Allegaert, Karel and Choonara, Imti (2016) All medicines have side effects. Archives of Disease in Childhood, 101. pp
|
|
- Aldous Norman
- 5 years ago
- Views:
Transcription
1 Allegaert, Karel and Choonara, Imti (2016) All medicines have side effects. Archives of Disease in Childhood, 101. pp ISSN Access from the University of Nottingham repository: Copyright and reuse: The Nottingham eprints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the University of Nottingham End User licence and may be reused according to the conditions of the licence. For more details see: A note on versions: The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher s version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. For more information, please contact eprints@nottingham.ac.uk
2 All medicines have side effects Karel Allegaert 1 2, Imti Choonara 3 1 Intensive Care and Department of Surgery, Erasmus MC-Sophia Children s Hospital, Rotterdam, the Netherlands 2 Department of Development and Regeneration, KU Leuven, Belgium. 3 Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK Corresponding author: Imti Choonara imti.choonara@nottingham.ac.uk Emeritus Professor in Child Health, Academic Unit of Child Health, The Medical School, University of Nottingham, Derbyshire Children s Hospital, Derby, UK Antihistamines are a widely used group of medicines. As well as being prescribed, they are available over the counter in many countries. A recent study from France highlighted that each year almost one in three children will receive an antihistamine and that in children aged between two and five years, almost one in two children will receive an antihistamine [1]. The paper by Vries and Hunsel from the Netherlands highlights reported suspected adverse drug reactions (ADRs) to first and second generation systemic antihistamines[2]. Skin eruptions and ADRs involving the central nervous system (headache, somnolence, aggression, agitation, hyperactivity and seizures) were the most commonly reported ADRs to second generation antihistamines. These ADRs are also the ADRs most frequently associated with first generation antihistamines. Second generation antihistamines are thought to be associated with fewer side effects. Their findings do not suggest that we should stop using antihistamines in children. They do, however, highlight that medicines we consider to be safe do have side effects. We know that many side effects are not recognised as such by health professionals. As antihistamines are used for the treatment of allergic reactions, one needs to be aware that skin eruptions are the most commonly reported ADRs to antihistamines. The mechanism of the skin eruptions due to antihistamines is unknown. The fact that it occurs with a variety of antihistamines suggests that it is a risk with all antihistamines. If therefore any child receiving an antihistamine develops a fixed skin eruption, one needs to consider the possibility that the drug prescribed is responsible. How common are ADRs? 1
3 The majority of ADRs are not reported. Additionally, many ADRs are not recognised. It is therefore difficult to accurately state how common ADRs in children are. We know that one in ten children in hospital will experience ADRs [3]. The prevalence of ADRs in the community, however, is uncertain. We know that from a regional study in Cuba that at least one in 500 children will experience an ADR each year [3]. This figure however is likely to be an underestimate. Certain medicines are more likely to be associated with ADRs. Cytotoxic agents and antiepileptic drugs are commonly associated with ADRs. It is important to recognise however that widely used medicines that we consider safe may also be associated with ADRs. The risk benefit for each medicine needs to be carefully considered. Pharmaceutical company sponsored studies Second generation systemic antihistamines are marketed as being safer than first generation antihistamines. It was of interest that the pharmaceutical company studies of second generation antihistamines did not describe the ADRs documented by Vries and Hunsel. One of the studies actually reported convulsions in four children receiving levocetirizine.[4] However, the authors considered that the drug was not responsible. The bias associated with pharmaceutical company studies is well recognised in adults. This bias has been documented mainly in relation to effectiveness. [5]. It is also a problem in relation to toxicity. We are uncertain whether paediatric health professionals are aware of this bias to the same extent. Looking for ADRs Randomised controlled trials are rightly considered to be the best way of determining whether a drug is effective or not. They are not however the best way to evaluate drug toxicity. [3] Most clinical trials are not sufficiently powered to detect ADRs. Additionally, ADRs are usually poorly reported. Prospective cohort studies and national spontaneous reporting schemes for ADRs are more effective methods for detecting uncommon ADRs [3]. Health professionals have a responsibility to report suspected ADRs to the regulatory agencies. All drugs may result in ADRs Reporting new and serious suspected ADRs is essential to improve pharmacotherapy Stopping a medication may be as important as starting one Using medicines rationally One needs to recognise that all medicines may have ADRs. Additionally, one also needs to be aware that many medicines that are prescribed are not actually needed. There is growing recognition in elderly patients that many long term medications are not required. There are numerous tools that have been developed to assess whether medicines prescribed to the elderly are appropriate or not. Within paediatrics, only one such tool has been developed - the POPI [6]. This is an important area of research that has been neglected in paediatrics. The rational use of medicines is recognised as being 2
