GIVE THEM A DROP THAT LASTS Proven effective through 16 hours1-3

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FOR PATIENTS WITH ITCHING DUE TO ALLERGIC CONJUNCTIVITIS INDICATIONS AND USAGE

25% is an H1 histamine receptor antagonist indicated for the prevention of itching

IMPORTANT SAFETY INFORMATION To minimize contaminating the dropper tip and solution,

tip of the bottle. Keep bottle tightly closed when not in use.

1 FOR PATIENTS WITH ITCHING DUE TO ALLERGIC CONJUNCTIVITIS INDICATIONS AND USAGE LASTACAFT (alcaftadine ophthalmic solution) 0.25% is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. IMPORTANT SAFETY INFORMATION To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use. LASTACAFT should not be used to treat contact lens-related irritation. Please see additional Important Safety Information inside. GIVE THEM A DROP THAT LASTS Proven effective through 16 hours1-3

2 For patients with itching due to allergic conjunctivitis DURATION OF LASTACAFT (alcaftadine ophthalmic solution) 0.25% PROVEN VS PATADAY AND PLACEBO Statistically Significant Results Shown Across 2 Trials 16 Hours Post Dosing (3 minutes post CAC) 4 Once-daily dosing 1 a Study Design and Methodology These 2 trials were phase 4, multicenter, double-masked, randomized, active- and placebo-controlled studies. In one study, 157 subjects were randomized to receive LASTACAFT (alcaftadine ophthalmic solution) 0.25% bilaterally (n = 53), Pataday bilaterally (n = 52), or placebo bilaterally (n = 52). In a second study, 127 subjects were randomized to receive LASTACAFT ophthalmic solution bilaterally (n = 43), Pataday bilaterally (n = 43), or placebo bilaterally (n = 41). Each trial included subjects 10 years of age in the intent-to-treat population. The Conjunctival Allergen Challenge (CAC) model was used to compare the duration of action for LASTACAFT, Pataday, and placebo at 16 hours post dosing. The trials were approximately 6 weeks and 5 weeks, respectively, and each subject received 1 dose of LASTACAFT (alcaftadine ophthalmic solution) 0.25%, Pataday, or placebo at visit 3. 4,5 The CAC was conducted 16 hours post dosing of study treatments, and the results shown were obtained 3 minutes post CAC. The main efficacy end point was ocular itching evaluated by the subject at 3 minutes post CAC at visit 3. Ratings were made on a scale of 0 to 4 (allowing half-unit increments), where 0 = none and 4 = an incapacitating itch with an irresistible urge to rub. 4,5 16 Hours Post Dosing (3 minutes post CAC) 5 b To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use. LASTACAFT (alcaftadine ophthalmic solution) 0.25% should not be used to treat contact lens-related irritation. Remove contact lenses prior to instillation of LASTACAFT. The preservative in LASTACAFT, benzalkonium chloride, may be absorbed by soft contact lenses. Lenses may be reinserted after 10 minutes following administration of LASTACAFT. The most frequent ocular adverse reactions, occurring in < 4% of LASTACAFT (alcaftadine ophthalmic solution) 0.25% treated eyes, were eye irritation, burning and/or stinging upon instillation, eye redness, and eye pruritus. The most frequent non-ocular adverse reactions, occurring in < 3% of subjects with LASTACAFT treated eyes, were nasopharyngitis, headache, and influenza. Some of these events were similar to the underlying disease being studied.

For patients with itching due to allergic conjunctivitis PRESCRIBE A FULL DAY OF EFFICACY Once-daily dosing 1 Works Fast at 3 Minutes 2,3 a Study Design and Methodology All clinical efficacy trials

The Conjunctival Allergen Challenge (CAC) model was used in all 3 studies to test the effect of LASTACAFT (alcaftadine ophthalmic solution) 0.25% at onset and duration of action.

6 At visit 3, the CAC was conducted 16 hours post dosing of LASTACAFT (alcaftadine ophthalmic solution) 0.25% or vehicle, and the results shown were obtained 3 minutes post CAC.

