug Reactions Reported - Antihistamines and Vitamins Species Adverse Drug Reactions No. of ADR Reported Class of Drugs Ranitidine Dog Convulsion 1 Vitamin-E and Selenium Multivitam ins Vitamin A Dog Allergic reactions Cattle, Sheep & Goat Salivation, Shivering, Cutaneous eruptions, Allergic reactions, Shock, Death Dog Allergic reaction, skin erythema, shivering Cattle Anarectic, Salivation, Allergic reactions, sudden fell down, Shock and death, Jerking of limbs Cattle Anaphylactic reaction 1 Dog B-complex Dog B-complex with liver extract Facial edema, Salivation, Reddening of skin, itching sensation Salivation, Vomiting, Allergic reaction, swelling of eyes, Unconsciousness Goat Respiratory distress 1 Cattle Anaphylactic reaction, hyperesthesia, convulsion Goat Nervous signs Feritas (Iron, sorbitol, citric acid, Folic acid, Cattle Swelling of head, salivation, tremors, death 1

12 Vaccines & Miscellaneous Drugs Class of Drugs Species Adverse Drug Reactions FMD Cattle & goat Hoof lesions developed, Animal fell down No. of ADR Reported Calcium borogluconate Cattle Tremor, fell down but recovered after few minutes Phosphorus Cattle & Goat Local swelling and Inflammatory changes, Dyspnoea Sodium bicarbonate Goat Pain, pedalling movement 1 Atropine Elephants Tremor, severe mydriasis 1 Triamcinolone Cattle Salivation, erythema, eruptions, respiratory distress 1 Oxytocin Cattle Death 1 Livodex Cattle Nervous symptoms 1

13 Sc1 Thank You

14 Slide 13 Sc1 Sarath chandra,