4 a major problem in low income countries but there is increasing awareness that it is also a problem in high income countries. One needs to ask the following questions before prescribing either a new medicine or repeating a prescription for an existing treatment. Is a medicine required? Is the medicine to be prescribed likely to be effective, in this age-group for this condition? What are the likely side-effects? What is the risk/benefit to this individual patient? How long is treatment required for? Ii is only by asking such questions that one will ensure that patients will receive the optimal treatment. Statement The Corresponding Author has the right to grant on behalf of all authors and does grant on behalf of all authors, an exclusive license (or non-exclusive for government employees) on a worldwide basis to the BMJ Group and co-owners or contracting owning societies (where published by the BMJ Group on their behalf), and its Licensees to permit this article (if accepted) to be published in Archives of Disease in Childhood and any other BMJ Group products and to exploit all subsidiary rights, as set out in our license. Acknowledgements Karel Allegaert was supported by the Fund for Scientific Research, Flanders (fundamental clinical investigatorship N) and facilitated by the agency for innovation by Science and Technology in Flanders (IWT, SAFEPEDRUG project IWT/SBO ). References 1. Drug us in French children: a population-based study. Bénard-Laribière A, Jové J, Lassalle R, et al. Arch Dis Child 2015; 100: Adverse drug reactions of systematic antihistamines in children in the Netherlands. de Vries TW, van Hunsel F. Arch Dis Child. Published online first: 18 th April doi: /archdischild Choonara I. Aspects of clinical pharmacology in children pharmacovigilance and safety. Eur J Pediatr 2013; 172: Simons FER on behalf of the Early Prevention of Asthma in Atopic Children (EPAAC) study group. Safety of levocetrizine treatment in young atopic children: an 18-month study. Pediatr Allergy Immunol 2007; 18: Lexchin J,Bero LA, Djulbegovic B, Clark O. Pharmaceutical industry sponsorship and research outcome and quality:systematic review. BMJ 2003; 326:1167 3
5 6. Prot-Labarthe S, Weil T, Angoulvant F, et al. POPI (Pediatrics: Omission of Prescriptions and Inappropriate prescriptions): development of a tool to identify inappropriate prescribing. PLoS One 2014; 9: e doi: /journal.pone
The Nottingham eprints service makes this work by researchers of the University of Nottingham available open access under the following conditions.
Tambe, Parag and Sammons, Helen M. and Choonara, Imti (2016) Child mortality of children aged 5-15 years in the UK and Sweden: a comparison. Archives of Disease in Childhood, 101 (4). pp. 409-410. ISSN
More informationChild mortality of children aged 5-15 years in the UK and Sweden: a comparison
Child mortality of children aged 5-15 years in the UK and Sweden: a comparison Parag Tambe, Helen M Sammons, Imti Choonara Academic Unit of Child Health, University of Nottingham, Derbyshire Children s
More informationThe Nottingham eprints service makes this work by researchers of the University of Nottingham available open access under the following conditions.
Hippisley-Cox, Julia and Coupland, Carol and Brindle, Peter (2017) Authors' response to letters on QRISK3 regarding the definition of severe mental illness and analysis of systolic blood pressure variability.
More informationMedicines regulation - National
Medicines regulation - National David Legge Savar, November 2018 (Several slides from Ken Harvey gratefully acknowledged) 1 National regulation Licensing of manufacturers and certification of foreign manufacture
More informationTrust the Original to help you turn it off.
Trust the Original to help you turn it off. Trust the Original to help you turn it off. Trust the Original to help you turn it off. Trust the Original to help you turn it off. Trust the Original to help
More informationNG80. Asthma: diagnosis, monitoring and chronic asthma management (NG80)
Asthma: diagnosis, monitoring and chronic asthma management (NG80) NG80 NICE has checked the use of its content in this product and the sponsor has had no influence on the content of this booklet. NICE
More informationFIP GUIDELINES Pharmaceutical Research in Paediatric Patients
Adopted by the FIP Council as an FIP statement of policy in Vienna in 2000, transformed to guidelines in 2014 FIP GUIDELINES Pharmaceutical Research in Paediatric Patients Introduction For many medicines,
More informationResponse to European Commission report on the Paediatric Regulation: consultation document
Response to European Commission report on the Paediatric Regulation: consultation document Introduction February 2017 1 The Nuffield Council on Bioethics is an independent UK body that examines and reports
More informationNEWSLETTER October The Pharmacovigilance Risk Assessment Committee July (PRAC) Meeting
The Pharmacovigilance Risk Assessment Committee (PRAC) Meeting 7-10 July 2014 Finalised safety procedure for methadone products containing povidone Only high molecular weight povidone was associated with
More informationBath, Philip M.W. and England, Timothy J. (2009) Thighlength compression stockings and DVT after stroke. Lancet. ISSN (In Press)
Bath, Philip M.W. and England, Timothy J. (2009) Thighlength compression stockings and DVT after stroke. Lancet. ISSN 0140-6736 (In Press) Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/1087/1/lancet_clots_1_20090522_4.pdf
More informationThis is a repository copy of Quadrupling or quintupling inhaled corticosteroid doses to prevent asthma exacerbations: The jury's still out.