The main study end point was ocular itching evaluated by the patient at 3 minutes post CAC at visits 3 and 4.

2,3,6 Lasts All Day Through 16 Hours 2,3 b To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the

3 For patients with itching due to allergic conjunctivitis PRESCRIBE A FULL DAY OF EFFICACY Once-daily dosing 1 Works Fast at 3 Minutes 2,3 a Study Design and Methodology All clinical efficacy trials were phase 3, double-masked, randomized, vehicle-controlled studies. These 3 trials included 274 patients 10 years of age in the intent-to-treat population. The Conjunctival Allergen Challenge (CAC) model was used in all 3 studies to test the effect of LASTACAFT (alcaftadine ophthalmic solution) 0.25% at onset and duration of action. Each study included 4 visits over approximately 5 weeks, and each patient received a total of 2 doses of LASTACAFT ophthalmic solution or vehicle. 6 At visit 3, the CAC was conducted 16 hours post dosing of LASTACAFT (alcaftadine ophthalmic solution) 0.25% or vehicle, and the results shown were obtained 3 minutes post CAC. At visit 4, the CAC was conducted 15 minutes post dosing of LASTACAFT ophthalmic solution or vehicle, and the results shown were obtained 3 minutes post CAC. The main study end point was ocular itching evaluated by the patient at 3 minutes post CAC at visits 3 and 4. Ratings were made on a scale of 0 to 4 (allowing half-unit increments), where 0 = none and 4 = an incapacitating itch with an irresistible urge to rub. 2,3,6 Lasts All Day Through 16 Hours 2,3 b To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use. LASTACAFT (alcaftadine ophthalmic solution) 0.25% should not be used to treat contact lens-related irritation. Remove contact lenses prior to instillation of LASTACAFT. The preservative in LASTACAFT, benzalkonium chloride, may be absorbed by soft contact lenses. Lenses may be reinserted after 10 minutes following administration of LASTACAFT. The most frequent ocular adverse reactions, occurring in < 4% of LASTACAFT (alcaftadine ophthalmic solution) 0.25% treated eyes, were eye irritation, burning and/or stinging upon instillation, eye redness, and eye pruritus. The most frequent non-ocular adverse reactions, occurring in < 3% of subjects with LASTACAFT treated eyes, were nasopharyngitis, headache, and influenza. Some of these events were similar to the underlying disease being studied.

USE IN SPECIFIC POPULATIONS Classified as a Pregnancy Category B product 1 FDA approved for use in patients as young as 2 years of age 1 Visit Lastacaft.

25% is an H 1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis.

dropper tip of the bottle. Keep bottle tightly closed when not in use. LASTACAFT should not be used to treat contact lensrelated irritation.

4 USE IN SPECIFIC POPULATIONS Classified as a Pregnancy Category B product 1 FDA approved for use in patients as young as 2 years of age 1 Visit Lastacaft.com for the latest savings offers for eligible patients INDICATIONS AND USAGE LASTACAFT (alcaftadine ophthalmic solution) 0.25% is an H 1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. IMPORTANT SAFETY INFORMATION To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use. LASTACAFT should not be used to treat contact lensrelated irritation. Remove contact lenses prior to instillation of LASTACAFT (alcaftadine ophthalmic solution) 0.25%. The preservative in LASTACAFT, benzalkonium chloride, may be absorbed by soft contact lenses. Lenses may be reinserted after 10 minutes following administration of LASTACAFT.

DO YOU WANT ALL-DAY ITCHY-EYE ALLERGY RELIEF? Just one LASTACAFT (alcaftadine ophthalmic solution) 0.

1 LASTACAFT ophthalmic solution is approved to prevent itching due to eye allergies 1 LASTACAFT works fast at 3 minutes and prevents itchy eyes

INDICATIONS AND USAGE LASTACAFT (alcaftadine ophthalmic solution) 0.

IMPORTANT SAFETY INFORMATION To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding

LASTACAFT should not be used to treat contact lens-related irritation.

