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1 CVM ADE Comprehensive Clinical Detail Report Listing: STARS Database Cumulative Date Range: 14-Sept-2004 thru- 14-Nov-2013 DRUG: SPINOSAD, MILBEMYCIN Species: Cat Route of Administration: ORAL ACCIDENTAL EXPOSURE 2 DIARRHEA 1 HYPERSALIVATION 1 VOMITING 1 PALLOR 1 TREMBLING 1 Species: Dog Route of Administration: INTRAOCULAR ANAPHYLAXIS/TOID 1 CONGESTION, EAR(S) 1 CONGESTION, SKIN 1 PRURITIS 1 URTICARIA 1 TREMBLING 1 Species: Dog Route of Administration: MISSING VOMITING 1 ANOREXIA 1 DEATH 1 DEPRESSION/LETHARGY 1 PRURITIS 1 ATAXIA 1 BIRTH DEFECT(S), HEAD/ 1 DEATH(NEWBORN) 1 Species: Dog Route of Administration: ORAL VOMITING 2265 Page 1 of 9
2 DEPRESSION/LETHARGY 627 INEFFECT, FLEAS 247 ANOREXIA 233 DIARRHEA 198 PRURITIS 168 ACCIDENTAL EXPOSURE 126 TREMBLING 116 ATAXIA 106 CONVULSION(S) 96 HYPERSALIVATION 68 DEATH 48 CONGESTION, SKIN 48 ANAPHYLAXIS/TOID 42 URTICARIA 39 POLYPNEA 38 VOCALIZATION 35 SHAKING 33 DYSPNEA 32 UNPALATABLE, WON'T EAT 28 FEVER, BODY 26 DIARRHEA, BLOODY 25 CONFUSION 25 INFLAM, SKIN 24 ALOPECIA 23 SGPT/ALT HI, BLD 21 DEHYDRATION 20 HYPERACTIVITY 19 STARING 19 ADIPSIA 18 PAIN, ABDOMEN 18 TWITCH 18 ALK PHOS HI, BLD 16 WEIGHT LOSS 16 EDEMA, HEAD/FACE 16 NERVOUSNESS 14 TACHYCARDIA 13 INTERACTION, DRUG(S) 13 COUGHING 13 CONGESTION, EAR(S) 11 WBC HI, BLD 11 Page 2 of 9
3 INEFFECT, ASCARIDS 10 INEFFECT, HOOKS 10 BUN HI, BLD 10 COLLAPSE 10 DEATH(EUTHANIZED) 10 POLYDIPSIA 10 PLATELETS LO, BLD 10 MYDRIASIS 10 DIARRHEA, MILD 9 MELENA 9 LIPASE HI, BLD 9 REACTION, UNSPECIFIED 9 APPREHENSION 9 STUPOR 9 HIDING 8 LICKING 8 NO SIGNS 8 UNPALATABLE 8 WEAKNESS 8 ANEMIA 8 RASH 8 VOMITING, UNPRODUCTIVE 7 POLYURIA 7 EDEMA, EYE(S)/LID(S) 7 SWELLING, EYE(S)/LID(S 7 INEFFECT, WHIPS 6 BEHAVIOR DISORDER 6 GLOBULIN HI, BLD 6 PROTEIN(TOT) HI, BLD 6 HAIR, SHEDDING 6 BRADYCARDIA 5 NAUSEA 5 BILIRUBIN(TOT) HI, BLD 5 CREATININE HI, BLD 5 STIFFNESS 5 TECH ERROR ADMINISTRAT 5 NEUROLOGICAL DISORDER 5 NYSTAGMUS 5 PACING 5 SQUINTING 5 Page 3 of 9