This is a repository copy of Quadrupling or quintupling inhaled corticosteroid doses to prevent asthma exacerbations: The jury's still out. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/134388/
More informationCase study 2 Diacomit and severe myoclonic epilepsy in infancy*... Payer approval
* Summary Need SMEI affects 0.4 in every 10,000 people. We didn t find an estimate of the number of children with this rare form of epilepsy across the UK, but the estimated patient numbers are: 75 in
More informationAntigen Leukocyte Antibody Test
Antigen Leukocyte Antibody Test Policy Number: 2.01.93 Last Review: 4/2014 Origination: 4/2014 Next Review: 4/2015 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will not provide coverage for
More informationFrequently asked questions
13 February 2017 EMA/527628/2011 Rev. 1 Directorate This document provides answers to the most frequently asked questions received by the European Medicines Agency (EMA).If the answer to your question
More informationPackage leaflet: Information for the patient
Xyzal 5 mg/ml oral drops, solution Page 1 of 5 Package leaflet: Information for the patient Xyzal 5 mg/ml oral drops, solution For adults and children aged 2 years and above Levocetirizine dihydrochloride
More informationUCB announces first presentation of primary data from latest Phase 3 study evaluating brivaracetam
UCB announces first presentation of primary data from latest Phase 3 study evaluating brivaracetam as adjunctive treatment of partial-onset seizures in epilepsy Primary efficacy and safety data from the
More informationHET SAFE-PEDRUG PROJECT. Pauline De Bruyne Johan Vande Walle
DE WEG NAAR WERKZAME EN VEILIGE GENEESMIDDELEN VOOR KINDEREN: HET SAFE-PEDRUG PROJECT Pauline De Bruyne Johan Vande Walle CLINICAL CASE Boy, 9yrs old. Hypertension. Management: Reversible causes? Non pharmacological
More informationComposition: Each tablet contain. Levocetirizine. Each 5ml contains. Montelukast. Pharmacokinetic properties:
Composition: Each tablet contain Montelukast Levocetirizine 10mg 5mg Each 5ml contains Montelukast Levocetirizine 4mg 2.5mg Pharmacokinetic properties: Peak plasma concentrations of montelukast are achieved
More informationHigh prevalence of Primary Ciliary Dyskinesia in a British Asian population
High prevalence of Primary Ciliary Dyskinesia in a British Asian population Chris O Callaghan 1, Phil Chetcuti 2, Eduardo Moya 3 1. University of Leicester, Leicester, United Kingdom 2. Leeds General Infirmary,
More informationEHR Developer Code of Conduct Frequently Asked Questions
EHR Developer Code of Conduct Frequently Asked Questions General What is the purpose of the EHR Developer Code of Conduct? EHR Association (the Association) members have a long tradition of working with
More informationFluticasone inhalation and behavioural changes in children
Fluticasone inhalation and al changes in children Introduction Fluticasone (Flixotide ) is an inhalation corticosteroid available on the Dutch market since 1994. It is registered for the prophylactic treatment
More informationMethods in Pharmacovigilance
Methods in Pharmacovigilance Dr. Linda Härmark, PharmDepidemiologist Head Innovation, Netherlands Pharmacovigilance Centre Lareb How can you monitor the safety of drugs after registration? Post marketing
More informationTable A: Summary of FDA and European Commission Guidance for Industry for Adverse Drug Reaction reporting in product information documents
Table A: Summary of FDA and European Commission Guidance for Industry for Adverse Drug Reaction reporting in product information documents Food and Drug Administration. Guidance for Industry Adverse Reactions
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 23 May 2012
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 23 May 2012 OKIMUS, coated tablets B/2 blister strips of 20 tablets (CIP code: 363 666-1) Applicant: BIOCODEX Quinine
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 21 July 2010
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 21 July 2010 GRAZAX 75 000 SQ-T, oral lyophilisate B/30 (CIP: 378 011-6) B/100 (CIP code: 378 012-2) B/90 (CIP code:
More informationRole of Pharmacoepidemiology in Drug Evaluation
Role of Pharmacoepidemiology in Drug Evaluation Martin Wong MD, MPH School of Public Health and Primary Care Faculty of Medicine Chinese University of Hog Kong Outline of Content Introduction: what is
More informationThe Yellow Card scheme why are GPs under-reporting?