5 DO YOU WANT ALL-DAY ITCHY-EYE ALLERGY RELIEF? Just one LASTACAFT (alcaftadine ophthalmic solution) 0.25% drop, once a day, helps prevent eyes from itching due to eye allergies all day (through 16 hours). 1 LASTACAFT ophthalmic solution is approved to prevent itching due to eye allergies 1 LASTACAFT works fast at 3 minutes and prevents itchy eyes all day through 16 hours 1 LASTACAFT ophthalmic solution was also evaluated for safety in a separate clinical study of 909 patients over 6 weeks 1 INDICATIONS AND USAGE LASTACAFT (alcaftadine ophthalmic solution) 0.25% is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. IMPORTANT SAFETY INFORMATION To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use. LASTACAFT should not be used to treat contact lens-related irritation. o The most common eye-related side effects that were reported in less than 4% of LASTACAFT treated eyes were: eye irritation, burning and/or stinging in the eyes after use, eye redness, and eye itching 1 o The most common non eyerelated side effects that were reported in less than 3% of patients with LASTACAFT treated eyes were: inflammation of the nose and the upper part of the throat, headache, and the flu 1 Please see additional Important Safety Information on next page.

Common allergens associated with eye allergies 7

ragweed Pollen from trees and grasses Dust mites Cat

com for the latest savings offers (continued) Remove

(alcaftadine ophthalmic solution) 0.25%.

< 4% of LASTACAFT treated eyes, were eye irritation,

6 Common allergens associated with eye allergies 7 Seasonal allergens Year-round allergens Pollen from ragweed Pollen from trees and grasses Dust mites Cat dander Visit Lastacaft.com for the latest savings offers (continued) Remove contact lenses prior to instillation of LASTACAFT (alcaftadine ophthalmic solution) 0.25%. The preservative in LASTACAFT, benzalkonium chloride, may be absorbed by soft contact lenses. Lenses may be reinserted after 10 minutes following administration of LASTACAFT. The most frequent ocular adverse reactions, occurring in < 4% of LASTACAFT treated eyes, were eye irritation, burning and/or stinging upon instillation, eye redness, and eye pruritus. The most frequent non-ocular adverse reactions, occurring in < 3% of subjects with LASTACAFT treated eyes, were nasopharyngitis, headache, and influenza. Some of these events were similar to the underlying disease being studied.

25% treated eyes, were eye irritation, burning and/or stinging upon instillation, eye redness, and eye pruritus.

7 PRESCRIBED FOR OVER PATIENTS 8, * Visit Lastacaft.com to learn about current savings offers for eligible patients The most frequent ocular adverse reactions, occurring in < 4% of LASTACAFT (alcaftadine ophthalmic solution) 0.25% treated eyes, were eye irritation, burning and/or stinging upon instillation, eye redness, and eye pruritus. The most frequent non-ocular adverse reactions, occurring in < 3% of subjects with LASTACAFT (alcaftadine ophthalmic solution) 0.25% treated eyes, were nasopharyngitis, headache, and influenza. Some of these events were similar to the underlying disease being studied. *Based on IMS Health, Inc., Total Patient Tracker data from March 2011 January Projected patient count was calculated using estimated total prescription counts via national audits and total prescription and patient counts from source-collected data. 1. LASTACAFT Prescribing Information. 2. Torkildsen G, Shedden A. The safety and efficacy of alcaftadine 0.25% ophthalmic solution for the prevention of itching associated with allergic conjunctivitis. Curr Med Res Opin. 2011;27(3): Data on file, Allergan, Inc., Data on file, Allergan, Inc., Data on file, Allergan, Inc., Data on file, Allergan, Inc., Bielory L. Ocular allergy. Mt Sinai J Med. 2011;78(5): IMS Health, Inc. Total Patient Tracker. Plymouth Meeting, PA: IMS Health, Inc.; October 25, Allergan, Inc., Irvine, CA marks owned by Allergan, Inc. Pataday is a registered trademark owned by Novartis AG. APC62OV

CONTRAINDICATIONS None.

CONTRAINDICATIONS None. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use PAZEO safely and effectively. See full prescribing information for PAZEO. PAZEO (olopatadine hydrochloride