4 DEFECATION 4 HEMATOCHEZIA 4 INEFFECT 4 DISCOMFORT 4 GLUCOSE LO, BLD 4 ICTERUS, BODY 4 PALLOR, MUCOUS MEMBRAN 4 SGOT/AST HI, BLD 4 URINATION ABN 4 SWELLING, EAR(S) 4 SWELLING, HEAD/FACE 4 LIVER ENZYMES HI, BLD 4 HEAD TILT 4 PARESIS, HIND LIMB(S) 4 HYPERPNEA 4 KIDNEY FAILURE 4 GI, ABNORMAL 3 ALBUMIN LO, BLD 3 LICKING, FEET/DIGIT(S) 3 P HI, BLD 3 PAIN 3 RECUMBENCY 3 STAGGERING 3 ANEMIA, AUTOIMMUNE HEM 3 WBC LO, BLD 3 DERMATITIS, MOIST 3 PRURITIS, EAR(S) 3 SKIN, SCAB(S) 3 BILE ACIDS HI, BLD 3 LIVER DISORDER 3 AGGRESSION 3 HEAD BOBBING 3 SOMNOLENCE 3 WHEEZING 3 CONGESTION, EYE(S)/LID 3 DEAFNESS 3 DISCHARGE, EYE(S)/LID(S) 3 URINATION 3 PR-HEART, LESION(S) 2 DIARRHEA, MUCOID 2 Page 4 of 9
5 PANCREATITIS 2 VOMITING, BLOODY 2 INEFFECT, HW LARVAE 2 INEFFECT, TICKS 2 AMYLASE HI, BLD 2 CYANOSIS, MUCOUS MEMBR 2 DIFFICULTY RISING 2 EDEMA, LIMB(S) 2 GAGGING 2 GGT HI, BLD 2 GLUCOSE HI, BLD 2 INCONTINENCE, URINARY 2 NA LO, BLD 2 POSTURE ABN 2 RADIOGRAPH(S) ABN 2 SHAKING, HEAD/FACE 2 SPEC GRAVITY LO, URINE 2 ENLARGEMENT, LYMPH NOD 2 NEOPLASM, LYMPH NODE(S 2 SEGS HI, BLD 2 ERUPTION(S) 2 SKIN, CRUST(S) 2 VESICLE(S)/BULLAE, SKI 2 LIVER FAILURE 2 CIRCLING 2 HORNER'S SYNDROME 2 OPISTHOTONOS 2 PICA 2 BREATHING ABN 2 SOUND ABN, RESPIRATORY 2 BLINDNESS 2 BLINDNESS, TEMP 2 CONJUNCTIVITIS 2 EYE DISORDER 2 MIOSIS 2 PROLAPSE, THIRD EYELID 2 ULCER(S), CORNEA(S) 2 BLD, URINE 2 CYSTITIS 2 STRANGURIA 2 Page 5 of 9
6 HEART FAILURE 1 MURMUR, HEART 1 PRESSURE LO, BLD 1 BLD, MOUTH/LIP(S) 1 BORBORYGMI 1 CONSTIPATION 1 DEFECATION ABN 1 DIARRHEA, PROJECTILE 1 DIARRHEA, WATERY 1 DYSPHAGIA 1 HYPOMOTILITY 1 INCONTINENCE, FECAL 1 LESION(S), MOUTH/LIP(S 1 PANCREAS ENZYMES HI, B 1 STOOL, MUCOID 1 VOMITING, SEVERE 1 INEFFECT, ASCARIDS PRE 1 INEFFECT, WHIPS PREVEN 1 ABN COLOR, URINE 1 ALBUMIN HI, BLD 1 BITING/CHEWING 1 BLD 1 BLD(PETECHIAE) 1 BLD, EYE(S) 1 CA HI, BLD 1 CA LO, BLD 1 CONGESTION 1 CULTURE/TITER DATA ABN 1 DISTENTION, ABDOMEN 1 EDEMA 1 ILL 1 IMMUNE DISORDER 1 INCONTINENCE 1 INFECTION 1 K HI, BLD 1 LAMENESS 1 MASS, ABDOMEN 1 MG LO, BLD 1 MUCOUS MEMBR, MUDDY 1 NA HI, BLD 1 Page 6 of 9