The Yellow Card scheme why are GPs under-reporting? Steve Chaplin MSc, MRPharmS Total number of reports 18000 16000 14000 12000 10000 8000 6000 The effectiveness of the Yellow Card scheme has been limited
More informationUSE OF UNLICENSED MEDICINES AND OFF-LABEL MEDICINES WHERE A LICENSED MEDICINE IS AVAILABLE
NHS Scotland Directors of Pharmacy and Scottish Association of Medical Directors USE OF UNLICENSED MEDICINES AND OFF-LABEL MEDICINES WHERE A LICENSED MEDICINE IS AVAILABLE CONSENSUS STATEMENT This consensus
More informationwarwick.ac.uk/lib-publications
Original citation: On behalf of the SAFE-TKR Study Group (Including: Gibbs, V., Price, A. and Wall, Peter D. H.). (2016) Surgical tourniquet use in total knee replacement surgery : a survey of BASK members.
More informationArticle: Min, T and Ford, AC (2016) Efficacy of mesalazine in IBS. Gut, 65 (1). pp ISSN
This is a repository copy of Efficacy of mesalazine in IBS. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/97338/ Version: Accepted Version Article: Min, T and Ford, AC (2016)
More informationResearch Topics. ENCePP Plenary Survey (April 2011) An agency of the European Union
Research Topics ENCePP Plenary Survey (April 2011) An agency of the European Union Q: Can you suggest any research topics that you would like to see included in public funding programmes? More than 40
More informationPART VI: SUMMARY OF THE RISK MANAGEMENT PLAN 2 RISKS ASSOCIATED WITH THE MEDICINE AND ACTIVITIES TO MINIMIZE OR FURTHER CHARACTERISE THE RISKS
PART VI: SUMMARY OF THE RISK MANAGEMENT PLAN Summary of risk management plan for Briviact This is a summary of the risk management plan (RMP) for Briviact. The RMP details important risks of Briviact,
More informationThe Nottingham eprints service makes this work by researchers of the University of Nottingham available open access under the following conditions.
Morriss, Richard and Mudigonda, Mohan and Bartlett, Peter and Chopra, Arun and Jones, Steven (2017) National survey of training of psychiatrists on advance directives to refuse treatment in relation to
More informationTITLE: SAFE USE OF MEDICINES IN ZANZIBAR A
Table of content Acknowledgements Introduction TITLE: SAFE USE OF MEDICINES IN ZANZIBAR A guide for health professionals in detecting and reporting adverse drug reaction. (Beautiful photograph tablets
More informationMethodological Framework and Tools for Cross-National comparisons of Drug Utilization Data
Methodological Framework and Tools for Cross-National comparisons of Drug Utilization Data Vander Stichele RH, MD, PhD Heymans Institute of Pharmacology, Ghent University, Belgium Summer School EACPT August
More informationAn overview of reports on lacosamide
An overview of reports on lacosamide Introduction Lacosamide (Vimpat ) was registered for the European market on August 29th 2008. Since then Lareb has received several reports of possible adverse drug
More informationArticle menu. Chronic cough postacute respiratory illness in children: a cohort study
1/5 This site uses cookies. More info Home / Online First Article info Article menu Original article Chronic cough postacute respiratory illness in children: a cohort study PDF Authors Kerry-Ann F O Grady
More informationSEDATION FOR SMALL PROCEDURES
SEDATION FOR SMALL PROCEDURES Sinno Simons Erasmus MC Sophia Children s Hospital Rotterdam, the Netherlands s.simons@erasmusmc.nl SEDATION in newborns How and when How to evaluate How to dose Why to use
More informationAnnex II. Scientific conclusions
Annex II Scientific conclusions 5 Scientific conclusions Beclometasone dipropionate (BDP) is a glucocorticoid and a prodrug of the active metabolite, beclometasone-17-monopropionate. Beclometasone dipropionate
More informationAdepu and Adusumilli: Drug-related Problems in Patients with Chronic Diseases in South India
Assessment of Drug-related Problems in Patients with Chronic Diseases through Health Status Survey in a South Indian Rural Community Setting R. ADEPU* AND P. K. ADUSUMILLI Department of Pharmacy Practice,
More informationThe Nottingham eprints service makes this work by researchers of the University of Nottingham available open access under the following conditions.
