Particularly Hazardous Substances

Transcription

1 The Minors in Research Laboratories Policy P66 prohibits Minors aged 4 5 years old and restricts 6 8 years old from working with Particularly ous Substances. This information and examples will help you determine which chemicals are in the class besides the obvious chemicals such as arsenic and cyanides. Acutely toxic chemicals are defined as having an LD 50 oral 50 or LD 50 contact 200 or LC 50 inhalation 200 ppm. New GHS Category: Acute Toxicity, Category and 2; signal word DANGER; symbol Skull & Crossbones. Carcinogen Any substance that is regulated by OSHA as a, or is listed under the category known to be s in the Annual Report on Carcinogens published by the National Toxicology Program () or is listed under Group ic to s, Group 2A or 2B reasonably to be s by the International Agency for Research on Cancer Monographs (IARC). The current and IARC lists can be found on the NIOSH web page Occupational Cancer : Reproductive hazard (mutagen or teratogen) Reproductive toxicity includes adverse effects on sexual function and fertility in adult males and females, as well as adverse effects on development of the offspring. The chemical can be considered a Particularly ous Substance if it has a: NFPA Health Rating of 4 (Very short exposure could cause death or serious residual injury even though prompt medical attention was given) or 3 (Short exposure could cause serious temporary or residual injury even though prompt medical attention was given). Blue stripe on the label (Health. Toxic if inhaled, ingested, or absorbed through skin. Store in secure area.) DOT Class of 6. ( Title 49 CFR 72.0 Table List of ous Materials) EPA P waste code ( The Material Safety Data Sheet (MSDS) is the best source for finding this information. Always review the MSDS before beginning work with chemicals. Minors must attach a copy of the MSDSs with their Risk Assessment/SOP Protocol. These documents can be used to develop the safety protocol: Assessment and SOP Template & Risk Evaluation Matrix

2 Here are some examples of Particularly ous Substances. There are many other chemicals used in laboratories that meet the definition of Particularly ous Substances. Acrylamide Oral (rat): 24 4 h >,500 (rat): 400 Acrylonitrile (Vinyl cyanide) 07 3 Oral (rat): 78 4 h 333 ppm (rabbit): 63 Barium chloride Oral (rat): 8 H30 + H3 Toxic if swallowed H37 May cause an allergic skin H39 Causes serious eye irritation. H332 Harmful if inhaled. H340 May cause genetic defects. H350 May cause H36 Suspected of damaging fertility or the unborn child. H30 Toxic if swallowed. H30 + H330 Fatal in contact H38 Causes serious eye H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H350 May cause H37 May cause damage to organs. IARC 2A Yes 0.3 mg/cu m Skin 6. U077 Blue Yes 2 ppm 6., 3 U009 No Yes 0.5 mg/cu m 6. D005 Blue Source: Sigma and Fisher MSDS

3 Caffeine Oral (rat): 92 Capsaicin Oral (rat) male: 6.2 Oral (rat) female: 48. (mouse): > 52 Carbon tetrachloride Oral (rat): 2,350 4 h 8000 ppm (rabbit): > 20,000 H30 Toxic if swallowed. No No None 6. Blue H30 + H3 Toxic if swallowed H37 May cause an allergic skin H38 Causes serious eye H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 May cause respiratory irritation. H30 + H3 Toxic if swallowed H36 Causes mild skin irritation. H320 Causes eye irritation. H33 Toxic if inhaled. H35 Suspected of causing H372 Causes damage to organs through prolonged or repeated exposure if inhaled. No No data None 6. No data 2 ppm 6. U2

4 Chloroform Oral (rat): h 47,702 (rabbit): > 20,000 Ethidium bromide Oral (rat):,503 2,77 h.8 34 mg/l Formaldehyde Oral (rat): mg/l 4 h H39 Causes serious eye irritation. H35 Suspected of causing H373 May cause damage to organs through prolonged or repeated exposure. H330 Fatal if inhaled. H34 Suspected of causing genetic defects. H30 + H3 Toxic if swallowed H37 May cause an allergic skin H38 Causes serious eye H33 Toxic if inhaled. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H35 Suspected of causing H370 Causes damage to organs. No data 2 ppm 6. U044 Blue No Yes 6. Blue IARC Anticipated Human Carcinogen OSHA Yes 0.75 ppm 3, 8 U22 Red (37%) Blue (0%)

5 2 Mercaptoethanol Oral (rat): 244 Oral (rat): h 625 ppm Mercuric chloride (Mercury(II) chloride) Methylene chloride (Dichloromethane) (rat): Oral (rat):,600 52,000 Nicotine 54 5 Oral (rat): 50 (rabbit): 50 H30 Toxic if swallowed. H30 + H330 Fatal in contact H37 May cause an allergic skin H38 Causes serious eye H300 + H30 Fatal if swallowed H34 Causes severe skin burns and eye H36 Suspected of damaging fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure. H35 + H320 Causes skin and eye irritation. H35 Suspected of causing H300 + H30 Fatal if swallowed No No data None 6. Blue No Yes 6. Blue OSHA No data 50 ppm 6. U080 Blue No Yes 0.5 mg/cu m, skin 6. P075 Blue

6 Nicotine tartrate Oral (rat): 65 Nitric oxide h,068 4 Nitrophenol Oral (rat): (rat):,024 Phenol Oral (rat): Oral (rat): h 900 (rabbit): Sodium azide Oral (rat): (rabbit): 20 H300 + H30 Fatal if swallowed H330 Fatal if inhaled. H30 Toxic if swallowed. H32 + H332 Harmful in contact H3 + H33 Toxic in contact H34 Causes severe skin burns and eye H34 Suspected of causing genetic defects. H37 May cause damage to organs. H373 May cause damage to organs through prolonged or repeated exposure. H300 + H30 Fatal if swallowed No Yes 0.5 mg/cu m, skin 6. P075 Blue No No 25 ppm 2.3 P076 No No data 6. U70 Blue No Yes 5 ppm 6. U88 White No No data 0. ppm skin 6. P05 Blue