7 ODOR 1 P LO, BLD 1 PAIN, NECK 1 PAWING 1 POLYPHAGIA 1 PR-MULT SITES, LESION(S) 1 REGURGITATION 1 SPASM 1 STIFFNESS, NECK 1 SWELLING, FEET/DIGIT(S 1 SWELLING, NECK 1 TECH ERROR 1 TRIGLYCERIDES HI, BLD 1 VESTIBULAR DISORDER 1 WEIGHT INCREASE 1 MONOS HI, BLD 1 NEOPLASM, SPLEEN 1 PR-LYMPH NODE(S), LESI 1 SEGS LO, BLD 1 DRY, SKIN 1 ERYTHEMA MULTIFORME 1 HAIR, ABN 1 INFECTION, SKIN 1 LESION(S), SKIN 1 PR-SKIN, LESION(S) 1 SCALE(S), SKIN 1 SKIN ABNORMAL 1 SKIN DISORDER 1 SKIN, DRY 1 SLOUGH, SKIN 1 ULCER(S), SKIN 1 PR-LIVER, LESION(S) 1 US-LIVER ABN 1 SWELLING, JOINT(S) 1 FLY BITING 1 HYPERESTHESIA 1 HYPERSENSITIVE, SOUND 1 PARALYSIS 1 PARALYSIS, FACIAL NERV 1 PARESIS, FORE LIMB(S) 1 Page 7 of 9
8 PROPRIOCEPTIVE DISORDE 1 REFLEX(ES) ABN 1 SEDATION 1 STUMBLING 1 THRASHING/PADDLING 1 TREMBLING, FACE 1 UNCONSCIOUS 1 PD-ODOR, ABN 1 PD-TABLET(S), ABN 1 BREATHING, PERIODIC 1 CONGESTION, LUNG(S) 1 DISCHARGE, NOSE 1 HYPOPNEA 1 PR-LUNG(S), EDEMA 1 SNEEZING 1 BLINDNESS, PARTIAL 1 CATARACT(S) 1 EPIPHORA 1 PHOTOPHOBIA 1 VISION DISORDER 1 PR-KIDNEY(S), LESION(S 1 DIABETES MELLITUS 1 HYPOADRENOCORTICISM 1 BIRTH DEFECT(S) 1 DEATH(NEWBORN) 1 ERECTION, ABN 1 FERTILITY, REDUCED 1 SPERM ABN 1 Species: Dog Route of Administration: Unknown DIARRHEA 1 INEFFECT, FLEAS 1 SGPT/ALT HI, BLD 1 CONVULSION(S) 1 Species: Human Route of Administration: ORAL ACCIDENTAL EXPOSURE 3 HUMAN EXPOSURE, INGEST 2 Page 8 of 9
9 DIARRHEA 1 NAUSEA 1 VOMITING 1 HUMAN EXPOSURE 1 HUMAN EXPOSURE, HAND(S 1 HUMAN EXPOSURE, TOPICA 1 IRRITATION, PHARYNX/TH 1 APPREHENSION 1 SOUND ABN, VOICE 1 VISION DISORDER 1 Species: Human Route of Administration: TOPICAL ACCIDENTAL EXPOSURE 5 HUMAN EXPOSURE 3 HUMAN EXPOSURE, TOPICA 2 HYPERESTHESIA 2 IRRITATION, MOUTH/LIP( 1 HUMAN EXPOSURE, HAND(S 1 CONGESTION, SKIN 1 RASH 1 URTICARIA 1 TASTE ABNORMALITY 1 Species: Human Route of Administration: UNKNOWN ACCIDENTAL EXPOSURE 1 HUMAN EXPOSURE, HAND(S 1 HUMAN EXPOSURE, TOPICA 1 RASH 1 Page 9 of 9
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