Naughton, Felix and Foster, Katharine and Emery, Jo and Cooper, Sue and Sutton, Stephen and Leonardi- Bee, Jo and Jones, Matthew and Ussher, Michael and Whitemore, Rachel and Leighton, Matthew and Montgomery,
More informationAdverse Events Following Immunisation
Adverse Events Following Immunisation (common, uncommon, shockin rare, and how do we know their likely cause?) Kevin Connolly Portiuncula Hospital, Sept. 18, 2017 Definitions Adverse Event (AE).. untoward
More informationDiscover the connection
Susan lives with daily rhinitis symptoms. Pollen House dust mites Timothy grass Underlying allergens affect rhinitis Discover the connection Specific IgE blood testing helps you identify allergic triggers,
More informationTrends in accessibility to medicines for children in New Zealand:
et al British Journal of Clinical Pharmacology DOI:10.1111/j.1365-2125.2004.02014.x Trends in accessibility to medicines for children in New Zealand: 1998 2002 Jocelyn Chui,1 June Tordoff,1 Julia Kennedy,
More informationAntigen Leukocyte Antibody Test. Description
Subject: Antigen Leukocyte Antibody Test Page: 1 of 6 Last Review Status/Date: June 2015 Antigen Leukocyte Antibody Test Description The Antigen Leukocyte Antibody Test (ALCAT) is intended to diagnose
More informationOriginal citation: Macdougall, Colin. (2009) Food intolerance in children (non-allergenic food hypersensitivity). Paediatrics and Child Health, Vol.19 (No.8). pp. 388-390. ISSN 1751-7222 Permanent WRAP
More informationSELF-ADMINISTERED MEDICATION AND EPINEPHRINE USE
COUNTY SCHOOLS 5330.02/page 1 of 7 REPLACEMENT POLICY - VOL. 8, NO. 2 SELF-ADMINISTERED MEDICATION AND EPINEPHRINE USE A student may carry and self-administer a metered dose inhaler, epinephrine auto injector,
More informationAccess from the University of Nottingham repository:
Coulson, Neil S. (2015) Exploring patients' engagement with web-based peer support for Inflammatory Bowel Disease: forums or Facebook? Health Psychology Update, 24 (2). pp. 3-9. ISSN 0954-2027 Access from
More informationCetirizine Proposed Core Safety Profile
Cetirizine Proposed Core Safety Profile Posology and method of administration Elderly subjects: data do not suggest that the dose needs to be reduced in elderly subjects provided that the renal function
More informationThe Pharmacovigilance of Complementary Medicines (CAMs) M. Dheda & S Banoo Civitas Building, Pretoria Feb 2014
The Pharmacovigilance of Complementary Medicines (CAMs) M. Dheda & S Banoo Civitas Building, Pretoria Feb 2014 Historical Perspective Thalidomide tragedy It was an effective tranquilizer & painkiller &
More informationMARKETING STANDARDS FOR MEMBERSHIP
MARKETING STANDARDS FOR MEMBERSHIP The Vapor Technology Association (VTA) is a leading national trade association in the electronic cigarette and vapor product industry. VTA represents the manufacturers,
More informationPharmacological interventions for children with Disruptive Behaviour Disorders or Conduct Disorder or Oppositional Defiant Disorder
updated 2012 Pharmacological interventions for children with Disruptive Behaviour Disorders or Conduct Disorder or Oppositional Defiant Disorder Q8: What is the effectiveness, safety and role of pharmacological
More informationPharmacoepidemiology in Finland Quo vadis?
Pharmacoepidemiology in Finland Quo vadis? Hannes Enlund, DSc, MPharm Head of Research Assessment of Pharmacotherapies Finnish Medicines Agency, Fimea Quo vadis? Wanderer, your footsteps are the road,
More informationWorkshop on Extrapolation and Evidence Synthesis in the Development and Therapeutic Use of Medicines in Children
Workshop on Extrapolation and Evidence Synthesis in the Development and Therapeutic Use of Medicines in Children Dr Oscar Della Pasqua WP 4 11th June 2013 Strathclyde University, Glasgow, UK Project AIMS
More informationAntigen Leukocyte Antibody Test
Antigen Leukocyte Antibody Test Policy Number: 2.01.93 Last Review: 4/2018 Origination: 4/2014 Next Review: 4/2019 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will not provide coverage for
More informationThe use of controller medications management of pediatric bronchial asthma -
Original Research Article The use of controller medications in the management of pediatric bronchial asthma - Dynamic patterns of LTRA Anna Todorova 1*, Antoaneta Tsvetkova 2, Silvia Mihaylova 2 1 Faculty
More informationThis is a repository copy of Benzodiazepines for Psychosis-Induced Aggression or Agitation.
This is a repository copy of Benzodiazepines for Psychosis-Induced Aggression or Agitation. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/135057/ Version: Published Version
More informationGuidance for Industry DRAFT GUIDANCE. This guidance document is being distributed for comment purposes only.
Compounded Drug Products That Are Essentially Copies of a Commercially Available Drug Product Under Section 503A of the Federal Food, Drug, and Cosmetic Act Guidance for Industry DRAFT GUIDANCE This guidance
More informationInactivated whole-cell (killed antigen) vaccines
Inactivated whole-cell (killed antigen) vaccines Inactivated vaccines are made from microorganisms (viruses, bacteria, other) that have been killed through physical or chemical processes. These killed
More informationPharmaceutical System in the UK
Pharmaceutical System in the UK David Kullman Medicines, i Pharmacy and Industry Group Department of Health PPRI Conference, Vienna 30 September 2011 Disclaimer Conflict of interest: Nothing to disclose
More informationPACKAGE LEAFLET: INFORMATION FOR THE USER. Variquel 1 mg powder and solvent for solution for injection Terlipressin acetate
PACKAGE LEAFLET: INFORMATION FOR THE USER Variquel 1 mg powder and solvent for solution for injection Terlipressin acetate Read all of this leaflet carefully before you start using this medicine because
More informationTGA: the current regulatory reform agenda
TGA: the current regulatory reform agenda ASMI 2012 Conference: 13 November 2012 Future proofing the consumer healthcare industry Dr John Skerritt, National Manager The Therapeutic Goods Administration
More informationDrug Development in Paediatric Oncology
Drug Development in Paediatric Oncology Koen Norga, MD, PhD Paediatric Oncology, UZA External clinical expert, FAMHP PDCO, vice-chair and member (BE), EMA CHMP, co-opted member (pharmacology), EMA Drug
More informationXYZAL 5 MG FILM-COATED TABLET
XYZAL 5 MG FILM-COATED TABLET Levocetirizine dihydrochloride Read all of this leaflet carefully because it contains important information for you. This medicine is available without prescription. However,
More informationLevocetirizine dihydrochloride
INSERT TEXT UAP Levocetirizine dihydrochloride Allerzet 5 mg Tablet Antihistamine FORMULATION Each film-coated tablet contains: Levocetirizine dihydrochloride.. 5 mg PRODUCT DESCRIPTION Levocetirine 5
More informationLECTOPAM PRODUCT MONOGRAPH. bromazepam. 3 mg and 6 mg Tablets. Anxiolytic - Sedative. Date of Revision: September 6, 2018
PRODUCT MONOGRAPH LECTOPAM bromazepam 3 mg and 6 mg Tablets Anxiolytic - Sedative Hoffmann-La Roche Limited 7070 Mississauga Road Mississauga, Ontario L5N 5M8 Date of Revision: September 6, 2018 www.rochecanada.com
More informationSummary details of suspected adverse reactions/events associated with the use of Gardasil 1st March st March 2015
Page 1 of 6 Adverse (s) Date Outcome 2014-019844 04/03/2014 13 Years Prophylaxis GARDASIL 04/12/2013 Nausea 04/12/2013 06/12/2013 Headache 04/12/2013 06/12/2013 Vomiting 04/12/2013 06/12/2013 Asthenia
More information4. The School is committed to the prevention of substance misuse through education and support. PROCEDURE
BISHOP WORDSWORTH S SCHOOL SUBSTANCE USE AND MISUSE POLICY Note: Parent(s) includes guardian(s) or any person who has parental responsibility for the boy or who has care of him. 1. General. This document
More informationSignal detection at Lareb
Signal detection at Lareb Presentation Halmed staff December 22, 2014 Dr. Linda Härmark, PharmD Head Innovation www.lareb.nl Outline Lareb as an organisation Signal detection in spontaneous reporting systems
More informationNon-Prescription Medicinal Products Containing Codeine: Guidance for Pharmacists on Safe Supply to Patients
Non-Prescription Medicinal Products Containing Codeine: Guidance for Pharmacists on Safe Supply to Patients Pharmaceutical Society of Ireland Version 3 October 2017 Updates made following the enactment
More informationHead : Momas Isabelle, EA 4064 UNIVERSITE PARIS DESCARTES ET MAIRIE DE PARIS CELLULE «COHORTE»
PARIS - Paris Cohort Head : Momas Isabelle, EA 4064 UNIVERSITE PARIS DESCARTES ET MAIRIE DE PARIS CELLULE «COHORTE» Last update : 08/01/2014 Version : 2 ID : 6942 General Identification Detailed name Sign
More informationImpact of Comorbidities on Self-Esteem of Children with Attention Deficit Hyperactivity Disorder
The International Journal of Indian Psychology ISSN 2348-5396 (e) ISSN: 2349-3429 (p) Volume 3, Issue 3, No.1, DIP: 18.01.011/20160303 ISBN: 978-1-365-03416-9 http://www.ijip.in April - June, 2016 Impact
More informationGlobal Pediatric Development: We Are Making Progress. PMDA Perspective. Junko Sato, PhD PMDA
Global Pediatric Development: We Are Making Progress PMDA Perspective Junko Sato, PhD PMDA Disclaimer The views and opinions expressed in the following PowerPoint slides are those of the individual presenter
More informationPSYCHOTROPIC MEDICATION UTILIZATION PARAMETERS FOR CHILDREN AND YOUTH IN FOSTER CARE
PSYCHOTROPIC MEDICATION UTILIZATION PARAMETERS FOR CHILDREN AND YOUTH IN FOSTER CARE Introduction and General Principles April 2017 Adapted for New Mexico from with permission from the Texas Department
More informationNot intended for UK based media. Merck Announces Detailed 26-Week Results from Phase IIIb Study with Kuvan in children with PKU below 4 years of age
Your Contact News Release Bettina Frank Phone +49 6151 72-4660 Not intended for UK based media Merck Announces Detailed 26-Week Results from Phase IIIb Study with Kuvan in children with PKU below 4 years
More informationAsthma control not associated with vitamin D deficiency: A single-center retrospective study in Saudi Arabia.
Curr Pediatr Res 2016; 20 (1&2): 164-168 ISSN 0971-9032 www.currentpediatrics.com Asthma control not associated with vitamin D deficiency: A single-center retrospective study in Saudi Arabia. Rawia Albar
More informationDRAFT. Consultees are asked to consider and comment on the CEPP National Audit: Antipsychotics in Dementia document.
Enclosure No: Agenda item No: Author: Contact: xx/xxxxx/xxxx0918 xx CEPP National Audit: Antipsychotics in Dementia All Wales Therapeutics and Toxicology Centre Tel: 02920 71 6900 awttc@wales.nhs.uk 1.0
More informationUsing medicines beyond licence
Using medicines beyond licence Information for patients Prepared on behalf of the Association for Palliative Medicine and the British Pain Society. November 2005 To be reviewed in November 2008. Copyright:
More informationPackage leaflet: Information for the patient
Page 1 of 5 Package leaflet: Information for the patient Xyzal 5 mg/ml oral drops, solution For adults and children aged 2 years and above Levocetirizine dihydrochloride Read all of this leaflet carefully
More informationThis is a repository copy of Early deaths from ischaemic heart disease in childhood-onset type 1 diabetes.
This is a repository copy of Early deaths from ischaemic heart disease in childhood-onset type 1 diabetes. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/127074/ Version:
More informationUses and misuses of the STROBE statement: bibliographic study
Uses and misuses of the STROBE statement: bibliographic study Bruno R. da Costa 1, Myriam Cevallos 1, 2, Douglas G. Altman 3, Anne W.S. Rutjes 1, Matthias Egger 1 1. Institute of Social & Preventive Medicine
More informationClinical Evidence in the Daily Work of an Anthroposophic Hospital Dr. med. Harald Matthes, Medical Director, Havelhöhe Hospital in Berlin
Programme Venue: Time: Chair: Presentations: Members Salon, European Parliament 8:00 9:30 am Marian Harkin MEP Research Evidence in Homeopathy: Overview of published clinical investigations Robert Mathie
More informationDocument ref. no: Trust Policy and Procedure. PP(16)234 Prescribing, Dispensing and Administration of Methotrexate Policy
Document ref. no: Trust Policy and Procedure PP(16)234 Prescribing, Dispensing and Administration of Methotrexate Policy For use in: For use by: For use for: Document owner: Status: All Clinical Areas
More informationCME/CE POSTTEST CME/CE QUESTIONS
CME/CE POSTTEST CME/CE QUESTIONS Controlling Asthma Severity: Identifying Unmet Needs and Optimizing Therapeutic Options There are no fees for participating in and receiving continuing medical education
More informationAn Update on Allergic Rhinitis. Mike Levin Division of Asthma and Allergy Department of Paediatrics University of Cape Town Red Cross Hospital
An Update on Allergic Rhinitis Mike Levin Division of Asthma and Allergy Department of Paediatrics University of Cape Town Red Cross Hospital Allergic Rhinitis Common condition with increasing prevalence
More informationIs it allergy? Debbie Shipley
Is it allergy? Debbie Shipley Topics Food Allergy and Eczema Hand Eczema and Patch Testing Urticaria Tackling Allergy Gell and Coombs classification Skin conditions with possible allergic component Allergy
More informationParental antibiotics and childhood asthma : a population-based study. Örtqvist, A.K.; Lundholma, C.; Fang, F.; Fall, T.; Almqvist, C.
This is an author produced version of a paper accepted by Journal of Allergy and Clinical Immunology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal
More informationSUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE MEDICINAL PRODUCT 2 QUALITATIVE AND QUANTITATIVE COMPOSITION
SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE MEDICINAL PRODUCT Zaditen 0.25 mg/ml, eye drops, solution 2 QUALITATIVE AND QUANTITATIVE COMPOSITION One ml contains 0.345 mg ketotifen fumarate corresponding
More informationPOISONS SCHEDULING. Monique Reyes Senior Pharmaceutical Officer Pharmaceutical Regulatory Unit NSW Ministry of Health
POISONS SCHEDULING Monique Reyes Senior Pharmaceutical Officer Pharmaceutical Regulatory Unit NSW Ministry of Health Topics Schedules of the Poisons Standard (Cth) Poisons and Therapeutic Goods Act 1966
More informationIssue: March 2016 PROFESSIONAL STANDARDS AND GUIDANCE FOR ADVERTISING MEDICINES AND PROFESSIONAL SERVICES
Issue: March 2016 PROFESSIONAL STANDARDS AND GUIDANCE FOR ADVERTISING MEDICINES AND PROFESSIONAL SERVICES PROFESSIONAL STANDARDS AND GUIDANCE FOR ADVERTISING MEDICINES AND PROFESSIONAL SERVICES CONTENTS
More informationJ. Indian Assoc. Child Adolesc. Ment. Health 2014; 10(3): Editorial
145 J. Indian Assoc. Child Adolesc. Ment. Health 2014; 10(3):145-149 Editorial Is ADHD being over diagnosed? An Indian perspective Vivek Agarwal MD, Sujit Kar MD Address for correspondence: Dr. Vivek Agarwal,
More informationRef: E 007. PGEU Response. Consultation on measures for improving the recognition of medical prescriptions issued in another Member State
Ref:11.11.24E 007 PGEU Response Consultation on measures for improving the recognition of medical prescriptions issued in another Member State PGEU The Pharmaceutical Group of the European Union (PGEU)
More informationThe International Person Centred Values Practice Network for Dementia Care
The International Person Centred Values Practice Network for Dementia Care By delivering skilled care we can prevent the excess disabilities, distress and harm caused by poor quality care. Getting this
More informationChapter 6 PHARMACOVIGELANCE. M.G.Rajanandh, Department of Pharmacy Practice, SRM College of Pharmacy, SRM University.
Chapter 6 PHARMACOVIGELANCE M.G.Rajanandh, Department of Pharmacy Practice, SRM College of Pharmacy, SRM University. DEFENITION: Pharmacovigilance (abbreviated PV or PhV) is the Pharmacological science
More information25 th Anniversary of the European Society for Developmental Perinatal and Paediatric Pharmacology
25 th Anniversary of the European Society for Developmental Perinatal and Paediatric Pharmacology 1988-2013 A short report to Pharmacology International, the semi-annual newsletter of the International
More informationUpdate to Product Monograph
Dear Healthcare Professional, July 2012 Please be informed that the AZILECT Product Monograph has been updated. The monograph format is in line with the new Product Monograph template Updated Contraindications
More informationScottish Medicines Consortium
Scottish Medicines Consortium levetiracetam, 250, 500, 750 and 1000mg tablets and levetiracetam oral solution 100mg/ml (Keppra ) No. (394/07) UCB Pharma Limited 10 August 2007 The Scottish Medicines Consortium
More information# BMJ entitled " Complete the antibiotic course to avoid resistance ; non-evidence-based dogma which has run its course?
Dear Dr. Llewelyn # BMJ.2017.037542 entitled " Complete the antibiotic course to avoid resistance ; non-evidence-based dogma which has run its course?" Thank you for sending us this paper and giving us
More informationIN THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF COLUMBIA
IN THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF COLUMBIA UNITED STATES OF AMERICA v. CRIMINAL NO. UCB, INC., Defendant. VIOLATION 21 U.S.C. 331(k), 352(f)(1), and 333(a)(1) (Causing drugs to be
More information